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Fusion gene ID: 41450 |
FusionGeneSummary for VGLL4_UPF2 |
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Fusion gene information | Fusion gene name: VGLL4_UPF2 | Fusion gene ID: 41450 | Hgene | Tgene | Gene symbol | VGLL4 | UPF2 | Gene ID | 9686 | 26019 |
Gene name | vestigial like family member 4 | UPF2, regulator of nonsense mediated mRNA decay | |
Synonyms | VGL-4 | HUPF2|RENT2|smg-3 | |
Cytomap | 3p25.3-p25.2 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription cofactor vestigial-like protein 4Vestigial-like 4vestigial like 4 | regulator of nonsense transcripts 2FRS2/UPF2/LEMD3 fusionLEMD3/UPF2 fusionUPF2 regulator of nonsense transcripts homolognonsense mRNA reducing factor 2smg-3 homolog, nonsense mediated mRNA decay factorup-frameshift suppressor 2 homologyeast Upf2p h | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14135 | Q9HAU5 | |
Ensembl transtripts involved in fusion gene | ENST00000273038, ENST00000430365, ENST00000404339, ENST00000480288, ENST00000413604, ENST00000451674, ENST00000424529, | ENST00000356352, ENST00000357604, ENST00000397053, ENST00000460569, | |
Fusion gene scores | * DoF score | 13 X 10 X 6=780 | 5 X 7 X 3=105 |
# samples | 17 | 10 | |
** MAII score | log2(17/780*10)=-2.19793937761191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/105*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: VGLL4 [Title/Abstract] AND UPF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-XF-A8HD-01A | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000273038 | ENST00000356352 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
Frame-shift | ENST00000273038 | ENST00000357604 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
Frame-shift | ENST00000273038 | ENST00000397053 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
5CDS-intron | ENST00000273038 | ENST00000460569 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000430365 | ENST00000356352 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000430365 | ENST00000357604 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000430365 | ENST00000397053 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-intron | ENST00000430365 | ENST00000460569 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
5UTR-3CDS | ENST00000404339 | ENST00000356352 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
5UTR-3CDS | ENST00000404339 | ENST00000357604 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
5UTR-3CDS | ENST00000404339 | ENST00000397053 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
5UTR-intron | ENST00000404339 | ENST00000460569 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000480288 | ENST00000356352 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000480288 | ENST00000357604 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000480288 | ENST00000397053 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-intron | ENST00000480288 | ENST00000460569 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000413604 | ENST00000356352 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000413604 | ENST00000357604 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000413604 | ENST00000397053 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-intron | ENST00000413604 | ENST00000460569 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000451674 | ENST00000356352 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000451674 | ENST00000357604 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000451674 | ENST00000397053 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-intron | ENST00000451674 | ENST00000460569 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000424529 | ENST00000356352 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000424529 | ENST00000357604 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-3CDS | ENST00000424529 | ENST00000397053 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
intron-intron | ENST00000424529 | ENST00000460569 | VGLL4 | chr3 | 11744445 | - | UPF2 | chr10 | 12021164 | - |
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FusionProtFeatures for VGLL4_UPF2 |
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Hgene | Tgene |
VGLL4 | UPF2 |
May act as a specific coactivator for the mammalianTEFs. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VGLL4_UPF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VGLL4_UPF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
VGLL4 | TEAD1, MEF2A, ELAVL1, TERF2IP, IRF2BP2, CDK6, IRF2BP1, IRF2BPL, TEAD4, TEAD3, USP11, TRIM25 | UPF2 | RPS25, UPF3B, EIF4A1, XRN2, UPF1, UPF2, DCP2, XRN1, EXOSC10, EXOSC2, EXOSC4, PARN, UPF3A, SMG1, POLD1, ELAVL1, RNPS1, PAIP1, PRPF31, MMS22L, RBM8A, HBB, TP63, RPS15, RPL5, RPS7, PHB2, MAP1LC3B, NOB1, RPL13, SERBP1, BLM, KRT18, TUBB2A, ENO1, ATP1B3, ITGB1, MRPL40, TOP3B, CALR, E4F1, HBZ, ZBTB48, HS3ST3A1, HSF2BP, CIZ1, NOMO1, RRP7A, WNK1, ZGPAT, SUMO3, TYMS, MIF, RPS6, COMTD1, NDUFA7, LDHA, RPL8, CYBA, TK1, SERF2, CENPU, GADD45GIP1, HMGA1, AGPAT1, GLTSCR2, MTERF3, ZNF44, RSRC2, TNNI2, ABCF2, PITX1, DPF2, EXOSC8, EXOSC6, ZNF408, ZFP36, DCP1B, EXOSC1, LSM1, SKIV2L2, MYB, MAP1A, ART4, LGR4, PUF60, FUS, SMARCD1, SMARCD2, SMARCD3, TRIP10, NTRK1, XPO1, KIF15 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VGLL4_UPF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VGLL4_UPF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |