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Fusion gene ID: 41665 |
FusionGeneSummary for VRK3_PPP6R1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VRK3_PPP6R1 | Fusion gene ID: 41665 | Hgene | Tgene | Gene symbol | VRK3 | PPP6R1 | Gene ID | 51231 | 22870 |
| Gene name | vaccinia related kinase 3 | protein phosphatase 6 regulatory subunit 1 | |
| Synonyms | - | KIAA1115|PP6R1|SAP190|SAPS1 | |
| Cytomap | 19q13.33 | 19q13.42 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inactive serine/threonine-protein kinase VRK3serine/threonine-protein kinase VRK3serine/threonine-protein pseudokinase VRK3 | serine/threonine-protein phosphatase 6 regulatory subunit 1SAPS domain family, member 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8IV63 | Q9UPN7 | |
| Ensembl transtripts involved in fusion gene | ENST00000316763, ENST00000377011, ENST00000599538, ENST00000443401, ENST00000601341, ENST00000594948, ENST00000601912, ENST00000594092, ENST00000593919, ENST00000424804, | ENST00000412770, ENST00000587283, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 3 X 3=27 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: VRK3 [Title/Abstract] AND PPP6R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PPP6R1 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-C5-A907-01A | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000316763 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| In-frame | ENST00000316763 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| In-frame | ENST00000377011 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| In-frame | ENST00000377011 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000599538 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000599538 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000443401 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000443401 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000601341 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000601341 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000594948 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000594948 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000601912 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000601912 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000594092 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000594092 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000593919 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| Frame-shift | ENST00000593919 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| 5UTR-3CDS | ENST00000424804 | ENST00000412770 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
| 5UTR-3CDS | ENST00000424804 | ENST00000587283 | VRK3 | chr19 | 50504047 | - | PPP6R1 | chr19 | 55753856 | - |
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FusionProtFeatures for VRK3_PPP6R1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VRK3 | PPP6R1 |
| Inactive kinase that suppresses ERK activity bypromoting phosphatase activity of DUSP3 which specificallydephosphorylates and inactivates ERK in the nucleus. {ECO:0000250,ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289}. | Regulatory subunit of protein phosphatase 6 (PP6). Mayfunction as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation inresponse to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | VRK3 | chr19:50504047 | chr19:55753856 | ENST00000316763 | - | 6 | 15 | 49_64 | 204 | 573 | Motif | Nuclear localization signal |
| Hgene | VRK3 | chr19:50504047 | chr19:55753856 | ENST00000377011 | - | 5 | 14 | 49_64 | 154 | 519 | Motif | Nuclear localization signal |
| Hgene | VRK3 | chr19:50504047 | chr19:55753856 | ENST00000594092 | - | 6 | 13 | 49_64 | 204 | 413 | Motif | Nuclear localization signal |
| Hgene | VRK3 | chr19:50504047 | chr19:55753856 | ENST00000594948 | - | 6 | 14 | 49_64 | 204 | 475 | Motif | Nuclear localization signal |
| Hgene | VRK3 | chr19:50504047 | chr19:55753856 | ENST00000599538 | - | 6 | 15 | 49_64 | 204 | 315 | Motif | Nuclear localization signal |
| Hgene | VRK3 | chr19:50504047 | chr19:55753856 | ENST00000601341 | - | 5 | 13 | 49_64 | 154 | 425 | Motif | Nuclear localization signal |
| Tgene | >PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000412770 | - | 4 | 24 | 624_631 | 206 | 882 | Compositional bias | Note=Poly-Glu |
