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Fusion gene ID: 41241 |
FusionGeneSummary for UTP14A_TRAF3 |
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Fusion gene information | Fusion gene name: UTP14A_TRAF3 | Fusion gene ID: 41241 | Hgene | Tgene | Gene symbol | UTP14A | TRAF3 | Gene ID | 10813 | 7187 |
Gene name | UTP14A, small subunit processome component | TNF receptor associated factor 3 | |
Synonyms | NYCO16|SDCCAG16|Utp14|dJ537K23.3 | CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118 | |
Cytomap | Xq26.1 | 14q32.32 | |
Type of gene | protein-coding | protein-coding | |
Description | U3 small nucleolar RNA-associated protein 14 homolog AUTP14, U3 small nucleolar ribonucleoprotein, homolog AUTP14A small subunit (SSU) processome componentantigen NY-CO-16serologically defined colon cancer antigen 16 | TNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q9BVJ6 | Q13114 | |
Ensembl transtripts involved in fusion gene | ENST00000425117, ENST00000394422, ENST00000371051, ENST00000371042, ENST00000498179, | ENST00000560371, ENST00000347662, ENST00000392745, ENST00000539721, ENST00000351691, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 4=64 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: UTP14A [Title/Abstract] AND TRAF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW860540 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000425117 | ENST00000560371 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000425117 | ENST00000347662 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000425117 | ENST00000392745 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000425117 | ENST00000539721 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000425117 | ENST00000351691 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000394422 | ENST00000560371 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000394422 | ENST00000347662 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000394422 | ENST00000392745 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000394422 | ENST00000539721 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000394422 | ENST00000351691 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371051 | ENST00000560371 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371051 | ENST00000347662 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371051 | ENST00000392745 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371051 | ENST00000539721 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371051 | ENST00000351691 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371042 | ENST00000560371 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371042 | ENST00000347662 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371042 | ENST00000392745 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371042 | ENST00000539721 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000371042 | ENST00000351691 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000498179 | ENST00000560371 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000498179 | ENST00000347662 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000498179 | ENST00000392745 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000498179 | ENST00000539721 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
intron-intron | ENST00000498179 | ENST00000351691 | UTP14A | chrX | 129048976 | + | TRAF3 | chr14 | 103265993 | + |
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FusionProtFeatures for UTP14A_TRAF3 |
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Hgene | Tgene |
UTP14A | TRAF3 |
May be required for ribosome biogenesis. {ECO:0000250}. | Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leadingto the production of cytokines and interferon. Required for normalantibody isotype switching from IgM to IgG. Plays a role T-celldependent immune responses. Plays a role in the regulation ofantiviral responses. Is an essential constituent of several E3ubiquitin-protein ligase complexes. May have E3 ubiquitin-proteinligase activity and promote 'Lys-63'-linked ubiquitination oftarget proteins. Inhibits activation of NF-kappa-B in response toLTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and therebyinhibits non-canonical activation of NF-kappa-B. Promotesubiquitination and proteasomal degradation of MAP3K14.{ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UTP14A_TRAF3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UTP14A_TRAF3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UTP14A_TRAF3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UTP14A_TRAF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TRAF3 | C3553868 | HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 3 | 1 | UNIPROT |