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Fusion gene ID: 41509 |
FusionGeneSummary for VPRBP_POC1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VPRBP_POC1A | Fusion gene ID: 41509 | Hgene | Tgene | Gene symbol | VPRBP | POC1A | Gene ID | 9730 | 25886 |
| Gene name | DDB1 and CUL4 associated factor 1 | POC1 centriolar protein A | |
| Synonyms | RIP|VPRBP | PIX2|SOFT|WDR51A | |
| Cytomap | 3p21.2 | 3p21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DDB1- and CUL4-associated factor 1HIV-1 Vpr-binding proteinVpr (HIV-1) binding proteinVpr-binding proteinprotein VPRBPserine/threonine-protein kinase VPRBPvpr-interacting protein | POC1 centriolar protein homolog AWD repeat domain 51AWD repeat-containing protein 51Aproteome of centriole protein 1A | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8NBT0 | ||
| Ensembl transtripts involved in fusion gene | ENST00000335891, | ENST00000296484, ENST00000394970, ENST00000474012, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 4=48 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: VPRBP [Title/Abstract] AND POC1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VPRBP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 24140421 |
| Hgene | VPRBP | GO:1990245 | histone H2A-T120 phosphorylation | 24140421 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-55-8301-01A | VPRBP | chr3 | 51497130 | - | POC1A | chr3 | 52185116 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000335891 | ENST00000296484 | VPRBP | chr3 | 51497130 | - | POC1A | chr3 | 52185116 | - |
| In-frame | ENST00000335891 | ENST00000394970 | VPRBP | chr3 | 51497130 | - | POC1A | chr3 | 52185116 | - |
| 5CDS-5UTR | ENST00000335891 | ENST00000474012 | VPRBP | chr3 | 51497130 | - | POC1A | chr3 | 52185116 | - |
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FusionProtFeatures for VPRBP_POC1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VPRBP | POC1A |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Plays an important role in centriole assembly and/orstability and ciliogenesis. Involved in early steps of centrioleduplication, as well as in the later steps of centriole lengthcontrol. Acts in concert with POC1B to ensure centriole integrityand proper mitotic spindle formation.{ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:23015594}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000296484 | - | 0 | 11 | 369_397 | 6 | 408 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000394970 | - | 0 | 10 | 369_397 | 6 | 360 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000474012 | - | 0 | 11 | 369_397 | -73 | 370 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000296484 | - | 0 | 11 | 101_140 | 6 | 408 | Repeat | Note=WD 3 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000296484 | - | 0 | 11 | 143_182 | 6 | 408 | Repeat | Note=WD 4 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000296484 | - | 0 | 11 | 17_56 | 6 | 408 | Repeat | Note=WD 1 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000296484 | - | 0 | 11 | 185_224 | 6 | 408 | Repeat | Note=WD 5 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000296484 | - | 0 | 11 | 227_266 | 6 | 408 | Repeat | Note=WD 6 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000296484 | - | 0 | 11 | 269_308 | 6 | 408 | Repeat | Note=WD 7 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000296484 | - | 0 | 11 | 59_98 | 6 | 408 | Repeat | Note=WD 2 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000394970 | - | 0 | 10 | 101_140 | 6 | 360 | Repeat | Note=WD 3 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000394970 | - | 0 | 10 | 143_182 | 6 | 360 | Repeat | Note=WD 4 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000394970 | - | 0 | 10 | 17_56 | 6 | 360 | Repeat | Note=WD 1 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000394970 | - | 0 | 10 | 185_224 | 6 | 360 | Repeat | Note=WD 5 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000394970 | - | 0 | 10 | 227_266 | 6 | 360 | Repeat | Note=WD 6 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000394970 | - | 0 | 10 | 269_308 | 6 | 360 | Repeat | Note=WD 7 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000394970 | - | 0 | 10 | 59_98 | 6 | 360 | Repeat | Note=WD 2 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000474012 | - | 0 | 11 | 101_140 | -73 | 370 | Repeat | Note=WD 3 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000474012 | - | 0 | 11 | 143_182 | -73 | 370 | Repeat | Note=WD 4 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000474012 | - | 0 | 11 | 17_56 | -73 | 370 | Repeat | Note=WD 1 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000474012 | - | 0 | 11 | 185_224 | -73 | 370 | Repeat | Note=WD 5 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000474012 | - | 0 | 11 | 227_266 | -73 | 370 | Repeat | Note=WD 6 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000474012 | - | 0 | 11 | 269_308 | -73 | 370 | Repeat | Note=WD 7 |
| Tgene | >POC1A | chr3:51497130 | chr3:52185116 | ENST00000474012 | - | 0 | 11 | 59_98 | -73 | 370 | Repeat | Note=WD 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1396_1500 | 125 | 1059 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 562_593 | 125 | 1059 | Domain | Note=Chromo |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 846_878 | 125 | 1059 | Domain | LisH |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1242_1249 | 125 | 1059 | Motif | Note=DWD box 1 |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1278_1285 | 125 | 1059 | Motif | Note=DWD box 2 |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1091_1290 | 125 | 1059 | Region | Note=WD repeat-like region |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 141_500 | 125 | 1059 | Region | Note=Protein kinase-like |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1091_1130 | 125 | 1059 | Repeat | Note=WD 1 |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1133_1174 | 125 | 1059 | Repeat | Note=WD 2 |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1176_1213 | 125 | 1059 | Repeat | Note=WD 3 |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1215_1247 | 125 | 1059 | Repeat | Note=WD 4 |
| Hgene | >VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1248_1290 | 125 | 1059 | Repeat | Note=WD 5 |
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FusionGeneSequence for VPRBP_POC1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_VPRBP_ENST00000335891_chr3_51497130_-_POC1A_ENST00000296484_chr3_52185116_-_527aa MTTVVVHVDSKAELTTLLEQWEKEHGSGQDMVPILTRMSQLIEKETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNALVN AYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHK DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVD >In-frame_VPRBP_ENST00000335891_chr3_51497130_-_POC1A_ENST00000394970_chr3_52185116_-_479aa MTTVVVHVDSKAELTTLLEQWEKEHGSGQDMVPILTRMSQLIEKETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNALVN AYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHK DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLTVSI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_VPRBP_ENST00000335891_chr3_51497130_-_POC1A_ENST00000296484_chr3_52185116_-_1581nt ATGACTACAGTAGTGGTACATGTGGACTCCAAAGCTGAGCTCACTACCCTGCTGGAGCAGTGGGAAAAGGAACATGGCAGTGGGCAGGAC ATGGTACCTATCCTTACCAGGATGTCTCAATTGATTGAAAAAGAAACTGAAGAGTATCGTAAAGGGGATCCAGACCCATTTGATGATCGA CATCCTGGTCGAGCTGATCCAGAGTGTATGCTGGGCCACTTGCTGAGAATACTCTTCAAGAATGATGATTTCATGAATGCACTGGTGAAT GCATATGTGATGACAAGCCGAGAGCCCCCTTTAAACACTGCAGCTTGCAGACTCCTATTAGACATCATGCCAGGGCTGGAAACTGCTGTC GTCTTTCAAGAAAAGGAGGACCCCTCGCTGGAAAGGCATTTTAAGGGCCACCGAGATGCAGTTACCTGTGTGGACTTCAGTATCAACACA AAGCAGCTGGCCAGTGGCTCCATGGACTCATGCCTCATGGTCTGGCACATGAAGCCGCAGTCACGCGCCTACCGCTTCACTGGCCACAAG GATGCCGTCACCTGTGTGAACTTCTCTCCTTCGGGACACCTGCTTGCTTCCGGCTCCCGAGACAAGACTGTCCGCATCTGGGTACCCAAT GTCAAAGGTGAGTCCACTGTGTTTCGTGCACACACAGCCACAGTGAGGAGTGTCCACTTCTGCAGTGATGGCCAGTCCTTCGTGACAGCC TCTGACGACAAGACAGTCAAAGTGTGGGCAACTCATCGCCAGAAATTCCTGTTCTCCCTGAGCCAGCATATCAACTGGGTCCGCTGTGCC AAGTTCTCCCCCGACGGGCGGCTCATCGTGTCTGCCAGTGATGACAAGACTGTTAAGCTGTGGGACAAGAGCAGCCGGGAATGTGTCCAC TCGTATTGTGAGCATGGCGGCTTTGTCACCTATGTGGACTTCCACCCCAGTGGGACGTGCATTGCCGCTGCCGGCATGGACAACACAGTG AAGGTGTGGGACGTGCGGACTCACCGGCTGCTGCAGCATTATCAGTTGCACAGTGCAGCAGTGAACGGGCTCTCTTTCCACCCGTCGGGA AACTACCTGATCACAGCCTCCAGTGACTCAACCCTGAAGATCCTGGACCTGATGGAGGGCCGGCTGCTCTACACACTCCACGGGCATCAG GGACCAGCCACCACTGTTGCCTTTTCAAGAACGGGGGAGTATTTTGCTTCTGGAGGCTCTGATGAACAAGTGATGGTTTGGAAGAGTAAC TTTGATATTGTTGATCATGGAGAAGTCACGAAAGTGCCGAGGCCCCCAGCCACACTGGCCAGCTCCATGGGGAATCTGCCAGAAGTGGAC TTCCCTGTCCCCCCAGGCAGAGGCAGGAGTGTGGAGTCTGTGCAGAGCCAGCCCCAGGAGCCCGTGAGTGTGCCCCAGACACTGACTAGC ACGCTGGAGCACATTGTGGGCCAGCTGGATGTCCTCACTCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAGCTG >In-frame_VPRBP_ENST00000335891_chr3_51497130_-_POC1A_ENST00000394970_chr3_52185116_-_1437nt ATGACTACAGTAGTGGTACATGTGGACTCCAAAGCTGAGCTCACTACCCTGCTGGAGCAGTGGGAAAAGGAACATGGCAGTGGGCAGGAC ATGGTACCTATCCTTACCAGGATGTCTCAATTGATTGAAAAAGAAACTGAAGAGTATCGTAAAGGGGATCCAGACCCATTTGATGATCGA CATCCTGGTCGAGCTGATCCAGAGTGTATGCTGGGCCACTTGCTGAGAATACTCTTCAAGAATGATGATTTCATGAATGCACTGGTGAAT GCATATGTGATGACAAGCCGAGAGCCCCCTTTAAACACTGCAGCTTGCAGACTCCTATTAGACATCATGCCAGGGCTGGAAACTGCTGTC GTCTTTCAAGAAAAGGAGGACCCCTCGCTGGAAAGGCATTTTAAGGGCCACCGAGATGCAGTTACCTGTGTGGACTTCAGTATCAACACA AAGCAGCTGGCCAGTGGCTCCATGGACTCATGCCTCATGGTCTGGCACATGAAGCCGCAGTCACGCGCCTACCGCTTCACTGGCCACAAG GATGCCGTCACCTGTGTGAACTTCTCTCCTTCGGGACACCTGCTTGCTTCCGGCTCCCGAGACAAGACTGTCCGCATCTGGGTACCCAAT GTCAAAGGTGAGTCCACTGTGTTTCGTGCACACACAGCCACAGTGAGGAGTGTCCACTTCTGCAGTGATGGCCAGTCCTTCGTGACAGCC TCTGACGACAAGACAGTCAAAGTGTGGGCAACTCATCGCCAGAAATTCCTGTTCTCCCTGAGCCAGCATATCAACTGGGTCCGCTGTGCC AAGTTCTCCCCCGACGGGCGGCTCATCGTGTCTGCCAGTGATGACAAGACTGTTAAGCTGTGGGACAAGAGCAGCCGGGAATGTGTCCAC TCGTATTGTGAGCATGGCGGCTTTGTCACCTATGTGGACTTCCACCCCAGTGGGACGTGCATTGCCGCTGCCGGCATGGACAACACAGTG AAGGTGTGGGACGTGCGGACTCACCGGCTGCTGCAGCATTATCAGTTGCACAGTGCAGCAGTGAACGGGCTCTCTTTCCACCCGTCGGGA AACTACCTGATCACAGCCTCCAGTGACTCAACCCTGAAGATCCTGGACCTGATGGAGGGCCGGCTGCTCTACACACTCCACGGGCATCAG GGACCAGCCACCACTGTTGCCTTTTCAAGAACGGGGGAGTATTTTGCTTCTGGAGGCTCTGATGAACAAGTGATGGTTTGGAAGAGTAAC TTTGATATTGTTGATCATGGAGAAGTCACGAAAGTGCCGAGGCCCCCAGCCACACTGGCCAGCTCCATGGGGAATCTGACAGTCTCCATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_VPRBP_ENST00000335891_chr3_51497130_-_POC1A_ENST00000296484_chr3_52185116_-_2225nt AGGCAAAGCCATGACTACAGTAGTGGTACATGTGGACTCCAAAGCTGAGCTCACTACCCTGCTGGAGCAGTGGGAAAAGGAACATGGCAG TGGGCAGGACATGGTACCTATCCTTACCAGGATGTCTCAATTGATTGAAAAAGAAACTGAAGAGTATCGTAAAGGGGATCCAGACCCATT TGATGATCGACATCCTGGTCGAGCTGATCCAGAGTGTATGCTGGGCCACTTGCTGAGAATACTCTTCAAGAATGATGATTTCATGAATGC ACTGGTGAATGCATATGTGATGACAAGCCGAGAGCCCCCTTTAAACACTGCAGCTTGCAGACTCCTATTAGACATCATGCCAGGGCTGGA AACTGCTGTCGTCTTTCAAGAAAAGGAGGACCCCTCGCTGGAAAGGCATTTTAAGGGCCACCGAGATGCAGTTACCTGTGTGGACTTCAG TATCAACACAAAGCAGCTGGCCAGTGGCTCCATGGACTCATGCCTCATGGTCTGGCACATGAAGCCGCAGTCACGCGCCTACCGCTTCAC TGGCCACAAGGATGCCGTCACCTGTGTGAACTTCTCTCCTTCGGGACACCTGCTTGCTTCCGGCTCCCGAGACAAGACTGTCCGCATCTG GGTACCCAATGTCAAAGGTGAGTCCACTGTGTTTCGTGCACACACAGCCACAGTGAGGAGTGTCCACTTCTGCAGTGATGGCCAGTCCTT CGTGACAGCCTCTGACGACAAGACAGTCAAAGTGTGGGCAACTCATCGCCAGAAATTCCTGTTCTCCCTGAGCCAGCATATCAACTGGGT CCGCTGTGCCAAGTTCTCCCCCGACGGGCGGCTCATCGTGTCTGCCAGTGATGACAAGACTGTTAAGCTGTGGGACAAGAGCAGCCGGGA ATGTGTCCACTCGTATTGTGAGCATGGCGGCTTTGTCACCTATGTGGACTTCCACCCCAGTGGGACGTGCATTGCCGCTGCCGGCATGGA CAACACAGTGAAGGTGTGGGACGTGCGGACTCACCGGCTGCTGCAGCATTATCAGTTGCACAGTGCAGCAGTGAACGGGCTCTCTTTCCA CCCGTCGGGAAACTACCTGATCACAGCCTCCAGTGACTCAACCCTGAAGATCCTGGACCTGATGGAGGGCCGGCTGCTCTACACACTCCA CGGGCATCAGGGACCAGCCACCACTGTTGCCTTTTCAAGAACGGGGGAGTATTTTGCTTCTGGAGGCTCTGATGAACAAGTGATGGTTTG GAAGAGTAACTTTGATATTGTTGATCATGGAGAAGTCACGAAAGTGCCGAGGCCCCCAGCCACACTGGCCAGCTCCATGGGGAATCTGCC AGAAGTGGACTTCCCTGTCCCCCCAGGCAGAGGCAGGAGTGTGGAGTCTGTGCAGAGCCAGCCCCAGGAGCCCGTGAGTGTGCCCCAGAC ACTGACTAGCACGCTGGAGCACATTGTGGGCCAGCTGGATGTCCTCACTCAGACAGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGA AGACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAACACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTG GATTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGGGGACTGAACTCTGTGGGAATCACATCCATACTGGAG CCCTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCTCCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCT CACACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGTAAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGT CCTGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTTCACTCATCATTTGGACATGTGACTGGCTTTTCCTAC CTCTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGGGGGTTTTCTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATC TGAGTCAGGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTTTTCAGTGGCCCTGATTTCTGTTCCACACGTGTTCACTGGAGCC >In-frame_VPRBP_ENST00000335891_chr3_51497130_-_POC1A_ENST00000394970_chr3_52185116_-_2048nt AGGCAAAGCCATGACTACAGTAGTGGTACATGTGGACTCCAAAGCTGAGCTCACTACCCTGCTGGAGCAGTGGGAAAAGGAACATGGCAG TGGGCAGGACATGGTACCTATCCTTACCAGGATGTCTCAATTGATTGAAAAAGAAACTGAAGAGTATCGTAAAGGGGATCCAGACCCATT TGATGATCGACATCCTGGTCGAGCTGATCCAGAGTGTATGCTGGGCCACTTGCTGAGAATACTCTTCAAGAATGATGATTTCATGAATGC ACTGGTGAATGCATATGTGATGACAAGCCGAGAGCCCCCTTTAAACACTGCAGCTTGCAGACTCCTATTAGACATCATGCCAGGGCTGGA AACTGCTGTCGTCTTTCAAGAAAAGGAGGACCCCTCGCTGGAAAGGCATTTTAAGGGCCACCGAGATGCAGTTACCTGTGTGGACTTCAG TATCAACACAAAGCAGCTGGCCAGTGGCTCCATGGACTCATGCCTCATGGTCTGGCACATGAAGCCGCAGTCACGCGCCTACCGCTTCAC TGGCCACAAGGATGCCGTCACCTGTGTGAACTTCTCTCCTTCGGGACACCTGCTTGCTTCCGGCTCCCGAGACAAGACTGTCCGCATCTG GGTACCCAATGTCAAAGGTGAGTCCACTGTGTTTCGTGCACACACAGCCACAGTGAGGAGTGTCCACTTCTGCAGTGATGGCCAGTCCTT CGTGACAGCCTCTGACGACAAGACAGTCAAAGTGTGGGCAACTCATCGCCAGAAATTCCTGTTCTCCCTGAGCCAGCATATCAACTGGGT CCGCTGTGCCAAGTTCTCCCCCGACGGGCGGCTCATCGTGTCTGCCAGTGATGACAAGACTGTTAAGCTGTGGGACAAGAGCAGCCGGGA ATGTGTCCACTCGTATTGTGAGCATGGCGGCTTTGTCACCTATGTGGACTTCCACCCCAGTGGGACGTGCATTGCCGCTGCCGGCATGGA CAACACAGTGAAGGTGTGGGACGTGCGGACTCACCGGCTGCTGCAGCATTATCAGTTGCACAGTGCAGCAGTGAACGGGCTCTCTTTCCA CCCGTCGGGAAACTACCTGATCACAGCCTCCAGTGACTCAACCCTGAAGATCCTGGACCTGATGGAGGGCCGGCTGCTCTACACACTCCA CGGGCATCAGGGACCAGCCACCACTGTTGCCTTTTCAAGAACGGGGGAGTATTTTGCTTCTGGAGGCTCTGATGAACAAGTGATGGTTTG GAAGAGTAACTTTGATATTGTTGATCATGGAGAAGTCACGAAAGTGCCGAGGCCCCCAGCCACACTGGCCAGCTCCATGGGGAATCTGAC AGTCTCCATTCTGGAGCAGCGGTTGACACTGACAGAAGACAAGCTGAAGCAGTGTCTGGAGAACCAGCAGCTAATCATGCAGAGAGCAAC ACCATGATCAGGGGAGCAGGAATCAGGAGCTCGGTGGATTTGCAGGTGGCAGGCCAGGGATTTGTACCATGGGACTTGGGTAAATAAAGG GGACTGAACTCTGTGGGAATCACATCCATACTGGAGCCCTGGATTTTTGCAGTTCTGCCCTCCACCTTGCTATCTGCACCAGGAGGCTCT CCACCTGGCAGCCAGAGGTCCCCAGTGGGCCGGGCTCACACACAAATGATGCTTCAGACCCGAATGAGAGGACCACATTTTGCTTAATGT AAAGGAGCCACTTGAAAATGTCTGCTCCTTCGGGGTCCTGAGATTGTGGCTCCCCCTCTGGAGGAGGTGGCTCCACGATGCCTTGATTTT CACTCATCATTTGGACATGTGACTGGCTTTTCCTACCTCTGCCATGGTGTAGAAATTGATTGCACATTGATTGGATGAGCCGGGGGTTTT CTCTAAATCTGACTAAAGGCCCAAAGTGGGCCCATCTGAGTCAGGTTTGTTGAGAACAAGCCCTCTCAAGTGGGTGGTGGCTTTTCAGTG |
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FusionGenePPI for VPRBP_POC1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| VPRBP | NF2, COPS5, COPS6, DDB1, DDA1, UNG, VPRBP, RBX1, CUL4A, UBXN7, DYRK2, UBR5, KATNA1, RAG1, RAG2, MCM10, SAMHD1, UBC, COPS3, COPS4, COPS7A, COPS7B, CUL1, COPS8, CUL4B, CUL5, DCUN1D1, NEDD8, HIST1H3A, TP53, HDAC1, PRKDC, ATM, ATR, RORA, EPS15, RFWD2, UBE2D2, U2AF1, RPS8, TERT, PNKP, MAP1LC3A, SOX2, TOPBP1, NR2C2, SIRT7, FTSJ3, CEP250, MOV10, HIST1H1A, HIST1H1C, HIST3H3, RPL13, RPL14, RPL6, ZNF707, DTNBP1, AP2M1, PYHIN1, EPB41L3, TET2, TET1, TET3, ANP32A, NCL, NTRK1, KRAS, CCNL2, CEP162, MAPK14, KIFC3, LLGL2, MYH6, TIMM13, SMG9, ZFC3H1, PYGO2, HDAC2, HDAC3, HDAC8, KSR1, PPP2R1A, PPP2R1B, POU5F1, MYO6, MOAP1, ESR1, RPL18, RPL15, FGFRL1, TCEANC2, AURKAIP1, MRPL35, XAGE1B, NOL9, ZNF263, RPL7, TP53TG5, WDR46, ZNF816, VTN, CFAP20, HLTF, CEP78, CCP110, MUS81 | POC1A | RNF168, FGFR1OP2, U2AF2, CCT7, CCT4, HSPA8, HSPA6, HSPA1L, CCT6A, CCT8, CCT3, TCP1, POC1B, CCT5, CCT2, PDCL, TXNDC9, CORO1A, RASSF8, IFT57, SIAE, POC5, AHCYL1, AKIP1, AP4B1, ATG2B, BTF3, R3HCC1L, CAMSAP1, CCDC66, CENPH, CEP44, CKAP2, CKB, COMMD2, COMMD4, CRYBG3, DDX3Y, DNAAF2, DNAJA2, ECD, ENO2, FAM161A, FKBP4, GTSE1, HAUS4, IBTK, LARP1B, LTV1, LUZP1, MAP7D1, MAP7D3, MAPRE2, MIIP, MTUS1, NCAPH, NOB1, NUDC, PDCL3, PELO, PFDN1, PFDN2, PFDN4, PFDN5, PFDN6, PLEKHA5, RIOK1, RPAP3, RRM2, SKA3, SLAIN2, SUGT1, TAF2, TCHP, TDRD3, TOP3B, TTK, UNC45A, VBP1, WDR45, XRN1, MYH11, SUPT5H, DAP3, SYNPO, MYO5C, SIL1, CCDC53, COG6, NELL2, IKZF1, TSKS, MDM1, CORO6, SSSCA1, POTEF |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | VPRBP | chr3:51497130 | chr3:52185116 | ENST00000335891 | - | 4 | 17 | 1418_1507 | 125 | 1059 | NF2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VPRBP_POC1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VPRBP_POC1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | POC1A | C3542022 | SHORT STATURE, ONYCHODYSPLASIA, FACIAL DYSMORPHISM, AND HYPOTRICHOSIS SYNDROME | 1 | ORPHANET;UNIPROT |
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