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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4125

FusionGeneSummary for BEX4_FAM13A

check button Fusion gene summary
Fusion gene informationFusion gene name: BEX4_FAM13A
Fusion gene ID: 4125
HgeneTgene
Gene symbol

BEX4

FAM13A

Gene ID

56271

10144

Gene namebrain expressed X-linked 4family with sequence similarity 13 member A
SynonymsBEXL1ARHGAP48|FAM13A1
Cytomap

Xq22.1

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionprotein BEX4BEX family member 4BEX1-like protein 1brain expressed X-linked-like 1nerve growth factor receptor-associated protein 3protein FAM13AFAM13A1_v2 proteinfamily with sequence similarity 13, member A1
Modification date2018052320180519
UniProtAcc

Q9NWD9

O94988

Ensembl transtripts involved in fusion geneENST00000372695, ENST00000372691, 
ENST00000395002, ENST00000264344, 
ENST00000503556, ENST00000511976, 
ENST00000508369, ENST00000513837, 
ENST00000502459, ENST00000509094, 
ENST00000515600, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 3=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BEX4 [Title/Abstract] AND FAM13A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA786663BEX4chrX

102470153

+FAM13Achr4

89671738

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000372695ENST00000395002BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372695ENST00000264344BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372695ENST00000503556BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372695ENST00000511976BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372695ENST00000508369BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372695ENST00000513837BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-intronENST00000372695ENST00000502459BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-intronENST00000372695ENST00000509094BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-intronENST00000372695ENST00000515600BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372691ENST00000395002BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372691ENST00000264344BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372691ENST00000503556BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372691ENST00000511976BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372691ENST00000508369BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-3CDSENST00000372691ENST00000513837BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-intronENST00000372691ENST00000502459BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-intronENST00000372691ENST00000509094BEX4chrX

102470153

+FAM13Achr4

89671738

-
5UTR-intronENST00000372691ENST00000515600BEX4chrX

102470153

+FAM13Achr4

89671738

-

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FusionProtFeatures for BEX4_FAM13A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BEX4

Q9NWD9

FAM13A

O94988

May play a role in microtubule deacetylation bynegatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate to the control of cell cycleprogression and genomic stability. {ECO:0000269|PubMed:27512957}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BEX4_FAM13A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BEX4_FAM13A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BEX4_FAM13A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BEX4_FAM13A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFAM13AC0024117Chronic Obstructive Airway Disease1CTD_human
TgeneFAM13AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET