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Fusion gene ID: 41239 |
FusionGeneSummary for UST_TRIML1 |
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Fusion gene information | Fusion gene name: UST_TRIML1 | Fusion gene ID: 41239 | Hgene | Tgene | Gene symbol | UST | TRIML1 | Gene ID | 10090 | 339976 |
Gene name | uronyl 2-sulfotransferase | tripartite motif family like 1 | |
Synonyms | 2OST | RNF209 | |
Cytomap | 6q25.1 | 4q35.2 | |
Type of gene | protein-coding | protein-coding | |
Description | uronyl 2-sulfotransferasedermatan/chondroitin sulfate 2-sulfotransferase | probable E3 ubiquitin-protein ligase TRIML1RING finger protein 209RING-type E3 ubiquitin transferase TRIML1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9Y2C2 | Q8N9V2 | |
Ensembl transtripts involved in fusion gene | ENST00000367463, ENST00000466695, | ENST00000332517, ENST00000507581, | |
Fusion gene scores | * DoF score | 8 X 6 X 4=192 | 1 X 1 X 1=1 |
# samples | 8 | 1 | |
** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: UST [Title/Abstract] AND TRIML1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-FX-A3NK-01A | UST | chr6 | 149208165 | + | TRIML1 | chr4 | 189063406 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000367463 | ENST00000332517 | UST | chr6 | 149208165 | + | TRIML1 | chr4 | 189063406 | + |
5CDS-intron | ENST00000367463 | ENST00000507581 | UST | chr6 | 149208165 | + | TRIML1 | chr4 | 189063406 | + |
intron-3CDS | ENST00000466695 | ENST00000332517 | UST | chr6 | 149208165 | + | TRIML1 | chr4 | 189063406 | + |
intron-intron | ENST00000466695 | ENST00000507581 | UST | chr6 | 149208165 | + | TRIML1 | chr4 | 189063406 | + |
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FusionProtFeatures for UST_TRIML1 |
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Hgene | Tgene |
UST | TRIML1 |
Sulfotransferase that catalyzes the transfer of sulfateto the position 2 of uronyl residues. Has mainly activity towardiduronyl residues in dermatan sulfate, and weaker activity towardglucuronyl residues of chondroitin sulfate. Has no activity towarddesulfated N-resulfated heparin. | Probable E3 ubiquitin-protein ligase which plays animportant role in blastocyst development.{ECO:0000250|UniProtKB:Q8BVP1}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | UST | chr6:149208165 | chr4:189063406 | ENST00000367463 | + | 2 | 8 | 1_49 | 97 | 407 | Topological domain | Cytoplasmic |
Hgene | UST | chr6:149208165 | chr4:189063406 | ENST00000367463 | + | 2 | 8 | 50_70 | 97 | 407 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Tgene | >TRIML1 | chr6:149208165 | chr4:189063406 | ENST00000332517 | + | 1 | 6 | 184_237 | 168 | 469 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >TRIML1 | chr6:149208165 | chr4:189063406 | ENST00000332517 | + | 1 | 6 | 267_468 | 168 | 469 | Domain | B30.2/SPRY |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >UST | chr6:149208165 | chr4:189063406 | ENST00000367463 | + | 2 | 8 | 71_406 | 97 | 407 | Topological domain | Lumenal |
Tgene | TRIML1 | chr6:149208165 | chr4:189063406 | ENST00000332517 | + | 1 | 6 | 133_158 | 168 | 469 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | TRIML1 | chr6:149208165 | chr4:189063406 | ENST00000332517 | + | 1 | 6 | 16_57 | 168 | 469 | Zinc finger | RING-type |
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FusionGeneSequence for UST_TRIML1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_UST_ENST00000367463_chr6_149208165_+_TRIML1_ENST00000332517_chr4_189063406_+_398aa MKKKQQHPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPFLRFSLRDYGFCMATLLVFCLGSLLYQLSGGPPRFLLDLRQYLGNSTYLDD HGPPPSKEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSKMIAQIESSSQSSAFESLEEVRGAL ERSEPLLLQCPEATTTELSLCRITGMKEMLRKFSTEITLDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGRH YWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVCKVGVFLDYESGHIAFYNGTDESLIYS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_UST_ENST00000367463_chr6_149208165_+_TRIML1_ENST00000332517_chr4_189063406_+_1194nt ATGAAGAAGAAGCAGCAGCATCCCGGCGGCGGCGCGGATCCCTGGCCCCATGGGGCCCCTATGGGGGGCGCCCCTCCGGGCCTGGGCAGC TGGAAGCGTCGGGTGCCCCTGCTGCCTTTCCTGCGCTTCTCCCTCCGGGACTACGGCTTCTGCATGGCCACCCTGCTGGTCTTCTGCCTG GGCTCCCTCCTCTATCAGCTCAGCGGGGGACCCCCTCGCTTCCTGCTCGACCTGCGGCAGTACTTGGGAAATTCCACTTACTTGGATGAC CATGGACCACCTCCTAGTAAGGAAGAAACAAAGACTTGTAAACAGGTTGTTGTGTCAGAATACATGAAAATGCACCAGTTCCTGAAGGAA GAGGAGCAGCTGCAACTCCAGCTACTAGAACAGGAAGAGAAAGAGAACATGAGGAAGCTGAGGAACAATGAGATCAAACTGACCCAGCAA ATCAGAAGCCTAAGCAAAATGATCGCACAGATTGAGTCCTCAAGTCAAAGCTCGGCTTTCGAATCTCTTGAGGAAGTGAGAGGAGCCCTG GAAAGGAGCGAGCCACTCTTGCTTCAGTGTCCAGAGGCCACCACCACAGAGCTGAGTCTGTGCCGCATCACGGGAATGAAGGAGATGCTA AGAAAATTCAGCACGGAGATAACGCTGGACCCAGCCACAGCTAATGCCTATCTCGTGTTGTCGGAGGATCTGAAGAGTGTGAAATATGGG GGAAGCAGACAGCAGCTACCCGACAACCCGGAAAGATTTGACCAGTCTGCGACTGTGCTGGGTACTCAGATCTTCACCAGTGGGAGACAC TACTGGGAGGTGGAGGTGGGAAACAAGACCGAGTGGGAAGTGGGCATCTGCAAGGACTCTGTGAGCAGAAAGGGGAATCTCCCCAAGCCA CCTGGGGACCTGTTCTCACTAATAGGTTTAAAAATCGGAGATGATTACAGCCTCTGGGTCTCGTCACCTTTGAAAGGTCAGCACGTCAGA GAGCCTGTGTGTAAGGTTGGTGTCTTCCTGGACTATGAATCTGGACATATAGCATTCTACAACGGGACGGATGAATCCCTCATCTACAGC TTCCCGCAGGCTTCTTTCCAAGAGGCCCTCAGGCCTATCTTTTCCCCCTGCCTCCCAAATGAGGGGACAAACACAGACCCTCTCACCATC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_UST_ENST00000367463_chr6_149208165_+_TRIML1_ENST00000332517_chr4_189063406_+_1547nt CGGCCCTCCCCATGTGCAGCCGGCCAGCCGGGCTCTCCTCCTCGCGGCGGATGGGTGACCTTTTCCTGGCACGGGCAGGCTGTGGGAGGC AGCGGAGCAGGCGATGAAGAAGAAGCAGCAGCATCCCGGCGGCGGCGCGGATCCCTGGCCCCATGGGGCCCCTATGGGGGGCGCCCCTCC GGGCCTGGGCAGCTGGAAGCGTCGGGTGCCCCTGCTGCCTTTCCTGCGCTTCTCCCTCCGGGACTACGGCTTCTGCATGGCCACCCTGCT GGTCTTCTGCCTGGGCTCCCTCCTCTATCAGCTCAGCGGGGGACCCCCTCGCTTCCTGCTCGACCTGCGGCAGTACTTGGGAAATTCCAC TTACTTGGATGACCATGGACCACCTCCTAGTAAGGAAGAAACAAAGACTTGTAAACAGGTTGTTGTGTCAGAATACATGAAAATGCACCA GTTCCTGAAGGAAGAGGAGCAGCTGCAACTCCAGCTACTAGAACAGGAAGAGAAAGAGAACATGAGGAAGCTGAGGAACAATGAGATCAA ACTGACCCAGCAAATCAGAAGCCTAAGCAAAATGATCGCACAGATTGAGTCCTCAAGTCAAAGCTCGGCTTTCGAATCTCTTGAGGAAGT GAGAGGAGCCCTGGAAAGGAGCGAGCCACTCTTGCTTCAGTGTCCAGAGGCCACCACCACAGAGCTGAGTCTGTGCCGCATCACGGGAAT GAAGGAGATGCTAAGAAAATTCAGCACGGAGATAACGCTGGACCCAGCCACAGCTAATGCCTATCTCGTGTTGTCGGAGGATCTGAAGAG TGTGAAATATGGGGGAAGCAGACAGCAGCTACCCGACAACCCGGAAAGATTTGACCAGTCTGCGACTGTGCTGGGTACTCAGATCTTCAC CAGTGGGAGACACTACTGGGAGGTGGAGGTGGGAAACAAGACCGAGTGGGAAGTGGGCATCTGCAAGGACTCTGTGAGCAGAAAGGGGAA TCTCCCCAAGCCACCTGGGGACCTGTTCTCACTAATAGGTTTAAAAATCGGAGATGATTACAGCCTCTGGGTCTCGTCACCTTTGAAAGG TCAGCACGTCAGAGAGCCTGTGTGTAAGGTTGGTGTCTTCCTGGACTATGAATCTGGACATATAGCATTCTACAACGGGACGGATGAATC CCTCATCTACAGCTTCCCGCAGGCTTCTTTCCAAGAGGCCCTCAGGCCTATCTTTTCCCCCTGCCTCCCAAATGAGGGGACAAACACAGA CCCTCTCACCATCTGCTCACTGAACAGCCACGTCTGAGGGGCGTGCCCTGAGCCGTCACAGCGGGCGATGTCTGAGACCAAGACACAACT ATTAAGACGATGAAGGCATCGACAGTATTAATGTCAGGTGATCTGAAATAAACTCCCGTAACCCCACCCCACCCCCAAGAGTTTCCATTA ACTTGATCCCATTATGAACAGCCACATTACACAATCAACTTCAACCCCAATAGAAGAGAGCTGATCATATTCTGTGTCTTTAAGTAAATG |
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FusionGenePPI for UST_TRIML1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UST | ELAVL1, CUL3, MRAP2, SLC27A6, INHBE, PPT2, CANX, DCAKD, PON2, GLG1, GOLIM4, XYLT2, MAN1A1, JAG2, OCIAD1, LDLR, IMPAD1, ERO1LB, OMA1 | TRIML1 | USP5, APP, RBCK1, MNAT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UST_TRIML1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UST_TRIML1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | UST | C0014175 | Endometriosis | 1 | CTD_human |