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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 41397

FusionGeneSummary for VCL_FGFR2

check button Fusion gene summary
Fusion gene informationFusion gene name: VCL_FGFR2
Fusion gene ID: 41397
HgeneTgene
Gene symbol

VCL

FGFR2

Gene ID

7414

2263

Gene namevinculinfibroblast growth factor receptor 2
SynonymsCMD1W|CMH15|HEL114|MV|MVCLBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25
Cytomap

10q22.2

10q26.13

Type of geneprotein-codingprotein-coding
Descriptionvinculinepididymis luminal protein 114meta-vinculinmetavinculinfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14
Modification date2018052220180527
UniProtAcc

P18206

P21802

Ensembl transtripts involved in fusion geneENST00000211998, ENST00000372755, 
ENST00000478896, ENST00000417648, 
ENST00000369061, ENST00000357555, 
ENST00000358487, ENST00000356226, 
ENST00000369060, ENST00000369059, 
ENST00000346997, ENST00000457416, 
ENST00000351936, ENST00000360144, 
ENST00000369056, ENST00000490349, 
ENST00000359354, ENST00000478859, 
Fusion gene scores* DoF score10 X 7 X 10=7007 X 6 X 7=294
# samples 1211
** MAII scorelog2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/294*10)=-1.4183126313117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VCL [Title/Abstract] AND FGFR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

TgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

TgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

TgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-EM-A3FP-01AVCLchr10

75758133

+FGFR2chr10

123239535

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000211998ENST00000369061VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000357555VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000358487VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000356226VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000369060VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000369059VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000346997VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000457416VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000351936VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000360144VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000369056VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000490349VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000359354VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000211998ENST00000478859VCLchr10

75758133

+FGFR2chr10

123239535

-
In-frameENST00000372755ENST00000369061VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000357555VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000358487VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000356226VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000369060VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000369059VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000346997VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000457416VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000351936VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000360144VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000369056VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000490349VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000359354VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000372755ENST00000478859VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-3CDSENST00000478896ENST00000369061VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000357555VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000358487VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000356226VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000369060VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000369059VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000346997VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000457416VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000351936VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000360144VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000369056VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000490349VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000359354VCLchr10

75758133

+FGFR2chr10

123239535

-
3UTR-intronENST00000478896ENST00000478859VCLchr10

75758133

+FGFR2chr10

123239535

-
In-frameENST00000417648ENST00000369061VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000357555VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000358487VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000356226VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000369060VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000369059VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000346997VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000457416VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000351936VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000360144VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000369056VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000490349VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000359354VCLchr10

75758133

+FGFR2chr10

123239535

-
5CDS-intronENST00000417648ENST00000478859VCLchr10

75758133

+FGFR2chr10

123239535

-

Top

FusionProtFeatures for VCL_FGFR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VCL

