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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 41295

FusionGeneSummary for UVRAG_MAP6

check button Fusion gene summary
Fusion gene informationFusion gene name: UVRAG_MAP6
Fusion gene ID: 41295
HgeneTgene
Gene symbol

UVRAG

MAP6

Gene ID

7405

4135

Gene nameUV radiation resistance associatedmicrotubule associated protein 6
SynonymsDHTX|VPS38|p63MAP6-N|MTAP6|N-STOP|STOP
Cytomap

11q13.5

11q13.5

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxymicrotubule-associated protein 6CTD-2530H12.7MAP-6stable tubule-only polypeptide
Modification date2018052320180523
UniProtAcc

Q9P2Y5

Q96JE9

Ensembl transtripts involved in fusion geneENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000304771, ENST00000526740, 
ENST00000434603, ENST00000526689, 
Fusion gene scores* DoF score29 X 10 X 12=34801 X 2 X 2=4
# samples 292
** MAII scorelog2(29/3480*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: UVRAG [Title/Abstract] AND MAP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A1JC-01AUVRAGchr11

75526569

+MAP6chr11

75319367

-
TCGARVSTADTCGA-RD-A8N4-01AUVRAGchr11

75526569

+MAP6chr11

75317049

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356136ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75319367

-
5CDS-5UTRENST00000356136ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75319367

-
5CDS-5UTRENST00000356136ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75319367

-
5CDS-intronENST00000356136ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-3CDSENST00000528420ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000528420ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000528420ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-intronENST00000528420ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-3CDSENST00000533454ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000533454ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000533454ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-intronENST00000533454ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-3CDSENST00000531818ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000531818ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000531818ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-intronENST00000531818ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-3CDSENST00000532130ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000532130ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000532130ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-intronENST00000532130ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-3CDSENST00000539288ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000539288ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000539288ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-intronENST00000539288ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-3CDSENST00000525872ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000525872ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000525872ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-intronENST00000525872ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-3CDSENST00000538870ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000538870ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-5UTRENST00000538870ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75319367

-
intron-intronENST00000538870ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75319367

-
In-frameENST00000356136ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75317049

-
In-frameENST00000356136ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75317049

-
In-frameENST00000356136ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75317049

-
5CDS-intronENST00000356136ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000528420ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000528420ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000528420ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-intronENST00000528420ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000533454ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000533454ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000533454ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-intronENST00000533454ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000531818ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000531818ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000531818ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-intronENST00000531818ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000532130ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000532130ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000532130ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-intronENST00000532130ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000539288ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000539288ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000539288ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-intronENST00000539288ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000525872ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000525872ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000525872ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-intronENST00000525872ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000538870ENST00000304771UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000538870ENST00000526740UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-3CDSENST00000538870ENST00000434603UVRAGchr11

75526569

+MAP6chr11

75317049

-
intron-intronENST00000538870ENST00000526689UVRAGchr11

75526569

+MAP6chr11

75317049

-

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FusionProtFeatures for UVRAG_MAP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UVRAG

Q9P2Y5

MAP6

Q96JE9

Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}. Involved in microtubule stabilization in many celltypes, including neuronal cells (By similarity). Specifically hasmicrotubule cold stabilizing activity (By similarity). Involved indendrite morphogenesis and maintenance by regulating lysosomaltrafficking via its interaction with TMEM106B (PubMed:24357581).Regulates KIF5A-mediated axonal cargo transport (By similarity).Regulates axonal growth during neuron polarization (Bysimilarity). {ECO:0000250|UniProtKB:Q63560,ECO:0000269|PubMed:24357581}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14490_804373814Compositional biasNote=Pro-rich
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13490_804373440Compositional biasNote=Pro-rich
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14384_398373814RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13384_398373440RegionCalmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75526569chr11:75317049ENST00000356136+115224_30539700Coiled coilOntology_term=ECO:0000255
HgeneUVRAGchr11:75526569chr11:75317049ENST00000356136+11544_12839700DomainNote=C2
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-1443_49373814Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-1343_49373440Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14118_141373814RegionMn 1
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14126_140373814RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14153_176373814RegionMn 2
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14162_176373814RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14189_203373814RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14298_321373814RegionMn 3
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14306_320373814RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000304771-14357_371373814RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13118_141373440RegionMn 1
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13126_140373440RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13153_176373440RegionMn 2
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13162_176373440RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13189_203373440RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13298_321373440RegionMn 3
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13306_320373440RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST00000434603-13357_371373440RegionCalmodulin-binding


