FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 41221

FusionGeneSummary for USP9X_MAGEB18

check button Fusion gene summary
Fusion gene informationFusion gene name: USP9X_MAGEB18
Fusion gene ID: 41221
HgeneTgene
Gene symbol

USP9X

MAGEB18

Gene ID

8239

286514

Gene nameubiquitin specific peptidase 9 X-linkedMAGE family member B18
SynonymsDFFRX|FAF|FAM|MRX99|MRXS99F-
Cytomap

Xp11.4

Xp21.3

Type of geneprotein-codingprotein-coding
Descriptionprobable ubiquitin carboxyl-terminal hydrolase FAF-XDrosophila fat facets related, X-linkeddeubiquitinating enzyme FAF-Xfat facets in mammalsfat facets protein related, X-linkedhFAMubiquitin specific protease 9, X chromosome (fat facets-like Drosophmelanoma-associated antigen B18MAGE-B18 antigenmelanoma antigen family B, 18melanoma antigen family B18
Modification date2018052320180519
UniProtAcc

Q93008

Q96M61

Ensembl transtripts involved in fusion geneENST00000378308, ENST00000324545, 
ENST00000325250, 
Fusion gene scores* DoF score14 X 8 X 10=11201 X 1 X 1=1
# samples 151
** MAII scorelog2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: USP9X [Title/Abstract] AND MAGEB18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP9X

GO:0016579

protein deubiquitination

19135894

HgeneUSP9X

GO:0030509

BMP signaling pathway

19135894

HgeneUSP9X

GO:1901537

positive regulation of DNA demethylation

25944111


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-BP-4349-01AUSP9XchrX

40945362

+MAGEB18chrX

26158297

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000378308ENST00000325250USP9XchrX

40945362

+MAGEB18chrX

26158297

+
5UTR-3UTRENST00000324545ENST00000325250USP9XchrX

40945362

+MAGEB18chrX

26158297

+

Top

FusionProtFeatures for USP9X_MAGEB18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP9X

Q93008

MAGEB18

Q96M61

Deubiquitinase involved both in the processing ofubiquitin precursors and of ubiquitinated proteins. May thereforeplay an important regulatory role at the level of protein turnoverby preventing degradation of proteins through the removal ofconjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essentialcomponent of TGF-beta/BMP signaling cascade. Specificallydeubiquitinates monoubiquitinated SMAD4, opposing the activity ofE3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylationrepair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilizeALKBH3, thereby promoting the repair of alkylated DNA lesions(PubMed:25944111). Regulates chromosome alignment and segregationin mitosis by regulating the localization of BIRC5/survivin tomitotic centromeres. Involved in axonal growth and neuronal cellmigration (PubMed:16322459, PubMed:18254724, PubMed:19135894,PubMed:24607389). {ECO:0000269|PubMed:16322459,ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894,ECO:0000269|PubMed:24607389, ECO:0000269|PubMed:25944111}. May enhance ubiquitin ligase activity of RING-type zincfinger-containing E3 ubiquitin-protein ligases. Proposed to actthrough recruitment and/or stabilization of the Ubl-conjugatingenzyme (E2) at the E3:substrate complex.{ECO:0000269|PubMed:20864041}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for USP9X_MAGEB18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for USP9X_MAGEB18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP9XNEK6, CASP4, CTNNB1, MLLT4, NUAK1, MARK4, ITCH, BIRC5, CDH1, TERF1, TERF2, MAP3K5, MCL1, HUWE1, HDAC5, PSD4, GPSM1, SNCA, SMAD1, SMAD2, SMAD3, SMAD4, DCX, SIRT7, PEX5, NFX1, MTOR, RPTOR, RICTOR, MAGED4, MAGED1, PJA1, MARCH7, RUVBL1, CUL3, CAND1, GRK5, SHC1, UBA52, UBE2B, UBE2V2, UBXN1, UBE2D1, UBE2L3, SSSCA1, UCHL3, UBR4, UBQLN2, UBE2C, SEC23A, SRXN1, ZYX, ATP6V1F, UBQLN1, UFM1, EFTUD2, AHCYL1, UFC1, UNK, UBE4B, SEC24C, TTLL12, PSMB4, PSMA4, UBE2D2, UBL7, USP34, SNRNP200, YAP1, IGBP1, ZFYVE19, UBXN7, PSMB8, ARL6IP5, NUDCD2, NUBP2, ECT2, IKBKAP, SMURF1, UBC, CFTR, BIRC2, BIRC3, SOX2, HDAC6, BCL10, MALT1, EGFR, CLK3, LATS2, MIB1, HECW2, CCT4, TCP1, DCAF6, ERG, ASB15, CSNK1E, IRS4, AURKA, CCDC8, PEG10, RASSF10, RPS6KB2, NTRK1, PRPF8, PRICKLE1, PRICKLE2, XPO1, SOD1, KIAA0368, CRY1, CRY2, OTUD4, ALKBH3, MCM2, AMOTL2, PCGF1, DPPA4, NANOG, POU5F1, SMN2, GEMIN2, DDX20, GEMIN4, GEMIN5, GEMIN8, SNRPB, TDRD3, AMOT, VHL, WWP2, ZNF746, PTPDC1, PTPN21, SUPV3L1, HEXIM2, ZNF263, SUV39H1, ZNF408, PTPN14, ZNHIT2, TRIM25, TES, WWC1, AMOTL1, SAV1, LATS1MAGEB18TRIM37, TP53, TNIP1, LNX1, GABPB1, HTT, ATXN1, CTAGE5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for USP9X_MAGEB18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for USP9X_MAGEB18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP9XC3806746MENTAL RETARDATION, X-LINKED 991UNIPROT