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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41233

FusionGeneSummary for UST_BIRC3

check button Fusion gene summary
Fusion gene informationFusion gene name: UST_BIRC3
Fusion gene ID: 41233
HgeneTgene
Gene symbol

UST

BIRC3

Gene ID

10090

330

Gene nameuronyl 2-sulfotransferasebaculoviral IAP repeat containing 3
Synonyms2OSTAIP1|API2|CIAP2|HAIP1|HIAP1|MALT2|MIHC|RNF49|c-IAP2
Cytomap

6q25.1

11q22.2

Type of geneprotein-codingprotein-coding
Descriptionuronyl 2-sulfotransferasedermatan/chondroitin sulfate 2-sulfotransferasebaculoviral IAP repeat-containing protein 3IAP homolog CIAP-1RING finger protein 49RING-type E3 ubiquitin transferase BIRC3TNFR2-TRAF signaling complex proteinTNFR2-TRAF-signaling complex protein 1apoptosis inhibitor 2cellular inhibitor of apoptos
Modification date2018052320180523
UniProtAcc

Q9Y2C2

Q13489

Ensembl transtripts involved in fusion geneENST00000367463, ENST00000466695, 
ENST00000526421, ENST00000263464, 
ENST00000532808, 
Fusion gene scores* DoF score8 X 6 X 4=1921 X 1 X 1=1
# samples 81
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: UST [Title/Abstract] AND BIRC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBIRC3

GO:0031398

positive regulation of protein ubiquitination

21931591


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A23T-01AUSTchr6

149068813

+BIRC3chr11

102207491

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367463ENST00000526421USTchr6

149068813

+BIRC3chr11

102207491

+
5CDS-intronENST00000367463ENST00000263464USTchr6

149068813

+BIRC3chr11

102207491

+
5CDS-intronENST00000367463ENST00000532808USTchr6

149068813

+BIRC3chr11

102207491

+
intron-intronENST00000466695ENST00000526421USTchr6

149068813

+BIRC3chr11

102207491

+
intron-intronENST00000466695ENST00000263464USTchr6

149068813

+BIRC3chr11

102207491

+
intron-intronENST00000466695ENST00000532808USTchr6

149068813

+BIRC3chr11

102207491

+

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FusionProtFeatures for UST_BIRC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UST

Q9Y2C2

BIRC3

Q13489

Sulfotransferase that catalyzes the transfer of sulfateto the position 2 of uronyl residues. Has mainly activity towardiduronyl residues in dermatan sulfate, and weaker activity towardglucuronyl residues of chondroitin sulfate. Has no activity towarddesulfated N-resulfated heparin. Multi-functional protein which regulates not onlycaspases and apoptosis, but also modulates inflammatory signalingand immunity, mitogenic kinase signaling and cell proliferation,as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates bothcanonical and non-canonical NF-kappa-B signaling by acting inopposite directions: acts as a positive regulator of the canonicalpathway and suppresses constitutive activation of non-canonicalNF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4,CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an importantregulator of innate immune signaling via regulation of Toll-likereceptors (TLRs), Nodlike receptors (NLRs) and RIG-I likereceptors (RLRs), collectively referred to as pattern recognitionreceptors (PRRs). Protects cells from spontaneous formation of theripoptosome, a large multi-protein complex that has the capabilityto kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation byubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:21931591,ECO:0000269|PubMed:23453969}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UST_BIRC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UST_BIRC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USTELAVL1, CUL3, MRAP2, SLC27A6, INHBE, PPT2, CANX, DCAKD, PON2, GLG1, GOLIM4, XYLT2, MAN1A1, JAG2, OCIAD1, LDLR, IMPAD1, ERO1LB, OMA1BIRC3HTRA2, CASP9, RIPK2, DIABLO, TRAF2, TRAF1, CASP3, CASP7, BCL10, BIRC3, RAF1, TNFRSF1A, UBE2D2, RIPK1, XAF1, UBE2N, BIRC5, UBE2L3, UBE2D1, UBE2D3, UBE2I, UBE2Q2, TRAF3, TRAF6, MAVS, RIPK3, RIPK4, UBXN1, USP19, TRIM32, NOD2, COMMD1, UBC, IKBKG, CASP1, BIRC2, XIAP, E2F1, GSK3B, SEPT4, UBE2V1, IKBKE, TANK, TAB1, RNF31, RBCK1, UBA1, UBR4, WDR1, WDR61, DCAF7, WDR82, USP15, USP7, USP9X, OTUB1, DZIP3, CD40LG, SNX7, SUMO1, RCHY1, CYFIP2, TNFAIP3, EGFR, PACS2, IRF1, SPHK1, MBTPS1, HAX1, CASP8, CASP10, IKBKB, NFKB1, REL, IRF5, EGLN3, LIMA1, TLR3, PELI1, GLMN, YOD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UST_BIRC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UST_BIRC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSTC0014175Endometriosis1CTD_human
TgeneBIRC3C0005695Bladder Neoplasm1CTD_human
TgeneBIRC3C0015695Fatty Liver1CTD_human
TgeneBIRC3C0019693HIV Infections1CTD_human
TgeneBIRC3C0023418leukemia1CTD_human
TgeneBIRC3C0023893Liver Cirrhosis, Experimental1CTD_human