FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 41273

FusionGeneSummary for UTRN_PLAGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: UTRN_PLAGL1
Fusion gene ID: 41273
HgeneTgene
Gene symbol

UTRN

PLAGL1

Gene ID

7402

5325

Gene nameutrophinPLAG1 like zinc finger 1
SynonymsDMDL|DRP|DRP1LOT1|ZAC|ZAC1
Cytomap

6q24.2

6q24.2

Type of geneprotein-codingprotein-coding
DescriptionutrophinDRP-1dystrophin-related protein 1zinc finger protein PLAGL1PLAG-like 1lost on transformation 1pleiomorphic adenoma gene-like 1tumor suppressor ZAC
Modification date2018051920180523
UniProtAcc

P46939

Q9UM63

Ensembl transtripts involved in fusion geneENST00000367545, ENST00000367526, 
ENST00000480333, 		ENST00000429150, 
ENST00000416623, ENST00000392309, 
ENST00000392307, ENST00000437412, 
ENST00000444202, ENST00000493898, 
ENST00000360537, ENST00000354765, 
ENST00000367572, ENST00000367571, 
Fusion gene scores* DoF score24 X 22 X 7=36966 X 4 X 4=96
# samples 256
** MAII scorelog2(25/3696*10)=-3.88596475675397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UTRN [Title/Abstract] AND PLAGL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLAGL1

GO:0045944

positive regulation of transcription by RNA polymerase II

9671765|15888726


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-CH-5741-01AUTRNchr6

144864006

+PLAGL1chr6

144306311

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367545ENST00000429150UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-5UTRENST00000367545ENST00000416623UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-intronENST00000367545ENST00000392309UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-intronENST00000367545ENST00000392307UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-intronENST00000367545ENST00000437412UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-5UTRENST00000367545ENST00000444202UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-5UTRENST00000367545ENST00000493898UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-intronENST00000367545ENST00000360537UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-intronENST00000367545ENST00000354765UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-intronENST00000367545ENST00000367572UTRNchr6

144864006

+PLAGL1chr6

144306311

-
5CDS-intronENST00000367545ENST00000367571UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000367526ENST00000429150UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-5UTRENST00000367526ENST00000416623UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000367526ENST00000392309UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000367526ENST00000392307UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000367526ENST00000437412UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-5UTRENST00000367526ENST00000444202UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-5UTRENST00000367526ENST00000493898UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000367526ENST00000360537UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000367526ENST00000354765UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000367526ENST00000367572UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000367526ENST00000367571UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000480333ENST00000429150UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-5UTRENST00000480333ENST00000416623UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000480333ENST00000392309UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000480333ENST00000392307UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000480333ENST00000437412UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-5UTRENST00000480333ENST00000444202UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-5UTRENST00000480333ENST00000493898UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000480333ENST00000360537UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000480333ENST00000354765UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000480333ENST00000367572UTRNchr6

144864006

+PLAGL1chr6

144306311

-
intron-intronENST00000480333ENST00000367571UTRNchr6

144864006

+PLAGL1chr6

144306311

-

Top

FusionProtFeatures for UTRN_PLAGL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UTRN

P46939

PLAGL1

Q9UM63

May play a role in anchoring the cytoskeleton to theplasma membrane. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for UTRN_PLAGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for UTRN_PLAGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UTRNSNTA1, SNTB2, DAG1, UTRN, DTNA, PGM5, USP21, MARK2, PIK3CG, TERF1, TERF2, MME, DISC1, SIRT7, THOC1, RRP9, THOC2, THOC6, THOC5, UBE2D1, ZC3H15, XPO4, THOC3, UBE3C, PTPN12, NPM1, ADRA1D, LATS2, SAV1, OBSL1, CCDC8, L3HYPDH, IER2, USP7, CALM1, PTEN, MED4, TMEM17, PDK3, PI4KB, TTK, RBM8A, MCM2, ATOH1, CDH1, TENC1, TNS1, TNS3, SNTG2, NDEL1, DMD, CPNE5, FAM167A, RHPN1, PTRF, VHL, CPNE4, TTC30B, FAM189B, PHF19, TESPLAGL1TP53, DAXX, PML, EP300, CREBBP, HDAC1, UBE2I, PIAS2, SMAD3, TP73, KAT2B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UTRN_PLAGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneUTRNP46939DB01593ZincUtrophinsmall moleculeapproved|investigational

Top

RelatedDiseases for UTRN_PLAGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLAGL1C0038356Stomach Neoplasms1CTD_human