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Fusion gene ID: 41221 |
FusionGeneSummary for USP9X_MAGEB18 |
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Fusion gene information | Fusion gene name: USP9X_MAGEB18 | Fusion gene ID: 41221 | Hgene | Tgene | Gene symbol | USP9X | MAGEB18 | Gene ID | 8239 | 286514 |
Gene name | ubiquitin specific peptidase 9 X-linked | MAGE family member B18 | |
Synonyms | DFFRX|FAF|FAM|MRX99|MRXS99F | - | |
Cytomap | Xp11.4 | Xp21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | probable ubiquitin carboxyl-terminal hydrolase FAF-XDrosophila fat facets related, X-linkeddeubiquitinating enzyme FAF-Xfat facets in mammalsfat facets protein related, X-linkedhFAMubiquitin specific protease 9, X chromosome (fat facets-like Drosoph | melanoma-associated antigen B18MAGE-B18 antigenmelanoma antigen family B, 18melanoma antigen family B18 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q93008 | Q96M61 | |
Ensembl transtripts involved in fusion gene | ENST00000378308, ENST00000324545, | ENST00000325250, | |
Fusion gene scores | * DoF score | 14 X 8 X 10=1120 | 1 X 1 X 1=1 |
# samples | 15 | 1 | |
** MAII score | log2(15/1120*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: USP9X [Title/Abstract] AND MAGEB18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | USP9X | GO:0016579 | protein deubiquitination | 19135894 |
Hgene | USP9X | GO:0030509 | BMP signaling pathway | 19135894 |
Hgene | USP9X | GO:1901537 | positive regulation of DNA demethylation | 25944111 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRC | TCGA-BP-4349-01A | USP9X | chrX | 40945362 | + | MAGEB18 | chrX | 26158297 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000378308 | ENST00000325250 | USP9X | chrX | 40945362 | + | MAGEB18 | chrX | 26158297 | + |
5UTR-3UTR | ENST00000324545 | ENST00000325250 | USP9X | chrX | 40945362 | + | MAGEB18 | chrX | 26158297 | + |
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FusionProtFeatures for USP9X_MAGEB18 |
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Hgene | Tgene |
USP9X | MAGEB18 |
Deubiquitinase involved both in the processing ofubiquitin precursors and of ubiquitinated proteins. May thereforeplay an important regulatory role at the level of protein turnoverby preventing degradation of proteins through the removal ofconjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essentialcomponent of TGF-beta/BMP signaling cascade. Specificallydeubiquitinates monoubiquitinated SMAD4, opposing the activity ofE3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylationrepair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilizeALKBH3, thereby promoting the repair of alkylated DNA lesions(PubMed:25944111). Regulates chromosome alignment and segregationin mitosis by regulating the localization of BIRC5/survivin tomitotic centromeres. Involved in axonal growth and neuronal cellmigration (PubMed:16322459, PubMed:18254724, PubMed:19135894,PubMed:24607389). {ECO:0000269|PubMed:16322459,ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894,ECO:0000269|PubMed:24607389, ECO:0000269|PubMed:25944111}. | May enhance ubiquitin ligase activity of RING-type zincfinger-containing E3 ubiquitin-protein ligases. Proposed to actthrough recruitment and/or stabilization of the Ubl-conjugatingenzyme (E2) at the E3:substrate complex.{ECO:0000269|PubMed:20864041}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP9X_MAGEB18 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP9X_MAGEB18 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
USP9X | NEK6, CASP4, CTNNB1, MLLT4, NUAK1, MARK4, ITCH, BIRC5, CDH1, TERF1, TERF2, MAP3K5, MCL1, HUWE1, HDAC5, PSD4, GPSM1, SNCA, SMAD1, SMAD2, SMAD3, SMAD4, DCX, SIRT7, PEX5, NFX1, MTOR, RPTOR, RICTOR, MAGED4, MAGED1, PJA1, MARCH7, RUVBL1, CUL3, CAND1, GRK5, SHC1, UBA52, UBE2B, UBE2V2, UBXN1, UBE2D1, UBE2L3, SSSCA1, UCHL3, UBR4, UBQLN2, UBE2C, SEC23A, SRXN1, ZYX, ATP6V1F, UBQLN1, UFM1, EFTUD2, AHCYL1, UFC1, UNK, UBE4B, SEC24C, TTLL12, PSMB4, PSMA4, UBE2D2, UBL7, USP34, SNRNP200, YAP1, IGBP1, ZFYVE19, UBXN7, PSMB8, ARL6IP5, NUDCD2, NUBP2, ECT2, IKBKAP, SMURF1, UBC, CFTR, BIRC2, BIRC3, SOX2, HDAC6, BCL10, MALT1, EGFR, CLK3, LATS2, MIB1, HECW2, CCT4, TCP1, DCAF6, ERG, ASB15, CSNK1E, IRS4, AURKA, CCDC8, PEG10, RASSF10, RPS6KB2, NTRK1, PRPF8, PRICKLE1, PRICKLE2, XPO1, SOD1, KIAA0368, CRY1, CRY2, OTUD4, ALKBH3, MCM2, AMOTL2, PCGF1, DPPA4, NANOG, POU5F1, SMN2, GEMIN2, DDX20, GEMIN4, GEMIN5, GEMIN8, SNRPB, TDRD3, AMOT, VHL, WWP2, ZNF746, PTPDC1, PTPN21, SUPV3L1, HEXIM2, ZNF263, SUV39H1, ZNF408, PTPN14, ZNHIT2, TRIM25, TES, WWC1, AMOTL1, SAV1, LATS1 | MAGEB18 | TRIM37, TP53, TNIP1, LNX1, GABPB1, HTT, ATXN1, CTAGE5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP9X_MAGEB18 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP9X_MAGEB18 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | USP9X | C3806746 | MENTAL RETARDATION, X-LINKED 99 | 1 | UNIPROT |