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Fusion gene ID: 4155 |
FusionGeneSummary for BICC1_STARD13 |
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Fusion gene information | Fusion gene name: BICC1_STARD13 | Fusion gene ID: 4155 | Hgene | Tgene | Gene symbol | BICC1 | STARD13 | Gene ID | 80114 | 90627 |
Gene name | BicC family RNA binding protein 1 | StAR related lipid transfer domain containing 13 | |
Synonyms | BICC|CYSRD | ARHGAP37|DLC2|GT650|LINC00464 | |
Cytomap | 10q21.1 | 13q13.1-q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein bicaudal C homolog 1FGFR2-BICC1 fusion kinase proteinbicaudal C homolog 1 | stAR-related lipid transfer protein 13Rho GTPase activating protein on chromosome 13q12StAR-related lipid transfer (START) domain containing 13deleted in liver cancer 2 proteinlong intergenic non-protein coding RNA 464 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9H694 | Q9Y3M8 | |
Ensembl transtripts involved in fusion gene | ENST00000373886, ENST00000263103, ENST00000476684, | ENST00000336934, ENST00000255486, ENST00000399365, ENST00000487412, ENST00000439831, | |
Fusion gene scores | * DoF score | 8 X 8 X 5=320 | 4 X 4 X 1=16 |
# samples | 8 | 4 | |
** MAII score | log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: BICC1 [Title/Abstract] AND STARD13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BICC1 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 21922595 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE143606 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000373886 | ENST00000336934 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000373886 | ENST00000255486 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000373886 | ENST00000399365 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000373886 | ENST00000487412 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000373886 | ENST00000439831 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000263103 | ENST00000336934 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000263103 | ENST00000255486 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000263103 | ENST00000399365 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000263103 | ENST00000487412 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000263103 | ENST00000439831 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000476684 | ENST00000336934 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000476684 | ENST00000255486 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000476684 | ENST00000399365 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000476684 | ENST00000487412 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
intron-intron | ENST00000476684 | ENST00000439831 | BICC1 | chr10 | 60563627 | - | STARD13 | chr13 | 33949231 | - |
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FusionProtFeatures for BICC1_STARD13 |
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Hgene | Tgene |
BICC1 | STARD13 |
Putative RNA-binding protein. Acts as a negativeregulator of Wnt signaling. May be involved in regulating geneexpression during embryonic development.{ECO:0000269|PubMed:21922595}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BICC1_STARD13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BICC1_STARD13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BICC1_STARD13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BICC1_STARD13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BICC1 | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | BICC1 | C0011581 | Depressive disorder | 2 | PSYGENET |
Hgene | BICC1 | C3275898 | RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO | 1 | UNIPROT |
Tgene | STARD13 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |