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Fusion gene ID: 41208 |
FusionGeneSummary for USP8_BDP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP8_BDP1 | Fusion gene ID: 41208 | Hgene | Tgene | Gene symbol | USP8 | BDP1 | Gene ID | 9101 | 55814 |
| Gene name | ubiquitin specific peptidase 8 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | |
| Synonyms | HumORF8|PITA4|SPG59|UBPY | HSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR | |
| Cytomap | 15q21.2 | 5q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 8deubiquitinating enzyme 8ubiquitin isopeptidase Yubiquitin thiolesterase 8ubiquitin-specific-processing protease 8 | transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P40818 | A6H8Y1 | |
| Ensembl transtripts involved in fusion gene | ENST00000307179, ENST00000433963, ENST00000396444, ENST00000425032, ENST00000558892, | ENST00000358731, ENST00000380675, | |
| Fusion gene scores | * DoF score | 8 X 8 X 7=448 | 3 X 4 X 3=36 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/448*10)=-2.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: USP8 [Title/Abstract] AND BDP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | USP8 | GO:0070536 | protein K63-linked deubiquitination | 16520378 |
| Hgene | USP8 | GO:0071108 | protein K48-linked deubiquitination | 16520378 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-BF-A5EQ-01A | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000307179 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| 5CDS-5UTR | ENST00000307179 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| Frame-shift | ENST00000433963 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| 5CDS-5UTR | ENST00000433963 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| Frame-shift | ENST00000396444 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| 5CDS-5UTR | ENST00000396444 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| Frame-shift | ENST00000425032 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| 5CDS-5UTR | ENST00000425032 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| intron-3CDS | ENST00000558892 | ENST00000358731 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
| intron-5UTR | ENST00000558892 | ENST00000380675 | USP8 | chr15 | 50769696 | + | BDP1 | chr5 | 70786811 | + |
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FusionProtFeatures for USP8_BDP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP8 | BDP1 |
| Hydrolase that can remove conjugated ubiquitin fromproteins and therefore plays an important regulatory role at thelevel of protein turnover by preventing degradation. Converts both'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activityis enhanced in the M phase. Involved in cell proliferation.Required to enter into S phase in response to serum stimulation.May regulate T-cell anergy mediated by RNF128 via the formation ofa complex containing RNF128 and OTUB1. Probably regulates thestability of STAM2 and RASGRF1. Regulates endosomal ubiquitindynamics, cargo sorting, membrane traffic at early endosomes, andmaintenance of ESCRT-0 stability. The level of proteinubiquitination on endosomes is essential for maintaining themorphology of the organelle. Deubiquitinates EPS15 and controlestyrosine kinase stability. Removes conjugated ubiquitin from EGFRthus regulating EGFR degradation and downstream MAPK signaling.Involved in acrosome biogenesis through interaction with thespermatid ESCRT-0 complex and microtubules. DeubiquitinatesBIRC6/bruce and KIF23/MKLP1. {ECO:0000269|PubMed:16520378,ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369,ECO:0000269|PubMed:9628861}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP8_BDP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP8_BDP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| USP8 | YWHAB, YWHAZ, YWHAQ, SFN, RNF41, OTUB1, RNF128, STAM2, STAM, GRB2, KIF23, BIRC6, KRT31, KRT85, KRT36, USP22, RPL6P1, AKT1, EPS15, EGFR, CHMP1B, CHMP1A, CHMP4C, CHMP7, KCNN4, YWHAG, SPP1, NBR1, USP8, UBC, CHMP2A, CHMP2B, GRAP2, PJA1, TRIM63, TRIM55, TRIM54, USP21, USP15, USP28, UBE2I, UBE2G1, FARSB, VPS4B, SRC, ERBB4, YWHAE, PTPN23, HTT, POLD3, STAT6, TSEN2, PTEN, LRIG1, TARDBP, VAMP8, PLA2G2A, SCNN1A, SCNN1B, SCNN1G, MCPH1, ACAA2, TATDN1, UBE2E1, NTRK1, HIST2H2AC, HIST2H2BE, C10orf76, PTAR1, BACE1, SNCA, CFLAR, CDH1, CD83, CBY1, RAB3IP, MAGEL2 | BDP1 | ZBTB43, BAX, MYH6, POLR2F, YWHAZ, RAPGEF2, POLR3E, RGMA, CDCA5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP8_BDP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP8_BDP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | USP8 | C0221406 | Pituitary-dependent Cushing's disease | 1 | CTD_human;ORPHANET |
| Hgene | USP8 | C1306214 | ACTH-Secreting Pituitary Adenoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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