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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 41285

FusionGeneSummary for UVRAG_CMPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: UVRAG_CMPK1
Fusion gene ID: 41285
HgeneTgene
Gene symbol

UVRAG

CMPK1

Gene ID

7405

51727

Gene nameUV radiation resistance associatedcytidine/uridine monophosphate kinase 1
SynonymsDHTX|VPS38|p63CK|CMK|CMPK|UMK|UMP-CMPK|UMPK
Cytomap

11q13.5

1p33

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxyUMP-CMP kinaseUMP/CMP kinasecytidine monophosphate (UMP-CMP) kinase 1, cytosoliccytidylate kinasedCMP kinasedeoxycytidylate kinasenucleoside-diphosphate kinaseuridine monophosphate kinaseuridine monophosphate/cytidine monophosphate kinase
Modification date2018052320180519
UniProtAcc

Q9P2Y5

P30085

Ensembl transtripts involved in fusion geneENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000371873, ENST00000450808, 
ENST00000471289, 
Fusion gene scores* DoF score29 X 10 X 12=34805 X 3 X 3=45
# samples 295
** MAII scorelog2(29/3480*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UVRAG [Title/Abstract] AND CMPK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840

TgeneCMPK1

GO:0006165

nucleoside diphosphate phosphorylation

23416111

TgeneCMPK1

GO:0009142

nucleoside triphosphate biosynthetic process

23416111


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-RD-A8N4-01AUVRAGchr11

75672593

+CMPK1chr1

47834141

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356136ENST00000371873UVRAGchr11

75672593

+CMPK1chr1

47834141

+
5CDS-intronENST00000356136ENST00000450808UVRAGchr11

75672593

+CMPK1chr1

47834141

+
5CDS-intronENST00000356136ENST00000471289UVRAGchr11

75672593

+CMPK1chr1

47834141

+
In-frameENST00000528420ENST00000371873UVRAGchr11

75672593

+CMPK1chr1

47834141

+
5CDS-intronENST00000528420ENST00000450808UVRAGchr11

75672593

+CMPK1chr1

47834141

+
5CDS-intronENST00000528420ENST00000471289UVRAGchr11

75672593

+CMPK1chr1

47834141

+
5UTR-3CDSENST00000533454ENST00000371873UVRAGchr11

75672593

+CMPK1chr1

47834141

+
5UTR-intronENST00000533454ENST00000450808UVRAGchr11

75672593

+CMPK1chr1

47834141

+
5UTR-intronENST00000533454ENST00000471289UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-3CDSENST00000531818ENST00000371873UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000531818ENST00000450808UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000531818ENST00000471289UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-3CDSENST00000532130ENST00000371873UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000532130ENST00000450808UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000532130ENST00000471289UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-3CDSENST00000539288ENST00000371873UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000539288ENST00000450808UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000539288ENST00000471289UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-3CDSENST00000525872ENST00000371873UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000525872ENST00000450808UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000525872ENST00000471289UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-3CDSENST00000538870ENST00000371873UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000538870ENST00000450808UVRAGchr11

75672593

+CMPK1chr1

47834141

+
intron-intronENST00000538870ENST00000471289UVRAGchr11

75672593

+CMPK1chr1

47834141

+

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FusionProtFeatures for UVRAG_CMPK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UVRAG

Q9P2Y5

CMPK1

P30085

Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}. Catalyzes the phosphorylation of pyrimidine nucleosidemonophosphates at the expense of ATP. Plays an important role inde novo pyrimidine nucleotide biosynthesis. Has preference for UMPand CMP as phosphate acceptors. Also displays broad nucleosidediphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172,ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132,ECO:0000269|PubMed:23416111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75672593chr1:47834141ENST00000356136+71544_128233700DomainNote=C2
TgeneCMPK1chr11:75672593chr1:47834141ENST00000371873+0661_6357229Nucleotide bindingNMP
TgeneCMPK1chr11:75672593chr1:47834141ENST00000371873+0693_9657229Nucleotide bindingNMP
TgeneCMPK1chr11:75672593chr1:47834141ENST00000450808+0513_18-11180Nucleotide bindingATP
TgeneCMPK1chr11:75672593chr1:47834141ENST00000450808+0561_63-11180Nucleotide bindingNMP
TgeneCMPK1chr11:75672593chr1:47834141ENST00000450808+0593_96-11180Nucleotide bindingNMP
TgeneCMPK1chr11:75672593chr1:47834141ENST00000371873+06133_14357229RegionLID
TgeneCMPK1chr11:75672593chr1:47834141ENST00000450808+05133_143-11180RegionLID
TgeneCMPK1chr11:75672593chr1:47834141ENST00000450808+0533_63-11180RegionNMPbind

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75672593chr1:47834141ENST00000356136+715224_305233700Coiled coilOntology_term=ECO:0000255
TgeneCMPK1chr11:75672593chr1:47834141ENST00000371873+0613_1857229Nucleotide bindingATP
TgeneCMPK1chr11:75672593chr1:47834141ENST00000371873+0633_6357229RegionNMPbind


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FusionGeneSequence for UVRAG_CMPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UVRAG_ENST00000356136_chr11_75672593_+_CMPK1_ENST00000371873_chr1_47834141_+_405aa
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSL
NPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILL
QVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKI
VPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEKRI

>In-frame_UVRAG_ENST00000528420_chr11_75672593_+_CMPK1_ENST00000371873_chr1_47834141_+_304aa
MPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSY
DVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISLLK
REMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPII


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UVRAG_ENST00000356136_chr11_75672593_+_CMPK1_ENST00000371873_chr1_47834141_+_1215nt
ATGAGCGCCTCCGCGTCGGTCGGGGGCCCCGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCC
CTGCATGTGGAGCTGCCGTCTCAGCAGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAG
CTCCTTGATACCTACTTTACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTG
AATCCCACGTGGCGAAGTCTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGA
AAGGAGAACATCTACCAGCTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAA
AATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTG
CAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAG
GTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAATATGGCTACACACACCTT
TCTGCAGGAGAGCTGCTTCGTGATGAAAGGAAGAACCCAGATTCACAGTATGGTGAACTTATTGAAAAGTACATTAAAGAAGGAAAGATT
GTACCAGTTGAGATAACCATCAGTTTATTAAAGAGGGAAATGGATCAGACAATGGCTGCCAATGCTCAGAAGAATAAATTCTTGATTGAT
GGGTTTCCAAGAAATCAAGACAACCTTCAAGGATGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTTCTCTTTTTTGACTGT
AATAATGAGATTTGTATTGAACGATGTCTTGAGAGGGGAAAGAGTAGTGGTAGGAGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATT
CAGACCTACCTTCAGTCAACAAAGCCAATTATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCTTCTAAATCTGTTGAT

>In-frame_UVRAG_ENST00000528420_chr11_75672593_+_CMPK1_ENST00000371873_chr1_47834141_+_912nt
ATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGAATGG
AAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATAC
TATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTAC
GATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAA
GAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAATATGGCTACACACACCTTTCTGCAGGAGAGCTGCTTCGTGATGAAAGGAAG
AACCCAGATTCACAGTATGGTGAACTTATTGAAAAGTACATTAAAGAAGGAAAGATTGTACCAGTTGAGATAACCATCAGTTTATTAAAG
AGGGAAATGGATCAGACAATGGCTGCCAATGCTCAGAAGAATAAATTCTTGATTGATGGGTTTCCAAGAAATCAAGACAACCTTCAAGGA
TGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTTCTCTTTTTTGACTGTAATAATGAGATTTGTATTGAACGATGTCTTGAG
AGGGGAAAGAGTAGTGGTAGGAGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACCTACCTTCAGTCAACAAAGCCAATTATT
GACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCTTCTAAATCTGTTGATGAAGTTTTTGATGAAGTTGTGCAGATTTTTGAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_UVRAG_ENST00000356136_chr11_75672593_+_CMPK1_ENST00000371873_chr1_47834141_+_3550nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGCG
GCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTT
GTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGG
AATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGA
ATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGG
ATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTC
TTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAAT
TGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAATATGGCTACACACACCTTTCTGCAGGAGAGCTGCTTCGTGATGAAAG
GAAGAACCCAGATTCACAGTATGGTGAACTTATTGAAAAGTACATTAAAGAAGGAAAGATTGTACCAGTTGAGATAACCATCAGTTTATT
AAAGAGGGAAATGGATCAGACAATGGCTGCCAATGCTCAGAAGAATAAATTCTTGATTGATGGGTTTCCAAGAAATCAAGACAACCTTCA
AGGATGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTTCTCTTTTTTGACTGTAATAATGAGATTTGTATTGAACGATGTCT
TGAGAGGGGAAAGAGTAGTGGTAGGAGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACCTACCTTCAGTCAACAAAGCCAAT
TATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCTTCTAAATCTGTTGATGAAGTTTTTGATGAAGTTGTGCAGATTTT
TGACAAGGAAGGCTAATTCTAAACCTGAAGGCATCCTTGAAATCATGCTTGAATATTGCTTTGATAGCTGCTATCATGACCCCTTTTTAA
GGCAATTCTAATCTTTCATAACTACATCTCAATTAGTGGCTGGAAAGTACATGGTAAAACAAAGTAAATTTTTTTATGTTCTTTTTTTTG
GTCACAGGAGTAGACAGTGAATTCAGGTTTAACTTCACCTTAGTTATGGTGCTCACCAAACGAAGGGTATCAGCTATTTTTTTTAAAATT
CAAAAAGAATATCCCTTTTATAGTTTGTGCCTTCTGTGAGCAAAACTTTTTAGTACGCGTATATATCCCTCTAGTAATCACAACATTTTA
GGATTTAGGGATACCCGCTTCCTCTTTTTCTTGCAAGTTTTAAATTTCCAACCTTAAGTGAATTTGTGGACCAAATTTCAAAGGAACTTT
TTGTGTAGTCAGTTCTTGCACAATGTGTTTGGTAAACAAACTCAAAATGGATTCTTAGGAGCATTTTAGTGTTTATTAAATAACTGACCA
TTTGCTGTAGAAAGATGAGAAAACTTAAGCTTTGTTTTACTACAACTTGTACAAAGTTGTATGACAGGGCATATTCTTTGCTTCCAAGAT
TTGGGTTGGGGGCACTAGGGGTTCAGAGCCTGGCAGAATTGTCAGCTTTAGTCTGACATAATCTAAGGGTATGGGGCAAGGATCACATCT
AATGCTTGTGTTCCTTATACTCTATTATATAGTGTTATTCATGATTCAGCTGATCTTAACAAAATTCGTAGCAGTGGAACCTTGAAATGC
ATGTGGCTAGATTTATGCTAAAATGATTCTCAGTTAGCATTTTAGTAACACTTCAAAGGTTTTTTTTTGTTTGTTTTCTAGACTTAATAA
AAGCTTAGGATTAATTAGAAGAAGCAATCTAGTTAAATTTCCCATTTGTATTTTATTTTCTTGAATACTTTTTTCATAGTTATTTGTTTA
AAAAGATTTAAAAATCATTGCACTTTGGTCAGAAAAATAATAAATATATCTTATAAATGTTTGATTCCCTTCCTTGCTATTTTTATTCAG
TAGATTTTTGTTTGGCATCATGTTGAAGCACCGAAAGATAAATGATTTTTAAAAGGCTATAGAGTCCAAAGGAATATTCTTTTACACCAA
TTCTTCCTTTAAAAATCTCTGAGGAATTTGTTTTCGCCTTACTTTTTTTTCTTCTGTCACAATGCTAAGTGGTATCCGAGGTTCTTAATA
TGAGATTTAAAATCTTAAAATGTTTCTTATTTTCAGCACTTACATCATTTGGTACACAGGGTCAAATAGGGCAAATAATTTTGTCTTTGT
ATAATAGATTTGATATTTAAAGTCACTGGAAATAGGACAAGTTAATGGATGTTTTTATATTTTAATAGAATCATTTATTTCTATGTGTTA
TGAAATTCACTTAATGATAAATTTTTCAACATACTTGCCATTAGAAAACAAAGTATTGCTAAGTACTATAACATATTGGCCACTAAAATT
CATATTGAGATTATCTTGGTTTCTTGGAAGAGATAGGAATGAGTTCTTATCTAGTGTTGCAGGCCAGCAAATACAGAGGTGGTTTAATCA
AACAGCTCTAGTATGAAGCAAGAGTAAAGACTAAGGTTTCGAGAGCATTCCTACTCACATAAGTGAAGAAATCTGTCAGATAGGAATCTA
AATATTTATAGTGAGATTGTGAAAGCAACCTTAAAGTTTTGAAGAAGACTGATGAGACTAGGTGCTTTGCTTCCTTTCATCAGGTATCTT
TCTGTGGCATTTGAGAACAGAAACCAAGAAACATGGTAATTACTAAATTATGAGGCTTTGCTTTTTGTTTGCTTTTAAGTAGAAAAACAT
GTTGGCAACATTGAGTTTTGGAGTTGATTGAGATAATATGACTTAACTAGTTTTGTCATTCCATTTGTTAAAGATACAGTCACCAAGAAT
GTTTTGAGTTTTTTGAAAGACCCCAATTTAAGCCTTGCTTATTTTTAAATTATTTCCATTCAGTGATGTTGGATGTATATCAGTTATTTA

>In-frame_UVRAG_ENST00000528420_chr11_75672593_+_CMPK1_ENST00000371873_chr1_47834141_+_3291nt
AGTGCTCAGCTCCCTTGCCATGCGATACCCTGCAAGTCCTCACCAGCAAAAAGGCTCTCACCAGAGGCTGCCCCTCGGCCTGTGTTATCA
GATTTTTTGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTT
ACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGT
CTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAG
CTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGG
CTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGT
GTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATT
GGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAATATGGCTACACACACCTTTCTGCAGGAGAGCTGCTT
CGTGATGAAAGGAAGAACCCAGATTCACAGTATGGTGAACTTATTGAAAAGTACATTAAAGAAGGAAAGATTGTACCAGTTGAGATAACC
ATCAGTTTATTAAAGAGGGAAATGGATCAGACAATGGCTGCCAATGCTCAGAAGAATAAATTCTTGATTGATGGGTTTCCAAGAAATCAA
GACAACCTTCAAGGATGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTTCTCTTTTTTGACTGTAATAATGAGATTTGTATT
GAACGATGTCTTGAGAGGGGAAAGAGTAGTGGTAGGAGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACCTACCTTCAGTCA
ACAAAGCCAATTATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCTTCTAAATCTGTTGATGAAGTTTTTGATGAAGTT
GTGCAGATTTTTGACAAGGAAGGCTAATTCTAAACCTGAAGGCATCCTTGAAATCATGCTTGAATATTGCTTTGATAGCTGCTATCATGA
CCCCTTTTTAAGGCAATTCTAATCTTTCATAACTACATCTCAATTAGTGGCTGGAAAGTACATGGTAAAACAAAGTAAATTTTTTTATGT
TCTTTTTTTTGGTCACAGGAGTAGACAGTGAATTCAGGTTTAACTTCACCTTAGTTATGGTGCTCACCAAACGAAGGGTATCAGCTATTT
TTTTTAAAATTCAAAAAGAATATCCCTTTTATAGTTTGTGCCTTCTGTGAGCAAAACTTTTTAGTACGCGTATATATCCCTCTAGTAATC
ACAACATTTTAGGATTTAGGGATACCCGCTTCCTCTTTTTCTTGCAAGTTTTAAATTTCCAACCTTAAGTGAATTTGTGGACCAAATTTC
AAAGGAACTTTTTGTGTAGTCAGTTCTTGCACAATGTGTTTGGTAAACAAACTCAAAATGGATTCTTAGGAGCATTTTAGTGTTTATTAA
ATAACTGACCATTTGCTGTAGAAAGATGAGAAAACTTAAGCTTTGTTTTACTACAACTTGTACAAAGTTGTATGACAGGGCATATTCTTT
GCTTCCAAGATTTGGGTTGGGGGCACTAGGGGTTCAGAGCCTGGCAGAATTGTCAGCTTTAGTCTGACATAATCTAAGGGTATGGGGCAA
GGATCACATCTAATGCTTGTGTTCCTTATACTCTATTATATAGTGTTATTCATGATTCAGCTGATCTTAACAAAATTCGTAGCAGTGGAA
CCTTGAAATGCATGTGGCTAGATTTATGCTAAAATGATTCTCAGTTAGCATTTTAGTAACACTTCAAAGGTTTTTTTTTGTTTGTTTTCT
AGACTTAATAAAAGCTTAGGATTAATTAGAAGAAGCAATCTAGTTAAATTTCCCATTTGTATTTTATTTTCTTGAATACTTTTTTCATAG
TTATTTGTTTAAAAAGATTTAAAAATCATTGCACTTTGGTCAGAAAAATAATAAATATATCTTATAAATGTTTGATTCCCTTCCTTGCTA
TTTTTATTCAGTAGATTTTTGTTTGGCATCATGTTGAAGCACCGAAAGATAAATGATTTTTAAAAGGCTATAGAGTCCAAAGGAATATTC
TTTTACACCAATTCTTCCTTTAAAAATCTCTGAGGAATTTGTTTTCGCCTTACTTTTTTTTCTTCTGTCACAATGCTAAGTGGTATCCGA
GGTTCTTAATATGAGATTTAAAATCTTAAAATGTTTCTTATTTTCAGCACTTACATCATTTGGTACACAGGGTCAAATAGGGCAAATAAT
TTTGTCTTTGTATAATAGATTTGATATTTAAAGTCACTGGAAATAGGACAAGTTAATGGATGTTTTTATATTTTAATAGAATCATTTATT
TCTATGTGTTATGAAATTCACTTAATGATAAATTTTTCAACATACTTGCCATTAGAAAACAAAGTATTGCTAAGTACTATAACATATTGG
CCACTAAAATTCATATTGAGATTATCTTGGTTTCTTGGAAGAGATAGGAATGAGTTCTTATCTAGTGTTGCAGGCCAGCAAATACAGAGG
TGGTTTAATCAAACAGCTCTAGTATGAAGCAAGAGTAAAGACTAAGGTTTCGAGAGCATTCCTACTCACATAAGTGAAGAAATCTGTCAG
ATAGGAATCTAAATATTTATAGTGAGATTGTGAAAGCAACCTTAAAGTTTTGAAGAAGACTGATGAGACTAGGTGCTTTGCTTCCTTTCA
TCAGGTATCTTTCTGTGGCATTTGAGAACAGAAACCAAGAAACATGGTAATTACTAAATTATGAGGCTTTGCTTTTTGTTTGCTTTTAAG
TAGAAAAACATGTTGGCAACATTGAGTTTTGGAGTTGATTGAGATAATATGACTTAACTAGTTTTGTCATTCCATTTGTTAAAGATACAG
TCACCAAGAATGTTTTGAGTTTTTTGAAAGACCCCAATTTAAGCCTTGCTTATTTTTAAATTATTTCCATTCAGTGATGTTGGATGTATA


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FusionGenePPI for UVRAG_CMPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UVRAGBECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226LCMPK1ELAVL1, MOV10, NXF1, TTC19, ACOT13, ETFA, ECE2, NIT2, TATDN1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UVRAG_CMPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCMPK1P30085DB00441GemcitabineUMP-CMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}small moleculeapproved

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RelatedDiseases for UVRAG_CMPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource