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Fusion gene ID: 41427 |
FusionGeneSummary for VEGFC_VEGFC |
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Fusion gene information | Fusion gene name: VEGFC_VEGFC | Fusion gene ID: 41427 | Hgene | Tgene | Gene symbol | VEGFC | VEGFC | Gene ID | 7424 | 7424 |
Gene name | vascular endothelial growth factor C | vascular endothelial growth factor C | |
Synonyms | Flt4-L|LMPH1D|VRP | Flt4-L|LMPH1D|VRP | |
Cytomap | 4q34.3 | 4q34.3 | |
Type of gene | protein-coding | protein-coding | |
Description | vascular endothelial growth factor CFLT4 ligand DHMvascular endothelial growth factor-related protein | vascular endothelial growth factor CFLT4 ligand DHMvascular endothelial growth factor-related protein | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | P49767 | P49767 | |
Ensembl transtripts involved in fusion gene | ENST00000280193, ENST00000507638, | ENST00000280193, ENST00000507638, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: VEGFC [Title/Abstract] AND VEGFC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | VEGFC | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 23878260 |
Hgene | VEGFC | GO:0050930 | induction of positive chemotaxis | 19275959 |
Hgene | VEGFC | GO:0060754 | positive regulation of mast cell chemotaxis | 19275959 |
Tgene | VEGFC | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 23878260 |
Tgene | VEGFC | GO:0050930 | induction of positive chemotaxis | 19275959 |
Tgene | VEGFC | GO:0060754 | positive regulation of mast cell chemotaxis | 19275959 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | N27674 | VEGFC | chr4 | 177691026 | - | VEGFC | chr4 | 177698221 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000280193 | ENST00000280193 | VEGFC | chr4 | 177691026 | - | VEGFC | chr4 | 177698221 | - |
intron-intron | ENST00000280193 | ENST00000507638 | VEGFC | chr4 | 177691026 | - | VEGFC | chr4 | 177698221 | - |
intron-intron | ENST00000507638 | ENST00000280193 | VEGFC | chr4 | 177691026 | - | VEGFC | chr4 | 177698221 | - |
intron-intron | ENST00000507638 | ENST00000507638 | VEGFC | chr4 | 177691026 | - | VEGFC | chr4 | 177698221 | - |
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FusionProtFeatures for VEGFC_VEGFC |
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Hgene | Tgene |
VEGFC | VEGFC |
Growth factor active in angiogenesis, and endothelialcell growth, stimulating their proliferation and migration andalso has effects on the permeability of blood vessels. Mayfunction in angiogenesis of the venous and lymphatic vascularsystems during embryogenesis, and also in the maintenance ofdifferentiated lymphatic endothelium in adults. Binds andactivates KDR/VEGFR2 and FLT4/VEGFR3 receptors.{ECO:0000269|PubMed:20145116}. | Growth factor active in angiogenesis, and endothelialcell growth, stimulating their proliferation and migration andalso has effects on the permeability of blood vessels. Mayfunction in angiogenesis of the venous and lymphatic vascularsystems during embryogenesis, and also in the maintenance ofdifferentiated lymphatic endothelium in adults. Binds andactivates KDR/VEGFR2 and FLT4/VEGFR3 receptors.{ECO:0000269|PubMed:20145116}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VEGFC_VEGFC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VEGFC_VEGFC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VEGFC_VEGFC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VEGFC_VEGFC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | VEGFC | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | VEGFC | C0018923 | Hemangiosarcoma | 1 | CTD_human |
Hgene | VEGFC | C0025202 | melanoma | 1 | CTD_human |
Tgene | VEGFC | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Tgene | VEGFC | C0018923 | Hemangiosarcoma | 1 | CTD_human |
Tgene | VEGFC | C0025202 | melanoma | 1 | CTD_human |