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Fusion gene ID: 41233 |
FusionGeneSummary for UST_BIRC3 |
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Fusion gene information | Fusion gene name: UST_BIRC3 | Fusion gene ID: 41233 | Hgene | Tgene | Gene symbol | UST | BIRC3 | Gene ID | 10090 | 330 |
Gene name | uronyl 2-sulfotransferase | baculoviral IAP repeat containing 3 | |
Synonyms | 2OST | AIP1|API2|CIAP2|HAIP1|HIAP1|MALT2|MIHC|RNF49|c-IAP2 | |
Cytomap | 6q25.1 | 11q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | uronyl 2-sulfotransferasedermatan/chondroitin sulfate 2-sulfotransferase | baculoviral IAP repeat-containing protein 3IAP homolog CIAP-1RING finger protein 49RING-type E3 ubiquitin transferase BIRC3TNFR2-TRAF signaling complex proteinTNFR2-TRAF-signaling complex protein 1apoptosis inhibitor 2cellular inhibitor of apoptos | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y2C2 | Q13489 | |
Ensembl transtripts involved in fusion gene | ENST00000367463, ENST00000466695, | ENST00000526421, ENST00000263464, ENST00000532808, | |
Fusion gene scores | * DoF score | 8 X 6 X 4=192 | 1 X 1 X 1=1 |
# samples | 8 | 1 | |
** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: UST [Title/Abstract] AND BIRC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BIRC3 | GO:0031398 | positive regulation of protein ubiquitination | 21931591 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A23T-01A | UST | chr6 | 149068813 | + | BIRC3 | chr11 | 102207491 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000367463 | ENST00000526421 | UST | chr6 | 149068813 | + | BIRC3 | chr11 | 102207491 | + |
5CDS-intron | ENST00000367463 | ENST00000263464 | UST | chr6 | 149068813 | + | BIRC3 | chr11 | 102207491 | + |
5CDS-intron | ENST00000367463 | ENST00000532808 | UST | chr6 | 149068813 | + | BIRC3 | chr11 | 102207491 | + |
intron-intron | ENST00000466695 | ENST00000526421 | UST | chr6 | 149068813 | + | BIRC3 | chr11 | 102207491 | + |
intron-intron | ENST00000466695 | ENST00000263464 | UST | chr6 | 149068813 | + | BIRC3 | chr11 | 102207491 | + |
intron-intron | ENST00000466695 | ENST00000532808 | UST | chr6 | 149068813 | + | BIRC3 | chr11 | 102207491 | + |
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FusionProtFeatures for UST_BIRC3 |
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Hgene | Tgene |
UST | BIRC3 |
Sulfotransferase that catalyzes the transfer of sulfateto the position 2 of uronyl residues. Has mainly activity towardiduronyl residues in dermatan sulfate, and weaker activity towardglucuronyl residues of chondroitin sulfate. Has no activity towarddesulfated N-resulfated heparin. | Multi-functional protein which regulates not onlycaspases and apoptosis, but also modulates inflammatory signalingand immunity, mitogenic kinase signaling and cell proliferation,as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates bothcanonical and non-canonical NF-kappa-B signaling by acting inopposite directions: acts as a positive regulator of the canonicalpathway and suppresses constitutive activation of non-canonicalNF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4,CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an importantregulator of innate immune signaling via regulation of Toll-likereceptors (TLRs), Nodlike receptors (NLRs) and RIG-I likereceptors (RLRs), collectively referred to as pattern recognitionreceptors (PRRs). Protects cells from spontaneous formation of theripoptosome, a large multi-protein complex that has the capabilityto kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation byubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:21931591,ECO:0000269|PubMed:23453969}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UST_BIRC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UST_BIRC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
UST | ELAVL1, CUL3, MRAP2, SLC27A6, INHBE, PPT2, CANX, DCAKD, PON2, GLG1, GOLIM4, XYLT2, MAN1A1, JAG2, OCIAD1, LDLR, IMPAD1, ERO1LB, OMA1 | BIRC3 | HTRA2, CASP9, RIPK2, DIABLO, TRAF2, TRAF1, CASP3, CASP7, BCL10, BIRC3, RAF1, TNFRSF1A, UBE2D2, RIPK1, XAF1, UBE2N, BIRC5, UBE2L3, UBE2D1, UBE2D3, UBE2I, UBE2Q2, TRAF3, TRAF6, MAVS, RIPK3, RIPK4, UBXN1, USP19, TRIM32, NOD2, COMMD1, UBC, IKBKG, CASP1, BIRC2, XIAP, E2F1, GSK3B, SEPT4, UBE2V1, IKBKE, TANK, TAB1, RNF31, RBCK1, UBA1, UBR4, WDR1, WDR61, DCAF7, WDR82, USP15, USP7, USP9X, OTUB1, DZIP3, CD40LG, SNX7, SUMO1, RCHY1, CYFIP2, TNFAIP3, EGFR, PACS2, IRF1, SPHK1, MBTPS1, HAX1, CASP8, CASP10, IKBKB, NFKB1, REL, IRF5, EGLN3, LIMA1, TLR3, PELI1, GLMN, YOD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UST_BIRC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UST_BIRC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | UST | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | BIRC3 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | BIRC3 | C0015695 | Fatty Liver | 1 | CTD_human |
Tgene | BIRC3 | C0019693 | HIV Infections | 1 | CTD_human |
Tgene | BIRC3 | C0023418 | leukemia | 1 | CTD_human |
Tgene | BIRC3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |