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Fusion gene ID: 4125 |
FusionGeneSummary for BEX4_FAM13A |
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Fusion gene information | Fusion gene name: BEX4_FAM13A | Fusion gene ID: 4125 | Hgene | Tgene | Gene symbol | BEX4 | FAM13A | Gene ID | 56271 | 10144 |
Gene name | brain expressed X-linked 4 | family with sequence similarity 13 member A | |
Synonyms | BEXL1 | ARHGAP48|FAM13A1 | |
Cytomap | Xq22.1 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein BEX4BEX family member 4BEX1-like protein 1brain expressed X-linked-like 1nerve growth factor receptor-associated protein 3 | protein FAM13AFAM13A1_v2 proteinfamily with sequence similarity 13, member A1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9NWD9 | O94988 | |
Ensembl transtripts involved in fusion gene | ENST00000372695, ENST00000372691, | ENST00000395002, ENST00000264344, ENST00000503556, ENST00000511976, ENST00000508369, ENST00000513837, ENST00000502459, ENST00000509094, ENST00000515600, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BEX4 [Title/Abstract] AND FAM13A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA786663 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000372695 | ENST00000395002 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372695 | ENST00000264344 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372695 | ENST00000503556 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372695 | ENST00000511976 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372695 | ENST00000508369 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372695 | ENST00000513837 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-intron | ENST00000372695 | ENST00000502459 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-intron | ENST00000372695 | ENST00000509094 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-intron | ENST00000372695 | ENST00000515600 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372691 | ENST00000395002 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372691 | ENST00000264344 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372691 | ENST00000503556 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372691 | ENST00000511976 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372691 | ENST00000508369 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-3CDS | ENST00000372691 | ENST00000513837 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-intron | ENST00000372691 | ENST00000502459 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-intron | ENST00000372691 | ENST00000509094 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
5UTR-intron | ENST00000372691 | ENST00000515600 | BEX4 | chrX | 102470153 | + | FAM13A | chr4 | 89671738 | - |
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FusionProtFeatures for BEX4_FAM13A |
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Hgene | Tgene |
BEX4 | FAM13A |
May play a role in microtubule deacetylation bynegatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate to the control of cell cycleprogression and genomic stability. {ECO:0000269|PubMed:27512957}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BEX4_FAM13A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BEX4_FAM13A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BEX4_FAM13A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BEX4_FAM13A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FAM13A | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
Tgene | FAM13A | C1800706 | Idiopathic Pulmonary Fibrosis | 1 | CTD_human;ORPHANET |