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Fusion gene ID: 4147 |
FusionGeneSummary for BHMT2_JMY |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BHMT2_JMY | Fusion gene ID: 4147 | Hgene | Tgene | Gene symbol | BHMT2 | JMY | Gene ID | 23743 | 133746 |
| Gene name | betaine--homocysteine S-methyltransferase 2 | junction mediating and regulatory protein, p53 cofactor | |
| Synonyms | - | WHAMM2|WHDC1L3 | |
| Cytomap | 5q14.1 | 5q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | S-methylmethionine--homocysteine S-methyltransferase BHMT2SMM-hcy methyltransferasebetaine-homocysteine methyltransferase 2 | junction-mediating and -regulatory proteinWAS protein homology region 2 domain containing 1-like 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H2M3 | Q8N9B5 | |
| Ensembl transtripts involved in fusion gene | ENST00000255192, ENST00000521567, | ENST00000396137, ENST00000412001, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: BHMT2 [Title/Abstract] AND JMY [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BHMT2 | GO:0006577 | amino-acid betaine metabolic process | 18230605 |
| Hgene | BHMT2 | GO:0033477 | S-methylmethionine metabolic process | 18230605 |
| Hgene | BHMT2 | GO:0046500 | S-adenosylmethionine metabolic process | 18230605 |
| Hgene | BHMT2 | GO:0071267 | L-methionine salvage | 18230605 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-BC-4073-01B | BHMT2 | chr5 | 78365638 | + | JMY | chr5 | 78573733 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000255192 | ENST00000396137 | BHMT2 | chr5 | 78365638 | + | JMY | chr5 | 78573733 | + |
| 5CDS-intron | ENST00000255192 | ENST00000412001 | BHMT2 | chr5 | 78365638 | + | JMY | chr5 | 78573733 | + |
| In-frame | ENST00000521567 | ENST00000396137 | BHMT2 | chr5 | 78365638 | + | JMY | chr5 | 78573733 | + |
| 5CDS-intron | ENST00000521567 | ENST00000412001 | BHMT2 | chr5 | 78365638 | + | JMY | chr5 | 78573733 | + |
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FusionProtFeatures for BHMT2_JMY |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BHMT2 | JMY |
| Involved in the regulation of homocysteine metabolism.Converts homocysteine to methionine using S-methylmethionine (SMM)as a methyl donor. {ECO:0000269|PubMed:18230605}. | Acts both as a nuclear p53/TP53-cofactor and acytoplasmic regulator of actin dynamics depending on conditions.In nucleus, acts as a cofactor that increases p53/TP53 responsevia its interaction with p300/EP300. Increases p53/TP53-dependenttranscription and apoptosis, suggesting an important role inp53/TP53 stress response such as DNA damage. In cytoplasm, acts asa nucleation-promoting factor for both branched and unbranchedactin filaments. Activates the Arp2/3 complex to induce branchedactin filament networks. Also catalyzes actin polymerization inthe absence of Arp2/3, creating unbranched filaments. Contributesto cell motility by controlling actin dynamics. May promote therapid formation of a branched actin network by first nucleatingnew mother filaments and then activating Arp2/3 to branch offthese filaments. The p53/TP53-cofactor and actin activatoractivities are regulated via its subcellular location (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >JMY | chr5:78365638 | chr5:78573733 | ENST00000396137 | + | 0 | 11 | 489_541 | 344 | 2361 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >JMY | chr5:78365638 | chr5:78573733 | ENST00000396137 | + | 0 | 11 | 590_621 | 344 | 2361 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >JMY | chr5:78365638 | chr5:78573733 | ENST00000396137 | + | 0 | 11 | 781_827 | 344 | 2361 | Compositional bias | Note=Pro-rich |
