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Fusion gene ID: 41345 |
FusionGeneSummary for VAPB_DMD |
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Fusion gene information | Fusion gene name: VAPB_DMD | Fusion gene ID: 41345 | Hgene | Tgene | Gene symbol | VAPB | DMD | Gene ID | 9217 | 1756 |
Gene name | VAMP associated protein B and C | dystrophin | |
Synonyms | ALS8|VAMP-B|VAP-B | BMD|CMD3B|DXS142|DXS164|DXS206|DXS230|DXS239|DXS268|DXS269|DXS270|DXS272|MRX85 | |
Cytomap | 20q13.32 | Xp21.2-p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | vesicle-associated membrane protein-associated protein B/CVAMP (vesicle-associated membrane protein)-associated protein B and CVAMP-associated 33 kDa protein | dystrophin | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | O95292 | P11532 | |
Ensembl transtripts involved in fusion gene | ENST00000475243, ENST00000395802, ENST00000265619, | ENST00000378707, ENST00000359836, ENST00000541735, ENST00000343523, ENST00000378677, ENST00000357033, ENST00000474231, ENST00000378723, ENST00000378702, ENST00000361471, ENST00000378680, ENST00000288447, ENST00000445312, | |
Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 16 X 18 X 7=2016 |
# samples | 7 | 18 | |
** MAII score | log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/2016*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: VAPB [Title/Abstract] AND DMD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | VAPB | GO:0019048 | modulation by virus of host morphology or physiology | 16227268 |
Tgene | DMD | GO:0043043 | peptide biosynthetic process | 16000376 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW993740 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000475243 | ENST00000378707 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000359836 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000541735 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000343523 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000378677 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000357033 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000474231 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000378723 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000378702 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000361471 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000378680 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000288447 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000475243 | ENST00000445312 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000378707 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000359836 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000541735 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000343523 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000378677 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000357033 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000474231 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000378723 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000378702 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000361471 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000378680 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000288447 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000395802 | ENST00000445312 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000378707 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000359836 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000541735 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000343523 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000378677 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000357033 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000474231 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000378723 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000378702 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000361471 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000378680 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000288447 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
intron-intron | ENST00000265619 | ENST00000445312 | VAPB | chr20 | 56979533 | + | DMD | chrX | 31213863 | - |
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FusionProtFeatures for VAPB_DMD |
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Hgene | Tgene |
VAPB | DMD |
Participates in the endoplasmic reticulum unfoldedprotein response (UPR) by inducing ERN1/IRE1 activity. Involved incellular calcium homeostasis regulation.{ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299,ECO:0000269|PubMed:22131369}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for VAPB_DMD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for VAPB_DMD |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for VAPB_DMD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VAPB_DMD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | VAPB | C1837728 | AMYOTROPHIC LATERAL SCLEROSIS 8 (disorder) | 4 | CTD_human;UNIPROT |
Tgene | DMD | C0013264 | Muscular Dystrophy, Duchenne | 16 | CTD_human;ORPHANET;UNIPROT |
Tgene | DMD | C0026850 | Muscular Dystrophy | 4 | CTD_human;HPO |
Tgene | DMD | C3668940 | Dmd-Associated Dilated Cardiomyopathy | 4 | CTD_human;UNIPROT |
Tgene | DMD | C0878544 | Cardiomyopathies | 3 | CTD_human;HPO |
Tgene | DMD | C0006663 | Calcinosis | 1 | CTD_human |
Tgene | DMD | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human;HPO |
Tgene | DMD | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | DMD | C0023269 | leiomyosarcoma | 1 | CTD_human |
Tgene | DMD | C0026851 | Muscular Dystrophy, Animal | 1 | CTD_human |
Tgene | DMD | C0027540 | Necrosis | 1 | CTD_human |
Tgene | DMD | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | DMD | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | DMD | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | DMD | C0038220 | Status Epilepticus | 1 | CTD_human |
Tgene | DMD | C0151786 | Muscle Weakness | 1 | CTD_human;HPO |
Tgene | DMD | C0206656 | Rhabdomyosarcoma, Embryonal | 1 | CTD_human |
Tgene | DMD | C0238198 | Gastrointestinal Stromal Tumors | 1 | CTD_human |
Tgene | DMD | C0242973 | Ventricular Dysfunction | 1 | CTD_human |
Tgene | DMD | C0917713 | Becker Muscular Dystrophy | 1 | ORPHANET;UNIPROT |