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Fusion gene ID: 41222 |
FusionGeneSummary for USP9X_MAPKAPK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP9X_MAPKAPK5 | Fusion gene ID: 41222 | Hgene | Tgene | Gene symbol | USP9X | MAPKAPK5 | Gene ID | 8239 | 8550 |
| Gene name | ubiquitin specific peptidase 9 X-linked | mitogen-activated protein kinase-activated protein kinase 5 | |
| Synonyms | DFFRX|FAF|FAM|MRX99|MRXS99F | MAPKAP-K5|MK-5|MK5|PRAK | |
| Cytomap | Xp11.4 | 12q24.12-q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ubiquitin carboxyl-terminal hydrolase FAF-XDrosophila fat facets related, X-linkeddeubiquitinating enzyme FAF-Xfat facets in mammalsfat facets protein related, X-linkedhFAMubiquitin specific protease 9, X chromosome (fat facets-like Drosoph | MAP kinase-activated protein kinase 5MAPK-activated protein kinase 5MAPKAP kinase 5MAPKAPK-5p38-regulated/activated protein kinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q93008 | Q8IW41 | |
| Ensembl transtripts involved in fusion gene | ENST00000378308, ENST00000324545, | ENST00000550735, ENST00000551404, ENST00000547305, ENST00000546394, | |
| Fusion gene scores | * DoF score | 14 X 8 X 10=1120 | 4 X 6 X 3=72 |
| # samples | 15 | 7 | |
| ** MAII score | log2(15/1120*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP9X [Title/Abstract] AND MAPKAPK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP9X | GO:0016579 | protein deubiquitination | 19135894 |
| Hgene | USP9X | GO:0030509 | BMP signaling pathway | 19135894 |
| Hgene | USP9X | GO:1901537 | positive regulation of DNA demethylation | 25944111 |
| Tgene | MAPKAPK5 | GO:0006417 | regulation of translation | 21329882 |
| Tgene | MAPKAPK5 | GO:0007265 | Ras protein signal transduction | 17254968 |
| Tgene | MAPKAPK5 | GO:0046777 | protein autophosphorylation | 21329882 |
| Tgene | MAPKAPK5 | GO:0090400 | stress-induced premature senescence | 17254968 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HC-7818-01A | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000378308 | ENST00000550735 | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
| In-frame | ENST00000378308 | ENST00000551404 | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
| 5CDS-intron | ENST00000378308 | ENST00000547305 | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
| 5CDS-3UTR | ENST00000378308 | ENST00000546394 | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
| In-frame | ENST00000324545 | ENST00000550735 | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
| In-frame | ENST00000324545 | ENST00000551404 | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
| 5CDS-intron | ENST00000324545 | ENST00000547305 | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
| 5CDS-3UTR | ENST00000324545 | ENST00000546394 | USP9X | chrX | 40982977 | + | MAPKAPK5 | chr12 | 112303054 | + |
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FusionProtFeatures for USP9X_MAPKAPK5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP9X | MAPKAPK5 |
| Deubiquitinase involved both in the processing ofubiquitin precursors and of ubiquitinated proteins. May thereforeplay an important regulatory role at the level of protein turnoverby preventing degradation of proteins through the removal ofconjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essentialcomponent of TGF-beta/BMP signaling cascade. Specificallydeubiquitinates monoubiquitinated SMAD4, opposing the activity ofE3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylationrepair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilizeALKBH3, thereby promoting the repair of alkylated DNA lesions(PubMed:25944111). Regulates chromosome alignment and segregationin mitosis by regulating the localization of BIRC5/survivin tomitotic centromeres. Involved in axonal growth and neuronal cellmigration (PubMed:16322459, PubMed:18254724, PubMed:19135894,PubMed:24607389). {ECO:0000269|PubMed:16322459,ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894,ECO:0000269|PubMed:24607389, ECO:0000269|PubMed:25944111}. | Tumor suppressor serine/threonine-protein kinaseinvolved in mTORC1 signaling and post-transcriptional regulation.Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1,p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation ofFOXO3: phosphorylation of FOXO3 leads to promote nuclearlocalization of FOXO3, enabling expression of miR-34b and miR-34c,2 post-transcriptional regulators of MYC that bind to the 3'UTR ofMYC transcript and prevent MYC translation. Acts as a negativeregulator of mTORC1 signaling by mediating phosphorylation andinhibition of RHEB. Part of the atypical MAPK signaling via itsinteraction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of thecomplex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, butthe complex follows a complex set of phosphorylation events: uponinteraction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4),ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediatesphosphorylation and activation of MAPKAPK5, which in turnphosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediatesphosphorylation of HSP27/HSPB1 in response to PKA/PRKACAstimulation, inducing F-actin rearrangement.{ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103,ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882,ECO:0000269|PubMed:9628874}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >MAPKAPK5 | chrX:40982977 | chr12:112303054 | ENST00000550735 | + | 0 | 14 | 409_440 | 12 | 472 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >MAPKAPK5 | chrX:40982977 | chr12:112303054 | ENST00000551404 | + | 0 | 14 | 409_440 | 12 | 474 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >MAPKAPK5 | chrX:40982977 | chr12:112303054 | ENST00000550735 | + | 0 | 14 | 22_304 | 12 | 472 | Domain | Protein kinase |
| Tgene | >MAPKAPK5 | chrX:40982977 | chr12:112303054 | ENST00000551404 | + | 0 | 14 | 22_304 | 12 | 474 | Domain | Protein kinase |
| Tgene | >MAPKAPK5 | chrX:40982977 | chr12:112303054 | ENST00000550735 | + | 0 | 14 | 28_36 | 12 | 472 | Nucleotide binding | ATP |
| Tgene | >MAPKAPK5 | chrX:40982977 | chr12:112303054 | ENST00000551404 | + | 0 | 14 | 28_36 | 12 | 474 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >USP9X | chrX:40982977 | chr12:112303054 | ENST00000324545 | + | 2 | 45 | 1557_1956 | 32 | 2571 | Domain | Note=USP |
| Hgene | >USP9X | chrX:40982977 | chr12:112303054 | ENST00000378308 | + | 2 | 45 | 1557_1956 | 32 | 2555 | Domain | Note=USP |
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FusionGeneSequence for USP9X_MAPKAPK5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_USP9X_ENST00000378308_chrX_40982977_+_MAPKAPK5_ENST00000550735_chr12_112303054_+_492aa MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNS LDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTI PKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANM RIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEAWKYNRECKLL >In-frame_USP9X_ENST00000378308_chrX_40982977_+_MAPKAPK5_ENST00000551404_chr12_112303054_+_494aa MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNS LDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTI PKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANM RIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECK >In-frame_USP9X_ENST00000324545_chrX_40982977_+_MAPKAPK5_ENST00000550735_chr12_112303054_+_492aa MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNS LDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTI PKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANM RIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEAWKYNRECKLL >In-frame_USP9X_ENST00000324545_chrX_40982977_+_MAPKAPK5_ENST00000551404_chr12_112303054_+_494aa MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNS LDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTI PKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANM RIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_USP9X_ENST00000378308_chrX_40982977_+_MAPKAPK5_ENST00000550735_chr12_112303054_+_1476nt ATGACAGCCACGACTCGTGGCTCTCCGGTCGGAGGGAATGACAACCAGGGCCAGGCTCCTGATGGACAGTCTCAGCCCCCCCTCCAACAG AATCAGGAAACTTCCATTTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAGAGTCTGTGTA AAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGTGCC ACACACCCAAACATAGTTCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGCCCGACTCTTAATT GTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACAAAG CAGATAGCTTTGGCTCTGCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAACTCT TTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGTA GCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAAG AGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTATC CCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGTT GTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCTG GATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACATG AGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCCA AAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTGT ATTCTCCCCCAGGCTGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAACTCCTA AGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAGCAGGTG >In-frame_USP9X_ENST00000378308_chrX_40982977_+_MAPKAPK5_ENST00000551404_chr12_112303054_+_1482nt ATGACAGCCACGACTCGTGGCTCTCCGGTCGGAGGGAATGACAACCAGGGCCAGGCTCCTGATGGACAGTCTCAGCCCCCCCTCCAACAG AATCAGGAAACTTCCATTTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAGAGTCTGTGTA AAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGTGCC ACACACCCAAACATAGTTCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGCCCGACTCTTAATT GTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACAAAG CAGATAGCTTTGGCTCTGCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAACTCT TTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGTA GCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAAG AGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTATC CCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGTT GTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCTG GATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACATG AGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCCA AAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTGT ATTCTCCCCCAGGCTGGTAAAGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAA CTCCTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAG >In-frame_USP9X_ENST00000324545_chrX_40982977_+_MAPKAPK5_ENST00000550735_chr12_112303054_+_1476nt ATGACAGCCACGACTCGTGGCTCTCCGGTCGGAGGGAATGACAACCAGGGCCAGGCTCCTGATGGACAGTCTCAGCCCCCCCTCCAACAG AATCAGGAAACTTCCATTTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAGAGTCTGTGTA AAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGTGCC ACACACCCAAACATAGTTCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGCCCGACTCTTAATT GTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACAAAG CAGATAGCTTTGGCTCTGCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAACTCT TTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGTA GCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAAG AGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTATC CCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGTT GTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCTG GATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACATG AGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCCA AAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTGT ATTCTCCCCCAGGCTGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAACTCCTA AGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAGCAGGTG >In-frame_USP9X_ENST00000324545_chrX_40982977_+_MAPKAPK5_ENST00000551404_chr12_112303054_+_1482nt ATGACAGCCACGACTCGTGGCTCTCCGGTCGGAGGGAATGACAACCAGGGCCAGGCTCCTGATGGACAGTCTCAGCCCCCCCTCCAACAG AATCAGGAAACTTCCATTTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAGAGTCTGTGTA AAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGTGCC ACACACCCAAACATAGTTCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGCCCGACTCTTAATT GTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACAAAG CAGATAGCTTTGGCTCTGCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAACTCT TTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGTA GCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAAG AGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTATC CCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGTT GTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCTG GATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACATG AGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCCA AAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTGT ATTCTCCCCCAGGCTGGTAAAGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAA CTCCTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_USP9X_ENST00000378308_chrX_40982977_+_MAPKAPK5_ENST00000550735_chr12_112303054_+_2464nt GCGGCCGCCTTAGCGCCCGGTGCTTGGGTCGGCGCCGGGAGCGAGGAGCGAGCTACTTCAAAGCCACCAGGCCTGGAGCGGGGACAGAGG CGGCGACTAGGGGAAGGTGAAGCCGTCGCTGCAGGAGGAGGAGCAGGAGGAGGTGACGCAGGAGAAACGCACCGCCCGGAGCCCGTCTGA GCTCAGCGAGAGCCCCAGCCTGAGGGGAGAAGGGGAAGAGGGCCGTCGCCGGCCAAGGAGGAGGAGGAGGCGGGCGCGGCGAGGAGCGAG TTCCGGCGCCGGTGTGCAGCCTTTTGGTTGAGACGCCCGCAGCCCCGAGCCCGGCCGCCGCAGCCTTTCGATACACTTTGTTGCCGGTCA CCCCCGGGCCTGGGATGCACCCAGGGTAGGTCTCGTCCCGGGACCGAGCCCCACCGTCGCCTGGTGCCTCCCGCCTCCGTGTGCCCTGGT TGTGAGAAGACGTCTGTGTCGTGCGGTTATGCAATGGTCTCTGCAAGATGGTTTATTCTTGAATTGGACCTTTTTAAGACTGACAAATGC TGGTACTTCATCTTCTATAAGTGGACTATAATTTCTTTTCTCAAGACAACTACATAAGCAGACAAAATTGCAAAGATCTGCCCTGTGTCG AGTATGACAGCCACGACTCGTGGCTCTCCGGTCGGAGGGAATGACAACCAGGGCCAGGCTCCTGATGGACAGTCTCAGCCCCCCCTCCAA CAGAATCAGGAAACTTCCATTTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAGAGTCTGT GTAAAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGT GCCACACACCCAAACATAGTTCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGCCCGACTCTTA ATTGTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACA AAGCAGATAGCTTTGGCTCTGCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAAC TCTTTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTAT GTAGCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAAC AAGAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACT ATCCCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGAT GTTGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCC CTGGATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAAC ATGAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAG CCAAAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAG TGTATTCTCCCCCAGGCTGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAACTC CTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAGCAG GTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAAATTATTCTTTAAT GTATAAAGTAATTTTATGTAAATTAATAAATCATAATTTCATTTCCACATTGATTAAAGCTGCTGTATAGATTTAGGGTGCAGGACTTAA TAATAGTATAGTTATTGTTTGTTTTTAAGAAAAGCTCAGTTCTAGAGACATACTATTACTTTAGGACTGTGTAGTTGTATATTTGTAAGA TGACAGATGATGCTGTCAAGCAATATTGTTTTATTTGTAATAAAATATACAAAAATCACTTGCCAGCAGTAGAAAAAGGACCGACTATAC >In-frame_USP9X_ENST00000378308_chrX_40982977_+_MAPKAPK5_ENST00000551404_chr12_112303054_+_2215nt GCGGCCGCCTTAGCGCCCGGTGCTTGGGTCGGCGCCGGGAGCGAGGAGCGAGCTACTTCAAAGCCACCAGGCCTGGAGCGGGGACAGAGG