![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 41700 |
FusionGeneSummary for VWC2_RAB20 |
![]() |
Fusion gene information | Fusion gene name: VWC2_RAB20 | Fusion gene ID: 41700 | Hgene | Tgene | Gene symbol | VWC2 | RAB20 | Gene ID | 375567 | 55647 |
Gene name | von Willebrand factor C domain containing 2 | RAB20, member RAS oncogene family | |
Synonyms | PSST739|UNQ739 | - | |
Cytomap | 7p12.2 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | brorinbrain-specific chordin-like proteinvon Willebrand factor C domain-containing protein 2 | ras-related protein Rab-20 | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | Q2TAL6 | Q9NX57 | |
Ensembl transtripts involved in fusion gene | ENST00000340652, | ENST00000267328, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 1 X 3=9 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: VWC2 [Title/Abstract] AND RAB20 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | GBM | TCGA-06-2558-01A | VWC2 | chr7 | 49815727 | + | RAB20 | chr13 | 111176544 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000340652 | ENST00000267328 | VWC2 | chr7 | 49815727 | + | RAB20 | chr13 | 111176544 | - |
Top |
FusionProtFeatures for VWC2_RAB20 |
![]() |
Hgene | Tgene |
VWC2 | RAB20 |
BMP antagonist which may play a role in neuraldevelopment. Promotes cell adhesion (By similarity).{ECO:0000250}. | Plays a role in apical endocytosis/recycling. Plays arole in the maturation and acidification of phagosomes that engulfpathogens, such as S.aureus and M.tuberculosis. Plays a role inthe fusion of phagosomes with lysosomes.{ECO:0000269|PubMed:21255211}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for VWC2_RAB20 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for VWC2_RAB20 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
VWC2 | RAB20 | NXF1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for VWC2_RAB20 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for VWC2_RAB20 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |