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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41506

FusionGeneSummary for VOPP1_RAPGEF5

check button Fusion gene summary
Fusion gene informationFusion gene name: VOPP1_RAPGEF5
Fusion gene ID: 41506
HgeneTgene
Gene symbol

VOPP1

RAPGEF5

Gene ID

81552

9771

Gene nameVOPP1, WBP1/VOPP1 family memberRap guanine nucleotide exchange factor 5
SynonymsECOP|GASP|WBP1L2GFR|MR-GEF|REPAC
Cytomap

7p11.2

7p15.3

Type of geneprotein-codingprotein-coding
Descriptionvesicular, overexpressed in cancer, prosurvival protein 1EGFR-coamplified and overexpressed proteinGlioblastoma-amplified secreted proteinhypothetical protein DKFZp564K0822putative NF-kappa-B-activating protein 055Nrap guanine nucleotide exchange factor 5M-Ras-regulated GEFM-Ras-regulated Rap GEFRap guanine nucleotide exchange factor (GEF) 5guanine nucleotide exchange factor for Rap1related to Epac
Modification date2018052320180519
UniProtAcc

Q96AW1

Q92565

Ensembl transtripts involved in fusion geneENST00000285279, ENST00000433959, 
ENST00000545390, ENST00000428648, 
ENST00000428097, ENST00000418904, 
ENST00000454227, ENST00000453256, 
ENST00000427700, ENST00000471168, 
ENST00000344041, ENST00000475788, 
ENST00000405243, ENST00000401957, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 4 X 2=32
# samples 64
** MAII scorelog2(6/18*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VOPP1 [Title/Abstract] AND RAPGEF5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-8089-01AVOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000285279ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
5CDS-intronENST00000285279ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
5CDS-intronENST00000285279ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
5CDS-intronENST00000285279ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-5UTRENST00000433959ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000433959ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000433959ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000433959ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-5UTRENST00000545390ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000545390ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000545390ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000545390ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-5UTRENST00000428648ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000428648ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000428648ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000428648ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-5UTRENST00000428097ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000428097ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000428097ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000428097ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-5UTRENST00000418904ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000418904ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000418904ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000418904ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-5UTRENST00000454227ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000454227ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000454227ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000454227ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-5UTRENST00000453256ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000453256ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000453256ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000453256ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
5UTR-5UTRENST00000427700ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
5UTR-intronENST00000427700ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
5UTR-intronENST00000427700ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
5UTR-intronENST00000427700ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-5UTRENST00000471168ENST00000344041VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000471168ENST00000475788VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000471168ENST00000405243VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-
intron-intronENST00000471168ENST00000401957VOPP1chr7

55639964

-RAPGEF5chr7

22357656

-

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FusionProtFeatures for VOPP1_RAPGEF5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VOPP1

Q96AW1

RAPGEF5

Q92565

Guanine nucleotide exchange factor (GEF) for RAP1A,RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1activation. {ECO:0000269|PubMed:10777494,ECO:0000269|PubMed:10934204}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VOPP1_RAPGEF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VOPP1_RAPGEF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VOPP1RAPGEF5RAP2A, RAP1A, MRAS, KCND3, PLAC9, VANGL1, TMEM253, ANK3, ANK1, MAPK8IP2, ANK2, DDHD2, TUBB1, HSP90AA4P, CCDC88A, UBB, HERC1, PPFIBP1, RICTOR, PLEC, ZNHIT2, WNK1, PRKAR1B, PPP2R5D, PRKACB, PIK3CB, FLNC, ATP2B2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VOPP1_RAPGEF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VOPP1_RAPGEF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVOPP1C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneVOPP1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneRAPGEF5C0005586Bipolar Disorder1PSYGENET
TgeneRAPGEF5C0033975Psychotic Disorders1PSYGENET
TgeneRAPGEF5C0036341Schizophrenia1PSYGENET
TgeneRAPGEF5C0041696Unipolar Depression1PSYGENET
TgeneRAPGEF5C0236733Amphetamine-Related Disorders1CTD_human
TgeneRAPGEF5C0349204Nonorganic psychosis1PSYGENET
TgeneRAPGEF5C1269683Major Depressive Disorder1PSYGENET