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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41204

FusionGeneSummary for USP7_SMARCA2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP7_SMARCA2
Fusion gene ID: 41204
HgeneTgene
Gene symbol

USP7

SMARCA2

Gene ID

7874

6595

Gene nameubiquitin specific peptidase 7SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SynonymsHAUSP|TEF1BAF190|BRM|NCBRS|SNF2|SNF2L2|SNF2LA|SWI2|Sth1p|hBRM|hSNF2a
Cytomap

16p13.2

9p24.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 7Herpes virus-associated ubiquitin-specific proteasedeubiquitinating enzyme 7ubiquitin specific peptidase 7 (herpes virus-associated)ubiquitin specific protease 7 (herpes virus-associated)ubiquitin thioesterase 7probable global transcription activator SNF2L2ATP-dependent helicase SMARCA2BAF190BBRG1-associated factor 190BSNF2-alphaSNF2/SWI2-like protein 2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2brahma homologglobal transcr
Modification date2018052320180519
UniProtAcc

Q93009

P51531

Ensembl transtripts involved in fusion geneENST00000344836, ENST00000381886, 
ENST00000535863, ENST00000566224, 
ENST00000357248, ENST00000349721, 
ENST00000382203, ENST00000382194, 
ENST00000491574, ENST00000324954, 
ENST00000302401, ENST00000382186, 
ENST00000382185, 
Fusion gene scores* DoF score2 X 2 X 3=1211 X 11 X 5=605
# samples 312
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/605*10)=-2.33390073655344
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP7 [Title/Abstract] AND SMARCA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP7

GO:0016579

protein deubiquitination

16964248|21745816|25172512

HgeneUSP7

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11279055

HgeneUSP7

GO:0035520

monoubiquitinated protein deubiquitination

26280536

HgeneUSP7

GO:0050821

protein stabilization

25172512

HgeneUSP7

GO:0051090

regulation of DNA binding transcription factor activity

16964248

HgeneUSP7

GO:1901537

positive regulation of DNA demethylation

25944111

TgeneSMARCA2

GO:0008285

negative regulation of cell proliferation

14660596

TgeneSMARCA2

GO:0045892

negative regulation of transcription, DNA-templated

12065415

TgeneSMARCA2

GO:0045893

positive regulation of transcription, DNA-templated

17984088

TgeneSMARCA2

GO:0045944

positive regulation of transcription by RNA polymerase II

15774904


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-AAML-01AUSP7chr16

9057064

-SMARCA2chr9

2161686

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344836ENST00000357248USP7chr16

9057064

-SMARCA2chr9

2161686

+
In-frameENST00000344836ENST00000349721USP7chr16

9057064

-SMARCA2chr9

2161686

+
In-frameENST00000344836ENST00000382203USP7chr16

9057064

-SMARCA2chr9

2161686

+
In-frameENST00000344836ENST00000382194USP7chr16

9057064

-SMARCA2chr9

2161686

+
5CDS-intronENST00000344836ENST00000491574USP7chr16

9057064

-SMARCA2chr9

2161686

+
5CDS-5UTRENST00000344836ENST00000324954USP7chr16

9057064

-SMARCA2chr9

2161686

+
5CDS-5UTRENST00000344836ENST00000302401USP7chr16

9057064

-SMARCA2chr9

2161686

+
5CDS-5UTRENST00000344836ENST00000382186USP7chr16

9057064

-SMARCA2chr9

2161686

+
5CDS-5UTRENST00000344836ENST00000382185USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000381886ENST00000357248USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000381886ENST00000349721USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000381886ENST00000382203USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000381886ENST00000382194USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-intronENST00000381886ENST00000491574USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000381886ENST00000324954USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000381886ENST00000302401USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000381886ENST00000382186USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000381886ENST00000382185USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000535863ENST00000357248USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000535863ENST00000349721USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000535863ENST00000382203USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000535863ENST00000382194USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-intronENST00000535863ENST00000491574USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000535863ENST00000324954USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000535863ENST00000302401USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000535863ENST00000382186USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000535863ENST00000382185USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000566224ENST00000357248USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000566224ENST00000349721USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000566224ENST00000382203USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-3CDSENST00000566224ENST00000382194USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-intronENST00000566224ENST00000491574USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000566224ENST00000324954USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000566224ENST00000302401USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000566224ENST00000382186USP7chr16

9057064

-SMARCA2chr9

2161686

+
intron-5UTRENST00000566224ENST00000382185USP7chr16

9057064

-SMARCA2chr9

2161686

+

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FusionProtFeatures for USP7_SMARCA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP7

Q93009

SMARCA2

P51531

Hydrolase that deubiquitinates target proteins such asFOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 andDAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248,PubMed:18716620, PubMed:25283148, PubMed:26678539). Together withDAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligaseactivity of MDM2 towards p53/TP53, thereby promoting p53/TP53ubiquitination and proteasomal degradation (PubMed:15053880,PubMed:16845383, PubMed:18566590, PubMed:20153724).Deubiquitinates p53/TP53, preventing degradation of p53/TP53, andenhances p53/TP53-dependent transcription regulation, cell growthrepression and apoptosis (PubMed:25283148). Deubiquitinatesp53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in thepresence of excess MDM2, and also induces p53/TP53-dependent cellgrowth repression and apoptosis (PubMed:11923872).Deubiquitination of FOXO4 in presence of hydrogen peroxide is notdependent on p53/TP53 and inhibits FOXO4-induced transcriptionalactivity (PubMed:16964248). In association with DAXX, is involvedin the deubiquitination and translocation of PTEN from the nucleusto the cytoplasm, both processes that are counteracted by PML(PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventingKMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539).Involved in cell proliferation during early embryonic development.Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sitesfollowing interaction with KIAA1530/UVSSA and promotesdeubiquitination of ERCC6, preventing UV-induced degradation ofERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenanceof DNA methylation via its interaction with UHRF1 and DNMT1: actsby mediating deubiquitination of UHRF1 and DNMT1, preventing theirdegradation and promoting DNA methylation by DNMT1(PubMed:21745816, PubMed:22411829). Deubiquitinates alkylationrepair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilizeALKBH3, thereby promoting the repair of alkylated DNA lesions(PubMed:25944111). Acts as a chromatin regulator via itsassociation with the Polycomb group (PcG) multiprotein PRC1-likecomplex; may act by deubiquitinating components of the PRC1-likecomplex (PubMed:20601937). Able to mediate deubiquitination ofhistone H2B; it is however unsure whether this activity takesplace in vivo (PubMed:20601937). Exhibits a preference towards'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increasesregulatory T-cells (Treg) suppressive capacity by deubiquitinatingand stabilizing the transcription factor FOXP3 which is crucialfor Treg cell function (PubMed:23973222).{ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880,ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248,ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620,ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937,ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829,ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612,ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222,ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25944111,ECO:0000269|PubMed:26678539}. (Microbial infection) Contributes to the overallstabilization and trans-activation capability of the herpesvirus 1trans-acting transcriptional protein ICP0/VMW110 during HSV-1infection. {ECO:0000269|PubMed:14506283,ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}. Involved in transcriptional activation and repression ofselect genes by chromatin remodeling (alteration of DNA-nucleosometopology). Component of SWI/SNF chromatin remodeling complexesthat carry out key enzymatic activities, changing chromatinstructure by altering DNA-histone contacts within a nucleosome inan ATP-dependent manner. Binds DNA non-specifically(PubMed:22952240, PubMed:26601204). Belongs to the neuralprogenitors-specific chromatin remodeling complex (npBAF complex)and the neuron-specific chromatin remodeling complex (nBAFcomplex). During neural development a switch from astem/progenitor to a postmitotic chromatin remodeling mechanismoccurs as neurons exit the cell cycle and become committed totheir adult state. The transition from proliferating neuralstem/progenitor cells to postmitotic neurons requires a switch insubunit composition of the npBAF and nBAF complexes. As neuralprogenitors exit mitosis and differentiate into neurons, npBAFcomplexes which contain ACTL6A/BAF53A and PHF10/BAF45A, areexchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45Bor DPF3/BAF45C subunits in neuron-specific complexes (nBAF). ThenpBAF complex is essential for the self-renewal/proliferativecapacity of the multipotent neural stem cells. The nBAF complexalong with CREST plays a role regulating the activity of genesessential for dendrite growth (By similarity).{ECO:0000250|UniProtKB:Q6DIC0, ECO:0000303|PubMed:22952240,ECO:0000303|PubMed:26601204}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP7chr16:9057064chr9:2161686ENST00000344836-1314_10261103Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+26341518_152913271591Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+26331518_152913271573Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+25321518_152913271573Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+26341518_152913271591Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+26341419_148913271591DomainBromo
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+26331419_148913271573DomainBromo
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+25321419_148913271573DomainBromo
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+26341419_148913271591DomainBromo

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP7chr16:9057064chr9:2161686ENST00000344836-131214_521261103DomainNote=USP
HgeneUSP7chr16:9057064chr9:2161686ENST00000344836-13168_195261103DomainMATH
HgeneUSP7chr16:9057064chr9:2161686ENST00000344836-13170_205261103RegionNote=Necessary for nuclear localization
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+26341297_130113271591Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634216_23813271591Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634245_25313271591Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634559_56213271591Compositional biasNote=Poly-Arg
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634643_65013271591Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+26331297_130113271573Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633216_23813271573Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633245_25313271573Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633559_56213271573Compositional biasNote=Poly-Arg
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633643_65013271573Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+25321297_130113271573Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532216_23813271573Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532245_25313271573Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532559_56213271573Compositional biasNote=Poly-Arg
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532643_65013271573Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+26341297_130113271591Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634216_23813271591Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634245_25313271591Compositional biasNote=Poly-Gln
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634559_56213271591Compositional biasNote=Poly-Arg
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634643_65013271591Compositional biasNote=Poly-Glu
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+26341054_121613271591DomainHelicase C-terminal
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634173_20813271591DomainQLQ
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634436_50813271591DomainHSA
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634736_90113271591DomainHelicase ATP-binding
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+26331054_121613271573DomainHelicase C-terminal
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633173_20813271573DomainQLQ
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633436_50813271573DomainHSA
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633736_90113271573DomainHelicase ATP-binding
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+25321054_121613271573DomainHelicase C-terminal
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532173_20813271573DomainQLQ
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532436_50813271573DomainHSA
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532736_90113271573DomainHelicase ATP-binding
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+26341054_121613271591DomainHelicase C-terminal
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634173_20813271591DomainQLQ
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634436_50813271591DomainHSA
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634736_90113271591DomainHelicase ATP-binding
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634851_85413271591MotifNote=DEGH box
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633851_85413271573MotifNote=DEGH box
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532851_85413271573MotifNote=DEGH box
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634851_85413271591MotifNote=DEGH box
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000349721+2634749_75613271591Nucleotide bindingATP
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000357248+2633749_75613271573Nucleotide bindingATP
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382194+2532749_75613271573Nucleotide bindingATP
TgeneSMARCA2chr16:9057064chr9:2161686ENST00000382203+2634749_75613271591Nucleotide bindingATP


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FusionGeneSequence for USP7_SMARCA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000357248_chr9_2161686_+_272aa
MNHQQQQQQQKAGEQQLSEPEDMEMEGHRRRQFGGNGRGSTAXEAKKTKKCGXRSCKRRCGKSXEEKRPPSRXETVTKSPQTDKADERYH
RYCDKLQRXFRATAQXSLHSVTFKERITRILXINXEASGFQKNKGKDSXSXVPEPRRPGEGCHASLSQRSDVQPGGIPDLXRLHRLTVSV
XECPAENCQRGREXGXKQXRGGRGRXRRVRVRGKISQGENXAQXKRXQRPGQRERQEKAKSRKSQTCSERFXQRXGAGXTXTVRRKWDGX

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000349721_chr9_2161686_+_290aa
MNHQQQQQQQKAGEQQLSEPEDMEMEGHRRRQFGGNGRGSTAXEAKKTKKCGXRSCKRRCGKSXEEKRPPSRXETVTKSPQTDKADERYH
RYCDKLQRXVXRGEGAQXFSVGNRRKQFRATAQXSLHSVTFKERITRILXINXEASGFQKNKGKDSXSXVPEPRRPGEGCHASLSQRSDV
QPGGIPDLXRLHRLTVSVXECPAENCQRGREXGXKQXRGGRGRXRRVRVRGKISQGENXAQXKRXQRPGQRERQEKAKSRKSQTCSERFX

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000382203_chr9_2161686_+_290aa
MNHQQQQQQQKAGEQQLSEPEDMEMEGHRRRQFGGNGRGSTAXEAKKTKKCGXRSCKRRCGKSXEEKRPPSRXETVTKSPQTDKADERYH
RYCDKLQRXVXRGEGAQXFSVGNRRKQFRATAQXSLHSVTFKERITRILXINXEASGFQKNKGKDSXSXVPEPRRPGEGCHASLSQRSDV
QPGGIPDLXRLHRLTVSVXECPAENCQRGREXGXKQXRGGRGRXRRVRVRGKISQGENXAQXKRXQRPGQRERQEKAKSRKSQTCSERFX

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000382194_chr9_2161686_+_272aa
MNHQQQQQQQKAGEQQLSEPEDMEMEGHRRRQFGGNGRGSTAXEAKKTKKCGXRSCKRRCGKSXEEKRPPSRXETVTKSPQTDKADERYH
RYCDKLQRXFRATAQXSLHSVTFKERITRILXINXEASGFQKNKGKDSXSXVPEPRRPGEGCHASLSQRSDVQPGGIPDLXRLHRLTVSV
XECPAENCQRGREXGXKQXRGGRGRXRRVRVRGKISQGENXAQXKRXQRPGQRERQEKAKSRKSQTCSERFXQRXGAGXTXTVRRKWDGX


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000357248_chr9_2161686_+_817nt
ATGAACCACCAGCAGCAGCAGCAGCAGCAGAAAGCGGGCGAGCAGCAGTTGAGCGAGCCCGAGGACATGGAGATGGAAGGCCATCGAAGA
CGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAGATCCTGCAAAAGAAGATGT
GGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAAAGCAGATGAACGCTATCAT
CGATACTGTGATAAACTACAAAGATAGTTCAGGGCGACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAAGGAAAGAATTACCAGAATA
CTATGAATTAATTAGGAAGCCAGTGGATTTCAAAAAAATAAAGGAAAGGATTCGTAATCATAAGTACCGGAGCCTAGGCGACCTGGAGAA
GGATGTCATGCTTCTCTGTCACAACGCTCAGACGTTCAACCTGGAGGGATCCCAGATCTATGAAGACTCCATCGTCTTACAGTCAGTGTT
TAAGAGTGCCCGGCAGAAAATTGCCAAAGAGGAAGAGAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGGAAGATGAAGAAGAGTCAGA
GTCCGAGGCAAAATCAGTCAAGGTGAAAATTAAGCTCAATAAAAAAGATGACAAAGGCCGGGACAAAGGGAAAGGCAAGAAAAGGCCAAA
TCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAGAAGGAAGTGGGACGGATGA

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000349721_chr9_2161686_+_871nt
ATGAACCACCAGCAGCAGCAGCAGCAGCAGAAAGCGGGCGAGCAGCAGTTGAGCGAGCCCGAGGACATGGAGATGGAAGGCCATCGAAGA
CGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAGATCCTGCAAAAGAAGATGT
GGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAAAGCAGATGAACGCTATCAT
CGATACTGTGATAAACTACAAAGATAGGTGTAACGTGGAGAAGGTGCCCAGTAATTCTCAGTTGGAAATAGAAGGAAACAGTTCAGGGCG
ACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAAGGAAAGAATTACCAGAATACTATGAATTAATTAGGAAGCCAGTGGATTTCAAAAA
AATAAAGGAAAGGATTCGTAATCATAAGTACCGGAGCCTAGGCGACCTGGAGAAGGATGTCATGCTTCTCTGTCACAACGCTCAGACGTT
CAACCTGGAGGGATCCCAGATCTATGAAGACTCCATCGTCTTACAGTCAGTGTTTAAGAGTGCCCGGCAGAAAATTGCCAAAGAGGAAGA
GAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGGAAGATGAAGAAGAGTCAGAGTCCGAGGCAAAATCAGTCAAGGTGAAAATTAAGCT
CAATAAAAAAGATGACAAAGGCCGGGACAAAGGGAAAGGCAAGAAAAGGCCAAATCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGA

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000382203_chr9_2161686_+_871nt
ATGAACCACCAGCAGCAGCAGCAGCAGCAGAAAGCGGGCGAGCAGCAGTTGAGCGAGCCCGAGGACATGGAGATGGAAGGCCATCGAAGA
CGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAGATCCTGCAAAAGAAGATGT
GGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAAAGCAGATGAACGCTATCAT
CGATACTGTGATAAACTACAAAGATAGGTGTAACGTGGAGAAGGTGCCCAGTAATTCTCAGTTGGAAATAGAAGGAAACAGTTCAGGGCG
ACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAAGGAAAGAATTACCAGAATACTATGAATTAATTAGGAAGCCAGTGGATTTCAAAAA
AATAAAGGAAAGGATTCGTAATCATAAGTACCGGAGCCTAGGCGACCTGGAGAAGGATGTCATGCTTCTCTGTCACAACGCTCAGACGTT
CAACCTGGAGGGATCCCAGATCTATGAAGACTCCATCGTCTTACAGTCAGTGTTTAAGAGTGCCCGGCAGAAAATTGCCAAAGAGGAAGA
GAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGGAAGATGAAGAAGAGTCAGAGTCCGAGGCAAAATCAGTCAAGGTGAAAATTAAGCT
CAATAAAAAAGATGACAAAGGCCGGGACAAAGGGAAAGGCAAGAAAAGGCCAAATCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGA

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000382194_chr9_2161686_+_817nt
ATGAACCACCAGCAGCAGCAGCAGCAGCAGAAAGCGGGCGAGCAGCAGTTGAGCGAGCCCGAGGACATGGAGATGGAAGGCCATCGAAGA
CGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAGATCCTGCAAAAGAAGATGT
GGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAAAGCAGATGAACGCTATCAT
CGATACTGTGATAAACTACAAAGATAGTTCAGGGCGACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAAGGAAAGAATTACCAGAATA
CTATGAATTAATTAGGAAGCCAGTGGATTTCAAAAAAATAAAGGAAAGGATTCGTAATCATAAGTACCGGAGCCTAGGCGACCTGGAGAA
GGATGTCATGCTTCTCTGTCACAACGCTCAGACGTTCAACCTGGAGGGATCCCAGATCTATGAAGACTCCATCGTCTTACAGTCAGTGTT
TAAGAGTGCCCGGCAGAAAATTGCCAAAGAGGAAGAGAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGGAAGATGAAGAAGAGTCAGA
GTCCGAGGCAAAATCAGTCAAGGTGAAAATTAAGCTCAATAAAAAAGATGACAAAGGCCGGGACAAAGGGAAAGGCAAGAAAAGGCCAAA
TCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAGAAGGAAGTGGGACGGATGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000357248_chr9_2161686_+_1901nt
GTACGTGCGCGTCTCCCTGCCGCCGCCGCCGCCCGCCGCGGGCCGCCCCGGGGCCGCCGTCGCCGACGACGCGCGGGAGGAGGAGGAGGA
GGCCGCCCCGCCGCCGCCGCCGCCGCCGCCGCCCCGGCTCGCCGCCGCCCGCCCGCCGGGCTCGCAGCCCCGGCCCCCGGCCGCAGGCGA
GGCCCAGGCCGCGGCCGACATGAACCACCAGCAGCAGCAGCAGCAGCAGAAAGCGGGCGAGCAGCAGTTGAGCGAGCCCGAGGACATGGA
GATGGAAGGCCATCGAAGACGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAG
ATCCTGCAAAAGAAGATGTGGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAA
AGCAGATGAACGCTATCATCGATACTGTGATAAACTACAAAGATAGTTCAGGGCGACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAA
GGAAAGAATTACCAGAATACTATGAATTAATTAGGAAGCCAGTGGATTTCAAAAAAATAAAGGAAAGGATTCGTAATCATAAGTACCGGA
GCCTAGGCGACCTGGAGAAGGATGTCATGCTTCTCTGTCACAACGCTCAGACGTTCAACCTGGAGGGATCCCAGATCTATGAAGACTCCA
TCGTCTTACAGTCAGTGTTTAAGAGTGCCCGGCAGAAAATTGCCAAAGAGGAAGAGAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGG
AAGATGAAGAAGAGTCAGAGTCCGAGGCAAAATCAGTCAAGGTGAAAATTAAGCTCAATAAAAAAGATGACAAAGGCCGGGACAAAGGGA
AAGGCAAGAAAAGGCCAAATCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAG
AAGGAAGTGGGACGGATGATGAGTGATCAGTATGGACCTTTTTCCTTGGTAGAACTGAATTCCTTCCTCCCCTGTCTCATTTCTACCCAG
TGAGTTCATTTGTCATATAGGCACTGGGTTGTTTCTATATCATCATCGTCTATAAACTAGCTTTAGGATAGTGCCAGACAAACATATGAT
ATCATGGTGTAAAAAACACACACATACACAAATATTTGTAACATATTGTGACCAAATGGGCCTCAAAGATTCAGATTGAAACAAACAAAA
AGCTTTTGATGGAAAATATGTGGGTGGATAGTATATTTCTATGGGTGGGTCTAATTTGGTAACGGTTTGATTGTGCCTGGTTTTATCACC
TGTTCAGATGAGAAGATTTTTGTCTTTTGTAGCACTGATAACCAGGAGAAGCCATTAAAAGCCACTGGTTATTTTATTTTTCATCAGGCA
ATTTTCGAGGTTTTTATTTGTTCGGTATTGTTTTTTTACACTGTGGTACATATAAGCAACTTTAATAGGTGATAAATGTACAGTAGTTAG
ATTTCACCTGCATATACATTTTTCCATTTTATGCTCTATGATCTGAACAAAAGCTTTTTGAATTGTATAAGATTTATGTCTACTGTAAAC
ATTGCTTAATTTTTTTGCTCTTGATTTAAAAAAAAGTTTTGTTGAAAGCGCTATTGAATATTGCAATCTATATAGTGTATTGGATGGCTT
CTTTTGTCACCCTGATCTCCTATGTTACCAATGTGTATCGTCTCCTTCTCCCTAAAGTGTACTTAATCTTTGCTTTCTTTGCACAATGTC
TTTGGTTGCAAGTCATAAGCCTGAGGCAAATAAAATTCCAGTAATTTCGAAGAATGTGGTGTTGGTGCTTTCCTAATAAAGAAATAATTT

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000349721_chr9_2161686_+_1955nt
GTACGTGCGCGTCTCCCTGCCGCCGCCGCCGCCCGCCGCGGGCCGCCCCGGGGCCGCCGTCGCCGACGACGCGCGGGAGGAGGAGGAGGA
GGCCGCCCCGCCGCCGCCGCCGCCGCCGCCGCCCCGGCTCGCCGCCGCCCGCCCGCCGGGCTCGCAGCCCCGGCCCCCGGCCGCAGGCGA
GGCCCAGGCCGCGGCCGACATGAACCACCAGCAGCAGCAGCAGCAGCAGAAAGCGGGCGAGCAGCAGTTGAGCGAGCCCGAGGACATGGA
GATGGAAGGCCATCGAAGACGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAG
ATCCTGCAAAAGAAGATGTGGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAA
AGCAGATGAACGCTATCATCGATACTGTGATAAACTACAAAGATAGGTGTAACGTGGAGAAGGTGCCCAGTAATTCTCAGTTGGAAATAG
AAGGAAACAGTTCAGGGCGACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAAGGAAAGAATTACCAGAATACTATGAATTAATTAGGA
AGCCAGTGGATTTCAAAAAAATAAAGGAAAGGATTCGTAATCATAAGTACCGGAGCCTAGGCGACCTGGAGAAGGATGTCATGCTTCTCT
GTCACAACGCTCAGACGTTCAACCTGGAGGGATCCCAGATCTATGAAGACTCCATCGTCTTACAGTCAGTGTTTAAGAGTGCCCGGCAGA
AAATTGCCAAAGAGGAAGAGAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGGAAGATGAAGAAGAGTCAGAGTCCGAGGCAAAATCAG
TCAAGGTGAAAATTAAGCTCAATAAAAAAGATGACAAAGGCCGGGACAAAGGGAAAGGCAAGAAAAGGCCAAATCGAGGAAAAGCCAAAC
CTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAGAAGGAAGTGGGACGGATGATGAGTGATCAGTATGGA
CCTTTTTCCTTGGTAGAACTGAATTCCTTCCTCCCCTGTCTCATTTCTACCCAGTGAGTTCATTTGTCATATAGGCACTGGGTTGTTTCT
ATATCATCATCGTCTATAAACTAGCTTTAGGATAGTGCCAGACAAACATATGATATCATGGTGTAAAAAACACACACATACACAAATATT
TGTAACATATTGTGACCAAATGGGCCTCAAAGATTCAGATTGAAACAAACAAAAAGCTTTTGATGGAAAATATGTGGGTGGATAGTATAT
TTCTATGGGTGGGTCTAATTTGGTAACGGTTTGATTGTGCCTGGTTTTATCACCTGTTCAGATGAGAAGATTTTTGTCTTTTGTAGCACT
GATAACCAGGAGAAGCCATTAAAAGCCACTGGTTATTTTATTTTTCATCAGGCAATTTTCGAGGTTTTTATTTGTTCGGTATTGTTTTTT
TACACTGTGGTACATATAAGCAACTTTAATAGGTGATAAATGTACAGTAGTTAGATTTCACCTGCATATACATTTTTCCATTTTATGCTC
TATGATCTGAACAAAAGCTTTTTGAATTGTATAAGATTTATGTCTACTGTAAACATTGCTTAATTTTTTTGCTCTTGATTTAAAAAAAAG
TTTTGTTGAAAGCGCTATTGAATATTGCAATCTATATAGTGTATTGGATGGCTTCTTTTGTCACCCTGATCTCCTATGTTACCAATGTGT
ATCGTCTCCTTCTCCCTAAAGTGTACTTAATCTTTGCTTTCTTTGCACAATGTCTTTGGTTGCAAGTCATAAGCCTGAGGCAAATAAAAT

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000382203_chr9_2161686_+_1955nt
GTACGTGCGCGTCTCCCTGCCGCCGCCGCCGCCCGCCGCGGGCCGCCCCGGGGCCGCCGTCGCCGACGACGCGCGGGAGGAGGAGGAGGA
GGCCGCCCCGCCGCCGCCGCCGCCGCCGCCGCCCCGGCTCGCCGCCGCCCGCCCGCCGGGCTCGCAGCCCCGGCCCCCGGCCGCAGGCGA
GGCCCAGGCCGCGGCCGACATGAACCACCAGCAGCAGCAGCAGCAGCAGAAAGCGGGCGAGCAGCAGTTGAGCGAGCCCGAGGACATGGA
GATGGAAGGCCATCGAAGACGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAG
ATCCTGCAAAAGAAGATGTGGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAA
AGCAGATGAACGCTATCATCGATACTGTGATAAACTACAAAGATAGGTGTAACGTGGAGAAGGTGCCCAGTAATTCTCAGTTGGAAATAG
AAGGAAACAGTTCAGGGCGACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAAGGAAAGAATTACCAGAATACTATGAATTAATTAGGA
AGCCAGTGGATTTCAAAAAAATAAAGGAAAGGATTCGTAATCATAAGTACCGGAGCCTAGGCGACCTGGAGAAGGATGTCATGCTTCTCT
GTCACAACGCTCAGACGTTCAACCTGGAGGGATCCCAGATCTATGAAGACTCCATCGTCTTACAGTCAGTGTTTAAGAGTGCCCGGCAGA
AAATTGCCAAAGAGGAAGAGAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGGAAGATGAAGAAGAGTCAGAGTCCGAGGCAAAATCAG
TCAAGGTGAAAATTAAGCTCAATAAAAAAGATGACAAAGGCCGGGACAAAGGGAAAGGCAAGAAAAGGCCAAATCGAGGAAAAGCCAAAC
CTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAGAAGGAAGTGGGACGGATGATGAGTGATCAGTATGGA
CCTTTTTCCTTGGTAGAACTGAATTCCTTCCTCCCCTGTCTCATTTCTACCCAGTGAGTTCATTTGTCATATAGGCACTGGGTTGTTTCT
ATATCATCATCGTCTATAAACTAGCTTTAGGATAGTGCCAGACAAACATATGATATCATGGTGTAAAAAACACACACATACACAAATATT
TGTAACATATTGTGACCAAATGGGCCTCAAAGATTCAGATTGAAACAAACAAAAAGCTTTTGATGGAAAATATGTGGGTGGATAGTATAT
TTCTATGGGTGGGTCTAATTTGGTAACGGTTTGATTGTGCCTGGTTTTATCACCTGTTCAGATGAGAAGATTTTTGTCTTTTGTAGCACT
GATAACCAGGAGAAGCCATTAAAAGCCACTGGTTATTTTATTTTTCATCAGGCAATTTTCGAGGTTTTTATTTGTTCGGTATTGTTTTTT
TACACTGTGGTACATATAAGCAACTTTAATAGGTGATAAATGTACAGTAGTTAGATTTCACCTGCATATACATTTTTCCATTTTATGCTC
TATGATCTGAACAAAAGCTTTTTGAATTGTATAAGATTTATGTCTACTGTAAACATTGCTTAATTTTTTTGCTCTTGATTTAAAAAAAAG
TTTTGTTGAAAGCGCTATTGAATATTGCAATCTATATAGTGTATTGGATGGCTTCTTTTGTCACCCTGATCTCCTATGTTACCAATGTGT
ATCGTCTCCTTCTCCCTAAAGTGTACTTAATCTTTGCTTTCTTTGCACAATGTCTTTGGTTGCAAGTCATAAGCCTGAGGCAAATAAAAT

>In-frame_USP7_ENST00000344836_chr16_9057064_-_SMARCA2_ENST00000382194_chr9_2161686_+_1854nt
GTACGTGCGCGTCTCCCTGCCGCCGCCGCCGCCCGCCGCGGGCCGCCCCGGGGCCGCCGTCGCCGACGACGCGCGGGAGGAGGAGGAGGA
GGCCGCCCCGCCGCCGCCGCCGCCGCCGCCGCCCCGGCTCGCCGCCGCCCGCCCGCCGGGCTCGCAGCCCCGGCCCCCGGCCGCAGGCGA
GGCCCAGGCCGCGGCCGACATGAACCACCAGCAGCAGCAGCAGCAGCAGAAAGCGGGCGAGCAGCAGTTGAGCGAGCCCGAGGACATGGA
GATGGAAGGCCATCGAAGACGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAG
ATCCTGCAAAAGAAGATGTGGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAA
AGCAGATGAACGCTATCATCGATACTGTGATAAACTACAAAGATAGTTCAGGGCGACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAA
GGAAAGAATTACCAGAATACTATGAATTAATTAGGAAGCCAGTGGATTTCAAAAAAATAAAGGAAAGGATTCGTAATCATAAGTACCGGA
GCCTAGGCGACCTGGAGAAGGATGTCATGCTTCTCTGTCACAACGCTCAGACGTTCAACCTGGAGGGATCCCAGATCTATGAAGACTCCA
TCGTCTTACAGTCAGTGTTTAAGAGTGCCCGGCAGAAAATTGCCAAAGAGGAAGAGAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGG
AAGATGAAGAAGAGTCAGAGTCCGAGGCAAAATCAGTCAAGGTGAAAATTAAGCTCAATAAAAAAGATGACAAAGGCCGGGACAAAGGGA
AAGGCAAGAAAAGGCCAAATCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAG
AAGGAAGTGGGACGGATGATGAGTGATCAGTATGGACCTTTTTCCTTGGTAGAACTGAATTCCTTCCTCCCCTGTCTCATTTCTACCCAG
TGAGTTCATTTGTCATATAGGCACTGGGTTGTTTCTATATCATCATCGTCTATAAACTAGCTTTAGGATAGTGCCAGACAAACATATGAT
ATCATGGTGTAAAAAACACACACATACACAAATATTTGTAACATATTGTGACCAAATGGGCCTCAAAGATTCAGATTGAAACAAACAAAA
AGCTTTTGATGGAAAATATGTGGGTGGATAGTATATTTCTATGGGTGGGTCTAATTTGGTAACGGTTTGATTGTGCCTGGTTTTATCACC
TGTTCAGATGAGAAGATTTTTGTCTTTTGTAGCACTGATAACCAGGAGAAGCCATTAAAAGCCACTGGTTATTTTATTTTTCATCAGGCA
ATTTTCGAGGTTTTTATTTGTTCGGTATTGTTTTTTTACACTGTGGTACATATAAGCAACTTTAATAGGTGATAAATGTACAGTAGTTAG
ATTTCACCTGCATATACATTTTTCCATTTTATGCTCTATGATCTGAACAAAAGCTTTTTGAATTGTATAAGATTTATGTCTACTGTAAAC
ATTGCTTAATTTTTTTGCTCTTGATTTAAAAAAAAGTTTTGTTGAAAGCGCTATTGAATATTGCAATCTATATAGTGTATTGGATGGCTT
CTTTTGTCACCCTGATCTCCTATGTTACCAATGTGTATCGTCTCCTTCTCCCTAAAGTGTACTTAATCTTTGCTTTCTTTGCACAATGTC


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FusionGenePPI for USP7_SMARCA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP7ATXN1, MAGEB2, RUVBL2, RNPS1, TP53, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, CLSPN, MDM2, PDCD6IP, GMPS, HIST3H2BB, CRKL, DNMT1, EIF4B, GTF2I, MCM4, MCM5, MCM6, NUP98, PPM1G, HLTF, SRP68, ZNF207, USP11, TCEAL1, TCEAL4, CCDC6, AKAP1, RAE1, USP14, BUB3, TRIP12, BRE, HUWE1, SCML2, USP19, KIF3A, FAM175B, DCAF4, BABAM1, RNF220, YLPM1, BRCC3, MCMBP, FBXO38, PPIL4, DOCK7, CHFR, FOXO4, FOXO3, ATG10, KLHDC10, SH3GLB1, PCGF2, BMI1, RING1, RNF2, CBX8, EZH2, SUZ12, EED, MDM4, UHRF1, DNMT3A, TSPYL5, FOXN2, CHEK1, DAXX, HDAC5, KAT5, MARK4, IKBKG, UBC, UBE2S, SMARCAD1, USP7, UVSSA, SIRT7, PCGF1, PCGF3, RYBP, YAF2, PSMA2, PSMA5, PSMA3, PSMB6, PSMB5, PSMB8, PSMB4, PML, MEX3C, CUL3, CUL4A, CUL4B, CDK2, COPS5, ERCC6, TBCB, TRIM22, WWP2, ACD, ARNT2, PLEKHO1, CREB3L3, DNAJA3, EWSR1, RADIL, BEND5, HECW1, HERPUD1, KLHL8, MAGEE1, MARCH7, PEG3, PICK1, ZMYND8, HTRA2, SYVN1, TMPO, TRO, ZNF423, BCOR, NECAB2, PPL, SMAD3, RFFL, PJA1, TRIM63, TRIM55, TRIM54, USP21, USP15, USP28, UQCRFS1, VAMP2, TXNL1, XPOT, ZCCHC8, WDR74, XRCC4, NR1H2, THTPA, HNRNPH1, VPS53, PRR12, UBAC1, UQCRFS1P1, NOTCH1, RELA, RARA, TRIM27, RBCK1, TRIM31, TRIM8, UHRF2, MAGEL2, VPS29, UBE2E1, BIRC2, BIRC3, SOX2, HDAC6, RNF11, MYD88, MAL, PHLDB2, PPARG, PTEN, CLK3, CDC37, COPS6, FKBP5, MAGED2, MMS19, PPP6C, PPP6R3, TRAP1, OGFR, ABL1, RPA3, RPA2, RPA1, RB1, SHFM1, XPC, PEPD, TPP1, PLA2G2A, MBD4, ZEB1, BRCA1, SVIL, ING1, UBA52, SIRT6, ABCE1, ARL6IP4, GAS2L1, RBM11, FAM170A, RBPJ, PHF7, ZBTB44, TRRAP, DARS, CEP112, SF3B3, TMEM87A, LMNA, GIN1, MYNN, CWC22, TNIP2, ZFP2, ZNF394, ZNF594, FBF1, ZC3H11A, MTCH1, CACNA2D1, DDX4, PITPNB, SP110, DICER1, F7, KLC1, GOLGB1, KRT1, UTRN, MYO3A, MYH9, MACF1, DBN1, DYNC1H1, ZNF169, RPS6KB2, POLH, HNRNPF, SNRPD1, DHX9, HSPH1, IQGAP1, PHGDH, PPP1R7, THOC2, NTRK1, IFI16, HIST2H2AC, HIST2H2BE, BCL6, BLMH, ETV6, STIL, TCF20, TMF1, KPNA1, KIF23, PKP4, YBX3, WDR1, FASTKD2, ZNF609, ATP6V1D, BCORL1, DHX40, ACTL8, KIAA2013, RNF169, AR, GLI1, GLI2, GLI3, NCL, PKM, PPP2CA, ANXA1, RAD18, CRY1, CRY2, OTUD4, ALKBH3, RNF168, UBE2D3, TFIP11, KMT2E, OGT, RNF126, NANOG, POU5F1, SUMO2, SNCA, MYC, UBB, PHF8, IRS2, SNAI1, STYX, POTEB3, POTEC, TULP3, ERCC3, LCOR, KHDRBS2, NKAP, PCGF6, CEP83, TSEN15, TCF25, ARHGEF6, UBE2E3, PAK7, NUAK2, IFT43, MEAF6, RSBN1, TRIM35, PLEKHG5, APC, AXIN1, CTNNB1, TRIM25, SUV39H1, IFNAR1SMARCA2BRCA1, SS18, SMARCB1, SMARCC1, POLR2A, SIN3A, HDAC1, HDAC2, RBBP4, ESR1, PHB, ARID1A, SMARCC2, SMARCE1, ACTL6A, CCNE1, ARID1B, ACTL6B, RUVBL1, CEBPB, MYB, CDK8, MECP2, ZMYND11, JOSD2, SMARCA4, AR, BANF1, ADD1, NR4A2, NR3C1, PITX1, MCPH1, H2AFX, BAZ1A, CEBPA, CDX2, PRMT5, SMARCD1, SMARCD2, SIN3B, MYC, PRPF6, KHDRBS1, TAF1, CHD3, ALL1, TAF6, RBBP7, TBP, MBD3, TAF9, SAP30, RAN, SSX2, HIF1A, NR0B2, NONO, SFPQ, DPF2, ZMAT3, BCL7A, GMNN, CBX5, HIST1H3A, STAT1, EP300, CREBBP, KAT2B, WHSC1L1, SIRT7, DPF3, RELA, PHF10, DPF1, SMARCD3, TOP2B, SLC9A3R2, NCOR1, SEC22B, PSMB2, SEPT11, EPAS1, SOX2, SMURF2, SDCBP, BEND7, MDM2, MDM4, EED, BMI1, HSPB1, BCL7B, BCL7C, FUBP1, HMGB1, KHSRP, POLR1C, NOP56, SMC3, RAP1A, KMT2A, CDC5L, BARD1, RELB, ACTBL2, SPTA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUSP7chr16:9057064chr9:2161686ENST00000344836-131622_801261103ICP0/VMW110
HgeneUSP7chr16:9057064chr9:2161686ENST00000344836-13153_208261103p53/TP53%2C MDM2 and EBNA1
HgeneUSP7chr16:9057064chr9:2161686ENST00000344836-1311_208261103TSPYL5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP7_SMARCA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP7_SMARCA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP7C0005695Bladder Neoplasm1CTD_human
TgeneSMARCA2C0036341Schizophrenia4PSYGENET
TgeneSMARCA2C1303073Nicolaides Baraitser syndrome2CTD_human;ORPHANET;UNIPROT
TgeneSMARCA2C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneSMARCA2C0265338Coffin-Siris syndrome1CTD_human
TgeneSMARCA2C0345967Malignant mesothelioma1CTD_human