![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 41534 |
FusionGeneSummary for VPS13B_SGCZ |
![]() |
Fusion gene information | Fusion gene name: VPS13B_SGCZ | Fusion gene ID: 41534 | Hgene | Tgene | Gene symbol | VPS13B | SGCZ | Gene ID | 157680 | 137868 |
Gene name | vacuolar protein sorting 13 homolog B | sarcoglycan zeta | |
Synonyms | CHS1|COH1 | ZSG1 | |
Cytomap | 8q22.2 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | vacuolar protein sorting-associated protein 13B | zeta-sarcoglycanzeta-SG | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q7Z7G8 | Q96LD1 | |
Ensembl transtripts involved in fusion gene | ENST00000395996, ENST00000358544, ENST00000357162, ENST00000355155, ENST00000441350, ENST00000521932, | ENST00000382080, ENST00000421524, | |
Fusion gene scores | * DoF score | 27 X 20 X 12=6480 | 5 X 4 X 5=100 |
# samples | 30 | 5 | |
** MAII score | log2(30/6480*10)=-4.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: VPS13B [Title/Abstract] AND SGCZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-97-8171-01A | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000395996 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
5CDS-intron | ENST00000395996 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
Frame-shift | ENST00000358544 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
5CDS-intron | ENST00000358544 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
Frame-shift | ENST00000357162 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
5CDS-intron | ENST00000357162 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
Frame-shift | ENST00000355155 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
5CDS-intron | ENST00000355155 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
intron-3CDS | ENST00000441350 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
intron-intron | ENST00000441350 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
3UTR-3CDS | ENST00000521932 | ENST00000382080 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
3UTR-intron | ENST00000521932 | ENST00000421524 | VPS13B | chr8 | 100205285 | + | SGCZ | chr8 | 14181713 | - |
Top |
FusionProtFeatures for VPS13B_SGCZ |
![]() |
Hgene | Tgene |
VPS13B | SGCZ |
Component of the sarcoglycan complex, a subcomplex ofthe dystrophin-glycoprotein complex which forms a link between theF-actin cytoskeleton and the extracellular matrix. May play a rolein the maintenance of striated muscle membrane stability (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for VPS13B_SGCZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for VPS13B_SGCZ |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
VPS13B | CSNK1E, SPACA1, FAM177A1, DNAJC7, CSNK1D, SNX20, SNX21, LGALS7, DOCK5, LYPD4, FUZ | SGCZ | SGCB, HARS, REEP5, GK, ACACA, GNPTAB, RANGRF, ATP5F1, C4orf32, SP3, RTN4, DAGLB, ATP5B |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for VPS13B_SGCZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for VPS13B_SGCZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | VPS13B | C0265223 | Cohen syndrome | 6 | CTD_human;ORPHANET;UNIPROT |
Tgene | SGCZ | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |