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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41427

FusionGeneSummary for VEGFC_VEGFC

check button Fusion gene summary
Fusion gene informationFusion gene name: VEGFC_VEGFC
Fusion gene ID: 41427
HgeneTgene
Gene symbol

VEGFC

VEGFC

Gene ID

7424

7424

Gene namevascular endothelial growth factor Cvascular endothelial growth factor C
SynonymsFlt4-L|LMPH1D|VRPFlt4-L|LMPH1D|VRP
Cytomap

4q34.3

4q34.3

Type of geneprotein-codingprotein-coding
Descriptionvascular endothelial growth factor CFLT4 ligand DHMvascular endothelial growth factor-related proteinvascular endothelial growth factor CFLT4 ligand DHMvascular endothelial growth factor-related protein
Modification date2018052720180527
UniProtAcc

P49767

P49767

Ensembl transtripts involved in fusion geneENST00000280193, ENST00000507638, 
ENST00000280193, ENST00000507638, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VEGFC [Title/Abstract] AND VEGFC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVEGFC

GO:0048010

vascular endothelial growth factor receptor signaling pathway

23878260

HgeneVEGFC

GO:0050930

induction of positive chemotaxis

19275959

HgeneVEGFC

GO:0060754

positive regulation of mast cell chemotaxis

19275959

TgeneVEGFC

GO:0048010

vascular endothelial growth factor receptor signaling pathway

23878260

TgeneVEGFC

GO:0050930

induction of positive chemotaxis

19275959

TgeneVEGFC

GO:0060754

positive regulation of mast cell chemotaxis

19275959


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N27674VEGFCchr4

177691026

-VEGFCchr4

177698221

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000280193ENST00000280193VEGFCchr4

177691026

-VEGFCchr4

177698221

-
intron-intronENST00000280193ENST00000507638VEGFCchr4

177691026

-VEGFCchr4

177698221

-
intron-intronENST00000507638ENST00000280193VEGFCchr4

177691026

-VEGFCchr4

177698221

-
intron-intronENST00000507638ENST00000507638VEGFCchr4

177691026

-VEGFCchr4

177698221

-

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FusionProtFeatures for VEGFC_VEGFC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VEGFC

P49767

VEGFC

P49767

Growth factor active in angiogenesis, and endothelialcell growth, stimulating their proliferation and migration andalso has effects on the permeability of blood vessels. Mayfunction in angiogenesis of the venous and lymphatic vascularsystems during embryogenesis, and also in the maintenance ofdifferentiated lymphatic endothelium in adults. Binds andactivates KDR/VEGFR2 and FLT4/VEGFR3 receptors.{ECO:0000269|PubMed:20145116}. Growth factor active in angiogenesis, and endothelialcell growth, stimulating their proliferation and migration andalso has effects on the permeability of blood vessels. Mayfunction in angiogenesis of the venous and lymphatic vascularsystems during embryogenesis, and also in the maintenance ofdifferentiated lymphatic endothelium in adults. Binds andactivates KDR/VEGFR2 and FLT4/VEGFR3 receptors.{ECO:0000269|PubMed:20145116}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VEGFC_VEGFC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VEGFC_VEGFC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VEGFC_VEGFC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VEGFC_VEGFC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVEGFCC1458155Mammary Neoplasms2CTD_human
HgeneVEGFCC0018923Hemangiosarcoma1CTD_human
HgeneVEGFCC0025202melanoma1CTD_human
TgeneVEGFCC1458155Mammary Neoplasms2CTD_human
TgeneVEGFCC0018923Hemangiosarcoma1CTD_human
TgeneVEGFCC0025202melanoma1CTD_human