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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41560

FusionGeneSummary for VPS18_ZFYVE19

check button Fusion gene summary
Fusion gene informationFusion gene name: VPS18_ZFYVE19
Fusion gene ID: 41560
HgeneTgene
Gene symbol

VPS18

ZFYVE19

Gene ID

57617

84936

Gene nameVPS18, CORVET/HOPS core subunitzinc finger FYVE-type containing 19
SynonymsPEP3ANCHR|MPFYVE
Cytomap

15q15.1

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 18 homologhVPS18vacuolar protein sorting 18 homologvacuolar protein sorting protein 18abscission/NoCut checkpoint regulatorMLL partner containing FYVE domainzinc finger FYVE domain-containing protein 19zinc finger, FYVE domain containing 19
Modification date2018052320180523
UniProtAcc

Q9P253

Q96K21

Ensembl transtripts involved in fusion geneENST00000220509, ENST00000558474, 
ENST00000570108, ENST00000564258, 
ENST00000355341, ENST00000336455, 
ENST00000299173, ENST00000563530, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VPS18 [Title/Abstract] AND ZFYVE19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVPS18

GO:0007032

endosome organization

18799622

HgeneVPS18

GO:0007040

lysosome organization

18799622


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-18-3421-01AVPS18chr15

41188277

+ZFYVE19chr15

41106346

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000220509ENST00000570108VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
Frame-shiftENST00000220509ENST00000564258VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
In-frameENST00000220509ENST00000355341VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
In-frameENST00000220509ENST00000336455VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
In-frameENST00000220509ENST00000299173VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
5CDS-intronENST00000220509ENST00000563530VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
Frame-shiftENST00000558474ENST00000570108VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
Frame-shiftENST00000558474ENST00000564258VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
In-frameENST00000558474ENST00000355341VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
In-frameENST00000558474ENST00000336455VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
In-frameENST00000558474ENST00000299173VPS18chr15

41188277

+ZFYVE19chr15

41106346

+
5CDS-intronENST00000558474ENST00000563530VPS18chr15

41188277

+ZFYVE19chr15

41106346

+

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FusionProtFeatures for VPS18_ZFYVE19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VPS18

Q9P253

ZFYVE19

Q96K21

Plays a role in vesicle-mediated protein trafficking tolysosomal compartments including the endocytic membrane transportand autophagic pathways. Believed to act as a core component ofthe putative HOPS and CORVET endosomal tethering complexes whichare proposed to be involved in the Rab5-to-Rab7 endosomeconversion probably implicating MON1A/B, and via binding SNAREsand SNARE complexes to mediate tethering and docking events duringSNARE-mediated membrane fusion. The HOPS complex is proposed to berecruited to Rab7 on the late endosomal membrane and to regulatelate endocytic, phagocytic and autophagic traffic towardslysosomes. The CORVET complex is proposed to function as a Rab5effector to mediate early endosome fusion probably in specificendosome subpopulations (PubMed:11382755, PubMed:23351085,PubMed:24554770, PubMed:25783203). Required for fusion ofendosomes and autophagosomes with lysosomes (PubMed:25783203).Involved in dendrite development of Pukinje cells (By similarity).{ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203,ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085,ECO:0000305|PubMed:25783203}. Key regulator of abscission step in cytokinesis: part ofthe cytokinesis checkpoint, a process required to delay abscissionto prevent both premature resolution of intercellular chromosomebridges and accumulation of DNA damage. Together with CHMP4C,required to retain abscission-competent VPS4 (VPS4A and/or VPS4B)at the midbody ring until abscission checkpoint signaling isterminated at late cytokinesis. Deactivation of AURKB results indephosphorylation of CHMP4C followed by its dissociation fromZFYVE19/ANCHR and VPS4 and subsequent abscission.{ECO:0000269|PubMed:24814515}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VPS18_ZFYVE19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VPS18_ZFYVE19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VPS18CCNA1, VPS11, VPS16, VPS33A, STX7, GGA1, GGA2, GGA3, UVRAG, HOOK1, AKTIP, UBE2D2, VPS41, UTP20, POLR3A, HSP90AA1, MON1B, SYNPO2, EP300, COPB1, CT55, LDLRAD4, RILP, RAB7A, NTRK1, MED23, ALDOA, BIN1, NDUFV3, PRSS1, UPP1, VCP, MTA1, TGFBRAP1, SRRM1, VPS8, DNAJB5, RSRC1, SCLY, ZGRF1, SERINC1, ELMO3, TSEN2, OBSCN, TJAP1, MIA3, STX17, TECPR2, UXS1, VIPR2, LYPD4ZFYVE19UCHL3, UNK, UBQLN4, UBA2, UBXN1, UFM1, TYMS, LAGE3, YAP1, UBXN7, USP34, TTC1, UBQLN2, UBE2D1, UBA52, VPS4B, UFC1, UBE2V2, UBE2A, UBE2B, UBE2C, UBE4B, SULT1A1, SEC24C, TTC9C, ATP6V1B2, DSTN, USP9X, IGBP1, AHCYL1, PRDX5, HTT, SFN, G6PD, PAK2, TGM2, YWHAZ, CAPN7, CCHCR1, MITD1, ZDHHC17, VPS4A, PSMD13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VPS18_ZFYVE19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VPS18_ZFYVE19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource