|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 41596 |
FusionGeneSummary for VPS37B_VPS33A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VPS37B_VPS33A | Fusion gene ID: 41596 | Hgene | Tgene | Gene symbol | VPS37B | VPS33A | Gene ID | 79720 | 65082 |
| Gene name | VPS37B, ESCRT-I subunit | VPS33A, CORVET/HOPS core subunit | |
| Synonyms | - | MPSPS | |
| Cytomap | 12q24.31 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vacuolar protein sorting-associated protein 37BESCRT-I complex subunit VPS37BhVps37Bvacuolar protein sorting 37 homolog Bvacuolar protein sorting 37B | vacuolar protein sorting-associated protein 33Avacuolar protein sorting 33 homolog Avacuolar protein sorting 33A | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9H9H4 | Q96AX1 | |
| Ensembl transtripts involved in fusion gene | ENST00000267202, | ENST00000267199, ENST00000542310, ENST00000451053, | |
| Fusion gene scores | * DoF score | 7 X 2 X 6=84 | 2 X 2 X 2=8 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: VPS37B [Title/Abstract] AND VPS33A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | VPS33A | GO:0016192 | vesicle-mediated transport | 15790593 |
| Tgene | VPS33A | GO:0032400 | melanosome localization | 15790593 |
| Tgene | VPS33A | GO:0032418 | lysosome localization | 15790593 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A25F-01A | VPS37B | chr12 | 123380499 | - | VPS33A | chr12 | 122727055 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000267202 | ENST00000267199 | VPS37B | chr12 | 123380499 | - | VPS33A | chr12 | 122727055 | - |
| 5CDS-intron | ENST00000267202 | ENST00000542310 | VPS37B | chr12 | 123380499 | - | VPS33A | chr12 | 122727055 | - |
| 5CDS-intron | ENST00000267202 | ENST00000451053 | VPS37B | chr12 | 123380499 | - | VPS33A | chr12 | 122727055 | - |
Top |
FusionProtFeatures for VPS37B_VPS33A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VPS37B | VPS33A |
| Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May beinvolved in cell growth and differentiation.{ECO:0000269|PubMed:15218037}. | Plays a role in vesicle-mediated protein trafficking tolysosomal compartments including the endocytic membrane transportand autophagic pathways. Believed to act as a core component ofthe putative HOPS and CORVET endosomal tethering complexes whichare proposed to be involved in the Rab5-to-Rab7 endosomeconversion probably implicating MON1A/B, and via binding SNAREsand SNARE complexes to mediate tethering and docking events duringSNARE-mediated membrane fusion. The HOPS complex is proposed to berecruited to Rab7 on the late endosomal membrane and to regulatelate endocytic, phagocytic and autophagic traffic towardslysosomes. The CORVET complex is proposed to function as a Rab5effector to mediate early endosome fusion probably in specificendosome subpopulations (PubMed:23351085, PubMed:24554770,PubMed:25266290, PubMed:25783203). Required for fusion ofendosomes and autophagosomes with lysosomes; the function isdependent on its association with VPS16 but not VIPAS39(PubMed:25783203). The function in autophagosome-lysosome fusionimplicates STX17 but not UVRAG (PubMed:24554770).{ECO:0000269|PubMed:24554770, ECO:0000269|PubMed:25783203,ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25266290,ECO:0000305|PubMed:25783203}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >VPS37B | chr12:123380499 | chr12:122727055 | ENST00000267202 | - | 1 | 4 | 170_280 | 37 | 286 | Compositional bias | Note=Pro-rich |
| Hgene | >VPS37B | chr12:123380499 | chr12:122727055 | ENST00000267202 | - | 1 | 4 | 84_173 | 37 | 286 | Domain | VPS37 C-terminal |
Top |
FusionGeneSequence for VPS37B_VPS33A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_VPS37B_ENST00000267202_chr12_123380499_-_VPS33A_ENST00000267199_chr12_122727055_-_311aa MAGAGSEARFAGLSLVQLNELLEDEGQLTEMVQKMEEERHNAKTVGEIKQFVSQLPHMQAARGSLANHTSIAELIKDVTTSEDFFDKLTV EQEFMSGIDTDKVNNYIEDCIAQKHSLIKVLRLVCLQSVCNSGLKQKVLDYYKREILQTYGYEHILTLHNLEKAGLLKPQTGGRNNYPTI RKTLRLWMDDVNEQNPTDISYVYSGYAPLSVRLAQLLSRPGWRSIEEVLRILPGPHFEERQPLPTGLQKKRQPGENRVTLIFFLGGVTFA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_VPS37B_ENST00000267202_chr12_123380499_-_VPS33A_ENST00000267199_chr12_122727055_-_933nt ATGGCGGGCGCCGGGAGCGAAGCCCGGTTCGCCGGGCTGTCGCTGGTGCAGCTCAACGAGCTGCTGGAGGACGAGGGCCAGCTGACGGAG ATGGTGCAGAAGATGGAGGAGGAAAGACACAATGCTAAGACCGTGGGGGAGATCAAGCAGTTTGTTTCCCAGTTGCCCCACATGCAGGCA GCAAGGGGCTCGCTTGCAAACCATACCTCAATTGCAGAATTGATCAAAGATGTCACTACTTCTGAAGACTTTTTTGATAAATTAACCGTG GAACAGGAGTTTATGTCTGGAATAGACACTGATAAGGTCAACAATTACATTGAGGATTGTATCGCCCAAAAGCACTCGTTGATCAAGGTG TTAAGACTAGTTTGCCTCCAATCCGTGTGTAATAGTGGGCTCAAACAAAAAGTTTTGGATTATTACAAAAGAGAGATTCTCCAGACATAC GGCTATGAGCACATATTGACCTTACACAACCTGGAGAAGGCCGGCCTGCTGAAACCGCAGACGGGGGGCAGAAACAATTACCCAACTATA CGGAAAACATTACGCCTCTGGATGGATGATGTTAATGAGCAAAACCCCACGGACATATCGTATGTGTACAGTGGGTATGCCCCGCTCAGT GTGCGGCTGGCCCAGCTGCTTTCCCGGCCTGGCTGGCGGAGCATCGAGGAGGTCCTCCGCATCCTCCCAGGGCCCCACTTTGAGGAGCGG CAGCCACTGCCCACAGGACTGCAGAAGAAACGTCAACCGGGAGAAAACCGAGTGACTCTGATATTTTTCCTTGGGGGCGTAACCTTCGCT GAAATTGCTGCCCTGCGATTTCTCTCCCAGTTGGAAGATGGAGGTACAGAATATGTCATTGCCACCACTAAACTAATGAATGGAACCAGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_VPS37B_ENST00000267202_chr12_123380499_-_VPS33A_ENST00000267199_chr12_122727055_-_3997nt GGGCTCACAGGCTGCGGGAACTTCCTTCCCACTGCCTGTTTTCCTTGGATCGCGGTATCTCTCTTCCTGGAGGAAAAAGGCTCTTATGAC CTCATGGCGCGCTCTCCCGAGCCGCAGTGACGTCATTAATGCGCTCACGCGTCACAGCCCAATCATAGGGCCCTTCCCCTCCCTTTAGAA GTCCCGACTGTCCCTGACACATTCCACTCCAAGCGAGCCGCGACACTTACGTCACGTCCGCCCGCCCGCGCGGTGATGACGTCACGACCC AGGGCTGGCGTCACGTGTCCCCCCCGCGGGGGGCGGCCCTTGAGGGCGGCGCTTCCGGTCGGCGGAGCCTGGTGGCCGCAGCGGCGGTGG CGACGACGGCCGAGACGTGGGGATGGCGGGCGCCGGGAGCGAAGCCCGGTTCGCCGGGCTGTCGCTGGTGCAGCTCAACGAGCTGCTGGA GGACGAGGGCCAGCTGACGGAGATGGTGCAGAAGATGGAGGAGGAAAGACACAATGCTAAGACCGTGGGGGAGATCAAGCAGTTTGTTTC CCAGTTGCCCCACATGCAGGCAGCAAGGGGCTCGCTTGCAAACCATACCTCAATTGCAGAATTGATCAAAGATGTCACTACTTCTGAAGA CTTTTTTGATAAATTAACCGTGGAACAGGAGTTTATGTCTGGAATAGACACTGATAAGGTCAACAATTACATTGAGGATTGTATCGCCCA AAAGCACTCGTTGATCAAGGTGTTAAGACTAGTTTGCCTCCAATCCGTGTGTAATAGTGGGCTCAAACAAAAAGTTTTGGATTATTACAA AAGAGAGATTCTCCAGACATACGGCTATGAGCACATATTGACCTTACACAACCTGGAGAAGGCCGGCCTGCTGAAACCGCAGACGGGGGG CAGAAACAATTACCCAACTATACGGAAAACATTACGCCTCTGGATGGATGATGTTAATGAGCAAAACCCCACGGACATATCGTATGTGTA CAGTGGGTATGCCCCGCTCAGTGTGCGGCTGGCCCAGCTGCTTTCCCGGCCTGGCTGGCGGAGCATCGAGGAGGTCCTCCGCATCCTCCC AGGGCCCCACTTTGAGGAGCGGCAGCCACTGCCCACAGGACTGCAGAAGAAACGTCAACCGGGAGAAAACCGAGTGACTCTGATATTTTT CCTTGGGGGCGTAACCTTCGCTGAAATTGCTGCCCTGCGATTTCTCTCCCAGTTGGAAGATGGAGGTACAGAATATGTCATTGCCACCAC TAAACTAATGAATGGAACCAGTTGGATAGAGGCTCTGATGGAAAAACCTTTCTAGGATGTTCAGAGGAGACTTAACAAGTGTACTGCAGA ATAAACTACCTCTTTGAAGAAATTGCTGAAAGGAAGTAAAACCCCATAGAAGAAACATGGGAATACAGAATATATTCTGGGGTCAGCTTC TTAAATTATACTACTGTTTACTGCTTTCTCCGTCTCTTTTGTATTCCCTTTTTTTTTTTCCTTTGAGACGGAGTCTTGCTCTGTCACCCA GACTAGAGTGCAGTGGCACGGTCTCACCTCACTGCAACCTCCACCTCCTAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTG GGACTACAGGCATGCACCACCACACCCGGCTAATTTTTGTATTTTTAGTAGCCATGGTGTTTCACCATGTTGGCCAGGCTGGTCTCAAAC TCCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCACAGTGCTGGGATTACAGGCCTGAGCCACCGTGCCTGGCCCCTAATCTGCTGAA GAAAGAAGAATAGAAGAAAATCAACCTGAGTAAAAGCAGCACTGGTTTTGAGTTTTCTAAGCTCAGGGTCTTCATTAGAGACCTCTGGAA ATACATTAAGGATGGTGGGGGTAGATAATCCATTCAGCCAGACAAACGGGGCCAGCTCTTAAAATAAGAAAGCTGAGACTGAGGAGGTGA AACTGAAAATAAAAAGAGAAAGTTCATCCTCTAATCCCCAGTGCTGTATTTCTTCAAGGCGCATCAGGCCTAGGACAGTGGTTAAGTGTT GGGAGCTGGAGATCATTTTATCACTGAGTTGAGATTTCTTTTTCCTGCAGAGTGTGGGAGATTATATTTAGGGTCATCAGTCACTGTCGC AACTGATCACTAAGGCAAGTTTGCTTCCTTCTACTTCTTACAAAGCAAGAGGTTTAGGGGAGCTTCTTGCCCAGAAACAAAGTTTATGCT CTATGTGATCAGCTACATCTCCTTAGGTTCCATACTTATCAGGGGCTTTTGACATGGAAGAATGTGATAATTGGGGAGCAACCTTCTGAG AATTCAGCCTTTGAAGTAATTCAAAGACAGTTTCTTAGCACACACGTTAACTCCAGACACAGCAGTGGTGGGTGCCTCCATTGAGGTTTC CGTTTTCTCTTCTGTCCATCAAGGGCCCAACATCCAACTGGTCCCACAGTGAGCAGGGGCAACTCTTGCTTCTTCAGCATCTGGCCACTT CGTTTCCATGGTAACTGCCACGTGTACTTTTCTAGCAGTCTGTGGCCACTCCGTACTCAGCTGAAAACACTGTTTCAGCCCCCTCTCTGG TGACCTCAGCCTTCTCCAGGTGTATCTCTTGATGATCTTGGAGACCAGCAGCCACAGCTGCTGCTACTCCTGCAGGAGACTGTCAGGCTG TGGTGGGGGGCAGGGGTGTTGGAGGAGAAGTTGAAAATCCGTGTGTTCTCTGCCCCTCTGCTCCTCCATCTTAGCTTCTGGAGGAGTTAA GGCACCAAGGGCACCAAGTCAGGTTGGCAGTTTTGCTGCCCTTGCCCAAGCCTCCAGCAAAACTAGCTGGTCCCCTGCTTTGCTGGGTCC CAGCCAGGTGTGATTTTGGTTGTTGATTAGTAACCACACATTGTTTTTCCCCACCTTTTTCATTAGTGGAGGTTTTTGTTTTGTTTTGTT TTTGTTTGTTTGAGACAGAGTCTCACGCTCTTTTCAGACTGGAGTGCAGTGGTGCGATGTCAGCTCACTGCAACCTCCACTTCCCGGGTT CAGACGATTCTCATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGATGTGCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGA TGGGGTTTCACCATATTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGCGATTGGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAG GTGTGAACCACCGTGCCCGGCCCATTAGTGGAGTTCTGATGGGCACGGTAAATATTATTAATGAAAGAGAAATTCTGTATACTTTTTTAA AAATCTCTTTAATGAAAGAATGAAGAGTGGCAGAGATAATAATTGAAAGATTAGTTTCTCATGGAATTAATTTGGCCTTGATATTCAGTA TTTGGAAATGTCTTAAAGAAAACCATTTTCATTGTAGAAAATCCTTTTTTAAATACTTGTTATATCCCAGGGAGATTAGTTTATACCTTC CACCTCAGGCAGTCATCAGCTGCTTTAGAGAATGGAATCCACCCTGCCCCTCCATTTTTTGGTTCCTGGGGCTCAATTCAAGTCTGGTCA AGTCTCCCTGGCTGGGGATTCTGTCCTGGGAACAGATACTCAGTTGTAGTCTCATGTGTCTGCACTCACCCAAGACTCTATATACTTGCT TGCTCAGAGCATAGTTAGGGCAGCTCCTAAAAATGCATTCAGCAGAAGACTGAAAAACTTCAATTGCTTCATTTGTATGCAAATAGAAAA TGGTAGATAATTATATATTATACGCCTTTGTGTAAGTTCATTTAATACTTGAAGCAGTCTTTGTCTCAAAAGAGTATGCCCTTACTGAGA AAGGATATGTGAACGGTACATTTATTGTTGGGGAGAGTGGATTGTTTACATCATGTCTGGACTTTTGTCTAGTTGGGTAGACAGTTCTAC |
Top |
FusionGenePPI for VPS37B_VPS33A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| VPS37B | TSG101, VPS28, SH3KBP1, CEP55, WDR12, USP14, XPO7, UNC13D, XPO1, MVB12A, AES, BYSL, ERCC1, PRKAA1, QARS, SMARCD1, NCK2, SORBS3, SH3YL1, DCUN1D1, CDC73, UBASH3B, FBF1, DNAJB1, NIF3L1, RPRD1A, WARS, YBX1, UBAP1, GRB2 | VPS33A | VPS11, VPS18, UVRAG, VIPAS39, VPS16, VPS41, UBR7, VIM, SREK1, MON1B, MON1A, SOX2, CT55, TEKT4, PKNOX1, CRYAB, FBXW11, VPS45, NTRK1, CNTRL, CDC5L, AP3D1, CLTB, TGFBRAP1, STX17, MTMR7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | VPS37B | chr12:123380499 | chr12:122727055 | ENST00000267202 | - | 1 | 4 | 50_170 | 37 | 286 | IST1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for VPS37B_VPS33A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for VPS37B_VPS33A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|