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Fusion gene ID: 41273 |
FusionGeneSummary for UTRN_PLAGL1 |
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Fusion gene information | Fusion gene name: UTRN_PLAGL1 | Fusion gene ID: 41273 | Hgene | Tgene | Gene symbol | UTRN | PLAGL1 | Gene ID | 7402 | 5325 |
Gene name | utrophin | PLAG1 like zinc finger 1 | |
Synonyms | DMDL|DRP|DRP1 | LOT1|ZAC|ZAC1 | |
Cytomap | 6q24.2 | 6q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | utrophinDRP-1dystrophin-related protein 1 | zinc finger protein PLAGL1PLAG-like 1lost on transformation 1pleiomorphic adenoma gene-like 1tumor suppressor ZAC | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P46939 | Q9UM63 | |
Ensembl transtripts involved in fusion gene | ENST00000367545, ENST00000367526, ENST00000480333, | ENST00000429150, ENST00000416623, ENST00000392309, ENST00000392307, ENST00000437412, ENST00000444202, ENST00000493898, ENST00000360537, ENST00000354765, ENST00000367572, ENST00000367571, | |
Fusion gene scores | * DoF score | 24 X 22 X 7=3696 | 6 X 4 X 4=96 |
# samples | 25 | 6 | |
** MAII score | log2(25/3696*10)=-3.88596475675397 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UTRN [Title/Abstract] AND PLAGL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PLAGL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9671765|15888726 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-CH-5741-01A | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000367545 | ENST00000429150 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-5UTR | ENST00000367545 | ENST00000416623 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-intron | ENST00000367545 | ENST00000392309 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-intron | ENST00000367545 | ENST00000392307 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-intron | ENST00000367545 | ENST00000437412 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-5UTR | ENST00000367545 | ENST00000444202 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-5UTR | ENST00000367545 | ENST00000493898 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-intron | ENST00000367545 | ENST00000360537 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-intron | ENST00000367545 | ENST00000354765 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-intron | ENST00000367545 | ENST00000367572 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
5CDS-intron | ENST00000367545 | ENST00000367571 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000367526 | ENST00000429150 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-5UTR | ENST00000367526 | ENST00000416623 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000367526 | ENST00000392309 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000367526 | ENST00000392307 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000367526 | ENST00000437412 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-5UTR | ENST00000367526 | ENST00000444202 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-5UTR | ENST00000367526 | ENST00000493898 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000367526 | ENST00000360537 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000367526 | ENST00000354765 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000367526 | ENST00000367572 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000367526 | ENST00000367571 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000480333 | ENST00000429150 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-5UTR | ENST00000480333 | ENST00000416623 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000480333 | ENST00000392309 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000480333 | ENST00000392307 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000480333 | ENST00000437412 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-5UTR | ENST00000480333 | ENST00000444202 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-5UTR | ENST00000480333 | ENST00000493898 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000480333 | ENST00000360537 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000480333 | ENST00000354765 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000480333 | ENST00000367572 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
intron-intron | ENST00000480333 | ENST00000367571 | UTRN | chr6 | 144864006 | + | PLAGL1 | chr6 | 144306311 | - |
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FusionProtFeatures for UTRN_PLAGL1 |
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Hgene | Tgene |
UTRN | PLAGL1 |
May play a role in anchoring the cytoskeleton to theplasma membrane. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UTRN_PLAGL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UTRN_PLAGL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UTRN | SNTA1, SNTB2, DAG1, UTRN, DTNA, PGM5, USP21, MARK2, PIK3CG, TERF1, TERF2, MME, DISC1, SIRT7, THOC1, RRP9, THOC2, THOC6, THOC5, UBE2D1, ZC3H15, XPO4, THOC3, UBE3C, PTPN12, NPM1, ADRA1D, LATS2, SAV1, OBSL1, CCDC8, L3HYPDH, IER2, USP7, CALM1, PTEN, MED4, TMEM17, PDK3, PI4KB, TTK, RBM8A, MCM2, ATOH1, CDH1, TENC1, TNS1, TNS3, SNTG2, NDEL1, DMD, CPNE5, FAM167A, RHPN1, PTRF, VHL, CPNE4, TTC30B, FAM189B, PHF19, TES | PLAGL1 | TP53, DAXX, PML, EP300, CREBBP, HDAC1, UBE2I, PIAS2, SMAD3, TP73, KAT2B, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UTRN_PLAGL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | UTRN | P46939 | DB01593 | Zinc | Utrophin | small molecule | approved|investigational |
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RelatedDiseases for UTRN_PLAGL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PLAGL1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |