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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41268

FusionGeneSummary for UTRN_MSRA

check button Fusion gene summary
Fusion gene informationFusion gene name: UTRN_MSRA
Fusion gene ID: 41268
HgeneTgene
Gene symbol

UTRN

MSRA

Gene ID

7402

4482

Gene nameutrophinmethionine sulfoxide reductase A
SynonymsDMDL|DRP|DRP1PMSR
Cytomap

6q24.2

8p23.1

Type of geneprotein-codingprotein-coding
DescriptionutrophinDRP-1dystrophin-related protein 1mitochondrial peptide methionine sulfoxide reductasecytosolic methionine-S-sulfoxide reductasepeptide Met(O) reductasepeptide met (O) reductasepeptide-methionine (S)-S-oxide reductase
Modification date2018051920180519
UniProtAcc

P46939

Q9UJ68

Ensembl transtripts involved in fusion geneENST00000367545, ENST00000367526, 
ENST00000480333, 		ENST00000317173, 
ENST00000441698, ENST00000518255, 
ENST00000521209, ENST00000528246, 
ENST00000382490, ENST00000517594, 
Fusion gene scores* DoF score24 X 22 X 7=36964 X 4 X 3=48
# samples 256
** MAII scorelog2(25/3696*10)=-3.88596475675397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UTRN [Title/Abstract] AND MSRA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-CH-5746-01AUTRNchr6

144801118

+MSRAchr8

10285658

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367545ENST00000317173UTRNchr6

144801118

+MSRAchr8

10285658

+
Frame-shiftENST00000367545ENST00000441698UTRNchr6

144801118

+MSRAchr8

10285658

+
5CDS-intronENST00000367545ENST00000518255UTRNchr6

144801118

+MSRAchr8

10285658

+
5CDS-intronENST00000367545ENST00000521209UTRNchr6

144801118

+MSRAchr8

10285658

+
5CDS-intronENST00000367545ENST00000528246UTRNchr6

144801118

+MSRAchr8

10285658

+
5CDS-intronENST00000367545ENST00000382490UTRNchr6

144801118

+MSRAchr8

10285658

+
5CDS-intronENST00000367545ENST00000517594UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-3CDSENST00000367526ENST00000317173UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-3CDSENST00000367526ENST00000441698UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000367526ENST00000518255UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000367526ENST00000521209UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000367526ENST00000528246UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000367526ENST00000382490UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000367526ENST00000517594UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-3CDSENST00000480333ENST00000317173UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-3CDSENST00000480333ENST00000441698UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000480333ENST00000518255UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000480333ENST00000521209UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000480333ENST00000528246UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000480333ENST00000382490UTRNchr6

144801118

+MSRAchr8

10285658

+
intron-intronENST00000480333ENST00000517594UTRNchr6

144801118

+MSRAchr8

10285658

+

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FusionProtFeatures for UTRN_MSRA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UTRN

P46939

MSRA

Q9UJ68

May play a role in anchoring the cytoskeleton to theplasma membrane. {ECO:0000250}. Has an important function as a repair enzyme forproteins that have been inactivated by oxidation. Catalyzes thereversible oxidation-reduction of methionine sulfoxide in proteinsto methionine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+2574150_25511693434DomainCalponin-homology (CH) 2
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+257431_13511693434DomainCalponin-homology (CH) 1
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741_24611693434RegionNote=Actin-binding
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741019_112111693434RepeatSpectrin 7
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+2574312_41611693434RepeatSpectrin 1
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+2574421_52511693434RepeatSpectrin 2
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+2574532_63611693434RepeatSpectrin 3
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+2574690_79511693434RepeatSpectrin 4
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+2574801_90111693434RepeatSpectrin 5
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+2574910_101211693434RepeatSpectrin 6

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25742812_284511693434DomainWW
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741128_122911693434RepeatSpectrin 8
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741236_133311693434RepeatSpectrin 9
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741335_143611693434RepeatSpectrin 10
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741438_154011693434RepeatSpectrin 11
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741547_164811693434RepeatSpectrin 12
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741653_174711693434RepeatSpectrin 13
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741748_184811693434RepeatSpectrin 14
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741849_196811693434RepeatSpectrin 15
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741979_208011693434RepeatSpectrin 16
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25742087_218611693434RepeatSpectrin 17
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25742229_233211693434RepeatSpectrin 18
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25742349_243911693434RepeatSpectrin 19
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25742446_255511693434RepeatSpectrin 20
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25742562_268711693434RepeatSpectrin 21
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25742694_279611693434RepeatSpectrin 22
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25743064_311111693434Zinc fingerZZ-type


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FusionGeneSequence for UTRN_MSRA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UTRN_ENST00000367545_chr6_144801118_+_MSRA_ENST00000317173_chr8_10285658_+_1224aa
MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGSTRVHAL
NNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWT
DGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLP
RKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELT
AHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLD
DDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL
LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLED
SSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMK
MQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDEL
EKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHL
ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEF
DDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE
TNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UTRN_ENST00000367545_chr6_144801118_+_MSRA_ENST00000317173_chr8_10285658_+_3672nt
ATGGCCAAGTATGGAGAACATGAAGCCAGTCCTGACAATGGGCAGAACGAATTCAGTGATATCATTAAGTCCAGATCTGATGAACACAAT
GACGTACAGAAGAAAACCTTTACCAAATGGATAAATGCTCGATTTTCAAAGAGTGGGAAACCACCCATCAATGATATGTTCACAGACCTC
AAAGATGGAAGGAAGCTATTGGATCTTCTAGAAGGCCTCACAGGAACATCACTGCCAAAGGAACGTGGTTCCACAAGGGTACATGCCTTA
AATAACGTCAACAGAGTGCTGCAGGTTTTACATCAGAACAATGTGGAATTAGTGAATATAGGGGGAACTGACATTGTGGATGGAAATCAC
AAACTGACTTTGGGGTTACTTTGGAGCATCATTTTGCACTGGCAGGTGAAAGATGTCATGAAGGATGTCATGTCGGACCTGCAGCAGACG
AACAGTGAGAAGATCCTGCTCAGCTGGGTGCGTCAGACCACCAGGCCCTACAGCCAAGTCAACGTCCTCAACTTCACCACCAGCTGGACA
GATGGACTCGCCTTTAATGCTGTCCTCCACCGACATAAACCTGATCTCTTCAGCTGGGATAAAGTTGTCAAAATGTCACCAATTGAGAGA
CTTGAACATGCCTTCAGCAAGGCTCAAACTTATTTGGGAATTGAAAAGCTGTTAGATCCTGAAGATGTTGCCGTTCAGCTTCCTGACAAG
AAATCCATAATTATGTATTTAACATCTTTGTTTGAGGTGCTACCTCAGCAAGTCACCATAGACGCCATCCGTGAGGTAGAGACACTCCCA
AGGAAATATAAAAAAGAATGTGAAGAAGAGGCAATTAATATACAGAGTACAGCGCCTGAGGAGGAGCATGAGAGTCCCCGAGCTGAAACT
CCCAGCACTGTCACTGAGGTTGACATGGATCTGGACAGCTATCAGATTGCGTTGGAGGAAGTGCTGACCTGGTTGCTTTCTGCTGAGGAC
ACTTTCCAGGAGCAGGATGATATTTCTGATGATGTTGAAGAAGTCAAAGACCAGTTTGCAACCCATGAAGCTTTTATGATGGAACTGACT
GCACACCAGAGCAGTGTGGGCAGCGTCCTGCAGGCAGGCAACCAACTGATAACACAAGGAACTCTGTCAGACGAAGAAGAATTTGAGATT
CAGGAACAGATGACCCTGCTGAATGCTAGATGGGAGGCTCTTAGGGTGGAGAGTATGGACAGACAGTCCCGGCTGCACGATGTGCTGATG
GAACTGCAGAAGAAGCAACTGCAGCAGCTCTCCGCCTGGTTAACACTCACAGAGGAGCGCATTCAGAAGATGGAAACTTGCCCCCTGGAT
GATGATGTAAAATCTCTACAAAAGCTGCTAGAAGAACATAAAAGTTTGCAAAGTGATCTTGAGGCTGAACAGGTGAAAGTAAATTCACTA
ACTCACATGGTGGTCATTGTTGATGAAAACAGTGGTGAGAGTGCTACAGCTATCCTAGAAGACCAGTTACAGAAACTTGGTGAGCGCTGG
ACAGCAGTATGCCGTTGGACTGAAGAACGCTGGAATAGGTTACAAGAAATCAATATATTGTGGCAGGAATTATTGGAAGAACAGTGCTTG
TTGAAAGCTTGGTTAACCGAAAAAGAAGAGGCTTTAAATAAAGTCCAGACAAGCAACTTCAAAGACCAAAAGGAACTAAGTGTCAGTGTT
CGACGTCTGGCTATTTTGAAGGAAGACATGGAAATGAAGCGTCAAACATTGGATCAGCTGAGTGAGATTGGCCAGGATGTGGGACAATTA
CTTGATAATTCCAAGGCATCTAAGAAGATCAACAGTGACTCAGAGGAACTGACTCAAAGATGGGATTCTTTGGTTCAGAGACTAGAAGAT
TCCTCCAACCAGGTGACTCAGGCTGTAGCAAAGCTGGGGATGTCTCAGATTCCTCAGAAGGACCTTTTGGAGACTGTTCGTGTAAGAGAA
CAAGCAATTACAAAAAAATCTAAGCAGGAACTGCCTCCTCCTCCTCCCCCAAAGAAGAGACAGATCCATGTGGATATTGAAGCTAAGAAA
AAGTTTGATGCTATAAGTGCAGAGCTGTTGAACTGGATTTTGAAATGGAAAACTGCCATTCAGACCACAGAGATAAAAGAGTATATGAAG
ATGCAAGACACTTCCGAAATGAAAAAGAAGTTGAAGGCATTAGAAAAAGAACAGAGAGAAAGAATCCCCAGAGCAGATGAATTAAACCAA
ACTGGACAAATCCTTGTGGAGCAAATGGGAAAAGAAGGCCTTCCTACTGAAGAAATAAAAAATGTTCTGGAGAAGGTTTCATCAGAATGG
AAGAATGTATCTCAACATTTGGAAGATCTAGAAAGAAAGATTCAGCTACAGGAAGATATAAATGCTTATTTCAAGCAGCTTGATGAGCTT
GAAAAGGTCATCAAGACAAAGGAGGAGTGGGTAAAACACACTTCCATTTCTGAATCTTCCCGGCAGTCCTTGCCAAGCTTGAAGGATTCC
TGTCAGCGGGAATTGACAAATCTTCTTGGCCTTCACCCCAAAATTGAAATGGCTCGTGCAAGCTGCTCGGCCCTGATGTCTCAGCCTTCT
GCCCCAGATTTTGTCCAGCGGGGCTTCGATAGCTTTCTGGGCCGCTACCAAGCTGTACAAGAGGCTGTAGAGGATCGTCAACAACATCTA
GAGAATGAACTGAAGGGCCAACCTGGACATGCATATCTGGAAACATTGAAAACACTGAAAGATGTGCTAAATGATTCAGAAAATAAGGCC
CAGGTGTCTCTGAATGTCCTTAATGATCTTGCCAAGGTGGAGAAGGCCCTGCAAGAAAAAAAGACCCTTGATGAAATCCTTGAGAATCAG
AAACCTGCATTACATAAACTTGCAGAAGAAACAAAGGCTCTGGAGAAAAATGTTCATCCTGATGTAGAAAAATTATATAAGCAAGAATTT
GATGATGTGCAAGGAAAGTGGAACAAGCTAAAGGTCTTGGTTTCCAAAGATCTACATTTGCTTGAGGAAATTGCTCTCACACTCAGAGCT
TTTGAGGCCGATTCAACAGTCATTGAGAAGTGGATGGATGGCGTGAAAGACTTCTTAATGAAACAGCAGGCTGCCCAAGGAGACGACGCA
GGTCTACAGAGGCAGTTAGACCAGTGCTCTGCATTTGTTAATGAAATAGAAACAATTGAATCATCTCTGAAAAACATGAAGGAAATAGAG
ACTAATCTTCGAAGTGGTCCAGTTGCTGGAATAAAAACTTGGGTGCAGACAAGACTAGGTGACTACCAAACTCAACTGGAGAAACTTAGC
AAGGAGATCGCTACTCAAAAAAGTAGGTTGTCTGAAAGTCAAGAAAAAGCTGCGAACCTGAAGAAAGACTTGGCAGAGATGCAGGAATGG
ATGACCCAGGCCGAGGAAGAATATTTGGAGCGGGATTTTGAGTACAAGTCACCAGAAGAGCTTGAGAGTGCTGTGGAAGAGATGAAGGTT
CTTTCAGAGCACGGCTTCGGCCCCATCACTACCGACATCCGGGAGGGACAGACTTTCTACTATGCGGAAGACTACCACCAGCAGTACCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_UTRN_ENST00000367545_chr6_144801118_+_MSRA_ENST00000317173_chr8_10285658_+_4251nt
ATGGCCAAGTATGGAGAACATGAAGCCAGTCCTGACAATGGGCAGAACGAATTCAGTGATATCATTAAGTCCAGATCTGATGAACACAAT
GACGTACAGAAGAAAACCTTTACCAAATGGATAAATGCTCGATTTTCAAAGAGTGGGAAACCACCCATCAATGATATGTTCACAGACCTC
AAAGATGGAAGGAAGCTATTGGATCTTCTAGAAGGCCTCACAGGAACATCACTGCCAAAGGAACGTGGTTCCACAAGGGTACATGCCTTA
AATAACGTCAACAGAGTGCTGCAGGTTTTACATCAGAACAATGTGGAATTAGTGAATATAGGGGGAACTGACATTGTGGATGGAAATCAC
AAACTGACTTTGGGGTTACTTTGGAGCATCATTTTGCACTGGCAGGTGAAAGATGTCATGAAGGATGTCATGTCGGACCTGCAGCAGACG
AACAGTGAGAAGATCCTGCTCAGCTGGGTGCGTCAGACCACCAGGCCCTACAGCCAAGTCAACGTCCTCAACTTCACCACCAGCTGGACA
GATGGACTCGCCTTTAATGCTGTCCTCCACCGACATAAACCTGATCTCTTCAGCTGGGATAAAGTTGTCAAAATGTCACCAATTGAGAGA
CTTGAACATGCCTTCAGCAAGGCTCAAACTTATTTGGGAATTGAAAAGCTGTTAGATCCTGAAGATGTTGCCGTTCAGCTTCCTGACAAG
AAATCCATAATTATGTATTTAACATCTTTGTTTGAGGTGCTACCTCAGCAAGTCACCATAGACGCCATCCGTGAGGTAGAGACACTCCCA
AGGAAATATAAAAAAGAATGTGAAGAAGAGGCAATTAATATACAGAGTACAGCGCCTGAGGAGGAGCATGAGAGTCCCCGAGCTGAAACT
CCCAGCACTGTCACTGAGGTTGACATGGATCTGGACAGCTATCAGATTGCGTTGGAGGAAGTGCTGACCTGGTTGCTTTCTGCTGAGGAC
ACTTTCCAGGAGCAGGATGATATTTCTGATGATGTTGAAGAAGTCAAAGACCAGTTTGCAACCCATGAAGCTTTTATGATGGAACTGACT
GCACACCAGAGCAGTGTGGGCAGCGTCCTGCAGGCAGGCAACCAACTGATAACACAAGGAACTCTGTCAGACGAAGAAGAATTTGAGATT
CAGGAACAGATGACCCTGCTGAATGCTAGATGGGAGGCTCTTAGGGTGGAGAGTATGGACAGACAGTCCCGGCTGCACGATGTGCTGATG
GAACTGCAGAAGAAGCAACTGCAGCAGCTCTCCGCCTGGTTAACACTCACAGAGGAGCGCATTCAGAAGATGGAAACTTGCCCCCTGGAT
GATGATGTAAAATCTCTACAAAAGCTGCTAGAAGAACATAAAAGTTTGCAAAGTGATCTTGAGGCTGAACAGGTGAAAGTAAATTCACTA
ACTCACATGGTGGTCATTGTTGATGAAAACAGTGGTGAGAGTGCTACAGCTATCCTAGAAGACCAGTTACAGAAACTTGGTGAGCGCTGG
ACAGCAGTATGCCGTTGGACTGAAGAACGCTGGAATAGGTTACAAGAAATCAATATATTGTGGCAGGAATTATTGGAAGAACAGTGCTTG
TTGAAAGCTTGGTTAACCGAAAAAGAAGAGGCTTTAAATAAAGTCCAGACAAGCAACTTCAAAGACCAAAAGGAACTAAGTGTCAGTGTT
CGACGTCTGGCTATTTTGAAGGAAGACATGGAAATGAAGCGTCAAACATTGGATCAGCTGAGTGAGATTGGCCAGGATGTGGGACAATTA
CTTGATAATTCCAAGGCATCTAAGAAGATCAACAGTGACTCAGAGGAACTGACTCAAAGATGGGATTCTTTGGTTCAGAGACTAGAAGAT
TCCTCCAACCAGGTGACTCAGGCTGTAGCAAAGCTGGGGATGTCTCAGATTCCTCAGAAGGACCTTTTGGAGACTGTTCGTGTAAGAGAA
CAAGCAATTACAAAAAAATCTAAGCAGGAACTGCCTCCTCCTCCTCCCCCAAAGAAGAGACAGATCCATGTGGATATTGAAGCTAAGAAA
AAGTTTGATGCTATAAGTGCAGAGCTGTTGAACTGGATTTTGAAATGGAAAACTGCCATTCAGACCACAGAGATAAAAGAGTATATGAAG
ATGCAAGACACTTCCGAAATGAAAAAGAAGTTGAAGGCATTAGAAAAAGAACAGAGAGAAAGAATCCCCAGAGCAGATGAATTAAACCAA
ACTGGACAAATCCTTGTGGAGCAAATGGGAAAAGAAGGCCTTCCTACTGAAGAAATAAAAAATGTTCTGGAGAAGGTTTCATCAGAATGG
AAGAATGTATCTCAACATTTGGAAGATCTAGAAAGAAAGATTCAGCTACAGGAAGATATAAATGCTTATTTCAAGCAGCTTGATGAGCTT
GAAAAGGTCATCAAGACAAAGGAGGAGTGGGTAAAACACACTTCCATTTCTGAATCTTCCCGGCAGTCCTTGCCAAGCTTGAAGGATTCC
TGTCAGCGGGAATTGACAAATCTTCTTGGCCTTCACCCCAAAATTGAAATGGCTCGTGCAAGCTGCTCGGCCCTGATGTCTCAGCCTTCT
GCCCCAGATTTTGTCCAGCGGGGCTTCGATAGCTTTCTGGGCCGCTACCAAGCTGTACAAGAGGCTGTAGAGGATCGTCAACAACATCTA
GAGAATGAACTGAAGGGCCAACCTGGACATGCATATCTGGAAACATTGAAAACACTGAAAGATGTGCTAAATGATTCAGAAAATAAGGCC
CAGGTGTCTCTGAATGTCCTTAATGATCTTGCCAAGGTGGAGAAGGCCCTGCAAGAAAAAAAGACCCTTGATGAAATCCTTGAGAATCAG
AAACCTGCATTACATAAACTTGCAGAAGAAACAAAGGCTCTGGAGAAAAATGTTCATCCTGATGTAGAAAAATTATATAAGCAAGAATTT
GATGATGTGCAAGGAAAGTGGAACAAGCTAAAGGTCTTGGTTTCCAAAGATCTACATTTGCTTGAGGAAATTGCTCTCACACTCAGAGCT
TTTGAGGCCGATTCAACAGTCATTGAGAAGTGGATGGATGGCGTGAAAGACTTCTTAATGAAACAGCAGGCTGCCCAAGGAGACGACGCA
GGTCTACAGAGGCAGTTAGACCAGTGCTCTGCATTTGTTAATGAAATAGAAACAATTGAATCATCTCTGAAAAACATGAAGGAAATAGAG
ACTAATCTTCGAAGTGGTCCAGTTGCTGGAATAAAAACTTGGGTGCAGACAAGACTAGGTGACTACCAAACTCAACTGGAGAAACTTAGC
AAGGAGATCGCTACTCAAAAAAGTAGGTTGTCTGAAAGTCAAGAAAAAGCTGCGAACCTGAAGAAAGACTTGGCAGAGATGCAGGAATGG
ATGACCCAGGCCGAGGAAGAATATTTGGAGCGGGATTTTGAGTACAAGTCACCAGAAGAGCTTGAGAGTGCTGTGGAAGAGATGAAGGTT
CTTTCAGAGCACGGCTTCGGCCCCATCACTACCGACATCCGGGAGGGACAGACTTTCTACTATGCGGAAGACTACCACCAGCAGTACCTG
AGCAAGAACCCCAATGGCTACTGCGGCCTTGGGGGCACCGGCGTGTCCTGCCCAGTGGGTATTAAAAAATAATTTCTCCCCACATGGTGG
GCCTTTGAGGTTCCAGTAAAAATGCTTTCAACAAATTGGGCAATGCTTGTGTGATTCACAATCGTGGCATTTAAAGTGCACAAAGTACAA
AGGAATTTATACAGATTGGGTTTACCGAAGTATAATCTATAGGAGGCGCGATGGCAAGTTGATAAAATGTGACTTATCTCCTAATAAGTT
ATGGTGGGAGTGGAGCTGTGCAGTTTCCTGTGTCTTCTGGGGTCTGAGTGAAGATAGCAGGGATGCTGTGTTCACCCTTCTTGGTAGAAG
CTAAGGTGTGAGCTGGGAGGTTGCTGGACAGGATGGGGGACCCCAGAAGTCCTTTATCTGTGCTCTCTGCCCGCCAGTGCCTTACAATTT
GCAAACGTGTATAGCCTCAGTGACTCATTCGCTGAAATCCTTCGCTTTACCAAATCTAGACATACATAAGGGGCTTTCTCTCCCTTTTCA
GCCCTCTCTGTGCAGAGAAAAGATGTGAGTCCGCTTGATGAATTCTAATGCTTTGCTTAGAGCTATGAGAAATGTTTGTTTTAATAAAAA


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FusionGenePPI for UTRN_MSRA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UTRNSNTA1, SNTB2, DAG1, UTRN, DTNA, PGM5, USP21, MARK2, PIK3CG, TERF1, TERF2, MME, DISC1, SIRT7, THOC1, RRP9, THOC2, THOC6, THOC5, UBE2D1, ZC3H15, XPO4, THOC3, UBE3C, PTPN12, NPM1, ADRA1D, LATS2, SAV1, OBSL1, CCDC8, L3HYPDH, IER2, USP7, CALM1, PTEN, MED4, TMEM17, PDK3, PI4KB, TTK, RBM8A, MCM2, ATOH1, CDH1, TENC1, TNS1, TNS3, SNTG2, NDEL1, DMD, CPNE5, FAM167A, RHPN1, PTRF, VHL, CPNE4, TTC30B, FAM189B, PHF19, TESMSRAHSPE1, DRD2, IRF3, ARNTL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+2574268_90511693434SYNM


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25741336_176811693434SYNM
HgeneUTRNchr6:144801118chr8:10285658ENST00000367545+25742798_316511693434SYNM


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UTRN_MSRA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneUTRNP46939DB01593ZincUtrophinsmall moleculeapproved|investigational

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RelatedDiseases for UTRN_MSRA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMSRAC0036341Schizophrenia2PSYGENET
TgeneMSRAC0236969Substance-Related Disorders1CTD_human