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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 41322

FusionGeneSummary for VAC14_WWOX

check button Fusion gene summary
Fusion gene informationFusion gene name: VAC14_WWOX
Fusion gene ID: 41322
HgeneTgene
Gene symbol

VAC14

WWOX

Gene ID

55697

51741

Gene nameVac14, PIKFYVE complex componentWW domain containing oxidoreductase
SynonymsArPIKfyve|TAX1BP2|TRXD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap

16q22.1-q22.2

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionprotein VAC14 homologTax1 (human T-cell leukemia virus type I) binding proteinWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2018052320180523
UniProtAcc

Q08AM6

Q9NZC7

Ensembl transtripts involved in fusion geneENST00000261776, ENST00000571759, 
ENST00000536184, 		ENST00000566780, 
ENST00000406884, ENST00000539474, 
ENST00000402655, ENST00000408984, 
ENST00000355860, ENST00000565791, 
ENST00000569818, 
Fusion gene scores* DoF score5 X 4 X 4=8014 X 7 X 7=686
# samples 516
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/686*10)=-2.10013667128545
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VAC14 [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-BT-A20V-01AVAC14chr16

70765398

-WWOXchr16

79245505

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261776ENST00000566780VAC14chr16

70765398

-WWOXchr16

79245505

+
In-frameENST00000261776ENST00000406884VAC14chr16

70765398

-WWOXchr16

79245505

+
Frame-shiftENST00000261776ENST00000539474VAC14chr16

70765398

-WWOXchr16

79245505

+
Frame-shiftENST00000261776ENST00000402655VAC14chr16

70765398

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000408984VAC14chr16

70765398

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000355860VAC14chr16

70765398

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000565791VAC14chr16

70765398

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000569818VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000566780VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000406884VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000539474VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000402655VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000408984VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000355860VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000565791VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000569818VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000536184ENST00000566780VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000536184ENST00000406884VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000536184ENST00000539474VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000536184ENST00000402655VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000536184ENST00000408984VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000536184ENST00000355860VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000536184ENST00000565791VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000536184ENST00000569818VAC14chr16

70765398

-WWOXchr16

79245505

+

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FusionProtFeatures for VAC14_WWOX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
VAC14

Q08AM6

WWOX

Q9NZC7

The PI(3,5)P2 regulatory complex regulates both thesynthesis and turnover of phosphatidylinositol 3,5-bisphosphate(PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinaseactivity. Also required to maintain normal levels ofphosphatidylinositol 3-phosphate (PtdIns(3)P) andphosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in thebiogenesis of endosome carrier vesicles (ECV) / multivesicularbodies (MVB) transport intermediates from early endosomes.{ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-1419171_208553783RepeatNote=HEAT 3
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-1419212_249553783RepeatNote=HEAT 4
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-1419438_475553783RepeatNote=HEAT 5
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-14195_42553783RepeatNote=HEAT 1
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-141989_126553783RepeatNote=HEAT 2
TgeneWWOXchr16:70765398chr16:79245505ENST00000355860+0616_49-34190DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST00000355860+0657_90-34190DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984+01016_49-29311DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984+01057_90-29311DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST00000569818+0116_49-3537DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST00000569818+0157_90-3537DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST00000355860+0650_55-34190MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984+01050_55-29311MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST00000569818+0150_55-3537MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST00000355860+06131_137-34190Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984+010131_137-29311Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST00000569818+01131_137-3537Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST00000355860+06209_273-34190RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST00000402655+35209_273136312RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST00000406884+46209_273172235RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984+010209_273-29311RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST00000569818+01209_273-3537RegionMediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-1419560_598553783RepeatNote=HEAT 6
TgeneWWOXchr16:70765398chr16:79245505ENST00000402655+3516_49136312DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST00000402655+3557_90136312DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST00000406884+4616_49172235DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST00000406884+4657_90172235DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST00000566780+7916_49352415DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST00000566780+7957_90352415DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST00000402655+3550_55136312MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST00000406884+4650_55172235MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST00000566780+7950_55352415MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST00000402655+35131_137136312Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST00000406884+46131_137172235Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST00000566780+79131_137352415Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST00000566780+79209_273352415RegionMediates targeting to the mitochondria


