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Fusion gene ID: 41726 |
FusionGeneSummary for WARS2_RPF1 |
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Fusion gene information | Fusion gene name: WARS2_RPF1 | Fusion gene ID: 41726 | Hgene | Tgene | Gene symbol | WARS2 | RPF1 | Gene ID | 10352 | 80135 |
Gene name | tryptophanyl tRNA synthetase 2, mitochondrial | ribosome production factor 1 homolog | |
Synonyms | NEMMLAS|TrpRS | BXDC5 | |
Cytomap | 1p12 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tryptophan--tRNA ligase, mitochondrial(Mt)TrpRStryptophan tRNA ligase 2, mitochondrial | ribosome production factor 12310066N05RikRNA processing factor 1 (RPF1)brix domain containing 5brix domain-containing protein 5ribosome biogenesis protein RPF1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UGM6 | Q9H9Y2 | |
Ensembl transtripts involved in fusion gene | ENST00000369426, ENST00000235521, ENST00000537870, ENST00000497761, | ENST00000370656, ENST00000370654, | |
Fusion gene scores | * DoF score | 12 X 5 X 10=600 | 2 X 2 X 2=8 |
# samples | 12 | 4 | |
** MAII score | log2(12/600*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/8*10)=2.32192809488736 | |
Context | PubMed: WARS2 [Title/Abstract] AND RPF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | DLBC | TCGA-GR-7353-01A | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000369426 | ENST00000370656 | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
5CDS-intron | ENST00000369426 | ENST00000370654 | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
5CDS-intron | ENST00000235521 | ENST00000370656 | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
5CDS-intron | ENST00000235521 | ENST00000370654 | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
intron-intron | ENST00000537870 | ENST00000370656 | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
intron-intron | ENST00000537870 | ENST00000370654 | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
5UTR-intron | ENST00000497761 | ENST00000370656 | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
5UTR-intron | ENST00000497761 | ENST00000370654 | WARS2 | chr1 | 119683178 | - | RPF1 | chr1 | 84961565 | + |
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FusionProtFeatures for WARS2_RPF1 |
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Hgene | Tgene |
WARS2 | RPF1 |
Mitochondrial aminoacyl-tRNA synthetase that activateand transfer the amino acids to their corresponding tRNAs duringthe translation of mitochondrial genes and protein synthesis.{ECO:0000305|PubMed:28650581}. | May be required for ribosome biogenesis.{ECO:0000269|PubMed:11864606}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for WARS2_RPF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for WARS2_RPF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
WARS2 | APP, RMND5A | RPF1 | KRTAP10-7, NOL12, RPL14, NIFK, NPM1, ZC3H3, KIAA0020, RPF2, RPL5, KRAS, IFI16, C10orf12, EGFR, MAK16, ZNF324, WDR74, ZNF324B, RPL26L1, CNBP, ZNF460, ZNF689, MAGEB10, RRP8, ZNF512, RPL30, E4F1, RPL18A, ZBTB11, RPL37A, H2AFY2, RPS16, SART3, ZCRB1, STAU2, UPF1, MRPS5, RPS6, FOXA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for WARS2_RPF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | WARS2 | Q9UGM6 | DB00150 | L-Tryptophan | Tryptophan--tRNA ligase, mitochondrial | small molecule | approved|nutraceutical|withdrawn |
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RelatedDiseases for WARS2_RPF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |