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Fusion gene ID: 41366 |
FusionGeneSummary for VAT1_HNRNPA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: VAT1_HNRNPA1 | Fusion gene ID: 41366 | Hgene | Tgene | Gene symbol | VAT1 | HNRNPA1 | Gene ID | 10493 | 3178 |
| Gene name | vesicle amine transport 1 | heterogeneous nuclear ribonucleoprotein A1 | |
| Synonyms | VATI | ALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|UP 1|hnRNP A1|hnRNP-A1 | |
| Cytomap | 17q21.31 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | synaptic vesicle membrane protein VAT-1 homologmembrane protein of cholinergic synaptic vesiclesvesicle amine transport protein 1 homolog (T. californica) | heterogeneous nuclear ribonucleoprotein A1helix-destabilizing proteinheterogeneous nuclear ribonucleoprotein A1B proteinheterogeneous nuclear ribonucleoprotein B2 proteinheterogeneous nuclear ribonucleoprotein core protein A1hnRNP core protein A1-lik | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q99536 | P09651 | |
| Ensembl transtripts involved in fusion gene | ENST00000355653, ENST00000587173, ENST00000420567, | ENST00000546500, ENST00000340913, ENST00000330752, ENST00000547276, ENST00000551803, | |
| Fusion gene scores | * DoF score | 8 X 6 X 2=96 | 5 X 5 X 4=100 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/96*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: VAT1 [Title/Abstract] AND HNRNPA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HNRNPA1 | GO:0032212 | positive regulation of telomere maintenance via telomerase | 23935072 |
| Tgene | HNRNPA1 | GO:0051168 | nuclear export | 8521471 |
| Tgene | HNRNPA1 | GO:0051170 | import into nucleus | 8521471 |
| Tgene | HNRNPA1 | GO:1903936 | cellular response to sodium arsenite | 27694260 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI339411 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000355653 | ENST00000546500 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000355653 | ENST00000340913 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000355653 | ENST00000330752 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000355653 | ENST00000547276 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000355653 | ENST00000551803 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000587173 | ENST00000546500 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000587173 | ENST00000340913 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000587173 | ENST00000330752 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000587173 | ENST00000547276 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000587173 | ENST00000551803 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000420567 | ENST00000546500 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000420567 | ENST00000340913 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000420567 | ENST00000330752 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000420567 | ENST00000547276 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
| intron-intron | ENST00000420567 | ENST00000551803 | VAT1 | chr17 | 41166905 | + | HNRNPA1 | chr12 | 54676659 | - |
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FusionProtFeatures for VAT1_HNRNPA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| VAT1 | HNRNPA1 |
| Possesses ATPase activity (By similarity). Plays a partin calcium-regulated keratinocyte activation in epidermal repairmechanisms. Has no effect on cell proliferation. Negativelyregulates mitochondrial fusion in cooperation with mitofusinproteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150,ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. | Involved in the packaging of pre-mRNA into hnRNPparticles, transport of poly(A) mRNA from the nucleus to thecytoplasm and may modulate splice site selection(PubMed:17371836). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000269|PubMed:17371836,ECO:0000269|PubMed:28431233}. (Microbial infection) May play a role in HCV RNAreplication. {ECO:0000269|PubMed:17229681}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VAT1_HNRNPA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VAT1_HNRNPA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VAT1_HNRNPA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VAT1_HNRNPA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HNRNPA1 | C3715156 | AMYOTROPHIC LATERAL SCLEROSIS 20 | 2 | UNIPROT |
| Tgene | HNRNPA1 | C3809469 | INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 3 | 2 | UNIPROT |
| Tgene | HNRNPA1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | HNRNPA1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
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