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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41241

FusionGeneSummary for UTP14A_TRAF3

check button Fusion gene summary
Fusion gene informationFusion gene name: UTP14A_TRAF3
Fusion gene ID: 41241
HgeneTgene
Gene symbol

UTP14A

TRAF3

Gene ID

10813

7187

Gene nameUTP14A, small subunit processome componentTNF receptor associated factor 3
SynonymsNYCO16|SDCCAG16|Utp14|dJ537K23.3CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118
Cytomap

Xq26.1

14q32.32

Type of geneprotein-codingprotein-coding
DescriptionU3 small nucleolar RNA-associated protein 14 homolog AUTP14, U3 small nucleolar ribonucleoprotein, homolog AUTP14A small subunit (SSU) processome componentantigen NY-CO-16serologically defined colon cancer antigen 16TNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3
Modification date2018052320180527
UniProtAcc

Q9BVJ6

Q13114

Ensembl transtripts involved in fusion geneENST00000425117, ENST00000394422, 
ENST00000371051, ENST00000371042, 
ENST00000498179, 
ENST00000560371, 
ENST00000347662, ENST00000392745, 
ENST00000539721, ENST00000351691, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 4=64
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UTP14A [Title/Abstract] AND TRAF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW860540UTP14AchrX

129048976

+TRAF3chr14

103265993

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000425117ENST00000560371UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000425117ENST00000347662UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000425117ENST00000392745UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000425117ENST00000539721UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000425117ENST00000351691UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000394422ENST00000560371UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000394422ENST00000347662UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000394422ENST00000392745UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000394422ENST00000539721UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000394422ENST00000351691UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371051ENST00000560371UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371051ENST00000347662UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371051ENST00000392745UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371051ENST00000539721UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371051ENST00000351691UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371042ENST00000560371UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371042ENST00000347662UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371042ENST00000392745UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371042ENST00000539721UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000371042ENST00000351691UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000498179ENST00000560371UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000498179ENST00000347662UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000498179ENST00000392745UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000498179ENST00000539721UTP14AchrX

129048976

+TRAF3chr14

103265993

+
intron-intronENST00000498179ENST00000351691UTP14AchrX

129048976

+TRAF3chr14

103265993

+

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FusionProtFeatures for UTP14A_TRAF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UTP14A

Q9BVJ6

TRAF3

Q13114

May be required for ribosome biogenesis. {ECO:0000250}. Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leadingto the production of cytokines and interferon. Required for normalantibody isotype switching from IgM to IgG. Plays a role T-celldependent immune responses. Plays a role in the regulation ofantiviral responses. Is an essential constituent of several E3ubiquitin-protein ligase complexes. May have E3 ubiquitin-proteinligase activity and promote 'Lys-63'-linked ubiquitination oftarget proteins. Inhibits activation of NF-kappa-B in response toLTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and therebyinhibits non-canonical activation of NF-kappa-B. Promotesubiquitination and proteasomal degradation of MAP3K14.{ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UTP14A_TRAF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UTP14A_TRAF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UTP14A_TRAF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UTP14A_TRAF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRAF3C3553868HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 31UNIPROT