FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 41701

FusionGeneSummary for VWCE_SH3D19

check button Fusion gene summary
Fusion gene informationFusion gene name: VWCE_SH3D19
Fusion gene ID: 41701
HgeneTgene
Gene symbol

VWCE

SH3D19

Gene ID

220001

152503

Gene namevon Willebrand factor C and EGF domainsSH3 domain containing 19
SynonymsURG11|VWC1EBP|EVE1|Eve-1|Kryn|SH3P19
Cytomap

11q12.2

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionvon Willebrand factor C and EGF domain-containing proteinHBV X protein up-regulated gene 11 proteinHBxAg up-regulated gene 11 proteinSH3 domain-containing protein 19ADAM-binding protein Eve-1EEN-binding proteinSH3 domain protein D19
Modification date2018051920180522
UniProtAcc

Q96DN2

Q5HYK7

Ensembl transtripts involved in fusion geneENST00000335613, ENST00000535710, 
ENST00000409598, ENST00000424281, 
ENST00000304527, ENST00000455740, 
ENST00000409252, ENST00000514152, 
ENST00000427414, ENST00000604030, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 8 X 8=384
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/384*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VWCE [Title/Abstract] AND SH3D19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-X6-A7WC-01AVWCEchr11

61048096

-SH3D19chr4

152098107

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000335613ENST00000409598VWCEchr11

61048096

-SH3D19chr4

152098107

-
5CDS-5UTRENST00000335613ENST00000424281VWCEchr11

61048096

-SH3D19chr4

152098107

-
5CDS-5UTRENST00000335613ENST00000304527VWCEchr11

61048096

-SH3D19chr4

152098107

-
5CDS-5UTRENST00000335613ENST00000455740VWCEchr11

61048096

-SH3D19chr4

152098107

-
5CDS-5UTRENST00000335613ENST00000409252VWCEchr11

61048096

-SH3D19chr4

152098107

-
5CDS-5UTRENST00000335613ENST00000514152VWCEchr11

61048096

-SH3D19chr4

152098107

-
5CDS-intronENST00000335613ENST00000427414VWCEchr11

61048096

-SH3D19chr4

152098107

-
5CDS-5UTRENST00000335613ENST00000604030VWCEchr11

61048096

-SH3D19chr4

152098107

-
intron-5UTRENST00000535710ENST00000409598VWCEchr11

61048096

-SH3D19chr4

152098107

-
intron-5UTRENST00000535710ENST00000424281VWCEchr11

61048096

-SH3D19chr4

152098107

-
intron-5UTRENST00000535710ENST00000304527VWCEchr11

61048096

-SH3D19chr4

152098107

-
intron-5UTRENST00000535710ENST00000455740VWCEchr11

61048096

-SH3D19chr4

152098107

-
intron-5UTRENST00000535710ENST00000409252VWCEchr11

61048096

-SH3D19chr4

152098107

-
intron-5UTRENST00000535710ENST00000514152VWCEchr11

61048096

-SH3D19chr4

152098107

-
intron-intronENST00000535710ENST00000427414VWCEchr11

61048096

-SH3D19chr4

152098107

-
intron-5UTRENST00000535710ENST00000604030VWCEchr11

61048096

-SH3D19chr4

152098107

-

Top

FusionProtFeatures for VWCE_SH3D19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VWCE

Q96DN2

SH3D19

Q5HYK7

May be a regulatory element in the beta-cateninsignaling pathway and a target for chemoprevention ofhapatocellular carcinoma. {ECO:0000269|PubMed:16496348}. May play a role in regulating A disintegrin andmetalloproteases (ADAMs) in the signaling of EGFR-ligand shedding.May be involved in suppression of Ras-induced cellulartransformation and Ras-mediated activation of ELK1. Plays a rolein the regulation of cell morphology and cytoskeletalorganization. {ECO:0000269|PubMed:14551139,ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for VWCE_SH3D19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for VWCE_SH3D19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VWCEMUS81, HSPA1A, ZNF444, ZNF747, ZNF669, ZNF764, KPTN, ZNF664, ITFG2, ZNF627, ZNF620, FIZ1, ZNF77, TTLL5, ZSCAN21, ZNF74, ZNF302, CILP2, ZNF460, ZBTB9, ZNF8, EGFL7, ZNF696, ZNF358, ZBTB33, ZNF316, COL26A1, HLA-DPA1, ZNF146, CBX4, ZNF324, CERK, LTBP1, E4F1, ZKSCAN1, POLRMT, SQSTM1, PIGA, ZNF430, HLA-DPB1, POMT2, TIMP3, EMILIN3, CTU1, NUFIP2, RPUSD4, POMT1, ZNHIT6, HSPA5, TMEM160, TSR3, LTBP4, FBN2, FBXO21, RECQL4, IDE, LAMB2SH3D19SH3YL1, GRB2, CDC42, ELAVL1, SH3KBP1, NPHP1, CDH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for VWCE_SH3D19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for VWCE_SH3D19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource