	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 41280

FusionGeneSummary for UTRN_WIF1

Fusion gene summary

Fusion gene information	Fusion gene name: UTRN_WIF1
	Fusion gene ID: 41280
		Hgene	Tgene
	Gene symbol	UTRN	WIF1
	Gene ID	7402	11197
	Gene name	utrophin	WNT inhibitory factor 1
	Synonyms	DMDL\|DRP\|DRP1	WIF-1
	Cytomap	6q24.2	12q14.3
	Type of gene	protein-coding	protein-coding
	Description	utrophinDRP-1dystrophin-related protein 1	wnt inhibitory factor 1
	Modification date	20180519	20180523
	UniProtAcc	P46939	Q9Y5W5
	Ensembl transtripts involved in fusion gene	ENST00000367545, ENST00000367526, ENST00000480333,	ENST00000286574,
Fusion gene scores	* DoF score	24 X 22 X 7=3696	8 X 8 X 4=256
	# samples	25	12
	** MAII score	log2(25/3696*10)=-3.88596475675397 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/256*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UTRN [Title/Abstract] AND WIF1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-HB-A3YV-01A	UTRN	chr6	144809970	+	WIF1	chr12	65471634	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000367545	ENST00000286574	UTRN	chr6	144809970	+	WIF1	chr12	65471634	-
intron-3CDS	ENST00000367526	ENST00000286574	UTRN	chr6	144809970	+	WIF1	chr12	65471634	-
intron-3CDS	ENST00000480333	ENST00000286574	UTRN	chr6	144809970	+	WIF1	chr12	65471634	-

Top

FusionProtFeatures for UTRN_WIF1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UTRN P46939	WIF1 Q9Y5W5
May play a role in anchoring the cytoskeleton to theplasma membrane. {ECO:0000250}.	Binds to WNT proteins and inhibits their activities. Maybe involved in mesoderm segmentation.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

150_255

1378

3434

Domain

Calponin-homology (CH) 2

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

31_135

1378

3434

Domain

Calponin-homology (CH) 1

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1_246

1378

3434

Region

Note=Actin-binding

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1019_1121

1378

3434

Repeat

Spectrin 7

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1128_1229

1378

3434

Repeat

Spectrin 8

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1236_1333

1378

3434

Repeat

Spectrin 9

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

312_416

1378

3434

Repeat

Spectrin 1

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

421_525

1378

3434

Repeat

Spectrin 2

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

532_636

1378

3434

Repeat

Spectrin 3

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

690_795

1378

3434

Repeat

Spectrin 4

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

801_901

1378

3434

Repeat

Spectrin 5

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

910_1012

1378

3434

Repeat

Spectrin 6

Tgene

WIF1

chr6:144809970

chr12:65471634

ENST00000286574

178_210

380

Domain

EGF-like 1

Tgene

WIF1

chr6:144809970

chr12:65471634

ENST00000286574

211_242

380

Domain

EGF-like 2

Tgene

WIF1

chr6:144809970

chr12:65471634

ENST00000286574

243_271

380

Domain

EGF-like 3

Tgene

WIF1

chr6:144809970

chr12:65471634

ENST00000286574

274_306

380

Domain

EGF-like 4

Tgene

WIF1

chr6:144809970

chr12:65471634

ENST00000286574

307_338

380

Domain

EGF-like 5

- In-frame and not-retained protein feature among the 13 regional features.

