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Fusion gene ID: 41479 |
FusionGeneSummary for VKORC1L1_ACHE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VKORC1L1_ACHE | Fusion gene ID: 41479 | Hgene | Tgene | Gene symbol | VKORC1L1 | ACHE | Gene ID | 154807 | 43 |
| Gene name | vitamin K epoxide reductase complex subunit 1 like 1 | acetylcholinesterase (Cartwright blood group) | |
| Synonyms | - | ACEE|ARACHE|N-ACHE|YT | |
| Cytomap | 7q11.21 | 7q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vitamin K epoxide reductase complex subunit 1-like protein 1VKORC1-like protein 1 | acetylcholinesteraseYt blood groupacetylcholinesterase (Yt blood group)apoptosis-related acetylcholinesterase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8N0U8 | P22303 | |
| Ensembl transtripts involved in fusion gene | ENST00000360768, ENST00000434382, | ENST00000419336, ENST00000241069, ENST00000428317, ENST00000302913, ENST00000412389, ENST00000411582, ENST00000497647, | |
| Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 3 X 3 X 3=27 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: VKORC1L1 [Title/Abstract] AND ACHE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | VKORC1L1 | GO:0042373 | vitamin K metabolic process | 21367861 |
| Tgene | ACHE | GO:0006581 | acetylcholine catabolic process | 1517212 |
| Tgene | ACHE | GO:0007155 | cell adhesion | 15454088 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | READ | TCGA-CI-6621-01A | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000360768 | ENST00000419336 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000360768 | ENST00000241069 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000360768 | ENST00000428317 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000360768 | ENST00000302913 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000360768 | ENST00000412389 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000360768 | ENST00000411582 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| 5CDS-intron | ENST00000360768 | ENST00000497647 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000434382 | ENST00000419336 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000434382 | ENST00000241069 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000434382 | ENST00000428317 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000434382 | ENST00000302913 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000434382 | ENST00000412389 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| In-frame | ENST00000434382 | ENST00000411582 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
| 5CDS-intron | ENST00000434382 | ENST00000497647 | VKORC1L1 | chr7 | 65338552 | + | ACHE | chr7 | 100488959 | - |
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FusionProtFeatures for VKORC1L1_ACHE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VKORC1L1 | ACHE |
| Involved in vitamin K metabolism. Can reduce inactivevitamin K 2,3-epoxide to active vitamin K (in vitro), and maycontribute to vitamin K-mediated protection against oxidativestress. Plays a role in vitamin K-dependent gamma-carboxylation ofGlu residues in target proteins. {ECO:0000269|PubMed:21367861,ECO:0000269|PubMed:23928358, ECO:0000269|PubMed:24532791}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | VKORC1L1 | chr7:65338552 | chr7:100488959 | ENST00000360768 | + | 1 | 3 | 1_16 | 64 | 177 | Topological domain | Cytoplasmic |
| Hgene | VKORC1L1 | chr7:65338552 | chr7:100488959 | ENST00000360768 | + | 1 | 3 | 17_37 | 64 | 177 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >VKORC1L1 | chr7:65338552 | chr7:100488959 | ENST00000360768 | + | 1 | 3 | 113_113 | 64 | 177 | Topological domain | Cytoplasmic |
| Hgene | >VKORC1L1 | chr7:65338552 | chr7:100488959 | ENST00000360768 | + | 1 | 3 | 156_176 | 64 | 177 | Topological domain | Cytoplasmic |
| Hgene | >VKORC1L1 | chr7:65338552 | chr7:100488959 | ENST00000360768 | + | 1 | 3 | 38_91 | 64 | 177 | Topological domain | Lumenal |
| Hgene | >VKORC1L1 | chr7:65338552 | chr7:100488959 | ENST00000360768 | + | 1 | 3 | 114_134 | 64 | 177 | Transmembrane | Helical |
| Hgene | >VKORC1L1 | chr7:65338552 | chr7:100488959 | ENST00000360768 | + | 1 | 3 | 135_155 | 64 | 177 | Transmembrane | Helical |
| Hgene | >VKORC1L1 | chr7:65338552 | chr7:100488959 | ENST00000360768 | + | 1 | 3 | 92_112 | 64 | 177 | Transmembrane | Helical |
| Tgene | ACHE | chr7:65338552 | chr7:100488959 | ENST00000241069 | - | 2 | 5 | 233_234 | 517 | 615 | Region | Galanthamine binding |
| Tgene | ACHE | chr7:65338552 | chr7:100488959 | ENST00000302913 | - | 2 | 5 | 233_234 | 517 | 618 | Region | Galanthamine binding |
| Tgene | ACHE | chr7:65338552 | chr7:100488959 | ENST00000411582 | - | 2 | 5 | 233_234 | 517 | 618 | Region | Galanthamine binding |
| Tgene | ACHE | chr7:65338552 | chr7:100488959 | ENST00000412389 | - | 1 | 4 | 233_234 | 517 | 615 | Region | Galanthamine binding |
| Tgene | ACHE | chr7:65338552 | chr7:100488959 | ENST00000419336 | - | 2 | 5 | 233_234 | 429 | 527 | Region | Galanthamine binding |
| Tgene | ACHE | chr7:65338552 | chr7:100488959 | ENST00000428317 | - | 2 | 5 | 233_234 | 517 | 615 | Region | Galanthamine binding |
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FusionGeneSequence for VKORC1L1_ACHE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000419336_chr7_100488959_-_162aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000241069_chr7_100488959_-_162aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000428317_chr7_100488959_-_162aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000302913_chr7_100488959_-_165aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000412389_chr7_100488959_-_162aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000411582_chr7_100488959_-_165aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000419336_chr7_100488959_-_162aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000241069_chr7_100488959_-_162aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000428317_chr7_100488959_-_162aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000302913_chr7_100488959_-_165aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000412389_chr7_100488959_-_162aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000411582_chr7_100488959_-_165aa MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRDPNEPRDPKAPQWPPYTAGAQQYVS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000419336_chr7_100488959_-_486nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGAC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000241069_chr7_100488959_-_486nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGAC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000428317_chr7_100488959_-_486nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGAC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000302913_chr7_100488959_-_495nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGCCTCGGAGGCTCCCAGCACCTGCCCAGGCTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTGCCCCTCCTCCTCCTC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000412389_chr7_100488959_-_486nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGAC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000411582_chr7_100488959_-_495nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGCCTCGGAGGCTCCCAGCACCTGCCCAGGCTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTGCCCCTCCTCCTCCTC >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000419336_chr7_100488959_-_486nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGAC >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000241069_chr7_100488959_-_486nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGAC >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000428317_chr7_100488959_-_486nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGAC >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000302913_chr7_100488959_-_495nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGCCTCGGAGGCTCCCAGCACCTGCCCAGGCTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTGCCCCTCCTCCTCCTC >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000412389_chr7_100488959_-_486nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGAC >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000411582_chr7_100488959_-_495nt ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTCTCC ATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC GCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTTAGT CTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCC ACCGCCTCGGAGGCTCCCAGCACCTGCCCAGGCTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTGCCCCTCCTCCTCCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000419336_chr7_100488959_-_811nt GGCGGCGGAGGCGGCGGTGGCGGCGGTGGCGGCTGGGTCGGGCCCCGACGGGCGGCGGCGGCTGAGGTGGAGGCGGAGGGAGGCGGCGGC GGCGGCGGCGGGAAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCC GGAATCCTGCTCTCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGG GTGAAGTGCTCCGCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCT CAGCAGTACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCC AAATTGCTCAGCGCCACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGG AAGAACCAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCC CCTAGCTGTATATACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACCCCACCCCGACGTCCCC CGGGGCTCCCGGTCCTCTGCATGTCTCAGGCTGAGCTCCCTCCCCCGCGGTGCCTTCGCCCCTCTGGGCTGCCAATAAACTGTTACAGCC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000241069_chr7_100488959_-_811nt GGCGGCGGAGGCGGCGGTGGCGGCGGTGGCGGCTGGGTCGGGCCCCGACGGGCGGCGGCGGCTGAGGTGGAGGCGGAGGGAGGCGGCGGC GGCGGCGGCGGGAAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCC GGAATCCTGCTCTCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGG GTGAAGTGCTCCGCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCT CAGCAGTACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCC AAATTGCTCAGCGCCACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGG AAGAACCAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCC CCTAGCTGTATATACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACCCCACCCCGACGTCCCC CGGGGCTCCCGGTCCTCTGCATGTCTCAGGCTGAGCTCCCTCCCCCGCGGTGCCTTCGCCCCTCTGGGCTGCCAATAAACTGTTACAGCC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000428317_chr7_100488959_-_811nt GGCGGCGGAGGCGGCGGTGGCGGCGGTGGCGGCTGGGTCGGGCCCCGACGGGCGGCGGCGGCTGAGGTGGAGGCGGAGGGAGGCGGCGGC GGCGGCGGCGGGAAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCC GGAATCCTGCTCTCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGG GTGAAGTGCTCCGCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCT CAGCAGTACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCC AAATTGCTCAGCGCCACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGG AAGAACCAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCC CCTAGCTGTATATACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACCCCACCCCGACGTCCCC CGGGGCTCCCGGTCCTCTGCATGTCTCAGGCTGAGCTCCCTCCCCCGCGGTGCCTTCGCCCCTCTGGGCTGCCAATAAACTGTTACAGCC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000302913_chr7_100488959_-_1563nt GGCGGCGGAGGCGGCGGTGGCGGCGGTGGCGGCTGGGTCGGGCCCCGACGGGCGGCGGCGGCTGAGGTGGAGGCGGAGGGAGGCGGCGGC GGCGGCGGCGGGAAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCC GGAATCCTGCTCTCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGG GTGAAGTGCTCCGCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCT CAGCAGTACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCC AAATTGCTCAGCGCCACCGCCTCGGAGGCTCCCAGCACCTGCCCAGGCTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTG CCCCTCCTCCTCCTCCACCAGCTTCTCCTCCTCTTCCTCTCCCACCTCCGGCGGCTGTGAACACGGCCTCTTCCCCTACGGCCACAGGGG CCCCTCCTCTAATGAGTGGTCGGACCGTGGGGAAGGGCCCCACTCAGGGATCTCAGACCTAGTGCTCCCTTCCTCCTCAAACCGAGAGAC TCACACTGGACAGGGCAGGAGGAGGGGGCCGTGCCTCCCACCCTTCTCAGGGACCCCCACGCCTTTGTTGTTTGAATGGAAATGGAAAAG CCAGTATTCTTTTATAAAATTATCTTTTGGAACCTGAGCCTGACATTGGGGGGAAGTGGGAGGCCCCGGACGGGGTAGCACCCCCCATTG GGGCTATAACGGTCAACCATTTCTGTCTCTTCTTTTTCCCCCAACCTCCCCCTCCTGTCCCCTCTGTTCCCGTCTTCCGGTCATTCTTTT CTCCTCCTCTCTCCTTCCTGCTGTCCTTCTCCGGCCCCGCCTCTGCCCTCATCCTCCCTCTCGTCTTTCGCACATTCTCCTGATCCTCTT GCCACCGTCCCACGTGGTCGCCTGCATTTCTCCGTGCGTCCTCCCTGCACTCATACCCCCCCTTCAACCCGCCCAAATGTCCGATCCCCG ACCTTCCTCGTGCCGTCCTCCCCTCCCGCCTCGCTGGGCGCCCTGGCCGCAGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAG TTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGG CGGGACCCCCATGTCCTCCGCTCCGCCCGGCCCCCTAGCTGTATATACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGA CTCTGCCCATCCCCACCCCACCCCGACGTCCCCCGGGGCTCCCGGTCCTCTGCATGTCTCAGGCTGAGCTCCCTCCCCCGCGGTGCCTTC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000412389_chr7_100488959_-_808nt GGCGGCGGAGGCGGCGGTGGCGGCGGTGGCGGCTGGGTCGGGCCCCGACGGGCGGCGGCGGCTGAGGTGGAGGCGGAGGGAGGCGGCGGC GGCGGCGGCGGGAAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCC GGAATCCTGCTCTCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGG GTGAAGTGCTCCGCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCT CAGCAGTACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCC AAATTGCTCAGCGCCACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGG AAGAACCAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCC CCTAGCTGTATATACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACCCCACCCCGACGTCCCC >In-frame_VKORC1L1_ENST00000360768_chr7_65338552_+_ACHE_ENST00000411582_chr7_100488959_-_842nt GGCGGCGGAGGCGGCGGTGGCGGCGGTGGCGGCTGGGTCGGGCCCCGACGGGCGGCGGCGGCTGAGGTGGAGGCGGAGGGAGGCGGCGGC GGCGGCGGCGGGAAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCC GGAATCCTGCTCTCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGG GTGAAGTGCTCCGCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCT CAGCAGTACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCC AAATTGCTCAGCGCCACCGCCTCGGAGGCTCCCAGCACCTGCCCAGGCTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTG CCCCTCCTCCTCCTCCACCAGCTTCTCCTCCTCTTCCTCTCCCACCTCCGGCGGCTGTGAACACGGCCTCTTCCCCTACGGCCACAGGGG CCCCTCCTCTAATGAGTGGTCGGACCGTGGGGAAGGGCCCCACTCAGGGATCTCAGACCTAGTGCTCCCTTCCTCCTCAAACCGAGAGAC TCACACTGGACAGGGCAGGAGGAGGGGGCCGTGCCTCCCACCCTTCTCAGGGACCCCCACGCCTTTGTTGTTTGAATGGAAATGGAAAAG >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000419336_chr7_100488959_-_709nt AAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTC TCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCC GCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTT AGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGC GCCACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTC GACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCCCCTAGCTGTATA TACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACCCCACCCCGACGTCCCCCGGGGCTCCCGG >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000241069_chr7_100488959_-_709nt AAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTC TCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCC GCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTT AGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGC GCCACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTC GACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCCCCTAGCTGTATA TACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACCCCACCCCGACGTCCCCCGGGGCTCCCGG >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000428317_chr7_100488959_-_709nt AAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTC TCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCC GCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTT AGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGC GCCACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTC GACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCCCCTAGCTGTATA TACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACCCCACCCCGACGTCCCCCGGGGCTCCCGG >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000302913_chr7_100488959_-_1461nt AAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTC TCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCC GCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTT AGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGC GCCACCGCCTCGGAGGCTCCCAGCACCTGCCCAGGCTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTGCCCCTCCTCCTC CTCCACCAGCTTCTCCTCCTCTTCCTCTCCCACCTCCGGCGGCTGTGAACACGGCCTCTTCCCCTACGGCCACAGGGGCCCCTCCTCTAA TGAGTGGTCGGACCGTGGGGAAGGGCCCCACTCAGGGATCTCAGACCTAGTGCTCCCTTCCTCCTCAAACCGAGAGACTCACACTGGACA GGGCAGGAGGAGGGGGCCGTGCCTCCCACCCTTCTCAGGGACCCCCACGCCTTTGTTGTTTGAATGGAAATGGAAAAGCCAGTATTCTTT TATAAAATTATCTTTTGGAACCTGAGCCTGACATTGGGGGGAAGTGGGAGGCCCCGGACGGGGTAGCACCCCCCATTGGGGCTATAACGG TCAACCATTTCTGTCTCTTCTTTTTCCCCCAACCTCCCCCTCCTGTCCCCTCTGTTCCCGTCTTCCGGTCATTCTTTTCTCCTCCTCTCT CCTTCCTGCTGTCCTTCTCCGGCCCCGCCTCTGCCCTCATCCTCCCTCTCGTCTTTCGCACATTCTCCTGATCCTCTTGCCACCGTCCCA CGTGGTCGCCTGCATTTCTCCGTGCGTCCTCCCTGCACTCATACCCCCCCTTCAACCCGCCCAAATGTCCGATCCCCGACCTTCCTCGTG CCGTCCTCCCCTCCCGCCTCGCTGGGCGCCCTGGCCGCAGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGG AGCTCCTACATGGTGCACTGGAAGAACCAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCAT GTCCTCCGCTCCGCCCGGCCCCCTAGCTGTATATACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCC CCACCCCACCCCGACGTCCCCCGGGGCTCCCGGTCCTCTGCATGTCTCAGGCTGAGCTCCCTCCCCCGCGGTGCCTTCGCCCCTCTGGGC >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000412389_chr7_100488959_-_706nt AAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTC TCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCC GCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTT AGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGC GCCACCGACACGCTCGACGAGGCGGAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAACCAGTTC GACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGACCCCGGCGGGACCCCCATGTCCTCCGCTCCGCCCGGCCCCCTAGCTGTATA TACTATTTATTTCAGGGCTGGGCTATAACACAGACGAGCCCCAGACTCTGCCCATCCCCACCCCACCCCGACGTCCCCCGGGGCTCCCGG >In-frame_VKORC1L1_ENST00000434382_chr7_65338552_+_ACHE_ENST00000411582_chr7_100488959_-_740nt AAGATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTATGCAGTGTGCGCTGCCGGAATCCTGCTC TCCATCTACGCCTACCACGTGGAGCGGGAGAAGGAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCC GCCGCCCTTGCCTCCAGGGATCCCAATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAGTACGTT AGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGCGCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGC GCCACCGCCTCGGAGGCTCCCAGCACCTGCCCAGGCTTCACCCATGGGGAGGCTGCTCCGAGGCCCGGCCTCCCCCTGCCCCTCCTCCTC CTCCACCAGCTTCTCCTCCTCTTCCTCTCCCACCTCCGGCGGCTGTGAACACGGCCTCTTCCCCTACGGCCACAGGGGCCCCTCCTCTAA TGAGTGGTCGGACCGTGGGGAAGGGCCCCACTCAGGGATCTCAGACCTAGTGCTCCCTTCCTCCTCAAACCGAGAGACTCACACTGGACA GGGCAGGAGGAGGGGGCCGTGCCTCCCACCCTTCTCAGGGACCCCCACGCCTTTGTTGTTTGAATGGAAATGGAAAAGCCAGTATTCTTT |
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FusionGenePPI for VKORC1L1_ACHE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| VKORC1L1 | ELAVL1, VKORC1, MOV10, TM4SF20, TSPAN5, GPM6A, PGAP3, AGTR1, GPR52, P2RY12, EDNRA, TCTN2, TCTN3, TMEM17, TMEM216, SLC39A12, TRIM25 | ACHE | APP, COL4A1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VKORC1L1_ACHE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | VKORC1L1 | Q8N0U8 | DB00170 | Menadione | Vitamin K epoxide reductase complex subunit 1-like protein 1 | small molecule | approved|nutraceutical |
| Tgene | ACHE | P22303 | DB00411 | Carbachol | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB00449 | Dipivefrin | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB00674 | Galantamine | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB00805 | Minaprine | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB00843 | Donepezil | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB00863 | Ranitidine | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB00944 | Demecarium | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB01122 | Ambenonium | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB01199 | Tubocurarine | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB01364 | Ephedrine | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB03128 | Acetylcholine | Acetylcholinesterase | small molecule | approved |
| Tgene | ACHE | P22303 | DB00545 | Pyridostigmine | Acetylcholinesterase | small molecule | approved|investigational |
| Tgene | ACHE | P22303 | DB00981 | Physostigmine | Acetylcholinesterase | small molecule | approved|investigational |
| Tgene | ACHE | P22303 | DB00989 | Rivastigmine | Acetylcholinesterase | small molecule | approved|investigational |
| Tgene | ACHE | P22303 | DB01233 | Metoclopramide | Acetylcholinesterase | small molecule | approved|investigational |
| Tgene | ACHE | P22303 | DB00122 | Choline | Acetylcholinesterase | small molecule | approved|nutraceutical |
| Tgene | ACHE | P22303 | DB00733 | Pralidoxime | Acetylcholinesterase | small molecule | approved|vet_approved |
| Tgene | ACHE | P22303 | DB01400 | Neostigmine | Acetylcholinesterase | small molecule | approved|vet_approved |
| Tgene | ACHE | P22303 | DB08996 | Dimetacrine | Acetylcholinesterase | small molecule | approved|withdrawn |
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RelatedDiseases for VKORC1L1_ACHE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ACHE | C0700359 | Organophosphate poisoning | 3 | CTD_human |
| Tgene | ACHE | C0002395 | Alzheimer's Disease | 2 | CTD_human |
| Tgene | ACHE | C0036572 | Seizures | 2 | CTD_human |
| Tgene | ACHE | C0002726 | Amyloidosis | 1 | CTD_human |
| Tgene | ACHE | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | ACHE | C0018273 | Growth Disorders | 1 | CTD_human |
| Tgene | ACHE | C0023186 | Learning Disorders | 1 | CTD_human |
| Tgene | ACHE | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ACHE | C0025261 | Memory Disorders | 1 | CTD_human |
| Tgene | ACHE | C0026650 | Movement Disorders | 1 | CTD_human |
| Tgene | ACHE | C0026850 | Muscular Dystrophy | 1 | CTD_human |
| Tgene | ACHE | C0027765 | nervous system disorder | 1 | CTD_human |
| Tgene | ACHE | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | ACHE | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | ACHE | C0040822 | Tremor | 1 | CTD_human |
| Tgene | ACHE | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Tgene | ACHE | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | ACHE | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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