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	FusionGenePPI
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Fusion gene ID: 41315

FusionGeneSummary for UXS1_PCBP2

Fusion gene summary

Fusion gene information	Fusion gene name: UXS1_PCBP2
	Fusion gene ID: 41315
		Hgene	Tgene
	Gene symbol	UXS1	PCBP2
	Gene ID	80146	5094
	Gene name	UDP-glucuronate decarboxylase 1	poly(rC) binding protein 2
	Synonyms	SDR6E1\|UGD	HNRNPE2\|HNRPE2\|hnRNP-E2
	Cytomap	2q12.2	12q13.13
	Type of gene	protein-coding	protein-coding
	Description	UDP-glucuronic acid decarboxylase 1UXS-1short chain dehydrogenase/reductase family 6E, member 12	poly(rC)-binding protein 2alpha-CP2heterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2
	Modification date	20180523	20180522
	UniProtAcc	Q8NBZ7	Q15366
	Ensembl transtripts involved in fusion gene	ENST00000283148, ENST00000540130, ENST00000409501, ENST00000409032, ENST00000428048, ENST00000479621,	ENST00000359282, ENST00000603815, ENST00000437231, ENST00000447282, ENST00000549863, ENST00000359462, ENST00000546463, ENST00000552296, ENST00000552819, ENST00000455667, ENST00000439930, ENST00000548933, ENST00000541275,
Fusion gene scores	* DoF score	4 X 4 X 3=48	14 X 14 X 7=1372
	# samples	4	15
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1372*10)=-3.19324607567693 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UXS1 [Title/Abstract] AND PCBP2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UXS1	GO:0051262	protein tetramerization	23656592
Tgene	PCBP2	GO:0039694	viral RNA genome replication	12414943
Tgene	PCBP2	GO:0075522	IRES-dependent viral translational initiation	12414943

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE156057	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000283148	ENST00000359282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000603815	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000437231	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000447282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000549863	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000359462	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000546463	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000552296	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000552819	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000455667	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000439930	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000548933	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000283148	ENST00000541275	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000359282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000603815	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000437231	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000447282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000549863	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000359462	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000546463	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000552296	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000552819	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000455667	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000439930	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000548933	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000540130	ENST00000541275	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000359282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000603815	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000437231	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000447282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000549863	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000359462	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000546463	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000552296	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000552819	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000455667	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000439930	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000548933	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409501	ENST00000541275	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000359282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000603815	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000437231	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000447282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000549863	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000359462	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000546463	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000552296	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000552819	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000455667	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000439930	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000548933	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000409032	ENST00000541275	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000359282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000603815	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000437231	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000447282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000549863	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000359462	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000546463	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000552296	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000552819	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000455667	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000439930	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000548933	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000428048	ENST00000541275	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000359282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000603815	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000437231	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000447282	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000549863	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000359462	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000546463	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000552296	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000552819	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000455667	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000439930	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000548933	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+
intron-intron	ENST00000479621	ENST00000541275	UXS1	chr2	106713264	+	PCBP2	chr12	53854515	+

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FusionProtFeatures for UXS1_PCBP2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UXS1 Q8NBZ7	PCBP2 Q15366
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis ofthe core tetrasaccharide in glycosaminoglycan biosynthesis.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for UXS1_PCBP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UXS1_PCBP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for UXS1_PCBP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for UXS1_PCBP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	UXS1	C0376634	Craniofacial Abnormalities	1	CTD_human

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Fusion gene ID: 41315

FusionGeneSummary for UXS1_PCBP2

FusionProtFeatures for UXS1_PCBP2

FusionGeneSequence for UXS1_PCBP2

FusionGenePPI for UXS1_PCBP2

RelatedDrugs for UXS1_PCBP2

RelatedDiseases for UXS1_PCBP2