| Tgene | >PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000412770 | - | 4 | 24 | 624_685 | 206 | 882 | Compositional bias | Note=Glu-rich |
| Tgene | >PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000412770 | - | 4 | 24 | 671_685 | 206 | 882 | Compositional bias | Note=Poly-Glu |
| Tgene | >PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000412770 | - | 4 | 24 | 697_878 | 206 | 882 | Compositional bias | Note=Pro-rich |
| Tgene | >PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000587283 | - | 3 | 23 | 624_631 | 206 | 882 | Compositional bias | Note=Poly-Glu |
| Tgene | >PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000587283 | - | 3 | 23 | 624_685 | 206 | 882 | Compositional bias | Note=Glu-rich |
| Tgene | >PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000587283 | - | 3 | 23 | 671_685 | 206 | 882 | Compositional bias | Note=Poly-Glu |
| Tgene | >PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000587283 | - | 3 | 23 | 697_878 | 206 | 882 | Compositional bias | Note=Pro-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >VRK3 | chr19:50504047 | chr19:55753856 | ENST00000316763 | - | 6 | 15 | 166_457 | 204 | 573 | Domain | Protein kinase |
| Hgene | >VRK3 | chr19:50504047 | chr19:55753856 | ENST00000377011 | - | 5 | 14 | 166_457 | 154 | 519 | Domain | Protein kinase |
| Hgene | >VRK3 | chr19:50504047 | chr19:55753856 | ENST00000594092 | - | 6 | 13 | 166_457 | 204 | 413 | Domain | Protein kinase |
| Hgene | >VRK3 | chr19:50504047 | chr19:55753856 | ENST00000594948 | - | 6 | 14 | 166_457 | 204 | 475 | Domain | Protein kinase |
| Hgene | >VRK3 | chr19:50504047 | chr19:55753856 | ENST00000599538 | - | 6 | 15 | 166_457 | 204 | 315 | Domain | Protein kinase |
| Hgene | >VRK3 | chr19:50504047 | chr19:55753856 | ENST00000601341 | - | 5 | 13 | 166_457 | 154 | 425 | Domain | Protein kinase |
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FusionGeneSequence for VRK3_PPP6R1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_VRK3_ENST00000316763_chr19_50504047_-_PPP6R1_ENST00000412770_chr19_55753856_-_880aa MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS SSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL YEAAPTSTLTCDSGPQKQKFSLKLQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVL LTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLL ASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDR VQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFN FPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEA QGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTD APTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIR >In-frame_VRK3_ENST00000316763_chr19_50504047_-_PPP6R1_ENST00000587283_chr19_55753856_-_880aa MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS SSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL YEAAPTSTLTCDSGPQKQKFSLKLQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVL LTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLL ASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDR VQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFN FPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEA QGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTD APTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIR >In-frame_VRK3_ENST00000377011_chr19_50504047_-_PPP6R1_ENST00000412770_chr19_55753856_-_830aa MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTL KRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLQHSNASQSLCDIIRLSREQMIQVQDS PEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRP RLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLS LGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQW EAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTAN ITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEE DEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQD PTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALT >In-frame_VRK3_ENST00000377011_chr19_50504047_-_PPP6R1_ENST00000587283_chr19_55753856_-_830aa MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTL KRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLQHSNASQSLCDIIRLSREQMIQVQDS PEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRP RLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLS LGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQW EAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTAN ITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEE DEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQD PTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_VRK3_ENST00000316763_chr19_50504047_-_PPP6R1_ENST00000412770_chr19_55753856_-_2640nt ATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAG CATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTCTCCT AAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCTGAGT TCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGACCAGG GGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACTTGAA GCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCATTCTC TATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCAACATTCCAACGCATCC CAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTGACCAACTGCTGGCCACCCTG GAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCGTCAGTGGGATCCAGGTGCTG CTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGGATGGGCAGCTGGAGCTCCTG GCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCTGCTTCCACCAGCTCCTGCTG GAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGCTGCACGTGGTCAAGCTCCTG GCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCATGCTGGACCTCTTCTTCCAT TATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCACCTCCTGACAGCAGCCCTGAG ACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGTCCTGGGAGGAGAACGACCGT GTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGCAGAACACGGAGAAGGGGCCC AATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCGTATCGGGGCCCCTGGCGGAG ACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACGACCGGCTCAAGGAGTTCAAC TTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCATTGACCACTTCGGCTTCAAT GATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCTCCCTCAATGCTGACGATGAG AACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAGAGGAGGACGAGGAAGAGGCC CAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTCTGGGCCAGCCACCTGGTGTC CGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGGGCATTGGCTGTGCAGCCCGT GGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCTTTGACCCAGTGCCTACAGAT GCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCCTCAGTGTGCCCCAGGGCCTC CCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCCCCTCAGCACCTCAGGAAGCC ACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGGCCACCTTCCACGGGATCCGT TCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACCAGCCCCCCCAGACCACAGAA GGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGATACCCAATGGCTCTGCCCCG >In-frame_VRK3_ENST00000316763_chr19_50504047_-_PPP6R1_ENST00000587283_chr19_55753856_-_2640nt ATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAG CATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTCTCCT AAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCTGAGT TCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGACCAGG GGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACTTGAA GCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCATTCTC TATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCAACATTCCAACGCATCC CAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTGACCAACTGCTGGCCACCCTG GAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCGTCAGTGGGATCCAGGTGCTG CTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGGATGGGCAGCTGGAGCTCCTG GCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCTGCTTCCACCAGCTCCTGCTG GAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGCTGCACGTGGTCAAGCTCCTG GCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCATGCTGGACCTCTTCTTCCAT TATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCACCTCCTGACAGCAGCCCTGAG ACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGTCCTGGGAGGAGAACGACCGT GTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGCAGAACACGGAGAAGGGGCCC AATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCGTATCGGGGCCCCTGGCGGAG ACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACGACCGGCTCAAGGAGTTCAAC TTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCATTGACCACTTCGGCTTCAAT GATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCTCCCTCAATGCTGACGATGAG AACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAGAGGAGGACGAGGAAGAGGCC CAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTCTGGGCCAGCCACCTGGTGTC CGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGGGCATTGGCTGTGCAGCCCGT GGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCTTTGACCCAGTGCCTACAGAT GCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCCTCAGTGTGCCCCAGGGCCTC CCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCCCCTCAGCACCTCAGGAAGCC ACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGGCCACCTTCCACGGGATCCGT TCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACCAGCCCCCCCAGACCACAGAA GGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGATACCCAATGGCTCTGCCCCG >In-frame_VRK3_ENST00000377011_chr19_50504047_-_PPP6R1_ENST00000412770_chr19_55753856_-_2490nt ATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAG CATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAG AAGACCAGGAAGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTG AAGCGGAGCCGAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCC TTCCAGACCAGGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTC TCACTCAAACTGCAACATTCCAACGCATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGC CCAGAGCCTGACCAACTGCTGGCCACCCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAG TCTGTCATCGTCAGTGGGATCCAGGTGCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTC AGCAGTGTGGATGGGCAGCTGGAGCTCCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCG CGGCTCAGCTGCTTCCACCAGCTCCTGCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGC AACACGCGGCTGCACGTGGTCAAGCTCCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTG CCCAACACCATGCTGGACCTCTTCTTCCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGC TTGGGGCCACCTCCTGACAGCAGCCCTGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGG ATCCTGACGTCCTGGGAGGAGAACGACCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGT GCCCTGGTGCAGAACACGGAGAAGGGGCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGG GAAGCCTTCGTATCGGGGCCCCTGGCGGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGAC GATGAGGACGACCGGCTCAAGGAGTTCAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACC TCTGCCTTCATTGACCACTTCGGCTTCAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAAC ATCACCTTCTCCCTCAATGCTGACGATGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGAT GATGAGGAAGAGGAGGACGAGGAAGAGGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGG GGGGCCCGTCTGGGCCAGCCACCTGGTGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAA GACGAGGAGGGCATTGGCTGTGCAGCCCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGG ACAGCCACCTTTGACCCAGTGCCTACAGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCA CAGGGGCCCCTCAGTGTGCCCCAGGGCCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGAC CCCACACCCCCCTCAGCACCTCAGGAAGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGG GACCTTCAGGCCACCTTCCACGGGATCCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCC GGGGCCCACCAGCCCCCCCAGACCACAGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACG >In-frame_VRK3_ENST00000377011_chr19_50504047_-_PPP6R1_ENST00000587283_chr19_55753856_-_2490nt ATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAG CATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAG AAGACCAGGAAGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTG AAGCGGAGCCGAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCC TTCCAGACCAGGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTC TCACTCAAACTGCAACATTCCAACGCATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGC CCAGAGCCTGACCAACTGCTGGCCACCCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAG TCTGTCATCGTCAGTGGGATCCAGGTGCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTC AGCAGTGTGGATGGGCAGCTGGAGCTCCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCG CGGCTCAGCTGCTTCCACCAGCTCCTGCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGC AACACGCGGCTGCACGTGGTCAAGCTCCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTG CCCAACACCATGCTGGACCTCTTCTTCCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGC TTGGGGCCACCTCCTGACAGCAGCCCTGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGG ATCCTGACGTCCTGGGAGGAGAACGACCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGT GCCCTGGTGCAGAACACGGAGAAGGGGCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGG GAAGCCTTCGTATCGGGGCCCCTGGCGGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGAC GATGAGGACGACCGGCTCAAGGAGTTCAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACC TCTGCCTTCATTGACCACTTCGGCTTCAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAAC ATCACCTTCTCCCTCAATGCTGACGATGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGAT GATGAGGAAGAGGAGGACGAGGAAGAGGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGG GGGGCCCGTCTGGGCCAGCCACCTGGTGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAA GACGAGGAGGGCATTGGCTGTGCAGCCCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGG ACAGCCACCTTTGACCCAGTGCCTACAGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCA CAGGGGCCCCTCAGTGTGCCCCAGGGCCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGAC CCCACACCCCCCTCAGCACCTCAGGAAGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGG GACCTTCAGGCCACCTTCCACGGGATCCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCC GGGGCCCACCAGCCCCCCCAGACCACAGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_VRK3_ENST00000316763_chr19_50504047_-_PPP6R1_ENST00000412770_chr19_55753856_-_3572nt GCTCTCCGCCCAGCGGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCC AGAATCCCACCCCAGTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATA AAGCATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGA GGAGCATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTC TCCTAAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCT GAGTTCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGAC CAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACT TGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCAT TCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCAACATTCCAACGC ATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTGACCAACTGCTGGCCAC CCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCGTCAGTGGGATCCAGGT GCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGGATGGGCAGCTGGAGCT CCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCTGCTTCCACCAGCTCCT GCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGCTGCACGTGGTCAAGCT CCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCATGCTGGACCTCTTCTT CCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCACCTCCTGACAGCAGCCC TGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGTCCTGGGAGGAGAACGA CCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGCAGAACACGGAGAAGGG GCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCGTATCGGGGCCCCTGGC GGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACGACCGGCTCAAGGAGTT CAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCATTGACCACTTCGGCTT CAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCTCCCTCAATGCTGACGA TGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAGAGGAGGACGAGGAAGA GGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTCTGGGCCAGCCACCTGG TGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGGGCATTGGCTGTGCAGC CCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCTTTGACCCAGTGCCTAC AGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCCTCAGTGTGCCCCAGGG CCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCCCCTCAGCACCTCAGGA AGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGGCCACCTTCCACGGGAT CCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACCAGCCCCCCCAGACCAC AGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGATACCCAATGGCTCTGC CCCGGAAGGGCCTGCATCCCCAGGCTCCCAATAGCTGCCTGGTGCGGCAGCGGCGGCCAAATCTTCCGTCCTCCCGTGGATCTCCCGGGG TGGGGGCAGGGCGGGTCCCACGATGGCCCCCATTGCCCTCATCACCCTGACACCCCCACATTCTCTCCTCTGGACCCCCAGGAGGCTGGT GCCAGGGAGACAGGCCCAACCCACCCCCATTTGCACTGAGAAGAGAAGTTTTGGAGCGTTGCCTCCTAGAATAAAGATACAGAGAGTCAA ATAGAGAGAATGGAGAGAGAGAAACATATATTATATATTATATAGAGAGAGGGAGGAGAGCGAGAGAGAGTGAGGACACCGAACTGGGCT GGCGGCTCCAAAGCACAGCCTTCCCTGTTCCGTCCCAGCGGGAGCTGGTGTTAGGGGTCCCAAGGTTGCCACCCACGTGCCCAGCTGTCC CACGCTGCAGCGCAGACGGCCACGCCCACACCCGGCCTTTTAGCTCAGGTCCACCATGGGGGACGGCCCAGCGTGGGTGGGGGTGCCAGA GGGTCCCGAGTGGGGGCCGTGCCTTTGCCCAGACCCTGCACTTTCAACCAGGCCAGTCCGGCTCTGGGGAGCAGGGGCCTCCCCGGCAAC AGCCCCAGGGGCCTTGAGGGTCTGAGGTCCCAGCCCTGTTGCCAAGTGACCTTGTCCCCAGCTCCCTCCTCCCAGGCTGGTGTGAGTGTG >In-frame_VRK3_ENST00000316763_chr19_50504047_-_PPP6R1_ENST00000587283_chr19_55753856_-_2862nt GCTCTCCGCCCAGCGGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCC AGAATCCCACCCCAGTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATA AAGCATGATCTCCTTCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGA GGAGCATGTAGGGTCCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCAAAGAGAGGGCTGAACTCCAGTTTTGAAACCTC TCCTAAGAAAGTGAAATGGTCCAGCACCGTCACCTCTCCCCGATTATCCCTCTTCTCAGATGGTGACAGTTCTGAGTCTGAAGATACTCT GAGTTCCTCTGAGAGATCCAAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGAAGAGCCCTCAGGTGAC CAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCCGAGTGACCACCTCACT TGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCAGGGACAACCAGGGCAT TCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAACTGCAACATTCCAACGC ATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTGACCAACTGCTGGCCAC CCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCGTCAGTGGGATCCAGGT GCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGGATGGGCAGCTGGAGCT CCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCTGCTTCCACCAGCTCCT GCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGCTGCACGTGGTCAAGCT CCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCATGCTGGACCTCTTCTT CCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCACCTCCTGACAGCAGCCC TGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGTCCTGGGAGGAGAACGA CCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGCAGAACACGGAGAAGGG GCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCGTATCGGGGCCCCTGGC GGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACGACCGGCTCAAGGAGTT CAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCATTGACCACTTCGGCTT CAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCTCCCTCAATGCTGACGA TGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAGAGGAGGACGAGGAAGA GGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTCTGGGCCAGCCACCTGG TGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGGGCATTGGCTGTGCAGC CCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCTTTGACCCAGTGCCTAC AGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCCTCAGTGTGCCCCAGGG CCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCCCCTCAGCACCTCAGGA AGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGGCCACCTTCCACGGGAT CCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACCAGCCCCCCCAGACCAC AGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGATACCCAATGGCTCTGC >In-frame_VRK3_ENST00000377011_chr19_50504047_-_PPP6R1_ENST00000412770_chr19_55753856_-_3408nt GGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCCAGAATCCCACCCCA GTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATAAAGCATGATCTCCT TCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAGCATGTAGGGT CCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGA AGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCC GAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCA GGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAAC TGCAACATTCCAACGCATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTG ACCAACTGCTGGCCACCCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCG TCAGTGGGATCCAGGTGCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGG ATGGGCAGCTGGAGCTCCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCT GCTTCCACCAGCTCCTGCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGC TGCACGTGGTCAAGCTCCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCA TGCTGGACCTCTTCTTCCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCAC CTCCTGACAGCAGCCCTGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGT CCTGGGAGGAGAACGACCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGC AGAACACGGAGAAGGGGCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCG TATCGGGGCCCCTGGCGGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACG ACCGGCTCAAGGAGTTCAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCA TTGACCACTTCGGCTTCAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCT CCCTCAATGCTGACGATGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAG AGGAGGACGAGGAAGAGGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTC TGGGCCAGCCACCTGGTGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGG GCATTGGCTGTGCAGCCCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCT TTGACCCAGTGCCTACAGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCC TCAGTGTGCCCCAGGGCCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCC CCTCAGCACCTCAGGAAGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGG CCACCTTCCACGGGATCCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACC AGCCCCCCCAGACCACAGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGA TACCCAATGGCTCTGCCCCGGAAGGGCCTGCATCCCCAGGCTCCCAATAGCTGCCTGGTGCGGCAGCGGCGGCCAAATCTTCCGTCCTCC CGTGGATCTCCCGGGGTGGGGGCAGGGCGGGTCCCACGATGGCCCCCATTGCCCTCATCACCCTGACACCCCCACATTCTCTCCTCTGGA CCCCCAGGAGGCTGGTGCCAGGGAGACAGGCCCAACCCACCCCCATTTGCACTGAGAAGAGAAGTTTTGGAGCGTTGCCTCCTAGAATAA AGATACAGAGAGTCAAATAGAGAGAATGGAGAGAGAGAAACATATATTATATATTATATAGAGAGAGGGAGGAGAGCGAGAGAGAGTGAG GACACCGAACTGGGCTGGCGGCTCCAAAGCACAGCCTTCCCTGTTCCGTCCCAGCGGGAGCTGGTGTTAGGGGTCCCAAGGTTGCCACCC ACGTGCCCAGCTGTCCCACGCTGCAGCGCAGACGGCCACGCCCACACCCGGCCTTTTAGCTCAGGTCCACCATGGGGGACGGCCCAGCGT GGGTGGGGGTGCCAGAGGGTCCCGAGTGGGGGCCGTGCCTTTGCCCAGACCCTGCACTTTCAACCAGGCCAGTCCGGCTCTGGGGAGCAG GGGCCTCCCCGGCAACAGCCCCAGGGGCCTTGAGGGTCTGAGGTCCCAGCCCTGTTGCCAAGTGACCTTGTCCCCAGCTCCCTCCTCCCA >In-frame_VRK3_ENST00000377011_chr19_50504047_-_PPP6R1_ENST00000587283_chr19_55753856_-_2698nt GGAAGTTTTCGCTGGGCAACTGAGAAGGTGAGTCCGGGTAACTGCGGAGGATCCGAGGGTCAGGCTGCAGAAGCCCAGAATCCCACCCCA GTCCCCAAGTACAGAGGTCGCTGTCAAGATGGAGTTTCCAACCCAGTAAATCCAAGGGCCAGACCGTGACCTCATAAAGCATGATCTCCT TCTGTCCAGACTGTGGCAAAAGTATCCAAGCGGCATTCAAATTCTGCCCCTACTGTGGAAATTCTTTGCCTGTAGAGGAGCATGTAGGGT CCCAGACCTTTGTCAATCCACATGTGTCATCCTTCCAAGGCTCCGGGAGCAGACCCCCAACCCCCAAAAGCAGCCCTCAGAAGACCAGGA AGAGCCCTCAGGTGACCAGGGGTAGCCCTCAGAAGACCAGCTGTAGCCCTCAGAAGACCAGGCAGAGCCCTCAGACGCTGAAGCGGAGCC GAGTGACCACCTCACTTGAAGCTTTGCCCACAGGGACAGTGCTGACAGACAAGAGTGGGCGACAGTGGAAGCTGAAGTCCTTCCAGACCA GGGACAACCAGGGCATTCTCTATGAAGCTGCACCCACCTCCACCCTCACCTGTGACTCAGGACCACAGAAGCAAAAGTTCTCACTCAAAC TGCAACATTCCAACGCATCCCAGTCCCTGTGTGACATCATCCGCCTGAGCCGGGAGCAGATGATCCAAGTCCAGGACAGCCCAGAGCCTG ACCAACTGCTGGCCACCCTGGAGAAGCAGGAGACGATTGAGCAGCTCTTAAGCAACATGTTCGAGGGGGAGCAGAGCCAGTCTGTCATCG TCAGTGGGATCCAGGTGCTGCTGACCCTGCTGGAGCCCAGGAGGCCGAGGTCCGAGTCCGTGACCGTGAACAGCTTCTTCAGCAGTGTGG ATGGGCAGCTGGAGCTCCTGGCCCAGGGGGCCCTGGAAAGCACTGTGTCCAGTGTGGGCGCCTTGCACGCCCTACGCCCGCGGCTCAGCT GCTTCCACCAGCTCCTGCTGGAGCCTCCCAAGCTGGAGCCGCTACAGATGACATGGGGCATGCTGGCTCCGCCTCTGGGCAACACGCGGC TGCACGTGGTCAAGCTCCTGGCCAGTGCCCTGAGCGCCAATGATGCAGCCCTGACGCACGAGCTCCTGGCACTGGACGTGCCCAACACCA TGCTGGACCTCTTCTTCCATTATGTCTTCAACAACTTCTTGCATGCCCAAGTAGAGGGATGCGTGAGCACCATGCTGAGCTTGGGGCCAC CTCCTGACAGCAGCCCTGAGACGCCCATCCAAAACCCTGTTGTGAAACATCTGCTGCAGCAGTGCCGCCTGGTGGAGCGGATCCTGACGT CCTGGGAGGAGAACGACCGTGTACAGTGTGCGGGAGGCCCTCGGAAAGGCTACATGGGTCACCTGACAAGAGTGGCCGGTGCCCTGGTGC AGAACACGGAGAAGGGGCCCAATGCAGAGCAGCTGCGGCAGCTGCTGAAGGAGCTGCCCAGCGAGCAGCAGGAGCAGTGGGAAGCCTTCG TATCGGGGCCCCTGGCGGAGACCAACAAGAAGAACATGGTGGACCTGGTGAACACCCACCACCTACACTCCTCCAGTGACGATGAGGACG ACCGGCTCAAGGAGTTCAACTTCCCTGAGGAGGCTGTGCTGCAGCAGGCCTTCATGGACTTCCAGATGCAGCGCATGACCTCTGCCTTCA TTGACCACTTCGGCTTCAATGATGAGGAGTTTGGGGAGCAGGAGGAGAGTGTGAACGCACCTTTTGACAAGACAGCCAACATCACCTTCT CCCTCAATGCTGACGATGAGAACCCCAACGCCAACCTACTTGAGATATGCTACAAGGACCGCATCCAGCAGTTTGATGATGATGAGGAAG AGGAGGACGAGGAAGAGGCCCAGGGCTCAGGGGAGTCTGATGGAGAAGATGGCGCCTGGCAGGGCAGCCAGCTGGCCAGGGGGGCCCGTC TGGGCCAGCCACCTGGTGTCCGGAGTGGAGGCAGCACAGACAGTGAGGACGAAGAAGAGGAGGACGAGGAGGAGGAGGAAGACGAGGAGG GCATTGGCTGTGCAGCCCGTGGAGGGGCCACCCCTCTGTCCTACCCCAGCCCTGGCCCTCAGCCTCCAGGCCCCAGCTGGACAGCCACCT TTGACCCAGTGCCTACAGATGCCCCGACCAGCCCCCGAGTCTCCGGGGAGGAAGAGCTGCACACTGGGCCTCCAGCCCCACAGGGGCCCC TCAGTGTGCCCCAGGGCCTCCCCACTCAGAGCCTGGCCAGCCCTCCTGCCCGTGACGCCCTGCAGCTCAGGTCTCAGGACCCCACACCCC CCTCAGCACCTCAGGAAGCCACAGAAGGCAGCAAAGTCACGGAGCCCTCAGCCCCTTGCCAGGCCTTGGTTAGCATCGGGGACCTTCAGG CCACCTTCCACGGGATCCGTTCTGCCCCCAGCTCCTCGGACAGTGCAACCAGAGACCCCTCTACCTCTGTCCCAGCCTCCGGGGCCCACC AGCCCCCCCAGACCACAGAAGGGGAGAAGAGCCCAGAGCCCTTGGGGCTTCCCCAAAGCCAGAGTGCCCAGGCCCTCACGCCTCCTCCGA |
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FusionGenePPI for VRK3_PPP6R1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| VRK3 | TWF2, CSNK2B, PLK1, TXNDC5, NR2E1, ZNF524, MAX, FOXD3, FOXP1, SP4 | PPP6R1 | TBK1, USP49, PPP6C, PRKDC, UBC, SH3GL2, MED14, MED24, BRCA1, NOTCH1, SOX2, HDAC11, EGFR, USP10, ANKRD28, MOB1A, MOB1B, ACAD11, ACSL3, ALDH3A2, ANKRD44, ANKRD52, ARHGEF2, CNOT1, CNOT10, GTF3C4, HADHA, HADHB, HSPA4, IKBKAP, ILVBL, C2CD5, KNTC1, PDCD2, PFDN2, PFDN5, PFDN6, PPP6R2, SGPL1, SRPR, SRPRB, TTF2, PPP6R3, AGO1, PNKD, DCLRE1C, PRG2, RPS6KB2, NTRK1, CEP44, XPO1, FOXK1, FOXL1, CDC14A, TRMT2A, CHRM4, NPAS1, CHRM3, CPA6, KIAA1683, MTNR1B, FBXL13 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000412770 | - | 4 | 24 | 10_403 | 206 | 882 | PPP6C |
| Tgene | PPP6R1 | chr19:50504047 | chr19:55753856 | ENST00000587283 | - | 3 | 23 | 10_403 | 206 | 882 | PPP6C |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VRK3_PPP6R1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VRK3_PPP6R1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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