Top

FusionGeneSequence for VAC14_WWOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_VAC14_ENST00000261776_chr16_70765398_-_WWOX_ENST00000566780_chr16_79245505_+_616aa
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLY
LKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTT
DDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQ
EGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQT
LSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSS

>In-frame_VAC14_ENST00000261776_chr16_70765398_-_WWOX_ENST00000406884_chr16_79245505_+_616aa
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLY
LKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTT
DDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQ
EGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQT
LSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_VAC14_ENST00000261776_chr16_70765398_-_WWOX_ENST00000566780_chr16_79245505_+_1850nt
ATGAACCCCGAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCG
CTGGAGATCGAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTT
GCCCTGTCTCAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTAC
CTGAAGGAGCTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATC
GTCAAGGTGGCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTG
AAAAGCGGATCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTG
CGAGAGAGGATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTG
CTGGATTACCTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTT
GGAGAATTCTTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACA
GATGACCTCATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATC
CTGACTGCTGTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAG
CTGGTCACCCCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAG
GAGGGCACAGCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGA
GCCCCAGTGACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCA
GTTCTCAAGTGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACG
TTATCGGATGAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCA
GGCCCCCTCGATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGT
ACCAAAGGCTTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGC
GAACGGAAGCTCCTGGAGGTCAGAGGCCCTTTCATCATCAGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGG
AGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGG

>In-frame_VAC14_ENST00000261776_chr16_70765398_-_WWOX_ENST00000406884_chr16_79245505_+_1850nt
ATGAACCCCGAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCG
CTGGAGATCGAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTT
GCCCTGTCTCAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTAC
CTGAAGGAGCTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATC
GTCAAGGTGGCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTG
AAAAGCGGATCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTG
CGAGAGAGGATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTG
CTGGATTACCTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTT
GGAGAATTCTTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACA
GATGACCTCATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATC
CTGACTGCTGTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAG
CTGGTCACCCCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAG
GAGGGCACAGCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGA
GCCCCAGTGACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCA
GTTCTCAAGTGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACG
TTATCGGATGAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCA
GGCCCCCTCGATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGT
ACCAAAGGCTTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGC
GAACGGAAGCTCCTGGAGGTCAGAGGCCCTTTCATCATCAGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGG
AGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_VAC14_ENST00000261776_chr16_70765398_-_WWOX_ENST00000566780_chr16_79245505_+_2982nt
TGTGACTCGAGTAACATGGCCGCTGTCTCGTGAGTCCCGCTAGTGCCGGGCGGGAGTTGTTAAGCGGCCAGGGTCAGGTGTGCTGGAGCG
GGGTCCGGGCCCGGGTTCCAGGGCGAGGCGGCGGAGCGTGGCAGGCAAGCCTAGAGCGGCGTGGTCCATGCGCCGGCGCCGGGGGCAGAG
CGGAGCCGCAGACTCCCCTGGCCCCGGCGCGGCCCCGGCAGCCGCGGGCTAAGGAGTCGCGAGGTTCCCCCAGCTGCCACCATGAACCCC
GAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCGCTGGAGATC
GAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTTGCCCTGTCT
CAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTACCTGAAGGAG
CTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATCGTCAAGGTG
GCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTGAAAAGCGGA
TCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTGCGAGAGAGG
ATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTGCTGGATTAC
CTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTTGGAGAATTC
TTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACAGATGACCTC
ATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATCCTGACTGCT
GTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAGCTGGTCACC
CCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAGGAGGGCACA
GCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGAGCCCCAGTG
ACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCAGTTCTCAAG
TGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACGTTATCGGAT
GAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCAGGCCCCCTC
GATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGTACCAAAGGC
TTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGCGAACGGAAG
CTCCTGGAGGTCAGAGGCCCTTTCATCATCAGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGG
GAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCG
AGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCC
TCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGT
GAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTT
TCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTA
CTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGG
GAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGC
AACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAG
GTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGA
TACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTT
GTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACAT

>In-frame_VAC14_ENST00000261776_chr16_70765398_-_WWOX_ENST00000406884_chr16_79245505_+_2982nt
TGTGACTCGAGTAACATGGCCGCTGTCTCGTGAGTCCCGCTAGTGCCGGGCGGGAGTTGTTAAGCGGCCAGGGTCAGGTGTGCTGGAGCG
GGGTCCGGGCCCGGGTTCCAGGGCGAGGCGGCGGAGCGTGGCAGGCAAGCCTAGAGCGGCGTGGTCCATGCGCCGGCGCCGGGGGCAGAG
CGGAGCCGCAGACTCCCCTGGCCCCGGCGCGGCCCCGGCAGCCGCGGGCTAAGGAGTCGCGAGGTTCCCCCAGCTGCCACCATGAACCCC
GAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCGCTGGAGATC
GAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTTGCCCTGTCT
CAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTACCTGAAGGAG
CTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATCGTCAAGGTG
GCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTGAAAAGCGGA
TCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTGCGAGAGAGG
ATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTGCTGGATTAC
CTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTTGGAGAATTC
TTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACAGATGACCTC
ATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATCCTGACTGCT
GTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAGCTGGTCACC
CCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAGGAGGGCACA
GCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGAGCCCCAGTG
ACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCAGTTCTCAAG
TGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACGTTATCGGAT
GAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCAGGCCCCCTC
GATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGTACCAAAGGC
TTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGCGAACGGAAG
CTCCTGGAGGTCAGAGGCCCTTTCATCATCAGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGG
GAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCG
AGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCC
TCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGT
GAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTT
TCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTA
CTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGG
GAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGC
AACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAG
GTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGA
TACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTT
GTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACAT


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FusionGenePPI for VAC14_WWOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
VAC14EIF4A2, FIG4, PIKFYVE, VAC14, NEURL4, APP, LSM4, PHKA1, PPIP5K2, PPIP5K1, EGFR, MVP, MPPED2, CASP1, CCBL1, COL8A1, PHF1, PPP2CA, TP53BP1, BHLHE40, SIGLEC5, PDE4DIP, SNF8, RBFOX2, DDAH2, SMUG1, C11orf54, CD209, PRR13, WDYHV1, PCMTD2, PELI1, SPRYD7, NGB, FNDC3B, MTMR9, ASB13, LPAL2, ZNF34, PRADC1, RHOXF2, ACSS1, PHYKPL, PRR20A, C4orf33, MGAT5B, TCEANC, LINC00518, CDRT4, KRTAP19-5, KRTAP19-7, CCDC103, JMJD7, BSG, CD274, PARP16, GNAI2, MICA, ARL13B, PFAS, NTRK1, CRK, SRPK2, XPO1, ERGIC2, ME1, KIAA1715, ZMPSTE24, CLCN7, ANK1, MAVS, RAB21, SLC26A6, MTCH2, ERGIC3, PRAF2, MPZL1, QKI, ATP2B2, ATP2B4, SLMAP, DHODH, VAMP3WWOXTP53, CPSF6, TNK2, ERBB4, MDM2, TP63, MAPK8, LMNA, POLR2A, POLR2B, SMARCC1, TCERG1, CPSF1, CPSF2, CPSF3, NUDT21, FIP1L1, CPSF7, HNRNPK, RPRD2, PABPC1, SF3A1, SF3B1, SF3B3, SFPQ, SYMPK, WIPF2, WDR33, WBP2, SF3B2, KHSRP, CSTF3, HSPA4, DHX15, KRT4, MIA3, OTUD7B, PRPF8, ACIN1, PATL1, P4HA1, DSP, ANXA1, HSPA1A, PRRC2A, SERPINB3, COIL, PGD, DIAPH3, CSNK2A1, SNRNP200, DAZAP1, RPRD1B, HSPA8, ENAH, PABPC4, IGF2BP1, HSD17B10, HDLBP, DVL2, SF3A3, CCT2, SNRPD2, SMARCA4, CDC5L, YWHAZ, UBAP2, CANX, SNRPD1, JUP, RARA, PRMT5, U2SURP, TGM3, TDRD3, PKLR, NOLC1, YLPM1, WASL, CSTF2, MATR3, TOE1, BCL9, CRNN, HIST2H2AA3, DVL3, P3H1, PRPF3, CSNK2A2, SCAF4, DSG3, RBMX, CYFIP1, USP6NL, DDX6, XRN2, IVL, XAB2, AMOTL1, MPDZ, DDX3Y, HNRNPUL1, DHX9, POLR2E, FBRS, WDR77, SEC23A, ZMAT5, DGCR14, LZTS2, NOSIP, DCAF7, GEMIN5, PRPF40A, EIF4A3, INPPL1, LSM4, DDX17, IGF2BP3, RC3H1, MPP5, POLR2C, FARSA, HNRNPH3, DHX30, RPRD1A, ZG16B, NONO, PREB, PABPC3, LONP2, ATN1, GABARAPL2, HNRNPR, HNRNPCL1, CYFIP2, ELAVL1, ITCH, DRG1, SNRPD3, RPAP3, DROSHA, HNRNPU, SMN2, CAD, CCT7, PTPN14, PPP1CA, HNRNPA3, DDX39B, SCGB2A1, KRT75, DDX21, SPG20, CSDE1, HNRNPF, SRSF10, SEC23IP, ATP2A1, DIAPH1, LCN1, DOCK7, CXorf57, SF3A2, HSPB1, TARDBP, SF3B6, A2ML1, AMOT, THOC6, KIF2A, LUC7L3, MYH7, MYH1, MYH4, MYH16, DDX1, ENO1, TP73, CCT6A, SMARCE1, ANXA2, ACLY, SCAF8, ALDH3A1, PPIB, EDC4, RPL6, USP39, EIF3A, H2AFZ, RPL30, KDM3B, FUS, SERPINB5, DVL1, RAPGEF2, DHX36, HN1L, POLR2G, BAIAP2, WDR91, DCTPP1, IQSEC1, PRDX5, LZTS3, RPS15AP21, SRSF3, ZNF598, LACRT, IGF2BP2, PAICS, KIAA1522, SLC4A1AP, ATXN2, THRAP3, RBM39, CAPZA1, SEC24C, NOP56, SRPK1, DKC1, IK, HADHA, OGT, PRPF31, DIDO1, ATAD3A, PDCD7, HUWE1, ATM, TRIM28, HIF1A, LATS1, FAM189B, TMEM171, FAM189A2, WBP1, TMEM92, LDLRAD4, CLNK, BTRC, NUP133, CDH1, FKBP15, SERPINA5, ARRDC3, NME2, GORASP1, ZBTB33, LYZ, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWWOXchr16:70765398chr16:79245505ENST00000355860+06125_414-34190MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984+010125_414-29311MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST00000569818+01125_414-3537MAPT


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr16:70765398chr16:79245505ENST00000402655+35125_414136312MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST00000406884+46125_414172235MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST00000566780+79125_414352415MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for VAC14_WWOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for VAC14_WWOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWWOXC0007137Squamous cell carcinoma1CTD_human
TgeneWWOXC0038356Stomach Neoplasms1CTD_human
TgeneWWOXC0042076Urologic Neoplasms1CTD_human
TgeneWWOXC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneWWOXC1458155Mammary Neoplasms1CTD_human
TgeneWWOXC3280452SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 121ORPHANET;UNIPROT
TgeneWWOXC3495559Juvenile arthritis1CTD_human
TgeneWWOXC4015519EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 281UNIPROT