P18206

FGFR2

P21802

Actin filament (F-actin)-binding protein involved incell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing bythe E-cadherin complex. May also play important roles in cellmorphology and locomotion. {ECO:0000269|PubMed:20484056}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-018154_247-216786DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-018256_358-216786DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-01825_125-216786DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-018481_770-216786DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-017154_247-107708DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-017256_358-107708DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-01725_125-107708DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-017481_770-107708DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-07154_247-163255DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-07256_358-163255DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-0725_125-163255DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-07481_770-163255DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-017154_247-207681DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-017256_358-207681DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-01725_125-207681DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-017481_770-207681DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-017154_247-8770DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-017256_358-8770DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-01725_125-8770DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-017481_770-8770DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-018487_495-216786Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-018565_567-216786Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-017487_495-107708Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-017565_567-107708Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-07487_495-163255Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-07565_567-163255Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-017487_495-207681Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-017565_567-207681Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-017487_495-8770Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-017565_567-8770Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-018161_178-216786RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-017161_178-107708RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-07161_178-163255RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-017161_178-207681RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-017161_178-8770RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-01822_377-216786Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-018399_821-216786Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-01722_377-107708Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-017399_821-107708Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-0722_377-163255Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-07399_821-163255Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-01722_377-207681Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-017399_821-207681Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-01722_377-8770Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-017399_821-8770Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000351936-018378_398-216786TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000357555-017378_398-107708TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000359354-07378_398-163255TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000360144-017378_398-207681TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369056-017378_398-8770TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+122837_878561135Compositional biasPro-rich
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+121837_878561067Compositional biasPro-rich
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+1221003_1046561135RegionFacilitates phospholipid membrane insertion
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+1221120_1134561135RegionFacilitates phospholipid membrane insertion
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+1221_835561135RegionN-terminal globular head
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+122259_589561135Region3 X 112 AA tandem repeats
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+122836_878561135RegionLinker (Pro-rich)
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+122879_1134561135RegionC-terminal tail
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+1211003_1046561067RegionFacilitates phospholipid membrane insertion
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+1211120_1134561067RegionFacilitates phospholipid membrane insertion
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+1211_835561067RegionN-terminal globular head
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+121259_589561067Region3 X 112 AA tandem repeats
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+121836_878561067RegionLinker (Pro-rich)
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+121879_1134561067RegionC-terminal tail
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+122259_369561135Repeat1
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+122370_479561135Repeat2
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+122480_589561135Repeat3
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+121259_369561067Repeat1
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+121370_479561067Repeat2
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+121480_589561067Repeat3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-1517154_247765820DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-1517256_358765820DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-151725_125765820DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-1517481_770765820DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-1416154_247650705DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-1416256_358650705DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-141625_125650705DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-1416481_770650705DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-1618154_247767822DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-1618256_358767822DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-161825_125767822DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-1618481_770767822DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-1416154_247651706DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-1416256_358651706DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-141625_125651706DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-1416481_770651706DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-1315154_247655710DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-1315256_358655710DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-131525_125655710DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-1315481_770655710DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-1618154_247768823DomainNote=Ig-like C2-type 2
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-1618256_358768823DomainNote=Ig-like C2-type 3
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-161825_125768823DomainNote=Ig-like C2-type 1
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-1618481_770768823DomainProtein kinase
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-1517487_495765820Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-1517565_567765820Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-1416487_495650705Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-1416565_567650705Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-1618487_495767822Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-1618565_567767822Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-1416487_495651706Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-1416565_567651706Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-1315487_495655710Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-1315565_567655710Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-1618487_495768823Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-1618565_567768823Nucleotide bindingATP
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-1517161_178765820RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-1416161_178650705RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-1618161_178767822RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-1416161_178651706RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-1315161_178655710RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-1618161_178768823RegionNote=Heparin-binding
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-151722_377765820Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-1517399_821765820Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-141622_377650705Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-1416399_821650705Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-161822_377767822Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-1618399_821767822Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-141622_377651706Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-1416399_821651706Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-131522_377655710Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-1315399_821655710Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-161822_377768823Topological domainExtracellular
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-1618399_821768823Topological domainCytoplasmic
TgeneFGFR2chr10:75758133chr10:123239535ENST00000346997-1517378_398765820TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000356226-1416378_398650705TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000358487-1618378_398767822TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369060-1416378_398651706TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000369061-1315378_398655710TransmembraneHelical
TgeneFGFR2chr10:75758133chr10:123239535ENST00000457416-1618378_398768823TransmembraneHelical


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FusionGeneSequence for VCL_FGFR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_VCL_ENST00000211998_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_111aa
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVREYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPD

>In-frame_VCL_ENST00000372755_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_111aa
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVREYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPD

>In-frame_VCL_ENST00000417648_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_111aa
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVREYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_VCL_ENST00000211998_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_333nt
ATGCCAGTGTTTCATACGCGCACGATCGAGAGCATCCTGGAGCCGGTGGCACAGCAGATCTCCCACCTGGTGATAATGCACGAGGAGGGC
GAGGTGGACGGCAAAGCCATTCCTGACCTCACCGCGCCCGTGGCCGCCGTGCAGGCGGCCGTCAGCAACCTCGTCCGGGAATACTTGGAC
CTCAGCCAACCTCTCGAACAGTATTCACCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCCAGAC

>In-frame_VCL_ENST00000372755_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_333nt
ATGCCAGTGTTTCATACGCGCACGATCGAGAGCATCCTGGAGCCGGTGGCACAGCAGATCTCCCACCTGGTGATAATGCACGAGGAGGGC
GAGGTGGACGGCAAAGCCATTCCTGACCTCACCGCGCCCGTGGCCGCCGTGCAGGCGGCCGTCAGCAACCTCGTCCGGGAATACTTGGAC
CTCAGCCAACCTCTCGAACAGTATTCACCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCCAGAC

>In-frame_VCL_ENST00000417648_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_333nt
ATGCCAGTGTTTCATACGCGCACGATCGAGAGCATCCTGGAGCCGGTGGCACAGCAGATCTCCCACCTGGTGATAATGCACGAGGAGGGC
GAGGTGGACGGCAAAGCCATTCCTGACCTCACCGCGCCCGTGGCCGCCGTGCAGGCGGCCGTCAGCAACCTCGTCCGGGAATACTTGGAC
CTCAGCCAACCTCTCGAACAGTATTCACCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCCAGAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_VCL_ENST00000211998_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_1950nt
GTAGTCGCTGCACAGTCTGTCTCTTCGCCGGTTCCCGGCCCCGTGGATCCTACTTCTCTGTCGCCCGCGGTTCGCCGCCCCGCTCGCCGC
CGCGATGCCAGTGTTTCATACGCGCACGATCGAGAGCATCCTGGAGCCGGTGGCACAGCAGATCTCCCACCTGGTGATAATGCACGAGGA
GGGCGAGGTGGACGGCAAAGCCATTCCTGACCTCACCGCGCCCGTGGCCGCCGTGCAGGCGGCCGTCAGCAACCTCGTCCGGGAATACTT
GGACCTCAGCCAACCTCTCGAACAGTATTCACCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCC
AGACCCCATGCCTTACGAACCATGCCTTCCTCAGTATCCACACATAAACGGCAGTGTTAAAACATGAATGACTGTGTCTGCCTGTCCCCA
AACAGGACAGCACTGGGAACCTAGCTACACTGAGCAGGGAGACCATGCCTCCCAGAGCTTGTTGTCTCCACTTGTATATATGGATCAGAG
GAGTAAATAATTGGAAAAGTAATCAGCATATGTGTAAAGATTTATACAGTTGAAAACTTGTAATCTTCCCCAGGAGGAGAAGAAGGTTTC
TGGAGCAGTGGACTGCCACAAGCCACCATGTAACCCCTCTCACCTGCCGTGCGTACTGGCTGTGGACCAGTAGGACTCAAGGTGGACGTG
CGTTCTGCCTTCCTTGTTAATTTTGTAATAATTGGAGAAGATTTATGTCAGCACACACTTACAGAGCACAAATGCAGTATATAGGTGCTG
GATGTATGTAAATATATTCAAATTATGTATAAATATATATTATATATTTACAAGGAGTTATTTTTTGTATTGATTTTAAATGGATGTCCC
AATGCACCTAGAAAATTGGTCTCTCTTTTTTTAATAGCTATTTGCTAAATGCTGTTCTTACACATAATTTCTTAATTTTCACCGAGCAGA
GGTGGAAAAATACTTTTGCTTTCAGGGAAAATGGTATAACGTTAATTTATTAATAAATTGGTAATATACAAAACAATTAATCATTTATAG
TTTTTTTTGTAATTTAAGTGGCATTTCTATGCAGGCAGCACAGCAGACTAGTTAATCTATTGCTTGGACTTAACTAGTTATCAGATCCTT
TGAAAAGAGAATATTTACAATATATGACTAATTTGGGGAAAATGAAGTTTTGATTTATTTGTGTTTAAATGCTGCTGTCAGACGATTGTT
CTTAGACCTCCTAAATGCCCCATATTAAAAGAACTCATTCATAGGAAGGTGTTTCATTTTGGTGTGCAACCCTGTCATTACGTCAACGCA
ACGTCTAACTGGACTTCCCAAGATAAATGGTACCAGCGTCCTCTTAAAAGATGCCTTAATCCATTCCTTGAGGACAGACCTTAGTTGAAA
TGATAGCAGAATGTGCTTCTCTCTGGCAGCTGGCCTTCTGCTTCTGAGTTGCACATTAATCAGATTAGCCTGTATTCTCTTCAGTGAATT
TTGATAATGGCTTCCAGACTCTTTGGCGTTGGAGACGCCTGTTAGGATCTTCAAGTCCCATCATAGAAAATTGAAACACAGAGTTGTTCT
GCTGATAGTTTTGGGGATACGTCCATCTTTTTAAGGGATTGCTTTCATCTAATTCTGGCAGGACCTCACCAAAAGATCCAGCCTCATACC
TACATCAGACAAAATATCGCCGTTGTTCCTTCTGTACTAAAGTATTGTGTTTTGCTTTGGAAACACCCACTCACTTTGCAATAGCCGTGC
AAGATGAATGCAGATTACACTGATCTTATGTGTTACAAAATTGGAGAAAGTATTTAATAAAACCTGTTAATTTTTATACTGACAATAAAA

