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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41315

FusionGeneSummary for UXS1_PCBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: UXS1_PCBP2
Fusion gene ID: 41315
HgeneTgene
Gene symbol

UXS1

PCBP2

Gene ID

80146

5094

Gene nameUDP-glucuronate decarboxylase 1poly(rC) binding protein 2
SynonymsSDR6E1|UGDHNRNPE2|HNRPE2|hnRNP-E2
Cytomap

2q12.2

12q13.13

Type of geneprotein-codingprotein-coding
DescriptionUDP-glucuronic acid decarboxylase 1UXS-1short chain dehydrogenase/reductase family 6E, member 12poly(rC)-binding protein 2alpha-CP2heterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2
Modification date2018052320180522
UniProtAcc

Q8NBZ7

Q15366

Ensembl transtripts involved in fusion geneENST00000283148, ENST00000540130, 
ENST00000409501, ENST00000409032, 
ENST00000428048, ENST00000479621, 
ENST00000359282, ENST00000603815, 
ENST00000437231, ENST00000447282, 
ENST00000549863, ENST00000359462, 
ENST00000546463, ENST00000552296, 
ENST00000552819, ENST00000455667, 
ENST00000439930, ENST00000548933, 
ENST00000541275, 
Fusion gene scores* DoF score4 X 4 X 3=4814 X 14 X 7=1372
# samples 415
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1372*10)=-3.19324607567693
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UXS1 [Title/Abstract] AND PCBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUXS1

GO:0051262

protein tetramerization

23656592

TgenePCBP2

GO:0039694

viral RNA genome replication

12414943

TgenePCBP2

GO:0075522

IRES-dependent viral translational initiation

12414943


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE156057UXS1chr2

106713264

+PCBP2chr12

53854515

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000283148ENST00000359282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000603815UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000437231UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000447282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000549863UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000359462UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000546463UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000552296UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000552819UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000455667UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000439930UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000548933UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000283148ENST00000541275UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000359282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000603815UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000437231UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000447282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000549863UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000359462UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000546463UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000552296UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000552819UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000455667UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000439930UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000548933UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000540130ENST00000541275UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000359282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000603815UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000437231UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000447282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000549863UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000359462UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000546463UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000552296UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000552819UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000455667UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000439930UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000548933UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409501ENST00000541275UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000359282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000603815UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000437231UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000447282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000549863UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000359462UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000546463UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000552296UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000552819UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000455667UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000439930UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000548933UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000409032ENST00000541275UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000359282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000603815UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000437231UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000447282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000549863UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000359462UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000546463UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000552296UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000552819UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000455667UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000439930UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000548933UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000428048ENST00000541275UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000359282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000603815UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000437231UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000447282UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000549863UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000359462UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000546463UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000552296UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000552819UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000455667UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000439930UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000548933UXS1chr2

106713264

+PCBP2chr12

53854515

+
intron-intronENST00000479621ENST00000541275UXS1chr2

106713264

+PCBP2chr12

53854515

+

Top

FusionProtFeatures for UXS1_PCBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UXS1

Q8NBZ7

PCBP2

Q15366

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis ofthe core tetrasaccharide in glycosaminoglycan biosynthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for UXS1_PCBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for UXS1_PCBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UXS1_PCBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for UXS1_PCBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUXS1C0376634Craniofacial Abnormalities1CTD_human