| Tgene | >JMY | chr5:78365638 | chr5:78573733 | ENST00000396137 | + | 0 | 11 | 921_938 | 344 | 2361 | Domain | WH2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >BHMT2 | chr5:78365638 | chr5:78573733 | ENST00000255192 | + | 1 | 8 | 11_305 | 11 | 364 | Domain | Hcy-binding |
| Hgene | >BHMT2 | chr5:78365638 | chr5:78573733 | ENST00000521567 | + | 1 | 7 | 11_305 | 11 | 300 | Domain | Hcy-binding |
| Tgene | JMY | chr5:78365638 | chr5:78573733 | ENST00000396137 | + | 0 | 11 | 324_360 | 344 | 2361 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for BHMT2_JMY |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BHMT2_ENST00000255192_chr5_78365638_+_JMY_ENST00000396137_chr5_78573733_+_656aa MAPAGRPGAKKLLDKHKNTESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDA DWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSL RGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQ QKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQ VILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPT ISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSASAPSAHLFDSSQLVSARK KLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPDTDPLTRSIHEA >In-frame_BHMT2_ENST00000521567_chr5_78365638_+_JMY_ENST00000396137_chr5_78573733_+_656aa MAPAGRPGAKKLLDKHKNTESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDA DWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSL RGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQ QKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQ VILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPT ISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSASAPSAHLFDSSQLVSARK KLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPDTDPLTRSIHEA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BHMT2_ENST00000255192_chr5_78365638_+_JMY_ENST00000396137_chr5_78573733_+_1968nt ATGGCACCTGCTGGACGCCCGGGGGCCAAGAAGCTCTTGGATAAGCACAAGAATACAGAGAGCATGGTGGAGCTTCTGGACTTGTATCAG ATGGAGGATGAAGCCTACAGCAGCCTTGCAGAAGCTACAACCGAACTCTATCAGTATTTACTACAGCCATTCCGAGACATGAGAGAACTT GCCATGCTACGAAGACAGCAGATCAAGATTTCCATGGAGAATGATTATCTGGGACCTCGAAGAATTGAGAGTCTACAAAAAGAAGATGCT GATTGGCAGCGGAAAGCTCACATGGCTGTACTGTCTATTCAAGATCTTACTGTCAAGTACTTTGAAATAACAGCTAAAGCTCAAAAAGCT GTGTATGATCGAATGCGAGCTGATCAGAAGAAATTTGGTAAAGCATCATGGGCAGCGGCTGCTGAACGGATGGAAAAACTCCAGTATGCA GTTTCTAAGGAAACTTTGCAGATGATGAGAGCTAAAGAGATATGCTTGGAACAGCGGAAACATGCACTAAAGGAAGAGATGCAGAGTTTG CGGGGTGGTACAGAAGCGATAGCACGATTGGATCAGTTAGAAGCTGATTATTATGATCTGCAACTTCAGTTGTATGAAGTACAGTTTGAA ATCTTGAAGTGTGAAGAGTTACTATTGACAGCGCAACTAGAAAGCATCAAAAGACTTATATCAGAAAAAAGAGATGAAGTGGTATACTAT GACACTTACGAAAGCATGGAGGCCATGCTGGAGAAGGAAGAGATGGCAGCATCTGCGTACTTACAGAGAGAAGAGCTGCAGAAACTTCAG CAGAAAGCACGCCAGCTGGAAGCAAGACGTGGACGGGTTTCTGCCAAGAAATCCTACCTCAGAAATAAAAAGGAAATATGTATTGCAAAA CACAATGAAAAAATCCAACAGCGCACTCGGATTGAAGATGAATATAGAACCCATCACACAGTACAACTAAAGAGAGAAAAATTACATGAT