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FusionGeneSequence for UVRAG_MAP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000304771_chr11_75317049_-_480aa
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDK
EQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEP
LKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVK
DQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVH
DSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGP

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000526740_chr11_75317049_-_480aa
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDK
EQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEP
LKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVK
DQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVH
DSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGP

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000434603_chr11_75317049_-_106aa
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000304771_chr11_75317049_-_1440nt
ATGAGCGCCTCCGCGTCGGTCGGGGGCCCCGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCC
CTGCATGTGGAGCTGCCGTCTCAGCAGGTGGAAAAACCTAGTGTTCAGAGTTCCAAACCAAAAAAGACCTCAGCGAGCCATAAGCCCACG
AGGAAGGCCAAAGACAAGCAGGCGGTGTCAGGCCAGGCTGCCAAGAAAAAGAGCGCGGAGGGCCCGAGTACCACCAAGCCAGACGACAAG
GAGCAAAGCAAAGAGATGAACAATAAACTGGCTGAGGCGAAAGAGAGCCTGGCTCAACCCGTCAGTGATTCAAGTAAGACTCAAGGTCCT
GTAGCCACAGAGCCAGACAAGGATCAAGGTTCTGTGGTCCCAGGCCTTCTGAAAGGTCAAGGTCCTATGGTGCAAGAGCCTCTGAAGAAG
CAAGGTTCTGTGGTCCCAGGGCCTCCAAAGGATCTAGGTCCCATGATCCCATTACCAGTCAAGGATCAAGATCACACGGTCCCTGAGCCT
TTAAAGAATGAAAGCCCTGTTATCTCAGCACCAGTCAAGGACCAAGGTCCCTCGGTCCCAGTTCCTCCAAAGAATCAAAGTCCTATGGTT
CCAGCAAAAGTTAAGGATCAAGGCTCTGTGGTACCAGAGTCTCTAAAGGATCAAGGTCCTAGGATTCCTGAGCCTGTGAAGAATCAAGCT
CCTATGGTCCCAGCACCTGTCAAGGATGAAGGTCCCATGGTCTCAGCATCTGTCAAGGATCAAGGTCCCATGGTCTCAGCACCTGTCAAG
GATCAAGGTCCCATAGTCCCAGCACCTGTCAAGGGTGAAGGTCCCATAGTCCCAGCACCTGTCAAGGATGAAGGTCCCATGGTCTCAGCA
CCTATCAAGGATCAAGATCCCATGGTCCCAGAGCATCCGAAGGATGAAAGTGCCATGGCCACAGCACCCATAAAGAATCAAGGTTCCATG
GTCTCTGAGCCTGTAAAGAATCAAGGTTTAGTGGTCTCAGGGCCAGTCAAGGATCAAGATGTTGTAGTCCCAGAGCATGCAAAGGTTCAC
GATTCTGCAGTTGTGGCACCTGTAAAGAATCAAGGTCCTGTGGTCCCCGAGTCCGTGAAGAATCAAGACCCCATTCTCCCAGTACTAGTT
AAGGATCAAGGCCCCACAGTCCTACAGCCTCCAAAGAATCAAGGTCGTATAGTCCCTGAACCTCTGAAGAATCAAGTTCCTATAGTCCCA
GTGCCTCTGAAGGATCAAGATCCTCTGGTGCCAGTACCAGCAAAGGACCAAGGTCCTGCAGTCCCTGAACCTCTGAAGACTCAAGGTCCC
AGGGACCCTCAGCTACCTACTGTCTCACCTCTACCCCGAGTCATGATCCCAACTGCCCCCCATACGGAATACATTGAGAGCTCCCCTTGA