>In-frame_VCL_ENST00000372755_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_1950nt
GTAGTCGCTGCACAGTCTGTCTCTTCGCCGGTTCCCGGCCCCGTGGATCCTACTTCTCTGTCGCCCGCGGTTCGCCGCCCCGCTCGCCGC
CGCGATGCCAGTGTTTCATACGCGCACGATCGAGAGCATCCTGGAGCCGGTGGCACAGCAGATCTCCCACCTGGTGATAATGCACGAGGA
GGGCGAGGTGGACGGCAAAGCCATTCCTGACCTCACCGCGCCCGTGGCCGCCGTGCAGGCGGCCGTCAGCAACCTCGTCCGGGAATACTT
GGACCTCAGCCAACCTCTCGAACAGTATTCACCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCC
AGACCCCATGCCTTACGAACCATGCCTTCCTCAGTATCCACACATAAACGGCAGTGTTAAAACATGAATGACTGTGTCTGCCTGTCCCCA
AACAGGACAGCACTGGGAACCTAGCTACACTGAGCAGGGAGACCATGCCTCCCAGAGCTTGTTGTCTCCACTTGTATATATGGATCAGAG
GAGTAAATAATTGGAAAAGTAATCAGCATATGTGTAAAGATTTATACAGTTGAAAACTTGTAATCTTCCCCAGGAGGAGAAGAAGGTTTC
TGGAGCAGTGGACTGCCACAAGCCACCATGTAACCCCTCTCACCTGCCGTGCGTACTGGCTGTGGACCAGTAGGACTCAAGGTGGACGTG
CGTTCTGCCTTCCTTGTTAATTTTGTAATAATTGGAGAAGATTTATGTCAGCACACACTTACAGAGCACAAATGCAGTATATAGGTGCTG
GATGTATGTAAATATATTCAAATTATGTATAAATATATATTATATATTTACAAGGAGTTATTTTTTGTATTGATTTTAAATGGATGTCCC
AATGCACCTAGAAAATTGGTCTCTCTTTTTTTAATAGCTATTTGCTAAATGCTGTTCTTACACATAATTTCTTAATTTTCACCGAGCAGA
GGTGGAAAAATACTTTTGCTTTCAGGGAAAATGGTATAACGTTAATTTATTAATAAATTGGTAATATACAAAACAATTAATCATTTATAG
TTTTTTTTGTAATTTAAGTGGCATTTCTATGCAGGCAGCACAGCAGACTAGTTAATCTATTGCTTGGACTTAACTAGTTATCAGATCCTT
TGAAAAGAGAATATTTACAATATATGACTAATTTGGGGAAAATGAAGTTTTGATTTATTTGTGTTTAAATGCTGCTGTCAGACGATTGTT
CTTAGACCTCCTAAATGCCCCATATTAAAAGAACTCATTCATAGGAAGGTGTTTCATTTTGGTGTGCAACCCTGTCATTACGTCAACGCA
ACGTCTAACTGGACTTCCCAAGATAAATGGTACCAGCGTCCTCTTAAAAGATGCCTTAATCCATTCCTTGAGGACAGACCTTAGTTGAAA
TGATAGCAGAATGTGCTTCTCTCTGGCAGCTGGCCTTCTGCTTCTGAGTTGCACATTAATCAGATTAGCCTGTATTCTCTTCAGTGAATT
TTGATAATGGCTTCCAGACTCTTTGGCGTTGGAGACGCCTGTTAGGATCTTCAAGTCCCATCATAGAAAATTGAAACACAGAGTTGTTCT
GCTGATAGTTTTGGGGATACGTCCATCTTTTTAAGGGATTGCTTTCATCTAATTCTGGCAGGACCTCACCAAAAGATCCAGCCTCATACC
TACATCAGACAAAATATCGCCGTTGTTCCTTCTGTACTAAAGTATTGTGTTTTGCTTTGGAAACACCCACTCACTTTGCAATAGCCGTGC
AAGATGAATGCAGATTACACTGATCTTATGTGTTACAAAATTGGAGAAAGTATTTAATAAAACCTGTTAATTTTTATACTGACAATAAAA

