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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41239

FusionGeneSummary for UST_TRIML1

check button Fusion gene summary
Fusion gene informationFusion gene name: UST_TRIML1
Fusion gene ID: 41239
HgeneTgene
Gene symbol

UST

TRIML1

Gene ID

10090

339976

Gene nameuronyl 2-sulfotransferasetripartite motif family like 1
Synonyms2OSTRNF209
Cytomap

6q25.1

4q35.2

Type of geneprotein-codingprotein-coding
Descriptionuronyl 2-sulfotransferasedermatan/chondroitin sulfate 2-sulfotransferaseprobable E3 ubiquitin-protein ligase TRIML1RING finger protein 209RING-type E3 ubiquitin transferase TRIML1
Modification date2018052320180519
UniProtAcc

Q9Y2C2

Q8N9V2

Ensembl transtripts involved in fusion geneENST00000367463, ENST00000466695, 
ENST00000332517, ENST00000507581, 
Fusion gene scores* DoF score8 X 6 X 4=1921 X 1 X 1=1
# samples 81
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: UST [Title/Abstract] AND TRIML1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A3NK-01AUSTchr6

149208165

+TRIML1chr4

189063406

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367463ENST00000332517USTchr6

149208165

+TRIML1chr4

189063406

+
5CDS-intronENST00000367463ENST00000507581USTchr6

149208165

+TRIML1chr4

189063406

+
intron-3CDSENST00000466695ENST00000332517USTchr6

149208165

+TRIML1chr4

189063406

+
intron-intronENST00000466695ENST00000507581USTchr6

149208165

+TRIML1chr4

189063406

+

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FusionProtFeatures for UST_TRIML1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UST

Q9Y2C2

TRIML1

Q8N9V2

Sulfotransferase that catalyzes the transfer of sulfateto the position 2 of uronyl residues. Has mainly activity towardiduronyl residues in dermatan sulfate, and weaker activity towardglucuronyl residues of chondroitin sulfate. Has no activity towarddesulfated N-resulfated heparin. Probable E3 ubiquitin-protein ligase which plays animportant role in blastocyst development.{ECO:0000250|UniProtKB:Q8BVP1}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSTchr6:149208165chr4:189063406ENST00000367463+281_4997407Topological domainCytoplasmic
HgeneUSTchr6:149208165chr4:189063406ENST00000367463+2850_7097407TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTRIML1chr6:149208165chr4:189063406ENST00000332517+16184_237168469Coiled coilOntology_term=ECO:0000255
TgeneTRIML1chr6:149208165chr4:189063406ENST00000332517+16267_468168469DomainB30.2/SPRY

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSTchr6:149208165chr4:189063406ENST00000367463+2871_40697407Topological domainLumenal
TgeneTRIML1chr6:149208165chr4:189063406ENST00000332517+16133_158168469Coiled coilOntology_term=ECO:0000255
TgeneTRIML1chr6:149208165chr4:189063406ENST00000332517+1616_57168469Zinc fingerRING-type


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FusionGeneSequence for UST_TRIML1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_UST_ENST00000367463_chr6_149208165_+_TRIML1_ENST00000332517_chr4_189063406_+_398aa
MKKKQQHPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPFLRFSLRDYGFCMATLLVFCLGSLLYQLSGGPPRFLLDLRQYLGNSTYLDD
HGPPPSKEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSKMIAQIESSSQSSAFESLEEVRGAL
ERSEPLLLQCPEATTTELSLCRITGMKEMLRKFSTEITLDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGRH
YWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVCKVGVFLDYESGHIAFYNGTDESLIYS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_UST_ENST00000367463_chr6_149208165_+_TRIML1_ENST00000332517_chr4_189063406_+_1194nt
ATGAAGAAGAAGCAGCAGCATCCCGGCGGCGGCGCGGATCCCTGGCCCCATGGGGCCCCTATGGGGGGCGCCCCTCCGGGCCTGGGCAGC
TGGAAGCGTCGGGTGCCCCTGCTGCCTTTCCTGCGCTTCTCCCTCCGGGACTACGGCTTCTGCATGGCCACCCTGCTGGTCTTCTGCCTG
GGCTCCCTCCTCTATCAGCTCAGCGGGGGACCCCCTCGCTTCCTGCTCGACCTGCGGCAGTACTTGGGAAATTCCACTTACTTGGATGAC
CATGGACCACCTCCTAGTAAGGAAGAAACAAAGACTTGTAAACAGGTTGTTGTGTCAGAATACATGAAAATGCACCAGTTCCTGAAGGAA
GAGGAGCAGCTGCAACTCCAGCTACTAGAACAGGAAGAGAAAGAGAACATGAGGAAGCTGAGGAACAATGAGATCAAACTGACCCAGCAA
ATCAGAAGCCTAAGCAAAATGATCGCACAGATTGAGTCCTCAAGTCAAAGCTCGGCTTTCGAATCTCTTGAGGAAGTGAGAGGAGCCCTG
GAAAGGAGCGAGCCACTCTTGCTTCAGTGTCCAGAGGCCACCACCACAGAGCTGAGTCTGTGCCGCATCACGGGAATGAAGGAGATGCTA
AGAAAATTCAGCACGGAGATAACGCTGGACCCAGCCACAGCTAATGCCTATCTCGTGTTGTCGGAGGATCTGAAGAGTGTGAAATATGGG
GGAAGCAGACAGCAGCTACCCGACAACCCGGAAAGATTTGACCAGTCTGCGACTGTGCTGGGTACTCAGATCTTCACCAGTGGGAGACAC
TACTGGGAGGTGGAGGTGGGAAACAAGACCGAGTGGGAAGTGGGCATCTGCAAGGACTCTGTGAGCAGAAAGGGGAATCTCCCCAAGCCA
CCTGGGGACCTGTTCTCACTAATAGGTTTAAAAATCGGAGATGATTACAGCCTCTGGGTCTCGTCACCTTTGAAAGGTCAGCACGTCAGA
GAGCCTGTGTGTAAGGTTGGTGTCTTCCTGGACTATGAATCTGGACATATAGCATTCTACAACGGGACGGATGAATCCCTCATCTACAGC
TTCCCGCAGGCTTCTTTCCAAGAGGCCCTCAGGCCTATCTTTTCCCCCTGCCTCCCAAATGAGGGGACAAACACAGACCCTCTCACCATC


* Fusion transcript sequences (Full-length transcript).
>In-frame_UST_ENST00000367463_chr6_149208165_+_TRIML1_ENST00000332517_chr4_189063406_+_1547nt
CGGCCCTCCCCATGTGCAGCCGGCCAGCCGGGCTCTCCTCCTCGCGGCGGATGGGTGACCTTTTCCTGGCACGGGCAGGCTGTGGGAGGC
AGCGGAGCAGGCGATGAAGAAGAAGCAGCAGCATCCCGGCGGCGGCGCGGATCCCTGGCCCCATGGGGCCCCTATGGGGGGCGCCCCTCC
GGGCCTGGGCAGCTGGAAGCGTCGGGTGCCCCTGCTGCCTTTCCTGCGCTTCTCCCTCCGGGACTACGGCTTCTGCATGGCCACCCTGCT
GGTCTTCTGCCTGGGCTCCCTCCTCTATCAGCTCAGCGGGGGACCCCCTCGCTTCCTGCTCGACCTGCGGCAGTACTTGGGAAATTCCAC
TTACTTGGATGACCATGGACCACCTCCTAGTAAGGAAGAAACAAAGACTTGTAAACAGGTTGTTGTGTCAGAATACATGAAAATGCACCA
GTTCCTGAAGGAAGAGGAGCAGCTGCAACTCCAGCTACTAGAACAGGAAGAGAAAGAGAACATGAGGAAGCTGAGGAACAATGAGATCAA
ACTGACCCAGCAAATCAGAAGCCTAAGCAAAATGATCGCACAGATTGAGTCCTCAAGTCAAAGCTCGGCTTTCGAATCTCTTGAGGAAGT
GAGAGGAGCCCTGGAAAGGAGCGAGCCACTCTTGCTTCAGTGTCCAGAGGCCACCACCACAGAGCTGAGTCTGTGCCGCATCACGGGAAT
GAAGGAGATGCTAAGAAAATTCAGCACGGAGATAACGCTGGACCCAGCCACAGCTAATGCCTATCTCGTGTTGTCGGAGGATCTGAAGAG
TGTGAAATATGGGGGAAGCAGACAGCAGCTACCCGACAACCCGGAAAGATTTGACCAGTCTGCGACTGTGCTGGGTACTCAGATCTTCAC
CAGTGGGAGACACTACTGGGAGGTGGAGGTGGGAAACAAGACCGAGTGGGAAGTGGGCATCTGCAAGGACTCTGTGAGCAGAAAGGGGAA
TCTCCCCAAGCCACCTGGGGACCTGTTCTCACTAATAGGTTTAAAAATCGGAGATGATTACAGCCTCTGGGTCTCGTCACCTTTGAAAGG
TCAGCACGTCAGAGAGCCTGTGTGTAAGGTTGGTGTCTTCCTGGACTATGAATCTGGACATATAGCATTCTACAACGGGACGGATGAATC
CCTCATCTACAGCTTCCCGCAGGCTTCTTTCCAAGAGGCCCTCAGGCCTATCTTTTCCCCCTGCCTCCCAAATGAGGGGACAAACACAGA
CCCTCTCACCATCTGCTCACTGAACAGCCACGTCTGAGGGGCGTGCCCTGAGCCGTCACAGCGGGCGATGTCTGAGACCAAGACACAACT
ATTAAGACGATGAAGGCATCGACAGTATTAATGTCAGGTGATCTGAAATAAACTCCCGTAACCCCACCCCACCCCCAAGAGTTTCCATTA
ACTTGATCCCATTATGAACAGCCACATTACACAATCAACTTCAACCCCAATAGAAGAGAGCTGATCATATTCTGTGTCTTTAAGTAAATG


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FusionGenePPI for UST_TRIML1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USTELAVL1, CUL3, MRAP2, SLC27A6, INHBE, PPT2, CANX, DCAKD, PON2, GLG1, GOLIM4, XYLT2, MAN1A1, JAG2, OCIAD1, LDLR, IMPAD1, ERO1LB, OMA1TRIML1USP5, APP, RBCK1, MNAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UST_TRIML1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UST_TRIML1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSTC0014175Endometriosis1CTD_human