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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41672

FusionGeneSummary for VSNL1_BTBD9

check button Fusion gene summary
Fusion gene informationFusion gene name: VSNL1_BTBD9
Fusion gene ID: 41672
HgeneTgene
Gene symbol

VSNL1

BTBD9

Gene ID

7447

114781

Gene namevisinin like 1BTB domain containing 9
SynonymsHLP3|HPCAL3|HUVISL1|VILIP|VILIP-1dJ322I12.1
Cytomap

2p24.2

6p21.2

Type of geneprotein-codingprotein-coding
Descriptionvisinin-like protein 1VLP-1hippocalcin-like protein 3BTB/POZ domain-containing protein 9BTB (POZ) domain containing 9
Modification date2018051920180523
UniProtAcc

P62760

Q96Q07

Ensembl transtripts involved in fusion geneENST00000404666, ENST00000295156, 
ENST00000406397, ENST00000483921, 
ENST00000314100, ENST00000481247, 
ENST00000419706, ENST00000408958, 
ENST00000403056, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 8 X 5=280
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VSNL1 [Title/Abstract] AND BTBD9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB301956VSNL1chr2

17836700

-BTBD9chr6

38141711

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000404666ENST00000314100VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-3UTRENST00000404666ENST00000481247VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000404666ENST00000419706VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000404666ENST00000408958VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000404666ENST00000403056VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-3UTRENST00000295156ENST00000314100VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-3UTRENST00000295156ENST00000481247VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000295156ENST00000419706VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000295156ENST00000408958VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000295156ENST00000403056VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-3UTRENST00000406397ENST00000314100VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-3UTRENST00000406397ENST00000481247VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000406397ENST00000419706VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000406397ENST00000408958VSNL1chr2

17836700

-BTBD9chr6

38141711

+
3UTR-intronENST00000406397ENST00000403056VSNL1chr2

17836700

-BTBD9chr6

38141711

+
intron-3UTRENST00000483921ENST00000314100VSNL1chr2

17836700

-BTBD9chr6

38141711

+
intron-3UTRENST00000483921ENST00000481247VSNL1chr2

17836700

-BTBD9chr6

38141711

+
intron-intronENST00000483921ENST00000419706VSNL1chr2

17836700

-BTBD9chr6

38141711

+
intron-intronENST00000483921ENST00000408958VSNL1chr2

17836700

-BTBD9chr6

38141711

+
intron-intronENST00000483921ENST00000403056VSNL1chr2

17836700

-BTBD9chr6

38141711

+

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FusionProtFeatures for VSNL1_BTBD9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VSNL1

P62760

BTBD9

Q96Q07

Regulates (in vitro) the inhibition of rhodopsinphosphorylation in a calcium-dependent manner. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VSNL1_BTBD9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VSNL1_BTBD9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VSNL1_BTBD9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VSNL1_BTBD9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVSNL1C0036341Schizophrenia2PSYGENET
HgeneVSNL1C0002395Alzheimer's Disease1CTD_human
TgeneBTBD9C0035258Restless Legs Syndrome1CTD_human
TgeneBTBD9C0036341Schizophrenia1PSYGENET