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Fusion gene ID: 41382 |
FusionGeneSummary for VAV3_RAB9B |
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Fusion gene information | Fusion gene name: VAV3_RAB9B | Fusion gene ID: 41382 | Hgene | Tgene | Gene symbol | VAV3 | RAB9B | Gene ID | 10451 | 51209 |
Gene name | vav guanine nucleotide exchange factor 3 | RAB9B, member RAS oncogene family | |
Synonyms | - | RAB9L|Rab-9L | |
Cytomap | 1p13.3 | Xq22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide exchange factor VAV3VAV-3vav 3 guanine nucleotide exchange factorvav 3 oncogene | ras-related protein Rab-9BRas-associated protein 9BRas-associated protein RAB9-like | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9UKW4 | Q9NP90 | |
Ensembl transtripts involved in fusion gene | ENST00000370056, ENST00000527011, ENST00000544443, ENST00000415432, ENST00000343258, ENST00000371846, | ENST00000243298, | |
Fusion gene scores | * DoF score | 5 X 6 X 2=60 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/60*10)=0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: VAV3 [Title/Abstract] AND RAB9B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-EW-A1PC-01B | VAV3 | chr1 | 108226110 | - | RAB9B | chrX | 103082008 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000370056 | ENST00000243298 | VAV3 | chr1 | 108226110 | - | RAB9B | chrX | 103082008 | - |
5CDS-5UTR | ENST00000527011 | ENST00000243298 | VAV3 | chr1 | 108226110 | - | RAB9B | chrX | 103082008 | - |
intron-5UTR | ENST00000544443 | ENST00000243298 | VAV3 | chr1 | 108226110 | - | RAB9B | chrX | 103082008 | - |
5CDS-5UTR | ENST00000415432 | ENST00000243298 | VAV3 | chr1 | 108226110 | - | RAB9B | chrX | 103082008 | - |
5UTR-5UTR | ENST00000343258 | ENST00000243298 | VAV3 | chr1 | 108226110 | - | RAB9B | chrX | 103082008 | - |
5CDS-5UTR | ENST00000371846 | ENST00000243298 | VAV3 | chr1 | 108226110 | - | RAB9B | chrX | 103082008 | - |
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FusionProtFeatures for VAV3_RAB9B |
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Hgene | Tgene |
VAV3 | RAB9B |
Involved in the transport of proteins between theendosomes and the trans Golgi network.{ECO:0000250|UniProtKB:P24408}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VAV3_RAB9B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VAV3_RAB9B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
VAV3 | GRB2, PDGFRB, EGFR, RAC1, RHOA, RHOG, ROS1, INSR, IGF1R, SHC1, BLNK, ESR1, ERBB2, ERBB3, TRAF6, TNFRSF11A, TRAF1, TRAF3 | RAB9B | CHML, CHM, ASPRV1, RABGGTA, CPA4, SERPINB5, HAL, RABGGTB, PHACTR4, TMEM206, POF1B |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VAV3_RAB9B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VAV3_RAB9B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | VAV3 | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
Hgene | VAV3 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | VAV3 | C0020578 | Hyperventilation | 1 | CTD_human |
Hgene | VAV3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | VAV3 | C0039231 | Tachycardia | 1 | CTD_human |