GAAGAAGAAAGAAAAAGTGCCTGGGTTAGCCAAGAGAGACAGAGAACACTGGATAGACTTCGAACATTTAAACAGAGGTATCCTGGGCAA GTCATACTTAAATCAACCAGATTACGACTAGCTCATGCAAGAAGAAAAGGTGCAGCAAGTCCTGTTCTCCAAGAGGATCATTGTGACTCT TTACCAAGTGTGTTACAGGTAGAAGAGAAAACTGAAGAGGTGGGAGAAGGAAGAGTCAAGCGTGGGCCATCACAGACAACAGAACCCCAG AGCCTTGTGCAACTTGAAGATACTTCATTAACACAACTTGAAGCCACCTCATTACCTCTCAGTGGTGTTACCTCTGAACTGCCTCCCACT ATATCTCTTCCACTTTTGAATAACAACCTCGAACCATGTTCTGTTACCATAAATCCACTCCCATCCCCTCTTCCTCCAACACCACCACCT CCCCCACCTCCTCCCCCTCCCCCACCACCACCACCTCTGCCTGTTGCTAAGGACAGTGGCCCAGAGACACTGGAGAAAGATCTGCCTAGA AAGGAGGGGAATGAGAAGAGGATCCCAAAGTCAGCCAGTGCCCCCTCAGCACACCTCTTTGACAGCAGCCAGCTGGTCAGTGCACGGAAG AAGCTCAGAAAGACTGCTGAAGGTTTGCAGAGGAGGAGAGTGAGCTCACCCATGGATGAGGTGCTAGCCTCCTTGAAGCGTGGTAGTTTT CATCTGAAAAAGGTTGAACAGCGAACTCTGCCTCCTTTTCCTGATGAAGATGATAGTAATAATATCTTGGCACAAATAAGGAAAGGGGTA AAATTGAAGAAGGTACAGAAGGATGTTTTGAGAGAATCCTTCACACTTCTACCCGATACAGACCCTCTAACACGGAGCATCCATGAAGCT >In-frame_BHMT2_ENST00000521567_chr5_78365638_+_JMY_ENST00000396137_chr5_78573733_+_1968nt ATGGCACCTGCTGGACGCCCGGGGGCCAAGAAGCTCTTGGATAAGCACAAGAATACAGAGAGCATGGTGGAGCTTCTGGACTTGTATCAG ATGGAGGATGAAGCCTACAGCAGCCTTGCAGAAGCTACAACCGAACTCTATCAGTATTTACTACAGCCATTCCGAGACATGAGAGAACTT GCCATGCTACGAAGACAGCAGATCAAGATTTCCATGGAGAATGATTATCTGGGACCTCGAAGAATTGAGAGTCTACAAAAAGAAGATGCT GATTGGCAGCGGAAAGCTCACATGGCTGTACTGTCTATTCAAGATCTTACTGTCAAGTACTTTGAAATAACAGCTAAAGCTCAAAAAGCT GTGTATGATCGAATGCGAGCTGATCAGAAGAAATTTGGTAAAGCATCATGGGCAGCGGCTGCTGAACGGATGGAAAAACTCCAGTATGCA GTTTCTAAGGAAACTTTGCAGATGATGAGAGCTAAAGAGATATGCTTGGAACAGCGGAAACATGCACTAAAGGAAGAGATGCAGAGTTTG CGGGGTGGTACAGAAGCGATAGCACGATTGGATCAGTTAGAAGCTGATTATTATGATCTGCAACTTCAGTTGTATGAAGTACAGTTTGAA ATCTTGAAGTGTGAAGAGTTACTATTGACAGCGCAACTAGAAAGCATCAAAAGACTTATATCAGAAAAAAGAGATGAAGTGGTATACTAT GACACTTACGAAAGCATGGAGGCCATGCTGGAGAAGGAAGAGATGGCAGCATCTGCGTACTTACAGAGAGAAGAGCTGCAGAAACTTCAG CAGAAAGCACGCCAGCTGGAAGCAAGACGTGGACGGGTTTCTGCCAAGAAATCCTACCTCAGAAATAAAAAGGAAATATGTATTGCAAAA CACAATGAAAAAATCCAACAGCGCACTCGGATTGAAGATGAATATAGAACCCATCACACAGTACAACTAAAGAGAGAAAAATTACATGAT GAAGAAGAAAGAAAAAGTGCCTGGGTTAGCCAAGAGAGACAGAGAACACTGGATAGACTTCGAACATTTAAACAGAGGTATCCTGGGCAA GTCATACTTAAATCAACCAGATTACGACTAGCTCATGCAAGAAGAAAAGGTGCAGCAAGTCCTGTTCTCCAAGAGGATCATTGTGACTCT TTACCAAGTGTGTTACAGGTAGAAGAGAAAACTGAAGAGGTGGGAGAAGGAAGAGTCAAGCGTGGGCCATCACAGACAACAGAACCCCAG AGCCTTGTGCAACTTGAAGATACTTCATTAACACAACTTGAAGCCACCTCATTACCTCTCAGTGGTGTTACCTCTGAACTGCCTCCCACT ATATCTCTTCCACTTTTGAATAACAACCTCGAACCATGTTCTGTTACCATAAATCCACTCCCATCCCCTCTTCCTCCAACACCACCACCT CCCCCACCTCCTCCCCCTCCCCCACCACCACCACCTCTGCCTGTTGCTAAGGACAGTGGCCCAGAGACACTGGAGAAAGATCTGCCTAGA AAGGAGGGGAATGAGAAGAGGATCCCAAAGTCAGCCAGTGCCCCCTCAGCACACCTCTTTGACAGCAGCCAGCTGGTCAGTGCACGGAAG AAGCTCAGAAAGACTGCTGAAGGTTTGCAGAGGAGGAGAGTGAGCTCACCCATGGATGAGGTGCTAGCCTCCTTGAAGCGTGGTAGTTTT CATCTGAAAAAGGTTGAACAGCGAACTCTGCCTCCTTTTCCTGATGAAGATGATAGTAATAATATCTTGGCACAAATAAGGAAAGGGGTA AAATTGAAGAAGGTACAGAAGGATGTTTTGAGAGAATCCTTCACACTTCTACCCGATACAGACCCTCTAACACGGAGCATCCATGAAGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BHMT2_ENST00000255192_chr5_78365638_+_JMY_ENST00000396137_chr5_78573733_+_7647nt GGGCTGGGGGCGGGCTCCTAGACGGCCGCGCGCCCGGGAACCCGGCGCCCACAGAGCCGCGGCACCATGGCACCTGCTGGACGCCCGGGG GCCAAGAAGCTCTTGGATAAGCACAAGAATACAGAGAGCATGGTGGAGCTTCTGGACTTGTATCAGATGGAGGATGAAGCCTACAGCAGC CTTGCAGAAGCTACAACCGAACTCTATCAGTATTTACTACAGCCATTCCGAGACATGAGAGAACTTGCCATGCTACGAAGACAGCAGATC AAGATTTCCATGGAGAATGATTATCTGGGACCTCGAAGAATTGAGAGTCTACAAAAAGAAGATGCTGATTGGCAGCGGAAAGCTCACATG GCTGTACTGTCTATTCAAGATCTTACTGTCAAGTACTTTGAAATAACAGCTAAAGCTCAAAAAGCTGTGTATGATCGAATGCGAGCTGAT CAGAAGAAATTTGGTAAAGCATCATGGGCAGCGGCTGCTGAACGGATGGAAAAACTCCAGTATGCAGTTTCTAAGGAAACTTTGCAGATG ATGAGAGCTAAAGAGATATGCTTGGAACAGCGGAAACATGCACTAAAGGAAGAGATGCAGAGTTTGCGGGGTGGTACAGAAGCGATAGCA CGATTGGATCAGTTAGAAGCTGATTATTATGATCTGCAACTTCAGTTGTATGAAGTACAGTTTGAAATCTTGAAGTGTGAAGAGTTACTA TTGACAGCGCAACTAGAAAGCATCAAAAGACTTATATCAGAAAAAAGAGATGAAGTGGTATACTATGACACTTACGAAAGCATGGAGGCC ATGCTGGAGAAGGAAGAGATGGCAGCATCTGCGTACTTACAGAGAGAAGAGCTGCAGAAACTTCAGCAGAAAGCACGCCAGCTGGAAGCA AGACGTGGACGGGTTTCTGCCAAGAAATCCTACCTCAGAAATAAAAAGGAAATATGTATTGCAAAACACAATGAAAAAATCCAACAGCGC ACTCGGATTGAAGATGAATATAGAACCCATCACACAGTACAACTAAAGAGAGAAAAATTACATGATGAAGAAGAAAGAAAAAGTGCCTGG GTTAGCCAAGAGAGACAGAGAACACTGGATAGACTTCGAACATTTAAACAGAGGTATCCTGGGCAAGTCATACTTAAATCAACCAGATTA CGACTAGCTCATGCAAGAAGAAAAGGTGCAGCAAGTCCTGTTCTCCAAGAGGATCATTGTGACTCTTTACCAAGTGTGTTACAGGTAGAA GAGAAAACTGAAGAGGTGGGAGAAGGAAGAGTCAAGCGTGGGCCATCACAGACAACAGAACCCCAGAGCCTTGTGCAACTTGAAGATACT TCATTAACACAACTTGAAGCCACCTCATTACCTCTCAGTGGTGTTACCTCTGAACTGCCTCCCACTATATCTCTTCCACTTTTGAATAAC AACCTCGAACCATGTTCTGTTACCATAAATCCACTCCCATCCCCTCTTCCTCCAACACCACCACCTCCCCCACCTCCTCCCCCTCCCCCA CCACCACCACCTCTGCCTGTTGCTAAGGACAGTGGCCCAGAGACACTGGAGAAAGATCTGCCTAGAAAGGAGGGGAATGAGAAGAGGATC CCAAAGTCAGCCAGTGCCCCCTCAGCACACCTCTTTGACAGCAGCCAGCTGGTCAGTGCACGGAAGAAGCTCAGAAAGACTGCTGAAGGT TTGCAGAGGAGGAGAGTGAGCTCACCCATGGATGAGGTGCTAGCCTCCTTGAAGCGTGGTAGTTTTCATCTGAAAAAGGTTGAACAGCGA ACTCTGCCTCCTTTTCCTGATGAAGATGATAGTAATAATATCTTGGCACAAATAAGGAAAGGGGTAAAATTGAAGAAGGTACAGAAGGAT GTTTTGAGAGAATCCTTCACACTTCTACCCGATACAGACCCTCTAACACGGAGCATCCATGAAGCTCTTAGAAGAATTAAAGAAGCATCC CCAGAGTCAGAGGACGAAGAGGAGGCTTTACCTTGCACAGACTGGGAGAACTAACAAGTGACATAACAGAAGAAAAATATCATTCAAGAT TGGTTCTGATTCTTTTGGAAAATGACAGTTTAAGCACTTGGTTCCTCAGTTGGATAACATTAGATCCAAAGTTCATTGGTTCAGTGGTGT GAAGAAAGGAAGCACAATTGGCAGGTTATCACTTTCCAGTCGTTCCAATAGATGATGGTTAACATGAATTTTACATGTGCAATGTTCCTG ACTGCAATGAAGAAAAGGCCTTCTGGAGATTTCTGTTTTTTAAGCACATTCTCCTTCCATCCACATATTTACATCCTTGTAATGGCCAGT TAAGCTAGGGCTTGCTGTAAGTTGGAAGAACACTGGGTTGACAGAGATCTACTGTGAGCTGTATTGGGACTGCTTTGAGAACCATCTTTC AATGCACTGAAAAGTCATCTGAAAAAATAGCTTCTTCCATATCAGCTTATATTAAATACTGTGACACTCTGAGAAAGTTTATCATCATGA TAGCTGTAAGTCAGGCATTAAAATCAAATGGAAATACACCTAAAATGTCCGCATTACTCATTTCCAAAGGATTTTTCATAAAGATGTTCA GCAACATCTGAAAAGCTGCATTTATGGAGATACATCTATTAATATGTTCACAACATGATACATTTAACATGGCATATTTTTAGGAGTCTT ATACTTTGTAAGGTTTTGAAGTTTCCGTGCTTTTAAATCACTCTTCATATTTCTTGAATTTATAATAGTTTGAATTTTATGTGCATCCTT GTTTATGGAAGGCAGTACTTTGATAATATTTCAAATTATTTTTATTTTGTTTGAATTATTGCTTGATTGCTATGACTGACATGACTTTCC TATTGAGAATCAAAAATCAAGATTCAATCATAGGGATGCAGATCTTAACTCTTTTCACAAATTACCATTTTAAGTTTTTATTTTTATGCT CCACAGTGAAAAGCATGTGCTCTACAAAGATAGAAAGTAGAGACAAGTCTCCGTGGCTGGCATTTCACCATCTTCACATGCACTGAATGG AATTTTGGGAGAATGCCTTTGTTATAGTCACTAAAATTTTAAACTTATACACAGCTTTAGGTGCTGATTTTGGCTGTGATGGAGTCCTGA AGGACACATTTATATGTTCCAGATTTTCAGCAGGATTGTTGTGGGCTTGAATACATGTAGATCATTGGACTCAGTGTGCAGTACCCTGTA CATATAATTCTGCATAAGACAGATCTTGGCCTTTCTGTGGAGGGAGTTAAGAACTAAAATACCAAAAATCACTTTATTTCTTTTAAGACA ATTATCTGGCCTAAACCCAGAAAGCAGTACTGGAGCAAAAGCCCAGTGTATATGAATTGGTATTCCTAGAGAAAAAAAGAAATGCTCACA CCTTTGTTATTTTAAAGTGTTTTCTTGAAAATAATTAGGGAGAAAATTTTCTGGCAACAGGTTATGTAAGACAACAACTTTTTTTATTAT TTCAAAACAAAACAGGCACATGCCACCATGCCCCAGCTAATTTTTATATTTTTTATAGAGACAGGGTTTTGCCATGTTGCCCACGCTGGT CTTGAACTCCTGGACTCAAGCAATCTGCCAGCCTCGGCCTGCTAAAGTGCTAGGATTATAGGCGTGAGCCTCTGTGCCCAGCCTGACAAA ATCTTTTATTTATTTAAATGTTAGTAATACGTTTATTGATGAGACTAGGAGCTTCTCTGCAGCATCTTCATAATACATTGGTTTTAGTTC CCACACTATTCCCACATCTTATCTGGGAAGATTAGAAATACAGATGTAATATGGAAGCTTCAACAGCATGGGGGTGGTGATAGTGTCCTA TTTGCCCTTGGTAAAATATTAAAGCGTATTTCTTAACCCAAAGAGTGATTGGTTATATGAATATATTTGAAAAAGTTAAAGCAAATTTGC AAACCTTTACAAAATCATGTATCAATTTTATGCTATCCAGTTTTTACGTACCCATGTGTCAACATTTCATATATCCAGTTCTTTGGGTGC TGGTTCACTTTTTTTCATTTATTCAAATTCAGAAAAATACGGACGGATCTAATGTTAAATTAACCAGAAACCCTGGAACATTCATATCTT GAGAGGGAATTTGCTACTCTTTTACTTTTGGGATTTCATTATAAAATAGGCTCATTTTATACATATGTCCTGTGGTCTGTCTTCCAGAGT GTGCTGTAATCATAAGTCTCTAGCAAAGAGTGGAGGGTGGAGGGTGTGTAGAACTCCACTCAGCCTCATGGATACATCTACAAGTCTCTC AACCCATCCTGTTACAGTTCTCCATGAGAGTCACCTCACACTTGGAAAAGAAGGAGGTTAAAGCAGAGTATTGTTGGCAGCCAGCTATGC CCATCCTCTTGTAAATAACTTTCCAACACACCCATTTCCTTGCCTTAAGGTGCAGGTTCCTACTTCTACAAAATTTCAAATGATTGCAGG TCAAAAACCTTTGGAGTTACTCACAAATAATAATAAAATTTCAAATAACTAGGGTCTACTTGTCCATCAAGATGACATTACCAGTGGAAC CCACCTGTTAATTTTAAAGTAGCTTCAGAACCCAACAAAAATTATGTAAGCCTGGTTAAATGTCCTTTTTTCTTCTTGCCTCTAATAAAA TCAGGATCTTCGGCCTTGATACTAAATATGTGTATATTTAGTTATGATGGTACTTGTAGATGCTCACATTTCCAGTTCCAAACTCGCCCG TACTTTTTATGTGCTTCAAAATATTGGACACATTTCTGTTAATATATGATTTCTGTATCCACAAACCGCTGTTTGCTTATGCTGAGTCAA TTTAGAAGTTAATTTCCAATCTAGTCTCAACTGCAATGCATTTAAAATAGGTAAAACAAGTAAATGAGTTTGGGACATTTTGAGATTAAT GTTACTGCCCACTTGACTGTCAATTTCAAATGGCTCCTAATGCAACCAAAATTATAACCAATGTAGCATGTGTAGGAAAGGTATTTTTAA TTATTTAAAATCATTGTGTATATTACAGCAGTATGAGGAATGCCTGGCTAAAGAGGATTTTTTAAAAGATGAAGAATGGTTTTGCTTGTA TTATATAGGCTTACTGAGTTTGTGAGCAGCATAAAAACAATCATTCCTTAATTCTTCATTGTGGAACTGAAATATTTCTGTAATGCATTT TTTAAAAGGAGACTCCTAGACACAGCTGTAATAGTGGGAATAGAAATGTAGAGCTTTTCTCATAACACAAAACCAGAAAATAATTTTCAG CACTTTGACTTACTCTATGTAATAAGGAAAAAAATTGTTTCCACAAAGTTGAACTATGTAGTAATATTTGGTAACATATGGCATGGCCAC TTTATATCACAGAATGTGTGTCAAGTTGCAAAGCATACTTGGGCCATAGTAGACACTAAGAATTAAAACTCTTAAATCAGTGAAACAAAA ACTAATGGGCAGCATTCTCTCTGTTTGGAATGGGATCAGTATACAATTAATACAATTTAATTTTACACATTCCCTAAGACACCATTTTTA AGTTACAGTCACATGAGTGTTTGTATAAATTTAAGTCAATGCTTTTAGCCTAGGCAAAGCTAAATACAAGGTTTTTGGGGTTTTCTTTTT TCAGCTTTATTATTGAAGTATTACAAACTTAACATCAGATACCAATGTGTAAAAAGTACTATTGGGTCCTTAAGGGCTCTATCAGGGAGT TGAAATTTCATACGCTTTACCAGGTTACTTGTAAAAAATGAACAGCTGTAAGACATTTCAAAACCATTGCAGACACATTGTTAAAATGCA GCCATTTGATAATGAAAGCAGAAACCTTAAGTTTTACCTAATTATTGCACTAAATGTAAATGATAACATAAAATTAAGTGTGCATTTTAA ACAGATTCTATTTCCCACTTACTGCTTAGCATAGAAAAAGAGCTATGGTTAGAGGAGTGACCAGCAAGATTTATTTCAGATGGAAAAGGG GTGAGAAAGTGGAAGCACCTTACTGTTAGAGCATGTTGCATCTATTTAGTGCTACTGAACAATTCAGTAGTTATTTCTGAACTTTGCTGC AAAGTGCTCTTTAGTTAAAGCACATTAAGAAGGGTCACTGCTTAATTGCTTTGTAAAATGAAGCAATGGTATTTTTTATCCGATATAGTG TAATTTAAAAGTTTTCCTACAAAGTGAGTTTATATTGTTGCCTAAACTATGTTATGTAAGCAAAGGGTTTGGAAAGGCGGGAGGGAGTCT AGATTCGGCGAGAGTGTGCGTTTGTGTGTGTGAATGTATGAAAAGTTTCCCCATTGGGTTATTCTTAAGATGTGTTTATTGTAAAGTTTT CTACGTTTTGCCCACAGTAAATGTACAACTTCGCAATTGTAGGATTTAATTGATTGAATTCCAAATTTATACTGTCTCTTCCCTTCTGCA GAGACATTATGCCACTGTAAGGTGCATGTACAGAAAATACCTCTGAGGTTGACTTGTTAAATAACTGATGAATGTTATTTCACACTGAAT CTCAAAGCAGTCATTTGTTTTGCGGGTTAGGGGAAAGTTTTGTTTTTTGCTGGTGTTTTTTGTTGTTTTTAATTAGGCACACTAAGAGTG GCTAAATTTGGGGGAATTGGTGGATAGGAAAGACCTTGAAAAGTGATGTGTAGATGAAAACACAAGGTATGGATGTTGGTTACAGAGTTC AGTTTTAACAAGGGAAATTTGGGGATTTTTTTTTTTTTTACTTGCATGTTCTATGGGTAGCTATCAAAGGGTGTAACAAATTATTCCAGC TTTTCCCAATACTAATTATATTGGTTTTAAAAAGTCTGCATAATCACTAGGTGGCATTTTCCCTTCATTTGTGAACCAAGAGGGGTAAAT GATGCTACCCATACAGTGACTTCTGAGTTCTTTAACTTTGACAGAATCTCCATTGTTTCATTGAATTTCTCATTGTATTATATGTCTTTC CAAGTGTGCAAACTATAATATGTAGTTAATGAAAAATGGAAGGCTGCAGATTATTTTGCATGAATAATTAATTGCCCATTAGGGCTAAGG AGACTGACATGATTTTTATCGGTTCTGGGTAAATGAAAATTTTAATGGAAAACTCATTCACCATTTACTAGCTTTGTGCAATATTATAAA AGGTAGAAGCAAAACACTAGCACATTGTGCTTTGCTTGGCTTGTAAGGATGGCTTTAGTACCATTACATTAAATGGACAGTGTGCACAGT GTATTGTAAATGCCAACTCTTGCAAATTTACAATACTTAAATATGTTCAATTAACATCCTAAAGTATTAAAAGTACAGAGGAAAAACTAA GCAAGCATTTATAGCAATACCATGAAATCTCCAGTAATCGTTTTGACTGTTGCCTTTTGCTCTTTAGTGCAGCTTTTCTGCATTGTAATT GTATTGCTTTGTATTTCATGTTTTTTACACTCATGACTTCAGAGTTAAGTACTTGTACACCAAGTATTGCAATCACCTTTCTCTTGTTGT >In-frame_BHMT2_ENST00000521567_chr5_78365638_+_JMY_ENST00000396137_chr5_78573733_+_7597nt ACAGAGCCGCGGCACCATGGCACCTGCTGGACGCCCGGGGGCCAAGAAGCTCTTGGATAAGCACAAGAATACAGAGAGCATGGTGGAGCT TCTGGACTTGTATCAGATGGAGGATGAAGCCTACAGCAGCCTTGCAGAAGCTACAACCGAACTCTATCAGTATTTACTACAGCCATTCCG AGACATGAGAGAACTTGCCATGCTACGAAGACAGCAGATCAAGATTTCCATGGAGAATGATTATCTGGGACCTCGAAGAATTGAGAGTCT ACAAAAAGAAGATGCTGATTGGCAGCGGAAAGCTCACATGGCTGTACTGTCTATTCAAGATCTTACTGTCAAGTACTTTGAAATAACAGC TAAAGCTCAAAAAGCTGTGTATGATCGAATGCGAGCTGATCAGAAGAAATTTGGTAAAGCATCATGGGCAGCGGCTGCTGAACGGATGGA AAAACTCCAGTATGCAGTTTCTAAGGAAACTTTGCAGATGATGAGAGCTAAAGAGATATGCTTGGAACAGCGGAAACATGCACTAAAGGA AGAGATGCAGAGTTTGCGGGGTGGTACAGAAGCGATAGCACGATTGGATCAGTTAGAAGCTGATTATTATGATCTGCAACTTCAGTTGTA TGAAGTACAGTTTGAAATCTTGAAGTGTGAAGAGTTACTATTGACAGCGCAACTAGAAAGCATCAAAAGACTTATATCAGAAAAAAGAGA TGAAGTGGTATACTATGACACTTACGAAAGCATGGAGGCCATGCTGGAGAAGGAAGAGATGGCAGCATCTGCGTACTTACAGAGAGAAGA GCTGCAGAAACTTCAGCAGAAAGCACGCCAGCTGGAAGCAAGACGTGGACGGGTTTCTGCCAAGAAATCCTACCTCAGAAATAAAAAGGA AATATGTATTGCAAAACACAATGAAAAAATCCAACAGCGCACTCGGATTGAAGATGAATATAGAACCCATCACACAGTACAACTAAAGAG AGAAAAATTACATGATGAAGAAGAAAGAAAAAGTGCCTGGGTTAGCCAAGAGAGACAGAGAACACTGGATAGACTTCGAACATTTAAACA GAGGTATCCTGGGCAAGTCATACTTAAATCAACCAGATTACGACTAGCTCATGCAAGAAGAAAAGGTGCAGCAAGTCCTGTTCTCCAAGA GGATCATTGTGACTCTTTACCAAGTGTGTTACAGGTAGAAGAGAAAACTGAAGAGGTGGGAGAAGGAAGAGTCAAGCGTGGGCCATCACA GACAACAGAACCCCAGAGCCTTGTGCAACTTGAAGATACTTCATTAACACAACTTGAAGCCACCTCATTACCTCTCAGTGGTGTTACCTC TGAACTGCCTCCCACTATATCTCTTCCACTTTTGAATAACAACCTCGAACCATGTTCTGTTACCATAAATCCACTCCCATCCCCTCTTCC TCCAACACCACCACCTCCCCCACCTCCTCCCCCTCCCCCACCACCACCACCTCTGCCTGTTGCTAAGGACAGTGGCCCAGAGACACTGGA GAAAGATCTGCCTAGAAAGGAGGGGAATGAGAAGAGGATCCCAAAGTCAGCCAGTGCCCCCTCAGCACACCTCTTTGACAGCAGCCAGCT GGTCAGTGCACGGAAGAAGCTCAGAAAGACTGCTGAAGGTTTGCAGAGGAGGAGAGTGAGCTCACCCATGGATGAGGTGCTAGCCTCCTT GAAGCGTGGTAGTTTTCATCTGAAAAAGGTTGAACAGCGAACTCTGCCTCCTTTTCCTGATGAAGATGATAGTAATAATATCTTGGCACA AATAAGGAAAGGGGTAAAATTGAAGAAGGTACAGAAGGATGTTTTGAGAGAATCCTTCACACTTCTACCCGATACAGACCCTCTAACACG GAGCATCCATGAAGCTCTTAGAAGAATTAAAGAAGCATCCCCAGAGTCAGAGGACGAAGAGGAGGCTTTACCTTGCACAGACTGGGAGAA CTAACAAGTGACATAACAGAAGAAAAATATCATTCAAGATTGGTTCTGATTCTTTTGGAAAATGACAGTTTAAGCACTTGGTTCCTCAGT TGGATAACATTAGATCCAAAGTTCATTGGTTCAGTGGTGTGAAGAAAGGAAGCACAATTGGCAGGTTATCACTTTCCAGTCGTTCCAATA GATGATGGTTAACATGAATTTTACATGTGCAATGTTCCTGACTGCAATGAAGAAAAGGCCTTCTGGAGATTTCTGTTTTTTAAGCACATT CTCCTTCCATCCACATATTTACATCCTTGTAATGGCCAGTTAAGCTAGGGCTTGCTGTAAGTTGGAAGAACACTGGGTTGACAGAGATCT ACTGTGAGCTGTATTGGGACTGCTTTGAGAACCATCTTTCAATGCACTGAAAAGTCATCTGAAAAAATAGCTTCTTCCATATCAGCTTAT ATTAAATACTGTGACACTCTGAGAAAGTTTATCATCATGATAGCTGTAAGTCAGGCATTAAAATCAAATGGAAATACACCTAAAATGTCC GCATTACTCATTTCCAAAGGATTTTTCATAAAGATGTTCAGCAACATCTGAAAAGCTGCATTTATGGAGATACATCTATTAATATGTTCA CAACATGATACATTTAACATGGCATATTTTTAGGAGTCTTATACTTTGTAAGGTTTTGAAGTTTCCGTGCTTTTAAATCACTCTTCATAT TTCTTGAATTTATAATAGTTTGAATTTTATGTGCATCCTTGTTTATGGAAGGCAGTACTTTGATAATATTTCAAATTATTTTTATTTTGT TTGAATTATTGCTTGATTGCTATGACTGACATGACTTTCCTATTGAGAATCAAAAATCAAGATTCAATCATAGGGATGCAGATCTTAACT CTTTTCACAAATTACCATTTTAAGTTTTTATTTTTATGCTCCACAGTGAAAAGCATGTGCTCTACAAAGATAGAAAGTAGAGACAAGTCT CCGTGGCTGGCATTTCACCATCTTCACATGCACTGAATGGAATTTTGGGAGAATGCCTTTGTTATAGTCACTAAAATTTTAAACTTATAC ACAGCTTTAGGTGCTGATTTTGGCTGTGATGGAGTCCTGAAGGACACATTTATATGTTCCAGATTTTCAGCAGGATTGTTGTGGGCTTGA ATACATGTAGATCATTGGACTCAGTGTGCAGTACCCTGTACATATAATTCTGCATAAGACAGATCTTGGCCTTTCTGTGGAGGGAGTTAA GAACTAAAATACCAAAAATCACTTTATTTCTTTTAAGACAATTATCTGGCCTAAACCCAGAAAGCAGTACTGGAGCAAAAGCCCAGTGTA TATGAATTGGTATTCCTAGAGAAAAAAAGAAATGCTCACACCTTTGTTATTTTAAAGTGTTTTCTTGAAAATAATTAGGGAGAAAATTTT CTGGCAACAGGTTATGTAAGACAACAACTTTTTTTATTATTTCAAAACAAAACAGGCACATGCCACCATGCCCCAGCTAATTTTTATATT TTTTATAGAGACAGGGTTTTGCCATGTTGCCCACGCTGGTCTTGAACTCCTGGACTCAAGCAATCTGCCAGCCTCGGCCTGCTAAAGTGC TAGGATTATAGGCGTGAGCCTCTGTGCCCAGCCTGACAAAATCTTTTATTTATTTAAATGTTAGTAATACGTTTATTGATGAGACTAGGA GCTTCTCTGCAGCATCTTCATAATACATTGGTTTTAGTTCCCACACTATTCCCACATCTTATCTGGGAAGATTAGAAATACAGATGTAAT ATGGAAGCTTCAACAGCATGGGGGTGGTGATAGTGTCCTATTTGCCCTTGGTAAAATATTAAAGCGTATTTCTTAACCCAAAGAGTGATT GGTTATATGAATATATTTGAAAAAGTTAAAGCAAATTTGCAAACCTTTACAAAATCATGTATCAATTTTATGCTATCCAGTTTTTACGTA CCCATGTGTCAACATTTCATATATCCAGTTCTTTGGGTGCTGGTTCACTTTTTTTCATTTATTCAAATTCAGAAAAATACGGACGGATCT AATGTTAAATTAACCAGAAACCCTGGAACATTCATATCTTGAGAGGGAATTTGCTACTCTTTTACTTTTGGGATTTCATTATAAAATAGG CTCATTTTATACATATGTCCTGTGGTCTGTCTTCCAGAGTGTGCTGTAATCATAAGTCTCTAGCAAAGAGTGGAGGGTGGAGGGTGTGTA GAACTCCACTCAGCCTCATGGATACATCTACAAGTCTCTCAACCCATCCTGTTACAGTTCTCCATGAGAGTCACCTCACACTTGGAAAAG AAGGAGGTTAAAGCAGAGTATTGTTGGCAGCCAGCTATGCCCATCCTCTTGTAAATAACTTTCCAACACACCCATTTCCTTGCCTTAAGG TGCAGGTTCCTACTTCTACAAAATTTCAAATGATTGCAGGTCAAAAACCTTTGGAGTTACTCACAAATAATAATAAAATTTCAAATAACT AGGGTCTACTTGTCCATCAAGATGACATTACCAGTGGAACCCACCTGTTAATTTTAAAGTAGCTTCAGAACCCAACAAAAATTATGTAAG CCTGGTTAAATGTCCTTTTTTCTTCTTGCCTCTAATAAAATCAGGATCTTCGGCCTTGATACTAAATATGTGTATATTTAGTTATGATGG TACTTGTAGATGCTCACATTTCCAGTTCCAAACTCGCCCGTACTTTTTATGTGCTTCAAAATATTGGACACATTTCTGTTAATATATGAT TTCTGTATCCACAAACCGCTGTTTGCTTATGCTGAGTCAATTTAGAAGTTAATTTCCAATCTAGTCTCAACTGCAATGCATTTAAAATAG GTAAAACAAGTAAATGAGTTTGGGACATTTTGAGATTAATGTTACTGCCCACTTGACTGTCAATTTCAAATGGCTCCTAATGCAACCAAA ATTATAACCAATGTAGCATGTGTAGGAAAGGTATTTTTAATTATTTAAAATCATTGTGTATATTACAGCAGTATGAGGAATGCCTGGCTA AAGAGGATTTTTTAAAAGATGAAGAATGGTTTTGCTTGTATTATATAGGCTTACTGAGTTTGTGAGCAGCATAAAAACAATCATTCCTTA ATTCTTCATTGTGGAACTGAAATATTTCTGTAATGCATTTTTTAAAAGGAGACTCCTAGACACAGCTGTAATAGTGGGAATAGAAATGTA GAGCTTTTCTCATAACACAAAACCAGAAAATAATTTTCAGCACTTTGACTTACTCTATGTAATAAGGAAAAAAATTGTTTCCACAAAGTT GAACTATGTAGTAATATTTGGTAACATATGGCATGGCCACTTTATATCACAGAATGTGTGTCAAGTTGCAAAGCATACTTGGGCCATAGT