>>>>>>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

2812_2845

1378

3434

Domain

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1335_1436

1378

3434

Repeat

Spectrin 10

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1438_1540

1378

3434

Repeat

Spectrin 11

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1547_1648

1378

3434

Repeat

Spectrin 12

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1653_1747

1378

3434

Repeat

Spectrin 13

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1748_1848

1378

3434

Repeat

Spectrin 14

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1849_1968

1378

3434

Repeat

Spectrin 15

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

1979_2080

1378

3434

Repeat

Spectrin 16

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

2087_2186

1378

3434

Repeat

Spectrin 17

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

2229_2332

1378

3434

Repeat

Spectrin 18

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

2349_2439

1378

3434

Repeat

Spectrin 19

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

2446_2555

1378

3434

Repeat

Spectrin 20

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

2562_2687

1378

3434

Repeat

Spectrin 21

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

2694_2796

1378

3434

Repeat

Spectrin 22

Hgene

UTRN

chr6:144809970

chr12:65471634

ENST00000367545

3064_3111

1378

3434

Zinc finger

ZZ-type

Tgene

WIF1

chr6:144809970

chr12:65471634

ENST00000286574

38_177

380

Domain

WIF

Top

FusionGeneSequence for UTRN_WIF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_UTRN_ENST00000367545_chr6_144809970_+_WIF1_ENST00000286574_chr12_65471634_-_1662aa
MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGSTRVHAL
NNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWT
DGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLP
RKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELT
AHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLD
DDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL
LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLED
SSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMK
MQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDEL
EKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHL
ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEF
DDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE
TNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKR
AKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE
VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQ
ESLGELDKQLTTYLTDRIDAFQVPQEAQAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDVIVMN
SEGNTILQTPQNAIFFKTCQQAECPGGCRNGGFCNERRICECPDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGVNCDKANCST
TCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCQEGWHGRHCN

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_UTRN_ENST00000367545_chr6_144809970_+_WIF1_ENST00000286574_chr12_65471634_-_4986nt
ATGGCCAAGTATGGAGAACATGAAGCCAGTCCTGACAATGGGCAGAACGAATTCAGTGATATCATTAAGTCCAGATCTGATGAACACAAT
GACGTACAGAAGAAAACCTTTACCAAATGGATAAATGCTCGATTTTCAAAGAGTGGGAAACCACCCATCAATGATATGTTCACAGACCTC
AAAGATGGAAGGAAGCTATTGGATCTTCTAGAAGGCCTCACAGGAACATCACTGCCAAAGGAACGTGGTTCCACAAGGGTACATGCCTTA
AATAACGTCAACAGAGTGCTGCAGGTTTTACATCAGAACAATGTGGAATTAGTGAATATAGGGGGAACTGACATTGTGGATGGAAATCAC
AAACTGACTTTGGGGTTACTTTGGAGCATCATTTTGCACTGGCAGGTGAAAGATGTCATGAAGGATGTCATGTCGGACCTGCAGCAGACG
AACAGTGAGAAGATCCTGCTCAGCTGGGTGCGTCAGACCACCAGGCCCTACAGCCAAGTCAACGTCCTCAACTTCACCACCAGCTGGACA
GATGGACTCGCCTTTAATGCTGTCCTCCACCGACATAAACCTGATCTCTTCAGCTGGGATAAAGTTGTCAAAATGTCACCAATTGAGAGA
CTTGAACATGCCTTCAGCAAGGCTCAAACTTATTTGGGAATTGAAAAGCTGTTAGATCCTGAAGATGTTGCCGTTCAGCTTCCTGACAAG
AAATCCATAATTATGTATTTAACATCTTTGTTTGAGGTGCTACCTCAGCAAGTCACCATAGACGCCATCCGTGAGGTAGAGACACTCCCA
AGGAAATATAAAAAAGAATGTGAAGAAGAGGCAATTAATATACAGAGTACAGCGCCTGAGGAGGAGCATGAGAGTCCCCGAGCTGAAACT
CCCAGCACTGTCACTGAGGTTGACATGGATCTGGACAGCTATCAGATTGCGTTGGAGGAAGTGCTGACCTGGTTGCTTTCTGCTGAGGAC
ACTTTCCAGGAGCAGGATGATATTTCTGATGATGTTGAAGAAGTCAAAGACCAGTTTGCAACCCATGAAGCTTTTATGATGGAACTGACT
GCACACCAGAGCAGTGTGGGCAGCGTCCTGCAGGCAGGCAACCAACTGATAACACAAGGAACTCTGTCAGACGAAGAAGAATTTGAGATT
CAGGAACAGATGACCCTGCTGAATGCTAGATGGGAGGCTCTTAGGGTGGAGAGTATGGACAGACAGTCCCGGCTGCACGATGTGCTGATG
GAACTGCAGAAGAAGCAACTGCAGCAGCTCTCCGCCTGGTTAACACTCACAGAGGAGCGCATTCAGAAGATGGAAACTTGCCCCCTGGAT
GATGATGTAAAATCTCTACAAAAGCTGCTAGAAGAACATAAAAGTTTGCAAAGTGATCTTGAGGCTGAACAGGTGAAAGTAAATTCACTA
ACTCACATGGTGGTCATTGTTGATGAAAACAGTGGTGAGAGTGCTACAGCTATCCTAGAAGACCAGTTACAGAAACTTGGTGAGCGCTGG
ACAGCAGTATGCCGTTGGACTGAAGAACGCTGGAATAGGTTACAAGAAATCAATATATTGTGGCAGGAATTATTGGAAGAACAGTGCTTG
TTGAAAGCTTGGTTAACCGAAAAAGAAGAGGCTTTAAATAAAGTCCAGACAAGCAACTTCAAAGACCAAAAGGAACTAAGTGTCAGTGTT
CGACGTCTGGCTATTTTGAAGGAAGACATGGAAATGAAGCGTCAAACATTGGATCAGCTGAGTGAGATTGGCCAGGATGTGGGACAATTA
CTTGATAATTCCAAGGCATCTAAGAAGATCAACAGTGACTCAGAGGAACTGACTCAAAGATGGGATTCTTTGGTTCAGAGACTAGAAGAT
TCCTCCAACCAGGTGACTCAGGCTGTAGCAAAGCTGGGGATGTCTCAGATTCCTCAGAAGGACCTTTTGGAGACTGTTCGTGTAAGAGAA
CAAGCAATTACAAAAAAATCTAAGCAGGAACTGCCTCCTCCTCCTCCCCCAAAGAAGAGACAGATCCATGTGGATATTGAAGCTAAGAAA
AAGTTTGATGCTATAAGTGCAGAGCTGTTGAACTGGATTTTGAAATGGAAAACTGCCATTCAGACCACAGAGATAAAAGAGTATATGAAG
ATGCAAGACACTTCCGAAATGAAAAAGAAGTTGAAGGCATTAGAAAAAGAACAGAGAGAAAGAATCCCCAGAGCAGATGAATTAAACCAA
ACTGGACAAATCCTTGTGGAGCAAATGGGAAAAGAAGGCCTTCCTACTGAAGAAATAAAAAATGTTCTGGAGAAGGTTTCATCAGAATGG
AAGAATGTATCTCAACATTTGGAAGATCTAGAAAGAAAGATTCAGCTACAGGAAGATATAAATGCTTATTTCAAGCAGCTTGATGAGCTT
GAAAAGGTCATCAAGACAAAGGAGGAGTGGGTAAAACACACTTCCATTTCTGAATCTTCCCGGCAGTCCTTGCCAAGCTTGAAGGATTCC
TGTCAGCGGGAATTGACAAATCTTCTTGGCCTTCACCCCAAAATTGAAATGGCTCGTGCAAGCTGCTCGGCCCTGATGTCTCAGCCTTCT
GCCCCAGATTTTGTCCAGCGGGGCTTCGATAGCTTTCTGGGCCGCTACCAAGCTGTACAAGAGGCTGTAGAGGATCGTCAACAACATCTA
GAGAATGAACTGAAGGGCCAACCTGGACATGCATATCTGGAAACATTGAAAACACTGAAAGATGTGCTAAATGATTCAGAAAATAAGGCC
CAGGTGTCTCTGAATGTCCTTAATGATCTTGCCAAGGTGGAGAAGGCCCTGCAAGAAAAAAAGACCCTTGATGAAATCCTTGAGAATCAG
AAACCTGCATTACATAAACTTGCAGAAGAAACAAAGGCTCTGGAGAAAAATGTTCATCCTGATGTAGAAAAATTATATAAGCAAGAATTT
GATGATGTGCAAGGAAAGTGGAACAAGCTAAAGGTCTTGGTTTCCAAAGATCTACATTTGCTTGAGGAAATTGCTCTCACACTCAGAGCT
TTTGAGGCCGATTCAACAGTCATTGAGAAGTGGATGGATGGCGTGAAAGACTTCTTAATGAAACAGCAGGCTGCCCAAGGAGACGACGCA
GGTCTACAGAGGCAGTTAGACCAGTGCTCTGCATTTGTTAATGAAATAGAAACAATTGAATCATCTCTGAAAAACATGAAGGAAATAGAG
ACTAATCTTCGAAGTGGTCCAGTTGCTGGAATAAAAACTTGGGTGCAGACAAGACTAGGTGACTACCAAACTCAACTGGAGAAACTTAGC
AAGGAGATCGCTACTCAAAAAAGTAGGTTGTCTGAAAGTCAAGAAAAAGCTGCGAACCTGAAGAAAGACTTGGCAGAGATGCAGGAATGG
ATGACCCAGGCCGAGGAAGAATATTTGGAGCGGGATTTTGAGTACAAGTCACCAGAAGAGCTTGAGAGTGCTGTGGAAGAGATGAAGAGG
GCAAAAGAGGATGTGTTGCAGAAGGAGGTGAGAGTGAAGATTCTCAAGGACAACATCAAGTTATTAGCTGCCAAGGTGCCCTCTGGTGGC
CAGGAGTTGACGTCTGAGCTGAATGTTGTGCTGGAGAATTACCAACTTCTTTGTAATAGAATTCGAGGAAAGTGCCACACGCTAGAGGAG
GTCTGGTCTTGTTGGATTGAACTGCTTCACTATTTGGATCTTGAAACTACCTGGTTAAACACTTTGGAAGAGCGGATGAAGAGCACAGAG
GTCCTGCCTGAGAAGACGGATGCTGTCAACGAAGCCCTGGAGTCTCTGGAATCTGTTCTGCGCCACCCGGCAGATAATCGCACCCAGATT
CGAGAGCTTGGCCAGACTCTGATTGATGGGGGGATCCTGGATGATATAATCAGTGAGAAACTGGAGGCTTTCAACAGCCGATATGAAGAT
CTAAGTCACCTGGCAGAGAGCAAGCAGATTTCTTTGGAAAAGCAACTCCAGGTGCTGCGGGAAACTGACCAGATGCTTCAAGTCTTGCAA
GAGAGCTTGGGGGAGCTGGACAAACAGCTCACCACATACCTGACTGACAGGATAGATGCTTTCCAAGTTCCACAGGAAGCTCAGGCAGAA
TACTTCTATGAATTCCTGTCCTTGCGCTCCCTGGATAAAGGCATCATGGCAGATCCAACCGTCAATGTCCCTCTGCTGGGAACAGTGCCT
CACAAGGCATCAGTTGTTCAAGTTGGTTTCCCATGTCTTGGAAAACAGGATGGGGTGGCAGCATTTGAAGTGGATGTGATTGTTATGAAT
TCTGAAGGCAACACCATTCTCCAAACACCTCAAAATGCTATCTTCTTTAAAACATGTCAACAAGCTGAGTGCCCAGGCGGGTGCCGAAAT
GGAGGCTTTTGTAATGAAAGACGCATCTGCGAGTGTCCTGATGGGTTCCACGGACCTCACTGTGAGAAAGCCCTTTGTACCCCACGATGT
ATGAATGGTGGACTTTGTGTGACTCCTGGTTTCTGCATCTGCCCACCTGGATTCTATGGAGTGAACTGTGACAAAGCAAACTGCTCAACC
ACCTGCTTTAATGGAGGGACCTGTTTCTACCCTGGAAAATGTATTTGCCCTCCAGGACTAGAGGGAGAGCAGTGTGAAATCAGCAAATGC
CCACAACCCTGTCGAAATGGAGGTAAATGCATTGGTAAAAGCAAATGTAAGTGTTCCAAAGGTTACCAGGGAGACCTCTGTTCAAAGCCT
GTCTGCGAGCCTGGCTGTGGTGCACATGGAACCTGCCATGAACCCAACAAATGCCAATGTCAAGAAGGTTGGCATGGAAGACACTGCAAT
AAAAGGTACGAAGCCAGCCTCATACATGCCCTGAGGCCAGCAGGCGCCCAGCTCAGGCAGCACACGCCTTCACTTAAAAAGGCCGAGGAG

* Fusion transcript sequences (Full-length transcript).

>In-frame_UTRN_ENST00000367545_chr6_144809970_+_WIF1_ENST00000286574_chr12_65471634_-_5709nt
ATGGCCAAGTATGGAGAACATGAAGCCAGTCCTGACAATGGGCAGAACGAATTCAGTGATATCATTAAGTCCAGATCTGATGAACACAAT
GACGTACAGAAGAAAACCTTTACCAAATGGATAAATGCTCGATTTTCAAAGAGTGGGAAACCACCCATCAATGATATGTTCACAGACCTC
AAAGATGGAAGGAAGCTATTGGATCTTCTAGAAGGCCTCACAGGAACATCACTGCCAAAGGAACGTGGTTCCACAAGGGTACATGCCTTA
AATAACGTCAACAGAGTGCTGCAGGTTTTACATCAGAACAATGTGGAATTAGTGAATATAGGGGGAACTGACATTGTGGATGGAAATCAC
AAACTGACTTTGGGGTTACTTTGGAGCATCATTTTGCACTGGCAGGTGAAAGATGTCATGAAGGATGTCATGTCGGACCTGCAGCAGACG
AACAGTGAGAAGATCCTGCTCAGCTGGGTGCGTCAGACCACCAGGCCCTACAGCCAAGTCAACGTCCTCAACTTCACCACCAGCTGGACA
GATGGACTCGCCTTTAATGCTGTCCTCCACCGACATAAACCTGATCTCTTCAGCTGGGATAAAGTTGTCAAAATGTCACCAATTGAGAGA
CTTGAACATGCCTTCAGCAAGGCTCAAACTTATTTGGGAATTGAAAAGCTGTTAGATCCTGAAGATGTTGCCGTTCAGCTTCCTGACAAG
AAATCCATAATTATGTATTTAACATCTTTGTTTGAGGTGCTACCTCAGCAAGTCACCATAGACGCCATCCGTGAGGTAGAGACACTCCCA
AGGAAATATAAAAAAGAATGTGAAGAAGAGGCAATTAATATACAGAGTACAGCGCCTGAGGAGGAGCATGAGAGTCCCCGAGCTGAAACT
CCCAGCACTGTCACTGAGGTTGACATGGATCTGGACAGCTATCAGATTGCGTTGGAGGAAGTGCTGACCTGGTTGCTTTCTGCTGAGGAC
ACTTTCCAGGAGCAGGATGATATTTCTGATGATGTTGAAGAAGTCAAAGACCAGTTTGCAACCCATGAAGCTTTTATGATGGAACTGACT
GCACACCAGAGCAGTGTGGGCAGCGTCCTGCAGGCAGGCAACCAACTGATAACACAAGGAACTCTGTCAGACGAAGAAGAATTTGAGATT
CAGGAACAGATGACCCTGCTGAATGCTAGATGGGAGGCTCTTAGGGTGGAGAGTATGGACAGACAGTCCCGGCTGCACGATGTGCTGATG
GAACTGCAGAAGAAGCAACTGCAGCAGCTCTCCGCCTGGTTAACACTCACAGAGGAGCGCATTCAGAAGATGGAAACTTGCCCCCTGGAT
GATGATGTAAAATCTCTACAAAAGCTGCTAGAAGAACATAAAAGTTTGCAAAGTGATCTTGAGGCTGAACAGGTGAAAGTAAATTCACTA
ACTCACATGGTGGTCATTGTTGATGAAAACAGTGGTGAGAGTGCTACAGCTATCCTAGAAGACCAGTTACAGAAACTTGGTGAGCGCTGG
ACAGCAGTATGCCGTTGGACTGAAGAACGCTGGAATAGGTTACAAGAAATCAATATATTGTGGCAGGAATTATTGGAAGAACAGTGCTTG
TTGAAAGCTTGGTTAACCGAAAAAGAAGAGGCTTTAAATAAAGTCCAGACAAGCAACTTCAAAGACCAAAAGGAACTAAGTGTCAGTGTT
CGACGTCTGGCTATTTTGAAGGAAGACATGGAAATGAAGCGTCAAACATTGGATCAGCTGAGTGAGATTGGCCAGGATGTGGGACAATTA
CTTGATAATTCCAAGGCATCTAAGAAGATCAACAGTGACTCAGAGGAACTGACTCAAAGATGGGATTCTTTGGTTCAGAGACTAGAAGAT
TCCTCCAACCAGGTGACTCAGGCTGTAGCAAAGCTGGGGATGTCTCAGATTCCTCAGAAGGACCTTTTGGAGACTGTTCGTGTAAGAGAA
CAAGCAATTACAAAAAAATCTAAGCAGGAACTGCCTCCTCCTCCTCCCCCAAAGAAGAGACAGATCCATGTGGATATTGAAGCTAAGAAA
AAGTTTGATGCTATAAGTGCAGAGCTGTTGAACTGGATTTTGAAATGGAAAACTGCCATTCAGACCACAGAGATAAAAGAGTATATGAAG
ATGCAAGACACTTCCGAAATGAAAAAGAAGTTGAAGGCATTAGAAAAAGAACAGAGAGAAAGAATCCCCAGAGCAGATGAATTAAACCAA
ACTGGACAAATCCTTGTGGAGCAAATGGGAAAAGAAGGCCTTCCTACTGAAGAAATAAAAAATGTTCTGGAGAAGGTTTCATCAGAATGG
AAGAATGTATCTCAACATTTGGAAGATCTAGAAAGAAAGATTCAGCTACAGGAAGATATAAATGCTTATTTCAAGCAGCTTGATGAGCTT
GAAAAGGTCATCAAGACAAAGGAGGAGTGGGTAAAACACACTTCCATTTCTGAATCTTCCCGGCAGTCCTTGCCAAGCTTGAAGGATTCC
TGTCAGCGGGAATTGACAAATCTTCTTGGCCTTCACCCCAAAATTGAAATGGCTCGTGCAAGCTGCTCGGCCCTGATGTCTCAGCCTTCT
GCCCCAGATTTTGTCCAGCGGGGCTTCGATAGCTTTCTGGGCCGCTACCAAGCTGTACAAGAGGCTGTAGAGGATCGTCAACAACATCTA
GAGAATGAACTGAAGGGCCAACCTGGACATGCATATCTGGAAACATTGAAAACACTGAAAGATGTGCTAAATGATTCAGAAAATAAGGCC
CAGGTGTCTCTGAATGTCCTTAATGATCTTGCCAAGGTGGAGAAGGCCCTGCAAGAAAAAAAGACCCTTGATGAAATCCTTGAGAATCAG
AAACCTGCATTACATAAACTTGCAGAAGAAACAAAGGCTCTGGAGAAAAATGTTCATCCTGATGTAGAAAAATTATATAAGCAAGAATTT
GATGATGTGCAAGGAAAGTGGAACAAGCTAAAGGTCTTGGTTTCCAAAGATCTACATTTGCTTGAGGAAATTGCTCTCACACTCAGAGCT
TTTGAGGCCGATTCAACAGTCATTGAGAAGTGGATGGATGGCGTGAAAGACTTCTTAATGAAACAGCAGGCTGCCCAAGGAGACGACGCA
GGTCTACAGAGGCAGTTAGACCAGTGCTCTGCATTTGTTAATGAAATAGAAACAATTGAATCATCTCTGAAAAACATGAAGGAAATAGAG
ACTAATCTTCGAAGTGGTCCAGTTGCTGGAATAAAAACTTGGGTGCAGACAAGACTAGGTGACTACCAAACTCAACTGGAGAAACTTAGC
AAGGAGATCGCTACTCAAAAAAGTAGGTTGTCTGAAAGTCAAGAAAAAGCTGCGAACCTGAAGAAAGACTTGGCAGAGATGCAGGAATGG
ATGACCCAGGCCGAGGAAGAATATTTGGAGCGGGATTTTGAGTACAAGTCACCAGAAGAGCTTGAGAGTGCTGTGGAAGAGATGAAGAGG
GCAAAAGAGGATGTGTTGCAGAAGGAGGTGAGAGTGAAGATTCTCAAGGACAACATCAAGTTATTAGCTGCCAAGGTGCCCTCTGGTGGC
CAGGAGTTGACGTCTGAGCTGAATGTTGTGCTGGAGAATTACCAACTTCTTTGTAATAGAATTCGAGGAAAGTGCCACACGCTAGAGGAG
GTCTGGTCTTGTTGGATTGAACTGCTTCACTATTTGGATCTTGAAACTACCTGGTTAAACACTTTGGAAGAGCGGATGAAGAGCACAGAG
GTCCTGCCTGAGAAGACGGATGCTGTCAACGAAGCCCTGGAGTCTCTGGAATCTGTTCTGCGCCACCCGGCAGATAATCGCACCCAGATT
CGAGAGCTTGGCCAGACTCTGATTGATGGGGGGATCCTGGATGATATAATCAGTGAGAAACTGGAGGCTTTCAACAGCCGATATGAAGAT
CTAAGTCACCTGGCAGAGAGCAAGCAGATTTCTTTGGAAAAGCAACTCCAGGTGCTGCGGGAAACTGACCAGATGCTTCAAGTCTTGCAA
GAGAGCTTGGGGGAGCTGGACAAACAGCTCACCACATACCTGACTGACAGGATAGATGCTTTCCAAGTTCCACAGGAAGCTCAGGCAGAA
TACTTCTATGAATTCCTGTCCTTGCGCTCCCTGGATAAAGGCATCATGGCAGATCCAACCGTCAATGTCCCTCTGCTGGGAACAGTGCCT
CACAAGGCATCAGTTGTTCAAGTTGGTTTCCCATGTCTTGGAAAACAGGATGGGGTGGCAGCATTTGAAGTGGATGTGATTGTTATGAAT
TCTGAAGGCAACACCATTCTCCAAACACCTCAAAATGCTATCTTCTTTAAAACATGTCAACAAGCTGAGTGCCCAGGCGGGTGCCGAAAT
GGAGGCTTTTGTAATGAAAGACGCATCTGCGAGTGTCCTGATGGGTTCCACGGACCTCACTGTGAGAAAGCCCTTTGTACCCCACGATGT
ATGAATGGTGGACTTTGTGTGACTCCTGGTTTCTGCATCTGCCCACCTGGATTCTATGGAGTGAACTGTGACAAAGCAAACTGCTCAACC
ACCTGCTTTAATGGAGGGACCTGTTTCTACCCTGGAAAATGTATTTGCCCTCCAGGACTAGAGGGAGAGCAGTGTGAAATCAGCAAATGC
CCACAACCCTGTCGAAATGGAGGTAAATGCATTGGTAAAAGCAAATGTAAGTGTTCCAAAGGTTACCAGGGAGACCTCTGTTCAAAGCCT
GTCTGCGAGCCTGGCTGTGGTGCACATGGAACCTGCCATGAACCCAACAAATGCCAATGTCAAGAAGGTTGGCATGGAAGACACTGCAAT
AAAAGGTACGAAGCCAGCCTCATACATGCCCTGAGGCCAGCAGGCGCCCAGCTCAGGCAGCACACGCCTTCACTTAAAAAGGCCGAGGAG
CGGCGGGATCCACCTGAATCCAATTACATCTGGTGAACTCCGACATCTGAAACGTTTTAAGTTACACCAAGTTCATAGCCTTTGTTAACC
TTTCATGTGTTGAATGTTCAAATAATGTTCATTACACTTAAGAATACTGGCCTGAATTTTATTAGCTTCATTATAAATCACTGAGCTGAT
ATTTACTCTTCCTTTTAAGTTTTCTAAGTACGTCTGTAGCATGATGGTATAGATTTTCTTGTTTCAGTGCTTTGGGACAGATTTTATATT
ATGTCAATTGATCAGGTTAAAATTTTCAGTGTGTAGTTGGCAGATATTTTCAAAATTACAATGCATTTATGGTGTCTGGGGGCAGGGGAA
CATCAGAAAGGTTAAATTGGGCAAAAATGCGTAAGTCACAAGAATTTGGATGGTGCAGTTAATGTTGAAGTTACAGCATTTCAGATTTTA
TTGTCAGATATTTAGATGTTTGTTACATTTTTAAAAATTGCTCTTAATTTTTAAACTCTCAATACAATATATTTTGACCTTACCATTATT
CCAGAGATTCAGTATTAAAAAAAAAAAAATTACACTGTGGTAGTGGCATTTAAACAATATAATATATTCTAAACACAATGAAATAGGGAA
TATAATGTATGAACTTTTTGCATTGGCTTGAAGCAATATAATATATTGTAAACAAAACACAGCTCTTACCTAATAAACATTTTATACTGT

Top

FusionGenePPI for UTRN_WIF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
UTRN	SNTA1, SNTB2, DAG1, UTRN, DTNA, PGM5, USP21, MARK2, PIK3CG, TERF1, TERF2, MME, DISC1, SIRT7, THOC1, RRP9, THOC2, THOC6, THOC5, UBE2D1, ZC3H15, XPO4, THOC3, UBE3C, PTPN12, NPM1, ADRA1D, LATS2, SAV1, OBSL1, CCDC8, L3HYPDH, IER2, USP7, CALM1, PTEN, MED4, TMEM17, PDK3, PI4KB, TTK, RBM8A, MCM2, ATOH1, CDH1, TENC1, TNS1, TNS3, SNTG2, NDEL1, DMD, CPNE5, FAM167A, RHPN1, PTRF, VHL, CPNE4, TTC30B, FAM189B, PHF19, TES	WIF1	WNT1, RPL37, ICOS, KRTAP10-8, KRTAP10-3, AURKA, FGFR4, RB1CC1

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	UTRN	chr6:144809970	chr12:65471634	ENST00000367545	+	29	74	268_905	1378	3434	SYNM

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	UTRN	chr6:144809970	chr12:65471634	ENST00000367545	+	29	74	1336_1768	1378	3434	SYNM
Hgene	UTRN	chr6:144809970	chr12:65471634	ENST00000367545	+	29	74	2798_3165	1378	3434	SYNM

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for UTRN_WIF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	UTRN	P46939	DB01593	Zinc	Utrophin	small molecule	approved\|investigational

Top

RelatedDiseases for UTRN_WIF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	WIF1	C0009404	Colorectal Neoplasms	1	CTD_human
Tgene	WIF1	C0014859	Esophageal Neoplasms	1	CTD_human
Tgene	WIF1	C0027439	Nasopharyngeal Neoplasms	1	CTD_human
Tgene	WIF1	C0038356	Stomach Neoplasms	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 41280

FusionGeneSummary for UTRN_WIF1

FusionProtFeatures for UTRN_WIF1

FusionGeneSequence for UTRN_WIF1

FusionGenePPI for UTRN_WIF1

RelatedDrugs for UTRN_WIF1

RelatedDiseases for UTRN_WIF1