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000526740_chr11_75317049_-_1440nt
ATGAGCGCCTCCGCGTCGGTCGGGGGCCCCGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCC
CTGCATGTGGAGCTGCCGTCTCAGCAGGTGGAAAAACCTAGTGTTCAGAGTTCCAAACCAAAAAAGACCTCAGCGAGCCATAAGCCCACG
AGGAAGGCCAAAGACAAGCAGGCGGTGTCAGGCCAGGCTGCCAAGAAAAAGAGCGCGGAGGGCCCGAGTACCACCAAGCCAGACGACAAG
GAGCAAAGCAAAGAGATGAACAATAAACTGGCTGAGGCGAAAGAGAGCCTGGCTCAACCCGTCAGTGATTCAAGTAAGACTCAAGGTCCT
GTAGCCACAGAGCCAGACAAGGATCAAGGTTCTGTGGTCCCAGGCCTTCTGAAAGGTCAAGGTCCTATGGTGCAAGAGCCTCTGAAGAAG
CAAGGTTCTGTGGTCCCAGGGCCTCCAAAGGATCTAGGTCCCATGATCCCATTACCAGTCAAGGATCAAGATCACACGGTCCCTGAGCCT
TTAAAGAATGAAAGCCCTGTTATCTCAGCACCAGTCAAGGACCAAGGTCCCTCGGTCCCAGTTCCTCCAAAGAATCAAAGTCCTATGGTT
CCAGCAAAAGTTAAGGATCAAGGCTCTGTGGTACCAGAGTCTCTAAAGGATCAAGGTCCTAGGATTCCTGAGCCTGTGAAGAATCAAGCT
CCTATGGTCCCAGCACCTGTCAAGGATGAAGGTCCCATGGTCTCAGCATCTGTCAAGGATCAAGGTCCCATGGTCTCAGCACCTGTCAAG
GATCAAGGTCCCATAGTCCCAGCACCTGTCAAGGGTGAAGGTCCCATAGTCCCAGCACCTGTCAAGGATGAAGGTCCCATGGTCTCAGCA
CCTATCAAGGATCAAGATCCCATGGTCCCAGAGCATCCGAAGGATGAAAGTGCCATGGCCACAGCACCCATAAAGAATCAAGGTTCCATG
GTCTCTGAGCCTGTAAAGAATCAAGGTTTAGTGGTCTCAGGGCCAGTCAAGGATCAAGATGTTGTAGTCCCAGAGCATGCAAAGGTTCAC
GATTCTGCAGTTGTGGCACCTGTAAAGAATCAAGGTCCTGTGGTCCCCGAGTCCGTGAAGAATCAAGACCCCATTCTCCCAGTACTAGTT
AAGGATCAAGGCCCCACAGTCCTACAGCCTCCAAAGAATCAAGGTCGTATAGTCCCTGAACCTCTGAAGAATCAAGTTCCTATAGTCCCA
GTGCCTCTGAAGGATCAAGATCCTCTGGTGCCAGTACCAGCAAAGGACCAAGGTCCTGCAGTCCCTGAACCTCTGAAGACTCAAGGTCCC
AGGGACCCTCAGCTACCTACTGTCTCACCTCTACCCCGAGTCATGATCCCAACTGCCCCCCATACGGAATACATTGAGAGCTCCCCTTGA

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000434603_chr11_75317049_-_318nt
ATGAGCGCCTCCGCGTCGGTCGGGGGCCCCGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCC
CTGCATGTGGAGCTGCCGTCTCAGCAGGTGGAAAAACCTAGTGTTCAGAGTTCCAAACCAAAAAAGACCTCAGCGAGCCATAAGCCCACG
AGGAAGGCCAAAGACAAGCAGGCGGTGTCAGGCCAGGCTGCCAAGAAAAAGAGCGCGGAGGGCCCGAGTACCACCAAGCCAGACGACAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000304771_chr11_75317049_-_1822nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGGT
GGAAAAACCTAGTGTTCAGAGTTCCAAACCAAAAAAGACCTCAGCGAGCCATAAGCCCACGAGGAAGGCCAAAGACAAGCAGGCGGTGTC
AGGCCAGGCTGCCAAGAAAAAGAGCGCGGAGGGCCCGAGTACCACCAAGCCAGACGACAAGGAGCAAAGCAAAGAGATGAACAATAAACT
GGCTGAGGCGAAAGAGAGCCTGGCTCAACCCGTCAGTGATTCAAGTAAGACTCAAGGTCCTGTAGCCACAGAGCCAGACAAGGATCAAGG
TTCTGTGGTCCCAGGCCTTCTGAAAGGTCAAGGTCCTATGGTGCAAGAGCCTCTGAAGAAGCAAGGTTCTGTGGTCCCAGGGCCTCCAAA
GGATCTAGGTCCCATGATCCCATTACCAGTCAAGGATCAAGATCACACGGTCCCTGAGCCTTTAAAGAATGAAAGCCCTGTTATCTCAGC
ACCAGTCAAGGACCAAGGTCCCTCGGTCCCAGTTCCTCCAAAGAATCAAAGTCCTATGGTTCCAGCAAAAGTTAAGGATCAAGGCTCTGT
GGTACCAGAGTCTCTAAAGGATCAAGGTCCTAGGATTCCTGAGCCTGTGAAGAATCAAGCTCCTATGGTCCCAGCACCTGTCAAGGATGA
AGGTCCCATGGTCTCAGCATCTGTCAAGGATCAAGGTCCCATGGTCTCAGCACCTGTCAAGGATCAAGGTCCCATAGTCCCAGCACCTGT
CAAGGGTGAAGGTCCCATAGTCCCAGCACCTGTCAAGGATGAAGGTCCCATGGTCTCAGCACCTATCAAGGATCAAGATCCCATGGTCCC
AGAGCATCCGAAGGATGAAAGTGCCATGGCCACAGCACCCATAAAGAATCAAGGTTCCATGGTCTCTGAGCCTGTAAAGAATCAAGGTTT
AGTGGTCTCAGGGCCAGTCAAGGATCAAGATGTTGTAGTCCCAGAGCATGCAAAGGTTCACGATTCTGCAGTTGTGGCACCTGTAAAGAA
TCAAGGTCCTGTGGTCCCCGAGTCCGTGAAGAATCAAGACCCCATTCTCCCAGTACTAGTTAAGGATCAAGGCCCCACAGTCCTACAGCC
TCCAAAGAATCAAGGTCGTATAGTCCCTGAACCTCTGAAGAATCAAGTTCCTATAGTCCCAGTGCCTCTGAAGGATCAAGATCCTCTGGT
GCCAGTACCAGCAAAGGACCAAGGTCCTGCAGTCCCTGAACCTCTGAAGACTCAAGGTCCCAGGGACCCTCAGCTACCTACTGTCTCACC
TCTACCCCGAGTCATGATCCCAACTGCCCCCCATACGGAATACATTGAGAGCTCCCCTTGACACTCACCCCTTGACACACCAATGAAGGA
GCTGACAGTGAGAGTGCTCCCCTCCCAGGGGCAGTGAAGACACATATTTAATCTGCATGAAACATGTACAGTAGTCTTGCTGGAATCTAA

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000526740_chr11_75317049_-_1821nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGGT
GGAAAAACCTAGTGTTCAGAGTTCCAAACCAAAAAAGACCTCAGCGAGCCATAAGCCCACGAGGAAGGCCAAAGACAAGCAGGCGGTGTC
AGGCCAGGCTGCCAAGAAAAAGAGCGCGGAGGGCCCGAGTACCACCAAGCCAGACGACAAGGAGCAAAGCAAAGAGATGAACAATAAACT
GGCTGAGGCGAAAGAGAGCCTGGCTCAACCCGTCAGTGATTCAAGTAAGACTCAAGGTCCTGTAGCCACAGAGCCAGACAAGGATCAAGG
TTCTGTGGTCCCAGGCCTTCTGAAAGGTCAAGGTCCTATGGTGCAAGAGCCTCTGAAGAAGCAAGGTTCTGTGGTCCCAGGGCCTCCAAA
GGATCTAGGTCCCATGATCCCATTACCAGTCAAGGATCAAGATCACACGGTCCCTGAGCCTTTAAAGAATGAAAGCCCTGTTATCTCAGC
ACCAGTCAAGGACCAAGGTCCCTCGGTCCCAGTTCCTCCAAAGAATCAAAGTCCTATGGTTCCAGCAAAAGTTAAGGATCAAGGCTCTGT
GGTACCAGAGTCTCTAAAGGATCAAGGTCCTAGGATTCCTGAGCCTGTGAAGAATCAAGCTCCTATGGTCCCAGCACCTGTCAAGGATGA
AGGTCCCATGGTCTCAGCATCTGTCAAGGATCAAGGTCCCATGGTCTCAGCACCTGTCAAGGATCAAGGTCCCATAGTCCCAGCACCTGT
CAAGGGTGAAGGTCCCATAGTCCCAGCACCTGTCAAGGATGAAGGTCCCATGGTCTCAGCACCTATCAAGGATCAAGATCCCATGGTCCC
AGAGCATCCGAAGGATGAAAGTGCCATGGCCACAGCACCCATAAAGAATCAAGGTTCCATGGTCTCTGAGCCTGTAAAGAATCAAGGTTT
AGTGGTCTCAGGGCCAGTCAAGGATCAAGATGTTGTAGTCCCAGAGCATGCAAAGGTTCACGATTCTGCAGTTGTGGCACCTGTAAAGAA
TCAAGGTCCTGTGGTCCCCGAGTCCGTGAAGAATCAAGACCCCATTCTCCCAGTACTAGTTAAGGATCAAGGCCCCACAGTCCTACAGCC
TCCAAAGAATCAAGGTCGTATAGTCCCTGAACCTCTGAAGAATCAAGTTCCTATAGTCCCAGTGCCTCTGAAGGATCAAGATCCTCTGGT
GCCAGTACCAGCAAAGGACCAAGGTCCTGCAGTCCCTGAACCTCTGAAGACTCAAGGTCCCAGGGACCCTCAGCTACCTACTGTCTCACC
TCTACCCCGAGTCATGATCCCAACTGCCCCCCATACGGAATACATTGAGAGCTCCCCTTGACACTCACCCCTTGACACACCAATGAAGGA
GCTGACAGTGAGAGTGCTCCCCTCCCAGGGGCAGTGAAGACACATATTTAATCTGCATGAAACATGTACAGTAGTCTTGCTGGAATCTAA