>In-frame_VCL_ENST00000417648_chr10_75758133_+_FGFR2_ENST00000369061_chr10_123239535_-_1948nt
AGTCGCTGCACAGTCTGTCTCTTCGCCGGTTCCCGGCCCCGTGGATCCTACTTCTCTGTCGCCCGCGGTTCGCCGCCCCGCTCGCCGCCG
CGATGCCAGTGTTTCATACGCGCACGATCGAGAGCATCCTGGAGCCGGTGGCACAGCAGATCTCCCACCTGGTGATAATGCACGAGGAGG
GCGAGGTGGACGGCAAAGCCATTCCTGACCTCACCGCGCCCGTGGCCGCCGTGCAGGCGGCCGTCAGCAACCTCGTCCGGGAATACTTGG
ACCTCAGCCAACCTCTCGAACAGTATTCACCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCCAG
ACCCCATGCCTTACGAACCATGCCTTCCTCAGTATCCACACATAAACGGCAGTGTTAAAACATGAATGACTGTGTCTGCCTGTCCCCAAA
CAGGACAGCACTGGGAACCTAGCTACACTGAGCAGGGAGACCATGCCTCCCAGAGCTTGTTGTCTCCACTTGTATATATGGATCAGAGGA
GTAAATAATTGGAAAAGTAATCAGCATATGTGTAAAGATTTATACAGTTGAAAACTTGTAATCTTCCCCAGGAGGAGAAGAAGGTTTCTG
GAGCAGTGGACTGCCACAAGCCACCATGTAACCCCTCTCACCTGCCGTGCGTACTGGCTGTGGACCAGTAGGACTCAAGGTGGACGTGCG
TTCTGCCTTCCTTGTTAATTTTGTAATAATTGGAGAAGATTTATGTCAGCACACACTTACAGAGCACAAATGCAGTATATAGGTGCTGGA
TGTATGTAAATATATTCAAATTATGTATAAATATATATTATATATTTACAAGGAGTTATTTTTTGTATTGATTTTAAATGGATGTCCCAA
TGCACCTAGAAAATTGGTCTCTCTTTTTTTAATAGCTATTTGCTAAATGCTGTTCTTACACATAATTTCTTAATTTTCACCGAGCAGAGG
TGGAAAAATACTTTTGCTTTCAGGGAAAATGGTATAACGTTAATTTATTAATAAATTGGTAATATACAAAACAATTAATCATTTATAGTT
TTTTTTGTAATTTAAGTGGCATTTCTATGCAGGCAGCACAGCAGACTAGTTAATCTATTGCTTGGACTTAACTAGTTATCAGATCCTTTG
AAAAGAGAATATTTACAATATATGACTAATTTGGGGAAAATGAAGTTTTGATTTATTTGTGTTTAAATGCTGCTGTCAGACGATTGTTCT
TAGACCTCCTAAATGCCCCATATTAAAAGAACTCATTCATAGGAAGGTGTTTCATTTTGGTGTGCAACCCTGTCATTACGTCAACGCAAC
GTCTAACTGGACTTCCCAAGATAAATGGTACCAGCGTCCTCTTAAAAGATGCCTTAATCCATTCCTTGAGGACAGACCTTAGTTGAAATG
ATAGCAGAATGTGCTTCTCTCTGGCAGCTGGCCTTCTGCTTCTGAGTTGCACATTAATCAGATTAGCCTGTATTCTCTTCAGTGAATTTT
GATAATGGCTTCCAGACTCTTTGGCGTTGGAGACGCCTGTTAGGATCTTCAAGTCCCATCATAGAAAATTGAAACACAGAGTTGTTCTGC
TGATAGTTTTGGGGATACGTCCATCTTTTTAAGGGATTGCTTTCATCTAATTCTGGCAGGACCTCACCAAAAGATCCAGCCTCATACCTA
CATCAGACAAAATATCGCCGTTGTTCCTTCTGTACTAAAGTATTGTGTTTTGCTTTGGAAACACCCACTCACTTTGCAATAGCCGTGCAA
GATGAATGCAGATTACACTGATCTTATGTGTTACAAAATTGGAGAAAGTATTTAATAAAACCTGTTAATTTTTATACTGACAATAAAAAT


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FusionGenePPI for VCL_FGFR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VCLABI2, C19orf57, TRIP6, CDH1, CTNNB1, PSME1, CORO2B, TGFB1I1, NRAP, PXN, GSN, BCAR1, VASP, SORBS1, SORBS2, CTNNA1, CLTC, DAG1, TUBA1A, SIRT7, CDK2, ITGB1, DNAJC5, TXNL1, SCAF4, URM1, ZC3HAV1L, SVIL, SSU72, SDHAF2, UBR1, VAPB, PGM5, USO1, ATP6V1A, UBA3, TPI1, UFC1, VCP, VCAM1, FN1, PRPF40A, ITGA4, ASNS, CTPS1, ECHS1, EIF5, FERMT2, GINS3, GSS, HSPA5, HSPA9, MSN, PDCD10, PDHA1, PDIA4, PPP1R2, PPP5C, RAP1GDS1, SFN, SNRPF, STK24, TUBB3, UBFD1, DCPS, ERP44, G6PD, GNAI3, ISOC1, PFAS, TBCB, XPO1, YWHAE, YWHAG, YWHAQ, YWHAZ, YWHAH, ASB7, VCL, TEKT1, UNK, PICALM, NTRK1, SELE, EWSR1, FBF1, LPXN, ACTG1, CAPZB, MYO1C, RPS27A, SPTAN1, TLN1, MKNK2, SEC16A, CDCA5, MPDZ, AP3M1, LIMA1, PPHLN1, RBM26, GKAP1, ASCC2, TRIM15, PAK4, FOCAD, TTC21B, UBE2N, HSD17B10, TRIM25, BRCA1FGFR2FGF1, FGFR2, FGF7, FGF10, PIK3R1, ITGA5, STAT3, PGR, STAT5A, STAT5B, NEDD4, FRS2, CBL, LYN, FYN, HGS, APP, PPM1A, TSPAN3, C8orf74, BEX1, BEX2, ERRFI1, GLCE, HOXC6, MTA3, PDLIM2, RASL10B, RHOBTB2, S100A14, TFF1, FGF5, FGF23, FGF8, PLCG1, FGF2, FGF3, FGF6, FGF9, FGF17, PVRL1, BRAF, MAP3K1, PTPN6, PTPN11, PTPN12, PTPRR, FGFR3, FGFR1, SNX24, GAPVD1, SNX22, UBE4A, IP6K1, RPS6KA3, IFFO2, TMEM30B, DNAJC30, XPR1, GOLGA3, KIDINS220, BCL11A, CEP295, CD44, RPS6KA2, LRRIQ1, RPS6KA1, LITAF, MRAP2, SDC2, FCGRT, SIGLECL1, RAET1E, FAM171B, CHERP, U2SURP, SLC9A6, TIMP1, CCDC120, CD83, PKP4, UBXN4, CTDSP1, CTDSPL, DUSP14, MTMR3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneVCLchr10:75758133chr10:123239535ENST00000211998+122741_764561135ACTN4
HgeneVCLchr10:75758133chr10:123239535ENST00000372755+121741_764561067ACTN4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VCL_FGFR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGFR2P21802DB00039PaliferminFibroblast growth factor receptor 2biotechapproved
TgeneFGFR2P21802DB08896RegorafenibFibroblast growth factor receptor 2small moleculeapproved
TgeneFGFR2P21802DB09079NintedanibFibroblast growth factor receptor 2small moleculeapproved
TgeneFGFR2P21802DB01109HeparinFibroblast growth factor receptor 2small moleculeapproved|investigational
TgeneFGFR2P21802DB08901PonatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
TgeneFGFR2P21802DB09078LenvatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
TgeneFGFR2P21802DB01041ThalidomideFibroblast growth factor receptor 2small moleculeapproved|investigational|withdrawn