AGACACTAAGAATTAAAACTCTTAAATCAGTGAAACAAAAACTAATGGGCAGCATTCTCTCTGTTTGGAATGGGATCAGTATACAATTAA TACAATTTAATTTTACACATTCCCTAAGACACCATTTTTAAGTTACAGTCACATGAGTGTTTGTATAAATTTAAGTCAATGCTTTTAGCC TAGGCAAAGCTAAATACAAGGTTTTTGGGGTTTTCTTTTTTCAGCTTTATTATTGAAGTATTACAAACTTAACATCAGATACCAATGTGT AAAAAGTACTATTGGGTCCTTAAGGGCTCTATCAGGGAGTTGAAATTTCATACGCTTTACCAGGTTACTTGTAAAAAATGAACAGCTGTA AGACATTTCAAAACCATTGCAGACACATTGTTAAAATGCAGCCATTTGATAATGAAAGCAGAAACCTTAAGTTTTACCTAATTATTGCAC TAAATGTAAATGATAACATAAAATTAAGTGTGCATTTTAAACAGATTCTATTTCCCACTTACTGCTTAGCATAGAAAAAGAGCTATGGTT AGAGGAGTGACCAGCAAGATTTATTTCAGATGGAAAAGGGGTGAGAAAGTGGAAGCACCTTACTGTTAGAGCATGTTGCATCTATTTAGT GCTACTGAACAATTCAGTAGTTATTTCTGAACTTTGCTGCAAAGTGCTCTTTAGTTAAAGCACATTAAGAAGGGTCACTGCTTAATTGCT TTGTAAAATGAAGCAATGGTATTTTTTATCCGATATAGTGTAATTTAAAAGTTTTCCTACAAAGTGAGTTTATATTGTTGCCTAAACTAT GTTATGTAAGCAAAGGGTTTGGAAAGGCGGGAGGGAGTCTAGATTCGGCGAGAGTGTGCGTTTGTGTGTGTGAATGTATGAAAAGTTTCC CCATTGGGTTATTCTTAAGATGTGTTTATTGTAAAGTTTTCTACGTTTTGCCCACAGTAAATGTACAACTTCGCAATTGTAGGATTTAAT TGATTGAATTCCAAATTTATACTGTCTCTTCCCTTCTGCAGAGACATTATGCCACTGTAAGGTGCATGTACAGAAAATACCTCTGAGGTT GACTTGTTAAATAACTGATGAATGTTATTTCACACTGAATCTCAAAGCAGTCATTTGTTTTGCGGGTTAGGGGAAAGTTTTGTTTTTTGC TGGTGTTTTTTGTTGTTTTTAATTAGGCACACTAAGAGTGGCTAAATTTGGGGGAATTGGTGGATAGGAAAGACCTTGAAAAGTGATGTG TAGATGAAAACACAAGGTATGGATGTTGGTTACAGAGTTCAGTTTTAACAAGGGAAATTTGGGGATTTTTTTTTTTTTTACTTGCATGTT CTATGGGTAGCTATCAAAGGGTGTAACAAATTATTCCAGCTTTTCCCAATACTAATTATATTGGTTTTAAAAAGTCTGCATAATCACTAG GTGGCATTTTCCCTTCATTTGTGAACCAAGAGGGGTAAATGATGCTACCCATACAGTGACTTCTGAGTTCTTTAACTTTGACAGAATCTC CATTGTTTCATTGAATTTCTCATTGTATTATATGTCTTTCCAAGTGTGCAAACTATAATATGTAGTTAATGAAAAATGGAAGGCTGCAGA TTATTTTGCATGAATAATTAATTGCCCATTAGGGCTAAGGAGACTGACATGATTTTTATCGGTTCTGGGTAAATGAAAATTTTAATGGAA AACTCATTCACCATTTACTAGCTTTGTGCAATATTATAAAAGGTAGAAGCAAAACACTAGCACATTGTGCTTTGCTTGGCTTGTAAGGAT GGCTTTAGTACCATTACATTAAATGGACAGTGTGCACAGTGTATTGTAAATGCCAACTCTTGCAAATTTACAATACTTAAATATGTTCAA TTAACATCCTAAAGTATTAAAAGTACAGAGGAAAAACTAAGCAAGCATTTATAGCAATACCATGAAATCTCCAGTAATCGTTTTGACTGT TGCCTTTTGCTCTTTAGTGCAGCTTTTCTGCATTGTAATTGTATTGCTTTGTATTTCATGTTTTTTACACTCATGACTTCAGAGTTAAGT ACTTGTACACCAAGTATTGCAATCACCTTTCTCTTGTTGTACATGCAATGTAACAACCTACAGTTTTGGTGCTTTTAACAATATTCCTCT |
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FusionGenePPI for BHMT2_JMY |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BHMT2 | APP, BHMT, INPPL1, TBCE | JMY | EP300, CCDC136, VAPB, PPP1R1A, MYH9, MYO1C, VAPA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | JMY | chr5:78365638 | chr5:78573733 | ENST00000396137 | + | 0 | 11 | 478_567 | 344 | 2361 | p300/EP300 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | JMY | chr5:78365638 | chr5:78573733 | ENST00000396137 | + | 0 | 11 | 1_126 | 344 | 2361 | p300/EP300 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BHMT2_JMY |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | BHMT2 | Q9H2M3 | DB00134 | Methionine | S-methylmethionine--homocysteine S-methyltransferase BHMT2 | small molecule | approved|nutraceutical |
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RelatedDiseases for BHMT2_JMY |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BHMT2 | C0008924 | Cleft Lip | 1 | CTD_human |
| Hgene | BHMT2 | C0008925 | Cleft Palate | 1 | CTD_human |
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