![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 41620 |
FusionGeneSummary for VPS52_FDPS |
![]() |
Fusion gene information | Fusion gene name: VPS52_FDPS | Fusion gene ID: 41620 | Hgene | Tgene | Gene symbol | VPS52 | FDPS | Gene ID | 6293 | 2224 |
Gene name | VPS52, GARP complex subunit | farnesyl diphosphate synthase | |
Synonyms | ARE1|SAC2|SACM2L|dJ1033B10.5 | FPPS|FPS|POROK9 | |
Cytomap | 6p21.32 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | vacuolar protein sorting-associated protein 52 homologSAC2 suppressor of actin mutations 2-like proteinvacuolar protein sorting 52 homolog | farnesyl pyrophosphate synthase(2E,6E)-farnesyl diphosphate synthaseFPP synthaseFPP synthetasefarnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8N1B4 | P14324 | |
Ensembl transtripts involved in fusion gene | ENST00000482399, ENST00000445902, ENST00000478934, ENST00000436044, ENST00000448042, ENST00000488583, ENST00000441058, ENST00000471761, ENST00000443860, ENST00000483351, ENST00000383210, ENST00000489236, ENST00000485418, ENST00000421357, ENST00000428608, ENST00000484649, | ENST00000447866, ENST00000368356, ENST00000487002, ENST00000356657, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 3 X 1=9 |
# samples | 5 | 5 | |
** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/9*10)=2.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: VPS52 [Title/Abstract] AND FDPS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | VPS52 | GO:0007041 | lysosomal transport | 25799061 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA312317 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000482399 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000482399 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000482399 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000482399 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000445902 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000445902 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000445902 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000445902 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000478934 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000478934 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000478934 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000478934 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000436044 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000436044 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000436044 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000436044 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000448042 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000448042 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000448042 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000448042 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000488583 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000488583 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000488583 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000488583 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000441058 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000441058 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000441058 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000441058 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000471761 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000471761 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000471761 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000471761 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000443860 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000443860 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000443860 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000443860 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000483351 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000483351 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000483351 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000483351 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000383210 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000383210 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000383210 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000383210 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000489236 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000489236 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000489236 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000489236 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000485418 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000485418 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000485418 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000485418 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000421357 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000421357 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000421357 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000421357 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000428608 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000428608 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000428608 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000428608 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000484649 | ENST00000447866 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000484649 | ENST00000368356 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000484649 | ENST00000487002 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
intron-intron | ENST00000484649 | ENST00000356657 | VPS52 | chr6 | 4708717 | + | FDPS | chr1 | 155285195 | - |
Top |
FusionProtFeatures for VPS52_FDPS |
![]() |
Hgene | Tgene |
VPS52 | FDPS |
Key enzyme in isoprenoid biosynthesis which catalyzesthe formation of farnesyl diphosphate (FPP), a precursor forseveral classes of essential metabolites including sterols,dolichols, carotenoids, and ubiquinones. FPP also serves assubstrate for protein farnesylation and geranylgeranylation.Catalyzes the sequential condensation of isopentenyl pyrophosphatewith the allylic pyrophosphates, dimethylallyl pyrophosphate, andthen with the resultant geranylpyrophosphate to the ultimateproduct farnesyl pyrophosphate. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for VPS52_FDPS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for VPS52_FDPS |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for VPS52_FDPS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | FDPS | P14324 | DB00282 | Pamidronate | Farnesyl pyrophosphate synthase | small molecule | approved |
Tgene | FDPS | P14324 | DB00399 | Zoledronic acid | Farnesyl pyrophosphate synthase | small molecule | approved |
Tgene | FDPS | P14324 | DB00630 | Alendronic acid | Farnesyl pyrophosphate synthase | small molecule | approved |
Tgene | FDPS | P14324 | DB00710 | Ibandronate | Farnesyl pyrophosphate synthase | small molecule | approved|investigational |
Tgene | FDPS | P14324 | DB00884 | Risedronate | Farnesyl pyrophosphate synthase | small molecule | approved|investigational |
Top |
RelatedDiseases for VPS52_FDPS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | VPS52 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | FDPS | C4225262 | POROKERATOSIS 9, MULTIPLE TYPES | 1 | UNIPROT |