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RelatedDiseases for VCL_FGFR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVCLC1969639Cardiomyopathy, Dilated, 1w2CTD_human;UNIPROT
HgeneVCLC0029456Osteoporosis1CTD_human
HgeneVCLC0948089Acute Coronary Syndrome1CTD_human
HgeneVCLC2750459CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 151CTD_human;UNIPROT
TgeneFGFR2C2931196Craniofacial dysostosis type 121ORPHANET;UNIPROT
TgeneFGFR2C0220658Pfeiffer Syndrome10UNIPROT
TgeneFGFR2C0001193Apert syndrome8ORPHANET;UNIPROT
TgeneFGFR2C1510455Acrocephalosyndactylia4CTD_human
TgeneFGFR2C0010278Craniosynostosis3CTD_human;HPO
TgeneFGFR2C0036341Schizophrenia3PSYGENET
TgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
TgeneFGFR2C1458155Mammary Neoplasms3CTD_human
TgeneFGFR2C0011570Mental Depression2PSYGENET
TgeneFGFR2C0011581Depressive disorder2PSYGENET
TgeneFGFR2C0038356Stomach Neoplasms2CTD_human
TgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION2CTD_human;ORPHANET;UNIPROT
TgeneFGFR2C0003090Ankylosis1CTD_human
TgeneFGFR2C0005586Bipolar Disorder1PSYGENET
TgeneFGFR2C0008924Cleft Lip1CTD_human
TgeneFGFR2C0008925Cleft Palate1CTD_human;HPO
TgeneFGFR2C0010273Craniofacial Dysostosis1CTD_human;HPO
TgeneFGFR2C0014170Endometrial Neoplasms1CTD_human
TgeneFGFR2C0018553Hamartoma Syndrome, Multiple1CTD_human
TgeneFGFR2C0023890Liver Cirrhosis1CTD_human
TgeneFGFR2C0024121Lung Neoplasms1CTD_human
TgeneFGFR2C0026613Motor Skills Disorders1CTD_human
TgeneFGFR2C0033975Psychotic Disorders1PSYGENET
TgeneFGFR2C0037268Skin Abnormalities1CTD_human
TgeneFGFR2C0037274Dermatologic disorders1CTD_human
TgeneFGFR2C0040427Tooth Abnormalities1CTD_human
TgeneFGFR2C0080178Spina Bifida1CTD_human
TgeneFGFR2C0206698Cholangiocarcinoma1CTD_human
TgeneFGFR2C0206762Limb Deformities, Congenital1CTD_human
TgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome1CTD_human;ORPHANET;UNIPROT
TgeneFGFR2C0349204Nonorganic psychosis1PSYGENET
TgeneFGFR2C1450010Plagiocephaly, Nonsynostotic1CTD_human;HPO
TgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson1CTD_human;ORPHANET;UNIPROT
TgeneFGFR2C2350233Antley-Bixler Syndrome Phenotype1CTD_human
TgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME1ORPHANET;UNIPROT
TgeneFGFR2C3714756Intellectual Disability1CTD_human;HPO