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Fusion gene ID: 41372 |
FusionGeneSummary for VAV2_CLNK |
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Fusion gene information | Fusion gene name: VAV2_CLNK | Fusion gene ID: 41372 | Hgene | Tgene | Gene symbol | VAV2 | CLNK | Gene ID | 7410 | 116449 |
Gene name | vav guanine nucleotide exchange factor 2 | cytokine dependent hematopoietic cell linker | |
Synonyms | VAV-2 | MIST | |
Cytomap | 9q34.2 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | guanine nucleotide exchange factor VAV2vav 2 guanine nucleotide exchange factorvav 2 oncogene | cytokine-dependent hematopoietic cell linkermast cell immunoreceptor signal transducer | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P52735 | Q7Z7G1 | |
Ensembl transtripts involved in fusion gene | ENST00000406606, ENST00000371850, ENST00000371851, ENST00000486113, | ENST00000226951, ENST00000442825, ENST00000507719, ENST00000515667, | |
Fusion gene scores | * DoF score | 11 X 9 X 9=891 | 3 X 3 X 2=18 |
# samples | 14 | 3 | |
** MAII score | log2(14/891*10)=-2.66999860457696 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: VAV2 [Title/Abstract] AND CLNK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CLNK | GO:0035556 | intracellular signal transduction | 10744659 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-D9-A1X3-06A | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000406606 | ENST00000226951 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-5UTR | ENST00000406606 | ENST00000442825 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-5UTR | ENST00000406606 | ENST00000507719 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-intron | ENST00000406606 | ENST00000515667 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
Frame-shift | ENST00000371850 | ENST00000226951 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-5UTR | ENST00000371850 | ENST00000442825 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-5UTR | ENST00000371850 | ENST00000507719 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-intron | ENST00000371850 | ENST00000515667 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
Frame-shift | ENST00000371851 | ENST00000226951 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-5UTR | ENST00000371851 | ENST00000442825 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-5UTR | ENST00000371851 | ENST00000507719 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5CDS-intron | ENST00000371851 | ENST00000515667 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5UTR-3CDS | ENST00000486113 | ENST00000226951 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5UTR-5UTR | ENST00000486113 | ENST00000442825 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5UTR-5UTR | ENST00000486113 | ENST00000507719 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
5UTR-intron | ENST00000486113 | ENST00000515667 | VAV2 | chr9 | 136857197 | - | CLNK | chr4 | 10599673 | - |
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FusionProtFeatures for VAV2_CLNK |
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Hgene | Tgene |
VAV2 | CLNK |
Plays a role in the regulation of immunoreceptorsignaling, including PLC-gamma-mediated B-cell antigen receptor(BCR) signaling and FC-epsilon R1-mediated mast celldegranulation. Involved in phosphorylation of LAT (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VAV2_CLNK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VAV2_CLNK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
VAV2 | GRB2, SOCS1, PDGFRB, EGFR, CD44, CD19, CBL, CCNO, BRDT, EIF4G3, RBBP6, ST13, TOM1L1, VCPIP1, PNMA1, BOD1L1, SRRT, FNTA, TCP11, MARCH7, HSPH1, BZW1, SERBP1, USP38, UBE4B, GAPVD1, POGZ, MRGBP, TARBP2, SF3A3, SNW1, IPO4, FUCA1, CHMP3, NCKAP5, CEP170, MED21, RAD23A, HNRNPF, DNAJC21, TTN, CCT3, DCUN1D4, STK24, PHF10, PPM1B, ARIH1, BIRC6, SRPK2, CCT2, CRCP, ELAVL1, SYK, FYN, SMAD3, CBLB, THOP1, ERBB2, ERBB3, CAV1, NTRK1, TPD52L2, PRKAR2B, RTEL1, TRIM25 | CLNK | EGFR, ERBB2, FAM217A, GLIS3, ARAP3, COQ9, CYB561D2, NME4, PIK3R1, PIK3R3, PPP1R7, PTK7, RPAIN, SFMBT1, SOCS6, ANKRD50, BMX, CRK, GRB2, GSTCD, P4HA2, PACSIN3, RASSF1, RB1, SMARCD1, STK36, TXK, WWOX |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VAV2_CLNK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VAV2_CLNK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CLNK | C0042900 | Vitiligo | 1 | CTD_human |