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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41372

FusionGeneSummary for VAV2_CLNK

check button Fusion gene summary
Fusion gene informationFusion gene name: VAV2_CLNK
Fusion gene ID: 41372
HgeneTgene
Gene symbol

VAV2

CLNK

Gene ID

7410

116449

Gene namevav guanine nucleotide exchange factor 2cytokine dependent hematopoietic cell linker
SynonymsVAV-2MIST
Cytomap

9q34.2

4p16.1

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide exchange factor VAV2vav 2 guanine nucleotide exchange factorvav 2 oncogenecytokine-dependent hematopoietic cell linkermast cell immunoreceptor signal transducer
Modification date2018051920180523
UniProtAcc

P52735

Q7Z7G1

Ensembl transtripts involved in fusion geneENST00000406606, ENST00000371850, 
ENST00000371851, ENST00000486113, 
ENST00000226951, ENST00000442825, 
ENST00000507719, ENST00000515667, 
Fusion gene scores* DoF score11 X 9 X 9=8913 X 3 X 2=18
# samples 143
** MAII scorelog2(14/891*10)=-2.66999860457696
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VAV2 [Title/Abstract] AND CLNK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLNK

GO:0035556

intracellular signal transduction

10744659


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D9-A1X3-06AVAV2chr9

136857197

-CLNKchr4

10599673

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000406606ENST00000226951VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-5UTRENST00000406606ENST00000442825VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-5UTRENST00000406606ENST00000507719VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-intronENST00000406606ENST00000515667VAV2chr9

136857197

-CLNKchr4

10599673

-
Frame-shiftENST00000371850ENST00000226951VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-5UTRENST00000371850ENST00000442825VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-5UTRENST00000371850ENST00000507719VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-intronENST00000371850ENST00000515667VAV2chr9

136857197

-CLNKchr4

10599673

-
Frame-shiftENST00000371851ENST00000226951VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-5UTRENST00000371851ENST00000442825VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-5UTRENST00000371851ENST00000507719VAV2chr9

136857197

-CLNKchr4

10599673

-
5CDS-intronENST00000371851ENST00000515667VAV2chr9

136857197

-CLNKchr4

10599673

-
5UTR-3CDSENST00000486113ENST00000226951VAV2chr9

136857197

-CLNKchr4

10599673

-
5UTR-5UTRENST00000486113ENST00000442825VAV2chr9

136857197

-CLNKchr4

10599673

-
5UTR-5UTRENST00000486113ENST00000507719VAV2chr9

136857197

-CLNKchr4

10599673

-
5UTR-intronENST00000486113ENST00000515667VAV2chr9

136857197

-CLNKchr4

10599673

-

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FusionProtFeatures for VAV2_CLNK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VAV2

P52735

CLNK

Q7Z7G1

Plays a role in the regulation of immunoreceptorsignaling, including PLC-gamma-mediated B-cell antigen receptor(BCR) signaling and FC-epsilon R1-mediated mast celldegranulation. Involved in phosphorylation of LAT (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for VAV2_CLNK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for VAV2_CLNK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VAV2GRB2, SOCS1, PDGFRB, EGFR, CD44, CD19, CBL, CCNO, BRDT, EIF4G3, RBBP6, ST13, TOM1L1, VCPIP1, PNMA1, BOD1L1, SRRT, FNTA, TCP11, MARCH7, HSPH1, BZW1, SERBP1, USP38, UBE4B, GAPVD1, POGZ, MRGBP, TARBP2, SF3A3, SNW1, IPO4, FUCA1, CHMP3, NCKAP5, CEP170, MED21, RAD23A, HNRNPF, DNAJC21, TTN, CCT3, DCUN1D4, STK24, PHF10, PPM1B, ARIH1, BIRC6, SRPK2, CCT2, CRCP, ELAVL1, SYK, FYN, SMAD3, CBLB, THOP1, ERBB2, ERBB3, CAV1, NTRK1, TPD52L2, PRKAR2B, RTEL1, TRIM25CLNKEGFR, ERBB2, FAM217A, GLIS3, ARAP3, COQ9, CYB561D2, NME4, PIK3R1, PIK3R3, PPP1R7, PTK7, RPAIN, SFMBT1, SOCS6, ANKRD50, BMX, CRK, GRB2, GSTCD, P4HA2, PACSIN3, RASSF1, RB1, SMARCD1, STK36, TXK, WWOX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VAV2_CLNK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VAV2_CLNK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLNKC0042900Vitiligo1CTD_human