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Fusion gene ID: 4168 |
FusionGeneSummary for BICD2_ASPN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BICD2_ASPN | Fusion gene ID: 4168 | Hgene | Tgene | Gene symbol | BICD2 | ASPN | Gene ID | 23299 | 54829 |
| Gene name | BICD cargo adaptor 2 | asporin | |
| Synonyms | SMALED2|bA526D8.1 | OS3|PLAP-1|PLAP1|SLRR1C | |
| Cytomap | 9q22.31 | 9q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein bicaudal D homolog 2bic-D 2bicaudal D homolog 2coiled-coil protein BICD2cytoskeleton-like bicaudal D protein homolog 2homolog of Drosophila bicaudal D | asporinasporin (LRR class 1)asporin proteoglycanperiodontal ligament associated protein 1small leucine-rich protein 1C | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q8TD16 | Q9BXN1 | |
| Ensembl transtripts involved in fusion gene | ENST00000375512, ENST00000356884, | ENST00000375543, ENST00000375544, ENST00000395538, ENST00000450139, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BICD2 [Title/Abstract] AND ASPN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ASPN | GO:0030282 | bone mineralization | 19589127 |
| Tgene | ASPN | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 17827158 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CV-7414-01A | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000375512 | ENST00000375543 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| In-frame | ENST00000375512 | ENST00000375544 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| In-frame | ENST00000375512 | ENST00000395538 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| 5CDS-intron | ENST00000375512 | ENST00000450139 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| intron-3CDS | ENST00000356884 | ENST00000375543 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| intron-3CDS | ENST00000356884 | ENST00000375544 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| intron-3CDS | ENST00000356884 | ENST00000395538 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
| intron-intron | ENST00000356884 | ENST00000450139 | BICD2 | chr9 | 95477535 | - | ASPN | chr9 | 95228853 | - |
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FusionProtFeatures for BICD2_ASPN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BICD2 | ASPN |
| Acts as an adapter protein linking the dynein motorcomplex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence ofdynactin. Facilitates and stabilizes the interaction betweendynein and dynactin and activates dynein processivity (the abilityto move along a microtubule for a long distance without fallingoff the track) (By similarity). Facilitates the binding of RAB6Ato the Golgi by stabilizing its GTP-bound form. Regulates coatcomplex coatomer protein I (COPI)-independent Golgi-endoplasmicreticulum transport via its interaction with RAB6A and recruitmentof the dynein-dynactin motor complex (PubMed:25962623).Contributes to nuclear and centrosomal positioning prior tomitotic entry through regulation of both dynein and kinesin-1.During G2 phase of the cell cycle, associates with RANBP2 at thenuclear pores and recruits dynein and dynactin to the nuclearenvelope to ensure proper positioning of the nucleus relative tocentrosomes prior to the onset of mitosis (By similarity).{ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25962623}. | Negatively regulates periodontal ligament (PDL)differentiation and mineralization to ensure that the PDL is notossified and to maintain homeostasis of the tooth-supportingsystem. Inhibits BMP2-induced cytodifferentiation of PDL cells bypreventing its binding to BMPR1B/BMP type-1B receptor, resultingin inhibition of BMP-dependent activation of SMAD proteins (Bysimilarity). Critical regulator of TGF-beta in articular cartilageand plays an essential role in cartilage homeostasis andosteoarthritis (OA) pathogenesis. Negatively regulateschondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting thecanonical TGF-beta/Smad signal. Binds calcium and plays a role inosteoblast-driven collagen biomineralization activity.{ECO:0000250, ECO:0000269|PubMed:17827158,ECO:0000269|PubMed:19589127}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000375512 | - | 7 | 8 | 20_269 | 823 | 825 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000375512 | - | 7 | 8 | 338_537 | 823 | 825 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000375512 | - | 7 | 8 | 666_808 | 823 | 825 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000375512 | - | 7 | 8 | 25_398 | 823 | 825 | Region | Interacts with DYNLL1%2C DYNC1H1%2C DYNC1I2%2C DCTN1 and DCTN2 |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000375512 | - | 7 | 8 | 666_814 | 823 | 825 | Region | Interacts with RAB6A |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 127_148 | 129 | 381 | Repeat | Note=LRR 2 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 151_173 | 129 | 381 | Repeat | Note=LRR 3 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 174_193 | 129 | 381 | Repeat | Note=LRR 4 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 196_219 | 129 | 381 | Repeat | Note=LRR 5 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 242_263 | 129 | 381 | Repeat | Note=LRR 6 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 266_287 | 129 | 381 | Repeat | Note=LRR 7 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 290_312 | 129 | 381 | Repeat | Note=LRR 8 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 313_334 | 129 | 381 | Repeat | Note=LRR 9 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 335_357 | 129 | 381 | Repeat | Note=LRR 10 |
| Tgene | >ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 358_380 | 129 | 381 | Repeat | Note=LRR 11 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >BICD2 | chr9:95477535 | chr9:95228853 | ENST00000356884 | - | 1 | 7 | 20_269 | -23 | 856 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >BICD2 | chr9:95477535 | chr9:95228853 | ENST00000356884 | - | 1 | 7 | 338_537 | -23 | 856 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >BICD2 | chr9:95477535 | chr9:95228853 | ENST00000356884 | - | 1 | 7 | 666_808 | -23 | 856 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >BICD2 | chr9:95477535 | chr9:95228853 | ENST00000356884 | - | 1 | 7 | 25_398 | -23 | 856 | Region | Interacts with DYNLL1%2C DYNC1H1%2C DYNC1I2%2C DCTN1 and DCTN2 |
| Hgene | >BICD2 | chr9:95477535 | chr9:95228853 | ENST00000356884 | - | 1 | 7 | 666_814 | -23 | 856 | Region | Interacts with RAB6A |
| Tgene | ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 35_53 | 129 | 381 | Compositional bias | Note=Poly-Asp |
| Tgene | ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 75_88 | 129 | 381 | Compositional bias | Note=Cys-rich |
| Tgene | ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 66_102 | 129 | 381 | Domain | Note=LRRNT |
| Tgene | ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 103_124 | 129 | 381 | Repeat | Note=LRR 1 |
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FusionGeneSequence for BICD2_ASPN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000375543_chr9_95228853_-_938aa MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHK KVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDS FYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELR EQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNL IAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR AKAAPKTKPATPSGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANP >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000375544_chr9_95228853_-_1075aa MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHK KVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDS FYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELR EQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNL IAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR AKAAPKTKPATPSGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANP LDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHL >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000395538_chr9_95228853_-_937aa MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHK KVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDS FYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELR EQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNL IAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR AKAAPKTKPATPSGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000375543_chr9_95228853_-_2814nt ATGTCGGCGCCGTCGGAGGAGGAGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCC CACGAGCTGGCCGAGACCACGCGTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAG TTCGAGGAGCTCGAGGTGGACTATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAG AAGGTGGCTGCTGACGGAGAGAGCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAG CTGCAGACGGAGCTGAAGCAGTTGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAG GAGATCAACCAGAATGTGGAGATCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGAC TACTCGGAACTGGAGGAGGAGAACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCAT GAGATCAAGCGTCTGGAGGAGGAGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTG GAGGAGGCGCTGGAGACCCTGAAGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCC TTCTACACCAGCCACCTGCATGTCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTC AATGGCTTTGAGCACGGCGGCCTGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCC AGCCTCGTCTCCGACCTACTCAGTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCG GGCCTGCTGGCAACGCTGCAGGACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTC ACAGAGAATCTGAGTGCCCTGCGGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAG GATGGGGACTACTACGAGGTGGACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGC GAGCAGCTCAAGGCACTGCGCAGCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCA CTCACGGAGAAGGTCTCCCTGCTAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGC GACGTCGCCGGCGAGACACAGGGCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCAC GTGTGCATGTGCAACAATGAGACACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGG GGCCGCACCAGCCCCGAGGCGCGTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGT GGGACGGGGGACAGCAGCCCCTCGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTG ATCGCTATCATCCGTGACCAGATCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAG CTGGGCCCCGCCGTGGACAAGGACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATC ACCACGCTGCGCACTGTGCTCAAGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCC ATGGTTACCGAGACCATGATGAAGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTT GCCACCAGGTGTGACGAGTACATTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCG CTGCTGCGCATGGCCATCCAGCAGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGT GCCAAAGCCGCCCCGAAGACCAAGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTT CTAACCACAAAGAAGTTGCGAAGGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTC AGAATTCATGAAAATAAAGTTAAGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCT CTTGATAATAATGGGATAGAGCCAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCT >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000375544_chr9_95228853_-_3225nt ATGTCGGCGCCGTCGGAGGAGGAGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCC CACGAGCTGGCCGAGACCACGCGTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAG TTCGAGGAGCTCGAGGTGGACTATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAG AAGGTGGCTGCTGACGGAGAGAGCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAG CTGCAGACGGAGCTGAAGCAGTTGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAG GAGATCAACCAGAATGTGGAGATCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGAC TACTCGGAACTGGAGGAGGAGAACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCAT GAGATCAAGCGTCTGGAGGAGGAGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTG GAGGAGGCGCTGGAGACCCTGAAGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCC TTCTACACCAGCCACCTGCATGTCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTC AATGGCTTTGAGCACGGCGGCCTGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCC AGCCTCGTCTCCGACCTACTCAGTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCG GGCCTGCTGGCAACGCTGCAGGACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTC ACAGAGAATCTGAGTGCCCTGCGGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAG GATGGGGACTACTACGAGGTGGACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGC GAGCAGCTCAAGGCACTGCGCAGCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCA CTCACGGAGAAGGTCTCCCTGCTAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGC GACGTCGCCGGCGAGACACAGGGCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCAC GTGTGCATGTGCAACAATGAGACACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGG GGCCGCACCAGCCCCGAGGCGCGTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGT GGGACGGGGGACAGCAGCCCCTCGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTG ATCGCTATCATCCGTGACCAGATCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAG CTGGGCCCCGCCGTGGACAAGGACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATC ACCACGCTGCGCACTGTGCTCAAGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCC ATGGTTACCGAGACCATGATGAAGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTT GCCACCAGGTGTGACGAGTACATTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCG CTGCTGCGCATGGCCATCCAGCAGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGT GCCAAAGCCGCCCCGAAGACCAAGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTT CTAACCACAAAGAAGTTGCGAAGGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTC AGAATTCATGAAAATAAAGTTAAGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCT CTTGATAATAATGGGATAGAGCCAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCT AAAGGCTTACCACCAACTTTATTGGAGCTTCACTTAGATTATAATAAAATTTCAACAGTGGAACTTGAGGATTTTAAACGATACAAAGAA CTACAAAGGCTGGGCCTAGGAAACAACAAAATCACAGATATCGAAAATGGGAGTCTTGCTAACATACCACGTGTGAGAGAAATACATTTG GAAAACAATAAACTAAAAAAAATCCCTTCAGGATTACCAGAGTTGAAATACCTCCAGATAATCTTCCTTCATTCTAATTCAATTGCAAGA GTGGGAGTAAATGACTTCTGTCCAACAGTGCCAAAGATGAAGAAATCTTTATACAGTGCAATAAGTTTATTCAACAACCCGGTGAAATAC >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000395538_chr9_95228853_-_2811nt ATGTCGGCGCCGTCGGAGGAGGAGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCC CACGAGCTGGCCGAGACCACGCGTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAG TTCGAGGAGCTCGAGGTGGACTATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAG AAGGTGGCTGCTGACGGAGAGAGCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAG CTGCAGACGGAGCTGAAGCAGTTGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAG GAGATCAACCAGAATGTGGAGATCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGAC TACTCGGAACTGGAGGAGGAGAACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCAT GAGATCAAGCGTCTGGAGGAGGAGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTG GAGGAGGCGCTGGAGACCCTGAAGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCC TTCTACACCAGCCACCTGCATGTCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTC AATGGCTTTGAGCACGGCGGCCTGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCC AGCCTCGTCTCCGACCTACTCAGTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCG GGCCTGCTGGCAACGCTGCAGGACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTC ACAGAGAATCTGAGTGCCCTGCGGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAG GATGGGGACTACTACGAGGTGGACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGC GAGCAGCTCAAGGCACTGCGCAGCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCA CTCACGGAGAAGGTCTCCCTGCTAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGC GACGTCGCCGGCGAGACACAGGGCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCAC GTGTGCATGTGCAACAATGAGACACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGG GGCCGCACCAGCCCCGAGGCGCGTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGT GGGACGGGGGACAGCAGCCCCTCGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTG ATCGCTATCATCCGTGACCAGATCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAG CTGGGCCCCGCCGTGGACAAGGACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATC ACCACGCTGCGCACTGTGCTCAAGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCC ATGGTTACCGAGACCATGATGAAGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTT GCCACCAGGTGTGACGAGTACATTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCG CTGCTGCGCATGGCCATCCAGCAGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGT GCCAAAGCCGCCCCGAAGACCAAGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTT CTAACCACAAAGAAGTTGCGAAGGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTC AGAATTCATGAAAATAAAGTTAAGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCT CTTGATAATAATGGGATAGAGCCAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000375543_chr9_95228853_-_4143nt GCGGCGGCGGCTGAGGAGGGCCCGGCCTGCGAGAGCCTCAGTGGGAGCCGGCTCAGCCCTCGGCCACCATGTCGGCGCCGTCGGAGGAGG AGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCCCACGAGCTGGCCGAGACCACGC GTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAGTTCGAGGAGCTCGAGGTGGACT ATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAGAAGGTGGCTGCTGACGGAGAGA GCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAGCTGCAGACGGAGCTGAAGCAGT TGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAGGAGATCAACCAGAATGTGGAGA TCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGACTACTCGGAACTGGAGGAGGAGA ACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCATGAGATCAAGCGTCTGGAGGAGG AGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTGGAGGAGGCGCTGGAGACCCTGA AGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCCTTCTACACCAGCCACCTGCATG TCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTCAATGGCTTTGAGCACGGCGGCC TGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCCAGCCTCGTCTCCGACCTACTCA GTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCGGGCCTGCTGGCAACGCTGCAGG ACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTCACAGAGAATCTGAGTGCCCTGC GGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAGGATGGGGACTACTACGAGGTGG ACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGCGAGCAGCTCAAGGCACTGCGCA GCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCACTCACGGAGAAGGTCTCCCTGC TAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGCGACGTCGCCGGCGAGACACAGG GCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCACGTGTGCATGTGCAACAATGAGA CACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGGGGCCGCACCAGCCCCGAGGCGC GTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGTGGGACGGGGGACAGCAGCCCCT CGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTGATCGCTATCATCCGTGACCAGA TCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAGCTGGGCCCCGCCGTGGACAAGG ACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATCACCACGCTGCGCACTGTGCTCA AGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCCATGGTTACCGAGACCATGATGA AGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTTGCCACCAGGTGTGACGAGTACA TTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCGCTGCTGCGCATGGCCATCCAGC AGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGTGCCAAAGCCGCCCCGAAGACCA AGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTTCTAACCACAAAGAAGTTGCGAA GGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTCAGAATTCATGAAAATAAAGTTA AGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCTCTTGATAATAATGGGATAGAGC CAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCTAAAGATAATCTTCCTTCATTCT AATTCAATTGCAAGAGTGGGAGTAAATGACTTCTGTCCAACAGTGCCAAAGATGAAGAAATCTTTATACAGTGCAATAAGTTTATTCAAC AACCCGGTGAAATACTGGGAAATGCAACCTGCAACATTTCGTTGTGTTTTGAGCAGAATGAGCGTTCAGCTTGGGAACTTTGGAATGTAA TAATTAGTAATTGGTAATGTCCATTTAATATAAGATTCAAAAATCCCTACATTTGGAATACTTGAACTCTATTAATAATGGTAGTATTAT ATATACAAGCAAATATCTATTCTCAAGTGGTAAGTCCACTGACTTATTTTATGACAAGAAATTTCAACGGAATTTTGCCAAACTATTGAT ACATAAGGGTTGAGAGAAACAAGCATCTATTGCAGTTTCTTTTTGCGTACAAATGATCTTACATAAATCTCATGCTTGACCATTCCTTTC TTCATAACAAAAAAGTAAGATATTCGGTATTTAACACTTTGTTATCAAGCATATTTTAAAAAGAACTGTACTGTAAATGGAATGCTTGAC TTAGCAAAATTTGTGCTCTTTCATTTGCTGTTAGAAAAACAGAATTAACAAAGACAGTAATGTGAAGAGTGCATTACACTATTCTTATTC TTTAGTAACTTGGGTAGTACTGTAATATTTTTAATCATCTTAAAGTATGATTTGATATAATCTTATTGAAATTACCTTATCATGTCTTAG AGCCCGTCTTTATGTTTAAAACTAATTTCTTAAAATAAAGCCTTCAGTAAATGTTCATTACCAACTTGATAAATGCTACTCATAAGAGCT GGTTTGGGGCTATAGCATATGCTTTTTTTTTTTTAATTATTACCTGATTTAAAAATCTCTGTAAAAACGTGTAGTGTTTCATAAAATCTG TAACTCGCATTTTAATGATCCGCTATTATAAGCTTTTAATAGCATGAAAATTGTTAGGCTATATAACATTGCCACTTCAACTCTAAGGAA TATTTTTGAGATATCCCTTTGGAAGACCTTGCTTGGAAGAGCCTGGACACTAACAATTCTACACCAAATTGTCTCTTCAAATACGTATGG ACTGGATAACTCTGAGAAACACATCTAGTATAACTGAATAAGCAGAGCATCAAATTAAACAGACAGAAACCGAAAGCTCTATATAAATGC TCAGAGTTCTTTATGTATTTCTTATTGGCATTCAACATATGTAAAATCAGAAAACAGGGAAATTTTCATTAAAAATATTGGTTTGAAATA >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000375544_chr9_95228853_-_4376nt GCGGCGGCGGCTGAGGAGGGCCCGGCCTGCGAGAGCCTCAGTGGGAGCCGGCTCAGCCCTCGGCCACCATGTCGGCGCCGTCGGAGGAGG AGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCCCACGAGCTGGCCGAGACCACGC GTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAGTTCGAGGAGCTCGAGGTGGACT ATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAGAAGGTGGCTGCTGACGGAGAGA GCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAGCTGCAGACGGAGCTGAAGCAGT TGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAGGAGATCAACCAGAATGTGGAGA TCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGACTACTCGGAACTGGAGGAGGAGA ACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCATGAGATCAAGCGTCTGGAGGAGG AGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTGGAGGAGGCGCTGGAGACCCTGA AGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCCTTCTACACCAGCCACCTGCATG TCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTCAATGGCTTTGAGCACGGCGGCC TGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCCAGCCTCGTCTCCGACCTACTCA GTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCGGGCCTGCTGGCAACGCTGCAGG ACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTCACAGAGAATCTGAGTGCCCTGC GGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAGGATGGGGACTACTACGAGGTGG ACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGCGAGCAGCTCAAGGCACTGCGCA GCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCACTCACGGAGAAGGTCTCCCTGC TAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGCGACGTCGCCGGCGAGACACAGG GCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCACGTGTGCATGTGCAACAATGAGA CACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGGGGCCGCACCAGCCCCGAGGCGC GTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGTGGGACGGGGGACAGCAGCCCCT CGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTGATCGCTATCATCCGTGACCAGA TCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAGCTGGGCCCCGCCGTGGACAAGG ACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATCACCACGCTGCGCACTGTGCTCA AGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCCATGGTTACCGAGACCATGATGA AGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTTGCCACCAGGTGTGACGAGTACA TTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCGCTGCTGCGCATGGCCATCCAGC AGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGTGCCAAAGCCGCCCCGAAGACCA AGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTTCTAACCACAAAGAAGTTGCGAA GGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTCAGAATTCATGAAAATAAAGTTA AGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCTCTTGATAATAATGGGATAGAGC CAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCTAAAGGCTTACCACCAACTTTAT TGGAGCTTCACTTAGATTATAATAAAATTTCAACAGTGGAACTTGAGGATTTTAAACGATACAAAGAACTACAAAGGCTGGGCCTAGGAA ACAACAAAATCACAGATATCGAAAATGGGAGTCTTGCTAACATACCACGTGTGAGAGAAATACATTTGGAAAACAATAAACTAAAAAAAA TCCCTTCAGGATTACCAGAGTTGAAATACCTCCAGATAATCTTCCTTCATTCTAATTCAATTGCAAGAGTGGGAGTAAATGACTTCTGTC CAACAGTGCCAAAGATGAAGAAATCTTTATACAGTGCAATAAGTTTATTCAACAACCCGGTGAAATACTGGGAAATGCAACCTGCAACAT TTCGTTGTGTTTTGAGCAGAATGAGCGTTCAGCTTGGGAACTTTGGAATGTAATAATTAGTAATTGGTAATGTCCATTTAATATAAGATT CAAAAATCCCTACATTTGGAATACTTGAACTCTATTAATAATGGTAGTATTATATATACAAGCAAATATCTATTCTCAAGTGGTAAGTCC ACTGACTTATTTTATGACAAGAAATTTCAACGGAATTTTGCCAAACTATTGATACATAAGGGTTGAGAGAAACAAGCATCTATTGCAGTT TCTTTTTGCGTACAAATGATCTTACATAAATCTCATGCTTGACCATTCCTTTCTTCATAACAAAAAAGTAAGATATTCGGTATTTAACAC TTTGTTATCAAGCATATTTTAAAAAGAACTGTACTGTAAATGGAATGCTTGACTTAGCAAAATTTGTGCTCTTTCATTTGCTGTTAGAAA AACAGAATTAACAAAGACAGTAATGTGAAGAGTGCATTACACTATTCTTATTCTTTAGTAACTTGGGTAGTACTGTAATATTTTTAATCA TCTTAAAGTATGATTTGATATAATCTTATTGAAATTACCTTATCATGTCTTAGAGCCCGTCTTTATGTTTAAAACTAATTTCTTAAAATA AAGCCTTCAGTAAATGTTCATTACCAACTTGATAAATGCTACTCATAAGAGCTGGTTTGGGGCTATAGCATATGCTTTTTTTTTTTTAAT TATTACCTGATTTAAAAATCTCTGTAAAAACGTGTAGTGTTTCATAAAATCTGTAACTCGCATTTTAATGATCCGCTATTATAAGCTTTT AATAGCATGAAAATTGTTAGGCTATATAACATTGCCACTTCAACTCTAAGGAATATTTTTGAGATATCCCTTTGGAAGACCTTGCTTGGA AGAGCCTGGACACTAACAATTCTACACCAAATTGTCTCTTCAAATACGTATGGACTGGATAACTCTGAGAAACACATCTAGTATAACTGA ATAAGCAGAGCATCAAATTAAACAGACAGAAACCGAAAGCTCTATATAAATGCTCAGAGTTCTTTATGTATTTCTTATTGGCATTCAACA >In-frame_BICD2_ENST00000375512_chr9_95477535_-_ASPN_ENST00000395538_chr9_95228853_-_2879nt GCGGCGGCGGCTGAGGAGGGCCCGGCCTGCGAGAGCCTCAGTGGGAGCCGGCTCAGCCCTCGGCCACCATGTCGGCGCCGTCGGAGGAGG AGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCCCACGAGCTGGCCGAGACCACGC GTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAGTTCGAGGAGCTCGAGGTGGACT ATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAGAAGGTGGCTGCTGACGGAGAGA GCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAGCTGCAGACGGAGCTGAAGCAGT TGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAGGAGATCAACCAGAATGTGGAGA TCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGACTACTCGGAACTGGAGGAGGAGA ACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCATGAGATCAAGCGTCTGGAGGAGG AGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTGGAGGAGGCGCTGGAGACCCTGA AGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCCTTCTACACCAGCCACCTGCATG TCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTCAATGGCTTTGAGCACGGCGGCC TGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCCAGCCTCGTCTCCGACCTACTCA GTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCGGGCCTGCTGGCAACGCTGCAGG ACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTCACAGAGAATCTGAGTGCCCTGC GGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAGGATGGGGACTACTACGAGGTGG ACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGCGAGCAGCTCAAGGCACTGCGCA GCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCACTCACGGAGAAGGTCTCCCTGC TAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGCGACGTCGCCGGCGAGACACAGG GCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCACGTGTGCATGTGCAACAATGAGA CACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGGGGCCGCACCAGCCCCGAGGCGC GTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGTGGGACGGGGGACAGCAGCCCCT CGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTGATCGCTATCATCCGTGACCAGA TCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAGCTGGGCCCCGCCGTGGACAAGG ACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATCACCACGCTGCGCACTGTGCTCA AGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCCATGGTTACCGAGACCATGATGA AGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTTGCCACCAGGTGTGACGAGTACA TTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCGCTGCTGCGCATGGCCATCCAGC AGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGTGCCAAAGCCGCCCCGAAGACCA AGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTTCTAACCACAAAGAAGTTGCGAA GGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTCAGAATTCATGAAAATAAAGTTA AGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCTCTTGATAATAATGGGATAGAGC 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Top |
FusionGenePPI for BICD2_ASPN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BICD2 | ACTR1A, DCTN2, DYNC1H1, RAB6A, ZRANB1, PLK1, DYNC1I1, DCTN1, DYNC1LI1, PAFAH1B1, ALK, ORC6, CORO1A, C17orf59, NEK9, HERC2, PCM1, CEP128, XPO1, PMF1, UNC5CL, MIS18A, NEFL, TCP10L, CCDC53, COG6, CAPN6, CPNE5 | ASPN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000375512 | - | 7 | 8 | 334_599 | 823 | 825 | KIF5A |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000375512 | - | 7 | 8 | 590_824 | 823 | 825 | RANBP2 |
| Tgene | ASPN | chr9:95477535 | chr9:95228853 | ENST00000375544 | - | 2 | 8 | 166_212 | 129 | 381 | TGFB1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000356884 | - | 1 | 7 | 334_599 | -23 | 856 | KIF5A |
| Hgene | BICD2 | chr9:95477535 | chr9:95228853 | ENST00000356884 | - | 1 | 7 | 590_824 | -23 | 856 | RANBP2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BICD2_ASPN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BICD2_ASPN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BICD2 | C3809049 | SPINAL MUSCULAR ATROPHY, LOWER EXTREMITY-PREDOMINANT, 2, AUTOSOMAL DOMINANT | 3 | ORPHANET;UNIPROT |
| Hgene | BICD2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ASPN | C0022548 | Keloid | 1 | CTD_human |
| Tgene | ASPN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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