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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 41305

FusionGeneSummary for UVRAG_RRAS2

check button Fusion gene summary
Fusion gene informationFusion gene name: UVRAG_RRAS2
Fusion gene ID: 41305
HgeneTgene
Gene symbol

UVRAG

RRAS2

Gene ID

7405

22800

Gene nameUV radiation resistance associatedRAS related 2
SynonymsDHTX|VPS38|p63TC21
Cytomap

11q13.5

11p15.2

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxyras-related protein R-Ras2ras-like protein TC21related RAS viral (r-ras) oncogene homolog 2teratocarcinoma oncogene
Modification date2018052320180519
UniProtAcc

Q9P2Y5

P62070

Ensembl transtripts involved in fusion geneENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000545643, ENST00000537760, 
ENST00000414023, ENST00000529237, 
ENST00000256196, ENST00000534746, 
ENST00000526063, ENST00000532814, 
Fusion gene scores* DoF score29 X 10 X 12=34803 X 1 X 3=9
# samples 293
** MAII scorelog2(29/3480*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UVRAG [Title/Abstract] AND RRAS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-UF-A7JV-01AUVRAGchr11

75526569

+RRAS2chr11

14317401

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356136ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
In-frameENST00000356136ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
In-frameENST00000356136ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000528420ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000528420ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000528420ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000533454ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000533454ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000533454ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000531818ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000531818ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000531818ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000532130ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000532130ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000532130ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000539288ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000539288ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000539288ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000525872ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000525872ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000525872ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000538870ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000538870ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000538870ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-

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FusionProtFeatures for UVRAG_RRAS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UVRAG

Q9P2Y5

RRAS2

P62070

Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}. It is a plasma membrane-associated GTP-binding proteinwith GTPase activity. Might transduce growth inhibitory signalsacross the cell membrane, exerting its effect through an effectorshared with the Ras proteins but in an antagonistic fashion.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRRAS2chr11:75526569chr11:14317401ENST00000256196-0643_5136205MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023--1543_51-12128MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST00000526063-0643_51-41128MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST00000529237-0643_51-41128MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST00000532814-0643_51-41128MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST00000534746-0643_51-41128MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST00000537760-0643_511170MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST00000256196-06127_13036205Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000256196-06157_15936205Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000256196-0668_7236205Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023--15127_130-12128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023--15157_159-12128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023--1521_29-12128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023--1568_72-12128Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000526063-06127_130-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000526063-06157_159-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000526063-0621_29-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000526063-0668_72-41128Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000529237-06127_130-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000529237-06157_159-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000529237-0621_29-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000529237-0668_72-41128Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000532814-06127_130-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000532814-06157_159-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000532814-0621_29-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000532814-0668_72-41128Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000534746-06127_130-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000534746-06157_159-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000534746-0621_29-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000534746-0668_72-41128Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000537760-06127_1301170Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000537760-06157_1591170Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000537760-0621_291170Nucleotide bindingNote=GTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000537760-0668_721170Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75526569chr11:14317401ENST00000356136+115224_30539700Coiled coilOntology_term=ECO:0000255
HgeneUVRAGchr11:75526569chr11:14317401ENST00000356136+11544_12839700DomainNote=C2
TgeneRRAS2chr11:75526569chr11:14317401ENST00000256196-0621_2936205Nucleotide bindingNote=GTP


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FusionGeneSequence for UVRAG_RRAS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000545643_chr11_14317401_-_39aa

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000537760_chr11_14317401_-_208aa
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGE
GFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRK

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000414023_chr11_14317401_-_39aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000545643_chr11_14317401_-_117nt
ATGAGCGCCTCCGCGTCGGTCGGGGGCCCCGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCC

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000537760_chr11_14317401_-_624nt
ATGAGCGCCTCCGCGTCGGTCGGGGGCCCCGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCC
CTGCATGTGGAGCTGCCGTCTCAGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATA
GATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAA
GGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGT
GATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGG
CAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAA

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000414023_chr11_14317401_-_117nt
ATGAGCGCCTCCGCGTCGGTCGGGGGCCCCGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000545643_chr11_14317401_-_990nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGTT
TTTTCTTTTCTTGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGC
AGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTT
GGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCC
AATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGT
AACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGCATGTCATCTATGC
TCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAGCAAAGTGGACCCTTCCAA
GGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCAGCTGCAGAGACTTTGAGTGAAGTAGCCTAAGAGGA

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000537760_chr11_14317401_-_2276nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGTC
CTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTT
GGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGA
TAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAA
TAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATC
AGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACC
AGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAA
AGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGA
AGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATC
TGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCT
AAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATA
GGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAA
AGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAA
CTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGAT
ATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAA
GTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATT
AATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCAT
AGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAAC
TGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGT
ACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGAT
AATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGA
TGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGT

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_RRAS2_ENST00000414023_chr11_14317401_-_2242nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGGC
AGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATA
TTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCA
CAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTG
GTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGG
CATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTT
CACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAG
GAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAG
ACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGAT
TATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGA
ATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAA
TATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTA
CAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTA
AAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTT
AGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTT
TCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGAT
GATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTT
TCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAG
AAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATA
GAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAAT
GGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTT


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FusionGenePPI for UVRAG_RRAS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UVRAGBECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226LRRAS2LGALS4, XRCC6, RAF1, PIK3R1, RALGDS, RIN1, MLLT4, CDK2, PAN2, TRAF2, CREB3, ARAF, CCDC8, RABGGTB, FNTB, DBN1, SNCA, TSNAX, SYNPO, LIMA1, FOXS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UVRAG_RRAS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UVRAG_RRAS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRRAS2C0023904Liver Neoplasms, Experimental1CTD_human
TgeneRRAS2C0349639Juvenile Myelomonocytic Leukemia1CTD_human