CGGCGACTAGGGGAAGGTGAAGCCGTCGCTGCAGGAGGAGGAGCAGGAGGAGGTGACGCAGGAGAAACGCACCGCCCGGAGCCCGTCTGA GCTCAGCGAGAGCCCCAGCCTGAGGGGAGAAGGGGAAGAGGGCCGTCGCCGGCCAAGGAGGAGGAGGAGGCGGGCGCGGCGAGGAGCGAG TTCCGGCGCCGGTGTGCAGCCTTTTGGTTGAGACGCCCGCAGCCCCGAGCCCGGCCGCCGCAGCCTTTCGATACACTTTGTTGCCGGTCA CCCCCGGGCCTGGGATGCACCCAGGGTAGGTCTCGTCCCGGGACCGAGCCCCACCGTCGCCTGGTGCCTCCCGCCTCCGTGTGCCCTGGT TGTGAGAAGACGTCTGTGTCGTGCGGTTATGCAATGGTCTCTGCAAGATGGTTTATTCTTGAATTGGACCTTTTTAAGACTGACAAATGC TGGTACTTCATCTTCTATAAGTGGACTATAATTTCTTTTCTCAAGACAACTACATAAGCAGACAAAATTGCAAAGATCTGCCCTGTGTCG AGTATGACAGCCACGACTCGTGGCTCTCCGGTCGGAGGGAATGACAACCAGGGCCAGGCTCCTGATGGACAGTCTCAGCCCCCCCTCCAA CAGAATCAGGAAACTTCCATTTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAGAGTCTGT GTAAAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGT GCCACACACCCAAACATAGTTCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGCCCGACTCTTA ATTGTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACA AAGCAGATAGCTTTGGCTCTGCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAAC TCTTTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTAT GTAGCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAAC AAGAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACT ATCCCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGAT GTTGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCC CTGGATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAAC ATGAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAG CCAAAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAG TGTATTCTCCCCCAGGCTGGTAAAGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGC AAACTCCTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTG AAGCAGGTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAAATTATTC >In-frame_USP9X_ENST00000324545_chrX_40982977_+_MAPKAPK5_ENST00000550735_chr12_112303054_+_2464nt GCGGCCGCCTTAGCGCCCGGTGCTTGGGTCGGCGCCGGGAGCGAGGAGCGAGCTACTTCAAAGCCACCAGGCCTGGAGCGGGGACAGAGG CGGCGACTAGGGGAAGGTGAAGCCGTCGCTGCAGGAGGAGGAGCAGGAGGAGGTGACGCAGGAGAAACGCACCGCCCGGAGCCCGTCTGA GCTCAGCGAGAGCCCCAGCCTGAGGGGAGAAGGGGAAGAGGGCCGTCGCCGGCCAAGGAGGAGGAGGAGGCGGGCGCGGCGAGGAGCGAG TTCCGGCGCCGGTGTGCAGCCTTTTGGTTGAGACGCCCGCAGCCCCGAGCCCGGCCGCCGCAGCCTTTCGATACACTTTGTTGCCGGTCA CCCCCGGGCCTGGGATGCACCCAGGGTAGGTCTCGTCCCGGGACCGAGCCCCACCGTCGCCTGGTGCCTCCCGCCTCCGTGTGCCCTGGT TGTGAGAAGACGTCTGTGTCGTGCGGTTATGCAATGGTCTCTGCAAGATGGTTTATTCTTGAATTGGACCTTTTTAAGACTGACAAATGC TGGTACTTCATCTTCTATAAGTGGACTATAATTTCTTTTCTCAAGACAACTACATAAGCAGACAAAATTGCAAAGATCTGCCCTGTGTCG AGTATGACAGCCACGACTCGTGGCTCTCCGGTCGGAGGGAATGACAACCAGGGCCAGGCTCCTGATGGACAGTCTCAGCCCCCCCTCCAA CAGAATCAGGAAACTTCCATTTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAGAGTCTGT GTAAAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGT GCCACACACCCAAACATAGTTCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGCCCGACTCTTA ATTGTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACA AAGCAGATAGCTTTGGCTCTGCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAAC TCTTTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTAT GTAGCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAAC AAGAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACT ATCCCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGAT GTTGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCC CTGGATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAAC ATGAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAG CCAAAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAG TGTATTCTCCCCCAGGCTGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAACTC CTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAGCAG GTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAAATTATTCTTTAAT GTATAAAGTAATTTTATGTAAATTAATAAATCATAATTTCATTTCCACATTGATTAAAGCTGCTGTATAGATTTAGGGTGCAGGACTTAA TAATAGTATAGTTATTGTTTGTTTTTAAGAAAAGCTCAGTTCTAGAGACATACTATTACTTTAGGACTGTGTAGTTGTATATTTGTAAGA TGACAGATGATGCTGTCAAGCAATATTGTTTTATTTGTAATAAAATATACAAAAATCACTTGCCAGCAGTAGAAAAAGGACCGACTATAC >In-frame_USP9X_ENST00000324545_chrX_40982977_+_MAPKAPK5_ENST00000551404_chr12_112303054_+_2215nt GCGGCCGCCTTAGCGCCCGGTGCTTGGGTCGGCGCCGGGAGCGAGGAGCGAGCTACTTCAAAGCCACCAGGCCTGGAGCGGGGACAGAGG CGGCGACTAGGGGAAGGTGAAGCCGTCGCTGCAGGAGGAGGAGCAGGAGGAGGTGACGCAGGAGAAACGCACCGCCCGGAGCCCGTCTGA GCTCAGCGAGAGCCCCAGCCTGAGGGGAGAAGGGGAAGAGGGCCGTCGCCGGCCAAGGAGGAGGAGGAGGCGGGCGCGGCGAGGAGCGAG TTCCGGCGCCGGTGTGCAGCCTTTTGGTTGAGACGCCCGCAGCCCCGAGCCCGGCCGCCGCAGCCTTTCGATACACTTTGTTGCCGGTCA CCCCCGGGCCTGGGATGCACCCAGGGTAGGTCTCGTCCCGGGACCGAGCCCCACCGTCGCCTGGTGCCTCCCGCCTCCGTGTGCCCTGGT TGTGAGAAGACGTCTGTGTCGTGCGGTTATGCAATGGTCTCTGCAAGATGGTTTATTCTTGAATTGGACCTTTTTAAGACTGACAAATGC TGGTACTTCATCTTCTATAAGTGGACTATAATTTCTTTTCTCAAGACAACTACATAAGCAGACAAAATTGCAAAGATCTGCCCTGTGTCG AGTATGACAGCCACGACTCGTGGCTCTCCGGTCGGAGGGAATGACAACCAGGGCCAGGCTCCTGATGGACAGTCTCAGCCCCCCCTCCAA CAGAATCAGGAAACTTCCATTTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGTTAGAGTCTGT GTAAAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCGTCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGT GCCACACACCCAAACATAGTTCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGCCCGACTCTTA ATTGTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCAGCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACA AAGCAGATAGCTTTGGCTCTGCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTTTAAGGATAAC TCTTTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTAT GTAGCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAAC AAGAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACT ATCCCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGAT GTTGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCC CTGGATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAAC ATGAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAG CCAAAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAG TGTATTCTCCCCCAGGCTGGTAAAGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGC AAACTCCTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTG AAGCAGGTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAAATTATTC 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FusionGenePPI for USP9X_MAPKAPK5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| USP9X | NEK6, CASP4, CTNNB1, MLLT4, NUAK1, MARK4, ITCH, BIRC5, CDH1, TERF1, TERF2, MAP3K5, MCL1, HUWE1, HDAC5, PSD4, GPSM1, SNCA, SMAD1, SMAD2, SMAD3, SMAD4, DCX, SIRT7, PEX5, NFX1, MTOR, RPTOR, RICTOR, MAGED4, MAGED1, PJA1, MARCH7, RUVBL1, CUL3, CAND1, GRK5, SHC1, UBA52, UBE2B, UBE2V2, UBXN1, UBE2D1, UBE2L3, SSSCA1, UCHL3, UBR4, UBQLN2, UBE2C, SEC23A, SRXN1, ZYX, ATP6V1F, UBQLN1, UFM1, EFTUD2, AHCYL1, UFC1, UNK, UBE4B, SEC24C, TTLL12, PSMB4, PSMA4, UBE2D2, UBL7, USP34, SNRNP200, YAP1, IGBP1, ZFYVE19, UBXN7, PSMB8, ARL6IP5, NUDCD2, NUBP2, ECT2, IKBKAP, SMURF1, UBC, CFTR, BIRC2, BIRC3, SOX2, HDAC6, BCL10, MALT1, EGFR, CLK3, LATS2, MIB1, HECW2, CCT4, TCP1, DCAF6, ERG, ASB15, CSNK1E, IRS4, AURKA, CCDC8, PEG10, RASSF10, RPS6KB2, NTRK1, PRPF8, PRICKLE1, PRICKLE2, XPO1, SOD1, KIAA0368, CRY1, CRY2, OTUD4, ALKBH3, MCM2, AMOTL2, PCGF1, DPPA4, NANOG, POU5F1, SMN2, GEMIN2, DDX20, GEMIN4, GEMIN5, GEMIN8, SNRPB, TDRD3, AMOT, VHL, WWP2, ZNF746, PTPDC1, PTPN21, SUPV3L1, HEXIM2, ZNF263, SUV39H1, ZNF408, PTPN14, ZNHIT2, TRIM25, TES, WWC1, AMOTL1, SAV1, LATS1 | MAPKAPK5 | HSPB1, HSPB2, MAPK6, MAPK14, RPL13, ZNF282, TAB1, MAPK4, MAPKAPK2, LSR, CDCA8, ZNF576, SRPK2, SRPK1, TP53, MAPK9, MAPK1, EIF4EBP1, MAPKAPK5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP9X_MAPKAPK5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP9X_MAPKAPK5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | USP9X | C3806746 | MENTAL RETARDATION, X-LINKED 99 | 1 | UNIPROT |
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