>In-frame_UVRAG_ENST00000356136_chr11_75526569_+_MAP6_ENST00000434603_chr11_75317049_-_3503nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGGT
GGAAAAACCTAGTGTTCAGAGTTCCAAACCAAAAAAGACCTCAGCGAGCCATAAGCCCACGAGGAAGGCCAAAGACAAGCAGGCGGTGTC
AGGCCAGGCTGCCAAGAAAAAGAGCGCGGAGGGCCCGAGTACCACCAAGCCAGACGACAAGGAGCAAAGCAAAGAGATGAACAATAAACT
GGCTGAGGCGAAAGAGTAAATTTCCCTGCACTTTCCTTTTACTCTTCTCTCTCTCTCCCTCCCCCCAACTTTTTTTTTTTAAACCAACAA
ACCAAAAAAGGCCACAAAATTAATTAGAGGCTTCTCATCTGCCTTGGTCCTGAGTGTTCCAGGAGCTCTTTGGTTTGGCTTCTTTTGATG
GAAGAATCCTGCTTCACAGACTGAGTGGCAGGCCTCCTCCTGAGGGCAGCCCCTGGAGCACCAGGAAGCGTTGCCGCTGGCTGTGCCCTC
CCCTGGCACTCTGACTGCATGCTGATGAGCAAGGCAGGCAGGTCTGAGAGGCGAAACGAATCTCCCGGCAGTGCTTGGAAGTGTCTGTGG
GGTCTCCTCCTCCCAGATCCCCAAGATCTGTGTCACTGGTCGATTTTGAACTTTAGGTACATGTGTTCTTTTCAAAAATTCAGAGAATCG
TCATGTGCCACAGAAGCTCAGCCTGGGCTTCAGCAATTGACAAAATTTGAAGAAATATTAAACAAAAATAACAAAAAAAGAAACAACCTT
GGCCTTAATGTCAATAAAAGGGAGTTGTGTCTGTTAAGTGGTCTTTTCATAGAATCGTCCATTAGAAATGTGTGCCTGTGTTTAGCTTCC
TATCAGTGGGCTTTAAATTGTATACCGAGTCATAGATACGCCACTGATAACTAAAACTAGATCAGGGCTGGTGAAGAAGGTTAGGTGTTT
TAGGTACATTCCAGCTGTCATAGGAAGATCACAGAAATGAGGAGGCTGTTTTCCTCTGATTCTCCTCGGCCGACCACCTGTCCAATGCTG
CTGGTTTCGCAGAGCGACCGGTTGGAGATGTCTGAGGAAGAAAGTTCAAGGTGTAGGGATAGTGTGTTTGGAATTTGACTTTCCATTTCT
GAGACCCAAGGGGGCGTAGATGTAGTGGCAAGTGTGGCGATGTTTACTCTCCCTTCCTGAACCGCTCTGGTCTGCTCCTCAGAGAGGGCA
GCGGTGCCAGGCCTCAGGTCAGGGAGAATGTCTGTGACTTAGCTGCAGACTAGGAGACTGCCCTGCTAACTAATTAGCAAGCAGCTTTGA
CCTCATTAATATATAAAAGCAGCTCTCAGTATATTCCGTGTCGTGTGTGTGTGTGGCCAAAGCCCCCAAGGGTGGCAAGTGCCACCTTCG
CTGTGCTAGAGTTGTGTTGTAGGAATTAGTCAGGGAGTTGTTGTGAAAAAAAAAACCCCAGTGCTTGTGAGGGAACTCAAAATAGTTACC
AGAAAAATAATATTTGCCAATATGACGTGTATATTGCTCAGCACACTCTGTATCTCCTGTCCTTAAAATCCTCTTGTCCCCGGCATTCTG
ACACACTGGGCTGCCGTCCGGTGTCAAGCCCCGGCGCAGGCTTGCTCTTCTTTTACAATGAAAGGGGTGAAGAGTGAGGGTCTCACAGTT
CCTTACCTCAAAGTCCCTTTAGGTCCTTCTGGTTTGGAGGAAGTGGAGCCTCCACGAACTCTCTCTTACTCCGACCATTCAGGCAGCAAA
GTCTCTGCTTACATCATTTTGGTTGTCACCTTGGGGCTGAGTGAGAAGTCTTTTGTAAATTAATTCGGCGTGTGCTACATGAGCCATAAT
TATTAACAGAACAGGAATATCAGAAACGAAGTTGTTGATCAGGCCCACTGCGACCTTCCTTTCTATCTCAGGGTTTAAAACTGTGAGGAA
GGAGAAGTATGAAGGAAGGTAGAAAATGCTGGTGGGTCTCCGTGTTTATGAGTCACAGATTTTGAAAGCTATCAGGAAATGACTAGAGTG
GATCCTGGCACTGATTCCAACTCTTTGCCAGCTAATCTTAACATTTAGCAGAAAGCTCTAGCAACATGATCTTAATTGTATCCAGAGGAT
TTGCCAATGTATGTTCAGTCTCTCAAGATTTGGCATTAGTCAGACATGTTGATGCTAGCCACAATTTGGATTTCTCCATAGAATAATCAT
TTATTTTTGCAGATCAAATAAATCAGAGTTTACAATGCACAGGGGATCATTTATTTAGCATTCCCTTGCTAGAAGCCCGTGTGCCAGGCA
CTGTGCTAGGCGTGGTGGGCAGTATAAAGAAATCTGTCTCCACAGCCACACAACCAGAGGGTGCACATGACTTGATCCCTATGACCAAGT
CAAGTTGGTGTTGCCCAAATCGCAGTTTGACATAAGGGTCCCACAGGCTTCCCCACCCCCCGCCCCCACTCACTGCCCCAGGGACCAACT
TCCTACCCTCACCCAAGGCTTTAGAGGACCTGTAGCATGTCTTTTTCAACCTGTCAGTATCCCCTTCTGCTTAACACACCCACTGAGAAA
ACCCTGTTTGTAGTTCACTTTGACTCTTGAATGTGTCACTTTACTGGCAAGAGACTTCCTTTGATTTCTACTGTTTACAAATAAAACTCA
GCCAGTCTCATTCTATATCCCAAACGTACTGAATGAAACTGATTTTGGTTCCACAAGCAGTGTTTGGGTGTTGCCTTCCTGAAGGTGACC
AAGCTTCCAAAGCTCGTCCCACTGGCCTCTGTACATTTCCCTGTGGTTCTCCGTCCTTCCCTGGCGAGGGAGCTGGGACTGAAGCTTTCC
CGCTGTTTCCCTGCCTGCAAAAGCAGCCCCAAGAGCTGCGCATTGGCTTCCCTCAGCAATCTGTCCTGTCTGTGCTCCCATTCGGTCCAC
ATAGCTTTCTTTGCCTCTCTGAGGCAGACAGGAAGTGTCTAATTACGATTTTGTGGCCTGGGTTTTGTTGCATACCACAGATTGTCTATG
TAACATGTAGCGCACACCTCTCTTGGTGCTATTTCATTCCTGCTGTAAGAGAATGACAAAAATATTCATGTATAGCCAATTGATTGTGAC


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FusionGenePPI for UVRAG_MAP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UVRAGBECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226LMAP6RARB, RARG, RORB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UVRAG_MAP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UVRAG_MAP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAP6C0036341Schizophrenia4PSYGENET
TgeneMAP6C0085633Mood swings1PSYGENET
TgeneMAP6C0424295Hyperactive behavior1CTD_human
TgeneMAP6C2678117Schizophrenia-like symptoms (uncommon)1PSYGENET