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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41656

FusionGeneSummary for VPS9D1_ZNF827

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS9D1_ZNF827
Fusion gene ID: 41656
HgeneTgene
Gene symbol

VPS9D1

ZNF827

Gene ID

9605

152485

Gene nameVPS9 domain containing 1zinc finger protein 827
SynonymsATP-BL|C16orf7-
Cytomap

16q24.3

4q31.21-q31.22

Type of geneprotein-codingprotein-coding
DescriptionVPS9 domain-containing protein 1zinc finger protein 827
Modification date2018051920180523
UniProtAcc

Q9Y2B5

Q17R98

Ensembl transtripts involved in fusion geneENST00000561976, ENST00000389386, 
ENST00000565452, 
ENST00000508784, 
ENST00000513320, ENST00000379448, 
ENST00000511534, 
Fusion gene scores* DoF score3 X 3 X 2=1810 X 4 X 7=280
# samples 310
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VPS9D1 [Title/Abstract] AND ZNF827 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-HT-7857-01AVPS9D1chr16

89787171

-ZNF827chr4

146700663

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000561976ENST00000508784VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
intron-3CDSENST00000561976ENST00000513320VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
intron-3CDSENST00000561976ENST00000379448VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
intron-intronENST00000561976ENST00000511534VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
Frame-shiftENST00000389386ENST00000508784VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
Frame-shiftENST00000389386ENST00000513320VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
Frame-shiftENST00000389386ENST00000379448VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
5CDS-intronENST00000389386ENST00000511534VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
intron-3CDSENST00000565452ENST00000508784VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
intron-3CDSENST00000565452ENST00000513320VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
intron-3CDSENST00000565452ENST00000379448VPS9D1chr16

89787171

-ZNF827chr4

146700663

-
intron-intronENST00000565452ENST00000511534VPS9D1chr16

89787171

-ZNF827chr4

146700663

-

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FusionProtFeatures for VPS9D1_ZNF827


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VPS9D1

Q9Y2B5

ZNF827

Q17R98

May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VPS9D1_ZNF827


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VPS9D1_ZNF827


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VPS9D1CHMP4BZNF827PPP1CA, UBE2E1, ATP6V1E1, CHERP, VPS45, UNC80, HDAC1, GATAD2A, GATAD2B, RBBP7, RBBP4, CHD3, CHD4, MTA1, MTA2, MTA3, HDAC2, MCPH1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VPS9D1_ZNF827


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VPS9D1_ZNF827


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource