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Fusion gene ID: 41506 |
FusionGeneSummary for VOPP1_RAPGEF5 |
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Fusion gene information | Fusion gene name: VOPP1_RAPGEF5 | Fusion gene ID: 41506 | Hgene | Tgene | Gene symbol | VOPP1 | RAPGEF5 | Gene ID | 81552 | 9771 |
Gene name | VOPP1, WBP1/VOPP1 family member | Rap guanine nucleotide exchange factor 5 | |
Synonyms | ECOP|GASP|WBP1L2 | GFR|MR-GEF|REPAC | |
Cytomap | 7p11.2 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | vesicular, overexpressed in cancer, prosurvival protein 1EGFR-coamplified and overexpressed proteinGlioblastoma-amplified secreted proteinhypothetical protein DKFZp564K0822putative NF-kappa-B-activating protein 055N | rap guanine nucleotide exchange factor 5M-Ras-regulated GEFM-Ras-regulated Rap GEFRap guanine nucleotide exchange factor (GEF) 5guanine nucleotide exchange factor for Rap1related to Epac | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q96AW1 | Q92565 | |
Ensembl transtripts involved in fusion gene | ENST00000285279, ENST00000433959, ENST00000545390, ENST00000428648, ENST00000428097, ENST00000418904, ENST00000454227, ENST00000453256, ENST00000427700, ENST00000471168, | ENST00000344041, ENST00000475788, ENST00000405243, ENST00000401957, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 4 X 2=32 |
# samples | 6 | 4 | |
** MAII score | log2(6/18*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: VOPP1 [Title/Abstract] AND RAPGEF5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-55-8089-01A | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000285279 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
5CDS-intron | ENST00000285279 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
5CDS-intron | ENST00000285279 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
5CDS-intron | ENST00000285279 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-5UTR | ENST00000433959 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000433959 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000433959 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000433959 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-5UTR | ENST00000545390 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000545390 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000545390 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000545390 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-5UTR | ENST00000428648 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000428648 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000428648 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000428648 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-5UTR | ENST00000428097 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000428097 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000428097 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000428097 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-5UTR | ENST00000418904 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000418904 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000418904 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000418904 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-5UTR | ENST00000454227 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000454227 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000454227 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000454227 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-5UTR | ENST00000453256 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000453256 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000453256 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000453256 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
5UTR-5UTR | ENST00000427700 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
5UTR-intron | ENST00000427700 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
5UTR-intron | ENST00000427700 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
5UTR-intron | ENST00000427700 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-5UTR | ENST00000471168 | ENST00000344041 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000471168 | ENST00000475788 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000471168 | ENST00000405243 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
intron-intron | ENST00000471168 | ENST00000401957 | VOPP1 | chr7 | 55639964 | - | RAPGEF5 | chr7 | 22357656 | - |
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FusionProtFeatures for VOPP1_RAPGEF5 |
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Hgene | Tgene |
VOPP1 | RAPGEF5 |
Guanine nucleotide exchange factor (GEF) for RAP1A,RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1activation. {ECO:0000269|PubMed:10777494,ECO:0000269|PubMed:10934204}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VOPP1_RAPGEF5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VOPP1_RAPGEF5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
VOPP1 | RAPGEF5 | RAP2A, RAP1A, MRAS, KCND3, PLAC9, VANGL1, TMEM253, ANK3, ANK1, MAPK8IP2, ANK2, DDHD2, TUBB1, HSP90AA4P, CCDC88A, UBB, HERC1, PPFIBP1, RICTOR, PLEC, ZNHIT2, WNK1, PRKAR1B, PPP2R5D, PRKACB, PIK3CB, FLNC, ATP2B2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VOPP1_RAPGEF5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VOPP1_RAPGEF5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | VOPP1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | VOPP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | RAPGEF5 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | RAPGEF5 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | RAPGEF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | RAPGEF5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | RAPGEF5 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Tgene | RAPGEF5 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | RAPGEF5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |