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Fusion gene ID: 41559 |
FusionGeneSummary for VPS18_VPS18 |
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Fusion gene information | Fusion gene name: VPS18_VPS18 | Fusion gene ID: 41559 | Hgene | Tgene | Gene symbol | VPS18 | VPS18 | Gene ID | 57617 | 57617 |
Gene name | VPS18, CORVET/HOPS core subunit | VPS18, CORVET/HOPS core subunit | |
Synonyms | PEP3 | PEP3 | |
Cytomap | 15q15.1 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | vacuolar protein sorting-associated protein 18 homologhVPS18vacuolar protein sorting 18 homologvacuolar protein sorting protein 18 | vacuolar protein sorting-associated protein 18 homologhVPS18vacuolar protein sorting 18 homologvacuolar protein sorting protein 18 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9P253 | Q9P253 | |
Ensembl transtripts involved in fusion gene | ENST00000220509, ENST00000558474, | ENST00000220509, ENST00000558474, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: VPS18 [Title/Abstract] AND VPS18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | VPS18 | GO:0007032 | endosome organization | 18799622 |
Hgene | VPS18 | GO:0007040 | lysosome organization | 18799622 |
Tgene | VPS18 | GO:0007032 | endosome organization | 18799622 |
Tgene | VPS18 | GO:0007040 | lysosome organization | 18799622 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU155386 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000220509 | ENST00000220509 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
5CDS-intron | ENST00000220509 | ENST00000558474 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
intron-3CDS | ENST00000558474 | ENST00000220509 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
intron-intron | ENST00000558474 | ENST00000558474 | VPS18 | chr15 | 41192633 | - | VPS18 | chr15 | 41192676 | + |
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FusionProtFeatures for VPS18_VPS18 |
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Hgene | Tgene |
VPS18 | VPS18 |
Plays a role in vesicle-mediated protein trafficking tolysosomal compartments including the endocytic membrane transportand autophagic pathways. Believed to act as a core component ofthe putative HOPS and CORVET endosomal tethering complexes whichare proposed to be involved in the Rab5-to-Rab7 endosomeconversion probably implicating MON1A/B, and via binding SNAREsand SNARE complexes to mediate tethering and docking events duringSNARE-mediated membrane fusion. The HOPS complex is proposed to berecruited to Rab7 on the late endosomal membrane and to regulatelate endocytic, phagocytic and autophagic traffic towardslysosomes. The CORVET complex is proposed to function as a Rab5effector to mediate early endosome fusion probably in specificendosome subpopulations (PubMed:11382755, PubMed:23351085,PubMed:24554770, PubMed:25783203). Required for fusion ofendosomes and autophagosomes with lysosomes (PubMed:25783203).Involved in dendrite development of Pukinje cells (By similarity).{ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203,ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085,ECO:0000305|PubMed:25783203}. | Plays a role in vesicle-mediated protein trafficking tolysosomal compartments including the endocytic membrane transportand autophagic pathways. Believed to act as a core component ofthe putative HOPS and CORVET endosomal tethering complexes whichare proposed to be involved in the Rab5-to-Rab7 endosomeconversion probably implicating MON1A/B, and via binding SNAREsand SNARE complexes to mediate tethering and docking events duringSNARE-mediated membrane fusion. The HOPS complex is proposed to berecruited to Rab7 on the late endosomal membrane and to regulatelate endocytic, phagocytic and autophagic traffic towardslysosomes. The CORVET complex is proposed to function as a Rab5effector to mediate early endosome fusion probably in specificendosome subpopulations (PubMed:11382755, PubMed:23351085,PubMed:24554770, PubMed:25783203). Required for fusion ofendosomes and autophagosomes with lysosomes (PubMed:25783203).Involved in dendrite development of Pukinje cells (By similarity).{ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203,ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085,ECO:0000305|PubMed:25783203}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VPS18_VPS18 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VPS18_VPS18 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VPS18_VPS18 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VPS18_VPS18 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |