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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41201

FusionGeneSummary for USP6NL_UPF2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP6NL_UPF2
Fusion gene ID: 41201
HgeneTgene
Gene symbol

USP6NL

UPF2

Gene ID

9712

26019

Gene nameUSP6 N-terminal likeUPF2, regulator of nonsense mediated mRNA decay
SynonymsRNTRE|TRE2NL|USP6NL-IT1HUPF2|RENT2|smg-3
Cytomap

10p14

10p14

Type of geneprotein-codingprotein-coding
DescriptionUSP6 N-terminal-like proteinrelated to the N-terminus of treregulator of nonsense transcripts 2FRS2/UPF2/LEMD3 fusionLEMD3/UPF2 fusionUPF2 regulator of nonsense transcripts homolognonsense mRNA reducing factor 2smg-3 homolog, nonsense mediated mRNA decay factorup-frameshift suppressor 2 homologyeast Upf2p h
Modification date2018052320180523
UniProtAcc

Q92738

Q9HAU5

Ensembl transtripts involved in fusion geneENST00000609104, ENST00000277575, 
ENST00000379237, ENST00000443016, 
ENST00000609853, 		ENST00000356352, 
ENST00000357604, ENST00000397053, 
ENST00000460569, 
Fusion gene scores* DoF score17 X 12 X 9=18365 X 7 X 3=105
# samples 1810
** MAII scorelog2(18/1836*10)=-3.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/105*10)=-0.070389327891398
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP6NL [Title/Abstract] AND UPF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP6NL

GO:0043547

positive regulation of GTPase activity

17562788


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8289-01AUSP6NLchr10

11523769

-UPF2chr10

11985167

-
TCGARVSTADTCGA-BR-4357-01AUSP6NLchr10

11532831

-UPF2chr10

11973781

-
ChiTaRS3.1BG385736USP6NLchr10

11639628

-UPF2chr10

11998520

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000609104ENST00000356352USP6NLchr10

11523769

-UPF2chr10

11985167

-
Frame-shiftENST00000609104ENST00000357604USP6NLchr10

11523769

-UPF2chr10

11985167

-
Frame-shiftENST00000609104ENST00000397053USP6NLchr10

11523769

-UPF2chr10

11985167

-
5CDS-intronENST00000609104ENST00000460569USP6NLchr10

11523769

-UPF2chr10

11985167

-
Frame-shiftENST00000277575ENST00000356352USP6NLchr10

11523769

-UPF2chr10

11985167

-
Frame-shiftENST00000277575ENST00000357604USP6NLchr10

11523769

-UPF2chr10

11985167

-
Frame-shiftENST00000277575ENST00000397053USP6NLchr10

11523769

-UPF2chr10

11985167

-
5CDS-intronENST00000277575ENST00000460569USP6NLchr10

11523769

-UPF2chr10

11985167

-
Frame-shiftENST00000379237ENST00000356352USP6NLchr10

11523769

-UPF2chr10

11985167

-
Frame-shiftENST00000379237ENST00000357604USP6NLchr10

11523769

-UPF2chr10

11985167

-
Frame-shiftENST00000379237ENST00000397053USP6NLchr10

11523769

-UPF2chr10

11985167

-
5CDS-intronENST00000379237ENST00000460569USP6NLchr10

11523769

-UPF2chr10

11985167

-
intron-3CDSENST00000443016ENST00000356352USP6NLchr10

11523769

-UPF2chr10

11985167

-
intron-3CDSENST00000443016ENST00000357604USP6NLchr10

11523769

-UPF2chr10

11985167

-
intron-3CDSENST00000443016ENST00000397053USP6NLchr10

11523769

-UPF2chr10

11985167

-
intron-intronENST00000443016ENST00000460569USP6NLchr10

11523769

-UPF2chr10

11985167

-
intron-3CDSENST00000609853ENST00000356352USP6NLchr10

11523769

-UPF2chr10

11985167

-
intron-3CDSENST00000609853ENST00000357604USP6NLchr10

11523769

-UPF2chr10

11985167

-
intron-3CDSENST00000609853ENST00000397053USP6NLchr10

11523769

-UPF2chr10

11985167

-
intron-intronENST00000609853ENST00000460569USP6NLchr10

11523769

-UPF2chr10

11985167

-
In-frameENST00000609104ENST00000356352USP6NLchr10

11532831

-UPF2chr10

11973781

-
In-frameENST00000609104ENST00000357604USP6NLchr10

11532831

-UPF2chr10

11973781

-
In-frameENST00000609104ENST00000397053USP6NLchr10

11532831

-UPF2chr10

11973781

-
5CDS-intronENST00000609104ENST00000460569USP6NLchr10

11532831

-UPF2chr10

11973781

-
In-frameENST00000277575ENST00000356352USP6NLchr10

11532831

-UPF2chr10

11973781

-
In-frameENST00000277575ENST00000357604USP6NLchr10

11532831

-UPF2chr10

11973781

-
In-frameENST00000277575ENST00000397053USP6NLchr10

11532831

-UPF2chr10

11973781

-
5CDS-intronENST00000277575ENST00000460569USP6NLchr10

11532831

-UPF2chr10

11973781

-
In-frameENST00000379237ENST00000356352USP6NLchr10

11532831

-UPF2chr10

11973781

-
In-frameENST00000379237ENST00000357604USP6NLchr10

11532831

-UPF2chr10

11973781

-
In-frameENST00000379237ENST00000397053USP6NLchr10

11532831

-UPF2chr10

11973781

-
5CDS-intronENST00000379237ENST00000460569USP6NLchr10

11532831

-UPF2chr10

11973781

-
intron-3CDSENST00000443016ENST00000356352USP6NLchr10

11532831

-UPF2chr10

11973781

-
intron-3CDSENST00000443016ENST00000357604USP6NLchr10

11532831

-UPF2chr10

11973781

-
intron-3CDSENST00000443016ENST00000397053USP6NLchr10

11532831

-UPF2chr10

11973781

-
intron-intronENST00000443016ENST00000460569USP6NLchr10

11532831

-UPF2chr10

11973781

-
intron-3CDSENST00000609853ENST00000356352USP6NLchr10

11532831

-UPF2chr10

11973781

-
intron-3CDSENST00000609853ENST00000357604USP6NLchr10

11532831

-UPF2chr10

11973781

-
intron-3CDSENST00000609853ENST00000397053USP6NLchr10

11532831

-UPF2chr10

11973781

-
intron-intronENST00000609853ENST00000460569USP6NLchr10

11532831

-UPF2chr10

11973781

-
Frame-shiftENST00000609104ENST00000356352USP6NLchr10

11639628

-UPF2chr10

11998520

-
Frame-shiftENST00000609104ENST00000357604USP6NLchr10

11639628

-UPF2chr10

11998520

-
Frame-shiftENST00000609104ENST00000397053USP6NLchr10

11639628

-UPF2chr10

11998520

-
5CDS-intronENST00000609104ENST00000460569USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000277575ENST00000356352USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000277575ENST00000357604USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000277575ENST00000397053USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-intronENST00000277575ENST00000460569USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000379237ENST00000356352USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000379237ENST00000357604USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000379237ENST00000397053USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-intronENST00000379237ENST00000460569USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000443016ENST00000356352USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000443016ENST00000357604USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000443016ENST00000397053USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-intronENST00000443016ENST00000460569USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000609853ENST00000356352USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000609853ENST00000357604USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-3CDSENST00000609853ENST00000397053USP6NLchr10

11639628

-UPF2chr10

11998520

-
intron-intronENST00000609853ENST00000460569USP6NLchr10

11639628

-UPF2chr10

11998520

-

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FusionProtFeatures for USP6NL_UPF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP6NL

Q92738

UPF2

Q9HAU5

Acts as a GTPase-activating protein for RAB5A and RAB43.Involved in receptor trafficking. In complex with EPS8 inhibitsinternalization of EGFR. Involved in retrograde transport from theendocytic pathway to the Golgi apparatus. Involved in thetransport of Shiga toxin from early and recycling endosomes to thetrans-Golgi network. Required for structural integrity of theGolgi complex. {ECO:0000269|PubMed:11099046,ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP6NLchr10:11532831chr10:11973781ENST00000277575-814100_292198846DomainRab-GAP TBC
HgeneUSP6NLchr10:11532831chr10:11973781ENST00000379237-814100_292204852DomainRab-GAP TBC
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-1721487_55911821273Coiled coilOntology_term=ECO:0000255
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-172154_13411821273Coiled coilOntology_term=ECO:0000255
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-1822487_55911821273Coiled coilOntology_term=ECO:0000255
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-182254_13411821273Coiled coilOntology_term=ECO:0000255
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-1822487_55911821273Coiled coilOntology_term=ECO:0000255
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-182254_13411821273Coiled coilOntology_term=ECO:0000255
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-17211025_109411821273Compositional biasNote=Glu-rich
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-17216_13611821273Compositional biasNote=Glu/Lys-rich
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-18221025_109411821273Compositional biasNote=Glu-rich
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-18226_13611821273Compositional biasNote=Glu/Lys-rich
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-18221025_109411821273Compositional biasNote=Glu-rich
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-18226_13611821273Compositional biasNote=Glu/Lys-rich
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-1721168_43111821273DomainNote=MIF4G 1
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-1721569_75811821273DomainNote=MIF4G 2
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-1721773_98611821273DomainNote=MIF4G 3
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-1822168_43111821273DomainNote=MIF4G 1
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-1822569_75811821273DomainNote=MIF4G 2
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-1822773_98611821273DomainNote=MIF4G 3
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-1822168_43111821273DomainNote=MIF4G 1
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-1822569_75811821273DomainNote=MIF4G 2
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-1822773_98611821273DomainNote=MIF4G 3


Top

FusionGeneSequence for USP6NL_UPF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_272aa
MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNT
EKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYN
TFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRR

>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_272aa
MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNT
EKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYN
TFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRR

>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_272aa
MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNT
EKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYN
TFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRR

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_289aa
MRTEAVVNSQGQTDYLTKDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIER
TTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYG
VKQQSLFHVLAAYSIYNTFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQH

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_289aa
MRTEAVVNSQGQTDYLTKDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIER
TTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYG
VKQQSLFHVLAAYSIYNTFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQH

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_289aa
MRTEAVVNSQGQTDYLTKDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIER
TTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYG
VKQQSLFHVLAAYSIYNTFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQH

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_295aa
MIQVLQIVKELVTPSRQKAATVKEDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQK
HLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIM
FRDRYGVKQQSLFHVLAAYSIYNTFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRER

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_295aa
MIQVLQIVKELVTPSRQKAATVKEDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQK
HLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIM
FRDRYGVKQQSLFHVLAAYSIYNTFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRER

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_295aa
MIQVLQIVKELVTPSRQKAATVKEDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQK
HLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIM
FRDRYGVKQQSLFHVLAAYSIYNTFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRER


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_816nt
ATGAATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAG
ATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAAT
GTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACT
GAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAA
GAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGC
ACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAAC
ACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGA
ATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCA
GCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTAATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGA

>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_816nt
ATGAATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAG
ATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAAT
GTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACT
GAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAA
GAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGC
ACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAAC
ACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGA
ATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCA
GCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTAATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGA

>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_816nt
ATGAATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAG
ATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAAT
GTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACT
GAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAA
GAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGC
ACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAAC
ACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGA
ATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCA
GCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTAATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGA

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_867nt
ATGAGGACTGAAGCTGTTGTTAATTCCCAAGGCCAGACTGATTATCTCACAAAGGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAG
GAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAA
GTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGA
ACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTC
CAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGA
GCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGT
GTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTT
GCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAA
CAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACAT

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_867nt
ATGAGGACTGAAGCTGTTGTTAATTCCCAAGGCCAGACTGATTATCTCACAAAGGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAG
GAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAA
GTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGA
ACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTC
CAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGA
GCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGT
GTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTT
GCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAA
CAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACAT

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_867nt
ATGAGGACTGAAGCTGTTGTTAATTCCCAAGGCCAGACTGATTATCTCACAAAGGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAG
GAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAA
GTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGA
ACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTC
CAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGA
GCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGT
GTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTT
GCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAA
CAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACAT

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_885nt
ATGATTCAAGTCTTGCAGATTGTAAAGGAGCTGGTGACACCATCAAGGCAAAAAGCAGCCACAGTGAAGGAAGATTCAGACCAGGATGTA
GCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCT
GATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAG
CACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATT
TACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTAT
AGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATG
TTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTA
CCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGAT
ATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGG

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_885nt
ATGATTCAAGTCTTGCAGATTGTAAAGGAGCTGGTGACACCATCAAGGCAAAAAGCAGCCACAGTGAAGGAAGATTCAGACCAGGATGTA
GCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCT
GATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAG
CACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATT
TACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTAT
AGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATG
TTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTA
CCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGAT
ATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGG

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_885nt
ATGATTCAAGTCTTGCAGATTGTAAAGGAGCTGGTGACACCATCAAGGCAAAAAGCAGCCACAGTGAAGGAAGATTCAGACCAGGATGTA
GCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCT
GATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAG
CACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATT
TACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTAT
AGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATG
TTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTA
CCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGAT
ATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_2487nt
CGGCCGCTGCGGTGACGGTTGGCGGCGGCCGGTGAGGCGGGCGGGGCCGGAGGCGCGGAGGCGGGGTCCCGGGCGAGCCGCCCTGGGAGG
CGGGGGCCGTTTCCATAGCGGCGGCAGGAGGTGTCGCGCCGGGGAACTTCCTGGTTCCCGGGCTCGGCTTCGCCGGGATCCTCTTGGAAG
GGAAACAATGGGGCGGAGGGCACTGCGGTAGCCGCCGCCGCCGCCGCGCCGCGCCGCGCCGGATCTGCTCGGCCGCCCGGGACCGCCAGC
TCTGTCCGCTGCCCACAGCCTAGCAGTCGGGACCGTACTGAGGACATGTATTCCTCTGAGAAACCTTGGACAGCAGATTTTGGTTTAATA
TCTGATTGGGACAACATTCAGACCCATTTCCAGTCATGAATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAG
TTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTG
GCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGA
AAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAG
TCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCAC
CTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCT
TATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGA
ACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAG
AAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTA
ATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTGGTT
AGTGGAGTCCTCCAGCAATTGAATGAGAGCAGTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGGCTG
GGGCCAGGAGGCAGAAACACCAGCCTCTGCCAACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGAAAT
CTCGCGAGGGTTAATCTTCTCTTGAGAATGGCAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCGTGA
AGGAGATGATTGAGCCAGAGAAGAAACGGGTTGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTTCAG
TGTCTCTGAATTGAACATCCCACGTTGGAAGAAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAAATC
TTCTAGTAAAACTTACATGCAGGACAACAAAATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAATTT
GTTTCAAGAGGAACAAGGGATGAGGGAGAAAAATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAAAAA
TGTGGAGACTATTTTACTATACAGAGAGCATTAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGCCCA
TTGTAAGTATCATTGAAAACAAAACATGCCCGTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTTGTT
GACCTTCATGGGTTTACAGCCTCTGTCTCTAAACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTTTTT
TTTTGTTTTCCCCCACTAAATAGAAATGAGGGTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTTGCT
TTCCAGCAGGCGTAGTATATTTAGTCGGAGAGCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTTTTC
TTTTACCATGTTTCAGTTTCTGCATGTAGATTTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCAATC

>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_2487nt
CGGCCGCTGCGGTGACGGTTGGCGGCGGCCGGTGAGGCGGGCGGGGCCGGAGGCGCGGAGGCGGGGTCCCGGGCGAGCCGCCCTGGGAGG
CGGGGGCCGTTTCCATAGCGGCGGCAGGAGGTGTCGCGCCGGGGAACTTCCTGGTTCCCGGGCTCGGCTTCGCCGGGATCCTCTTGGAAG
GGAAACAATGGGGCGGAGGGCACTGCGGTAGCCGCCGCCGCCGCCGCGCCGCGCCGCGCCGGATCTGCTCGGCCGCCCGGGACCGCCAGC
TCTGTCCGCTGCCCACAGCCTAGCAGTCGGGACCGTACTGAGGACATGTATTCCTCTGAGAAACCTTGGACAGCAGATTTTGGTTTAATA
TCTGATTGGGACAACATTCAGACCCATTTCCAGTCATGAATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAG
TTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTG
GCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGA
AAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAG
TCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCAC
CTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCT
TATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGA
ACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAG
AAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTA
ATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTGGTT
AGTGGAGTCCTCCAGCAATTGAATGAGAGCAGTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGGCTG
GGGCCAGGAGGCAGAAACACCAGCCTCTGCCAACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGAAAT
CTCGCGAGGGTTAATCTTCTCTTGAGAATGGCAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCGTGA
AGGAGATGATTGAGCCAGAGAAGAAACGGGTTGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTTCAG
TGTCTCTGAATTGAACATCCCACGTTGGAAGAAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAAATC
TTCTAGTAAAACTTACATGCAGGACAACAAAATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAATTT
GTTTCAAGAGGAACAAGGGATGAGGGAGAAAAATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAAAAA
TGTGGAGACTATTTTACTATACAGAGAGCATTAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGCCCA
TTGTAAGTATCATTGAAAACAAAACATGCCCGTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTTGTT
GACCTTCATGGGTTTACAGCCTCTGTCTCTAAACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTTTTT
TTTTGTTTTCCCCCACTAAATAGAAATGAGGGTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTTGCT
TTCCAGCAGGCGTAGTATATTTAGTCGGAGAGCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTTTTC
TTTTACCATGTTTCAGTTTCTGCATGTAGATTTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCAATC

>In-frame_USP6NL_ENST00000609104_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_2486nt
CGGCCGCTGCGGTGACGGTTGGCGGCGGCCGGTGAGGCGGGCGGGGCCGGAGGCGCGGAGGCGGGGTCCCGGGCGAGCCGCCCTGGGAGG
CGGGGGCCGTTTCCATAGCGGCGGCAGGAGGTGTCGCGCCGGGGAACTTCCTGGTTCCCGGGCTCGGCTTCGCCGGGATCCTCTTGGAAG
GGAAACAATGGGGCGGAGGGCACTGCGGTAGCCGCCGCCGCCGCCGCGCCGCGCCGCGCCGGATCTGCTCGGCCGCCCGGGACCGCCAGC
TCTGTCCGCTGCCCACAGCCTAGCAGTCGGGACCGTACTGAGGACATGTATTCCTCTGAGAAACCTTGGACAGCAGATTTTGGTTTAATA
TCTGATTGGGACAACATTCAGACCCATTTCCAGTCATGAATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAG
TTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTG
GCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGA
AAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAG
TCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCAC
CTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCT
TATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGA
ACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAG
AAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTA
ATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTGGTT
AGTGGAGTCCTCCAGCAATTGAATGAGAGCAGTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGGCTG
GGGCCAGGAGGCAGAAACACCAGCCTCTGCCAACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGAAAT
CTCGCGAGGGTTAATCTTCTCTTGAGAATGGCAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCGTGA
AGGAGATGATTGAGCCAGAGAAGAAACGGGTTGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTTCAG
TGTCTCTGAATTGAACATCCCACGTTGGAAGAAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAAATC
TTCTAGTAAAACTTACATGCAGGACAACAAAATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAATTT
GTTTCAAGAGGAACAAGGGATGAGGGAGAAAAATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAAAAA
TGTGGAGACTATTTTACTATACAGAGAGCATTAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGCCCA
TTGTAAGTATCATTGAAAACAAAACATGCCCGTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTTGTT
GACCTTCATGGGTTTACAGCCTCTGTCTCTAAACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTTTTT
TTTTGTTTTCCCCCACTAAATAGAAATGAGGGTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTTGCT
TTCCAGCAGGCGTAGTATATTTAGTCGGAGAGCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTTTTC
TTTTACCATGTTTCAGTTTCTGCATGTAGATTTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCAATC

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_2186nt
ACTATAAAATAATAATGAAATCTTGGAATAGATAAGTTACTCTATGAGGACTGAAGCTGTTGTTAATTCCCAAGGCCAGACTGATTATCT
CACAAAGGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGC
AGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCA
TAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAA
CACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAAT
GAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAA
CCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTA
TAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGAT
GAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGC
TCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTAATGCAGATCTAATCTTTAAGACTGGTGGGAG
GAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTGGTTAGTGGAGTCCTCCAGCAATTGAATGAGAGCA
GTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGGCTGGGGCCAGGAGGCAGAAACACCAGCCTCTGCC
AACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGAAATCTCGCGAGGGTTAATCTTCTCTTGAGAATGG
CAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCGTGAAGGAGATGATTGAGCCAGAGAAGAAACGGGT
TGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTTCAGTGTCTCTGAATTGAACATCCCACGTTGGAAG
AAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAAATCTTCTAGTAAAACTTACATGCAGGACAACAAA
ATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAATTTGTTTCAAGAGGAACAAGGGATGAGGGAGAAA
AATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAAAAATGTGGAGACTATTTTACTATACAGAGAGCAT
TAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGCCCATTGTAAGTATCATTGAAAACAAAACATGCCC
GTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTTGTTGACCTTCATGGGTTTACAGCCTCTGTCTCTA
AACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTTTTTTTTTGTTTTCCCCCACTAAATAGAAATGAGG
GTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTTGCTTTCCAGCAGGCGTAGTATATTTAGTCGGAGA
GCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTTTTCTTTTACCATGTTTCAGTTTCTGCATGTAGAT
TTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCAATCTTCACCAGCTTCAGAAATCTGACCTTTGCCG

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_2186nt
ACTATAAAATAATAATGAAATCTTGGAATAGATAAGTTACTCTATGAGGACTGAAGCTGTTGTTAATTCCCAAGGCCAGACTGATTATCT
CACAAAGGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGC
AGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCA
TAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAA
CACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAAT
GAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAA
CCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTA
TAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGAT
GAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGC
TCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTAATGCAGATCTAATCTTTAAGACTGGTGGGAG
GAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTGGTTAGTGGAGTCCTCCAGCAATTGAATGAGAGCA
GTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGGCTGGGGCCAGGAGGCAGAAACACCAGCCTCTGCC
AACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGAAATCTCGCGAGGGTTAATCTTCTCTTGAGAATGG
CAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCGTGAAGGAGATGATTGAGCCAGAGAAGAAACGGGT
TGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTTCAGTGTCTCTGAATTGAACATCCCACGTTGGAAG
AAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAAATCTTCTAGTAAAACTTACATGCAGGACAACAAA
ATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAATTTGTTTCAAGAGGAACAAGGGATGAGGGAGAAA
AATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAAAAATGTGGAGACTATTTTACTATACAGAGAGCAT
TAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGCCCATTGTAAGTATCATTGAAAACAAAACATGCCC
GTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTTGTTGACCTTCATGGGTTTACAGCCTCTGTCTCTA
AACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTTTTTTTTTGTTTTCCCCCACTAAATAGAAATGAGG
GTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTTGCTTTCCAGCAGGCGTAGTATATTTAGTCGGAGA
GCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTTTTCTTTTACCATGTTTCAGTTTCTGCATGTAGAT
TTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCAATCTTCACCAGCTTCAGAAATCTGACCTTTGCCG

>In-frame_USP6NL_ENST00000277575_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_2185nt
ACTATAAAATAATAATGAAATCTTGGAATAGATAAGTTACTCTATGAGGACTGAAGCTGTTGTTAATTCCCAAGGCCAGACTGATTATCT
CACAAAGGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAATAGTTGCTAAATATGACAGAGGACGAGAAGGTGC
AGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGATTTGGCTTTTTACATGAGGAGGAGCTCCCAGATCA
TAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGCTGAAAATGCTGAAAGGATGGGAAAAATACAAGAA
CACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTGAAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAAT
GAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTTCACCTGACATCAGACAAATAGACCTGGATGTCAA
CCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAATCCTTATTCCATGTGCTTGCTGCCTATTCTATTTA
TAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACTGGAACCAGCAACAGGCAGAACAAGAAGAGAGGAT
GAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGC
TCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCACCTAATGCAGATCTAATCTTTAAGACTGGTGGGAG
GAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTGGTTAGTGGAGTCCTCCAGCAATTGAATGAGAGCA
GTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGGCTGGGGCCAGGAGGCAGAAACACCAGCCTCTGCC
AACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGAAATCTCGCGAGGGTTAATCTTCTCTTGAGAATGG
CAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCGTGAAGGAGATGATTGAGCCAGAGAAGAAACGGGT
TGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTTCAGTGTCTCTGAATTGAACATCCCACGTTGGAAG
AAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAAATCTTCTAGTAAAACTTACATGCAGGACAACAAA
ATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAATTTGTTTCAAGAGGAACAAGGGATGAGGGAGAAA
AATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAAAAATGTGGAGACTATTTTACTATACAGAGAGCAT
TAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGCCCATTGTAAGTATCATTGAAAACAAAACATGCCC
GTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTTGTTGACCTTCATGGGTTTACAGCCTCTGTCTCTA
AACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTTTTTTTTTGTTTTCCCCCACTAAATAGAAATGAGG
GTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTTGCTTTCCAGCAGGCGTAGTATATTTAGTCGGAGA
GCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTTTTCTTTTACCATGTTTCAGTTTCTGCATGTAGAT
TTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCAATCTTCACCAGCTTCAGAAATCTGACCTTTGCCG

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000356352_chr10_11973781_-_2220nt
GATGAAACCTGTTGGATTTCTAGAGGAAGCAGCTGGAGTCTTTGGCTTGTTAACTAGCAATGATTCAAGTCTTGCAGATTGTAAAGGAGC
TGGTGACACCATCAAGGCAAAAAGCAGCCACAGTGAAGGAAGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAA
TAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGAT
TTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGC
TGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTG
AAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTT
CACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAAT
CCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACT
GGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATC
AAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCAC
CTAATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTG
GTTAGTGGAGTCCTCCAGCAATTGAATGAGAGCAGTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGG
CTGGGGCCAGGAGGCAGAAACACCAGCCTCTGCCAACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGA
AATCTCGCGAGGGTTAATCTTCTCTTGAGAATGGCAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCG
TGAAGGAGATGATTGAGCCAGAGAAGAAACGGGTTGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTT
CAGTGTCTCTGAATTGAACATCCCACGTTGGAAGAAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAA
ATCTTCTAGTAAAACTTACATGCAGGACAACAAAATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAA
TTTGTTTCAAGAGGAACAAGGGATGAGGGAGAAAAATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAA
AAATGTGGAGACTATTTTACTATACAGAGAGCATTAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGC
CCATTGTAAGTATCATTGAAAACAAAACATGCCCGTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTT
GTTGACCTTCATGGGTTTACAGCCTCTGTCTCTAAACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTT
TTTTTTTGTTTTCCCCCACTAAATAGAAATGAGGGTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTT
GCTTTCCAGCAGGCGTAGTATATTTAGTCGGAGAGCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTT
TTCTTTTACCATGTTTCAGTTTCTGCATGTAGATTTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCA

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000357604_chr10_11973781_-_2220nt
GATGAAACCTGTTGGATTTCTAGAGGAAGCAGCTGGAGTCTTTGGCTTGTTAACTAGCAATGATTCAAGTCTTGCAGATTGTAAAGGAGC
TGGTGACACCATCAAGGCAAAAAGCAGCCACAGTGAAGGAAGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAA
TAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGAT
TTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGC
TGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTG
AAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTT
CACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAAT
CCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACT
GGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATC
AAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCAC
CTAATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTG
GTTAGTGGAGTCCTCCAGCAATTGAATGAGAGCAGTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGG
CTGGGGCCAGGAGGCAGAAACACCAGCCTCTGCCAACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGA
AATCTCGCGAGGGTTAATCTTCTCTTGAGAATGGCAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCG
TGAAGGAGATGATTGAGCCAGAGAAGAAACGGGTTGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTT
CAGTGTCTCTGAATTGAACATCCCACGTTGGAAGAAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAA
ATCTTCTAGTAAAACTTACATGCAGGACAACAAAATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAA
TTTGTTTCAAGAGGAACAAGGGATGAGGGAGAAAAATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAA
AAATGTGGAGACTATTTTACTATACAGAGAGCATTAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGC
CCATTGTAAGTATCATTGAAAACAAAACATGCCCGTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTT
GTTGACCTTCATGGGTTTACAGCCTCTGTCTCTAAACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTT
TTTTTTTGTTTTCCCCCACTAAATAGAAATGAGGGTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTT
GCTTTCCAGCAGGCGTAGTATATTTAGTCGGAGAGCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTT
TTCTTTTACCATGTTTCAGTTTCTGCATGTAGATTTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCA

>In-frame_USP6NL_ENST00000379237_chr10_11532831_-_UPF2_ENST00000397053_chr10_11973781_-_2219nt
GATGAAACCTGTTGGATTTCTAGAGGAAGCAGCTGGAGTCTTTGGCTTGTTAACTAGCAATGATTCAAGTCTTGCAGATTGTAAAGGAGC
TGGTGACACCATCAAGGCAAAAAGCAGCCACAGTGAAGGAAGATTCAGACCAGGATGTAGCACTCAAACTTGCCCAGGAGCGAGCTGAAA
TAGTTGCTAAATATGACAGAGGACGAGAAGGTGCAGAGATTGAACCTTGGGAAGATGCTGATTACCTTGTTTACAAAGTCACAGATAGAT
TTGGCTTTTTACATGAGGAGGAGCTCCCAGATCATAATGTGGCTGTGGAACGGCAAAAGCACCTGGAAATTGAAAGAACTACCAAATGGC
TGAAAATGCTGAAAGGATGGGAAAAATACAAGAACACTGAAAAGTTTCATAGGCGAATTTACAAAGGAATACCACTCCAGCTCAGAGGTG
AAGTCTGGGCCCTCCTTCTTGAGATCCCTAAAATGAAAGAAGAAACAAGGGACCTGTATAGTAAATTAAAACACAGAGCACGGGGCTGTT
CACCTGACATCAGACAAATAGACCTGGATGTCAACCGCACATTTCGGGACCACATTATGTTTAGAGACAGATATGGTGTTAAGCAACAAT
CCTTATTCCATGTGCTTGCTGCCTATTCTATTTATAACACGTTTAAGATCCTTAATGTACCCATGTCCTCTCAACTTGCTGCAAATCACT
GGAACCAGCAACAGGCAGAACAAGAAGAGAGGATGAGAATGAAAAAGCTCACACTAGATATCAATGAACGGCAAGAACAAGAAGATTATC
AAGAAATGTTGCAGTCTCTTGCACAGCGCCCAGCTCCAGCAAACACCAATCGTGAGAGGCGGCCTCGCTACCAACATCCGAAGGGAGCAC
CTAATGCAGATCTAATCTTTAAGACTGGTGGGAGGAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTATCTGATGTTGTG
GTTAGTGGAGTCCTCCAGCAATTGAATGAGAGCAGTGGACACATCTCAGCAGGTCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGG
CTGGGGCCAGGAGGCAGAAACACCAGCCTCTGCCAACACCGGAACAAGCCGACGCTTCCAGACAAGGCGGAAAAGGCCTTTTGTAATGGA
AATCTCGCGAGGGTTAATCTTCTCTTGAGAATGGCAGTCAAGAAATGAGATGGTTCACTTGACTACTGAGCAGTTACACCAAGGAGAGCG
TGAAGGAGATGATTGAGCCAGAGAAGAAACGGGTTGTGATGGTAATGGTGTGGGGGAAATGAACTTGAGCTTTAAACTTGATTTGAGTTT
CAGTGTCTCTGAATTGAACATCCCACGTTGGAAGAAGATACATTTGGGGGCTCCAGGACTACAGTAGAAAAGTATAGAGCAAGCAGGAAA
ATCTTCTAGTAAAACTTACATGCAGGACAACAAAATGATGAAAGATATCCAAATACCAGATAATCCACCAGGAAGGCTTTTGTTTAGGAA
TTTGTTTCAAGAGGAACAAGGGATGAGGGAGAAAAATCCGTTTTATCCATCAGAGTCAGTGCTATAAAATTGCCTATTAAGGTAAAAGAA
AAATGTGGAGACTATTTTACTATACAGAGAGCATTAATTCAGATGGCTTAGAAAAGTGATACCAGCCCAAGAACAGGGATCTAGGTGAGC
CCATTGTAAGTATCATTGAAAACAAAACATGCCCGTCAACATGTCACAGAAAACGAACGAAGGACAACAAGAAGTGGATGAGAATATTTT
GTTGACCTTCATGGGTTTACAGCCTCTGTCTCTAAACAAAGTATGGAAACAAGTAGAGCTTTTATTTTGCTTTTGTTTTTGTTTTGTTTT
TTTTTTTGTTTTCCCCCACTAAATAGAAATGAGGGTCCTTAGTCTGTTTCTGACAATCTGTTAATTTCTTAGGACAGCTGTCTTTGGTTT
GCTTTCCAGCAGGCGTAGTATATTTAGTCGGAGAGCACATCTGTATGCGACAACTTGATTACATCTTTTTTTCTAGCTATTTTGCATTTT
TTCTTTTACCATGTTTCAGTTTCTGCATGTAGATTTAAATAAAAAACAAAACTTGTAAAGTTGTAACATTTCACATGGAAATGCTGCCCA


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FusionGenePPI for USP6NL_UPF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP6NLACTN4, GRB2, APP, WWOX, SHMT2, NXF1, TMEM17, CCNA2, COMT, ANAPC15, UBE2S, CDH1UPF2RPS25, UPF3B, EIF4A1, XRN2, UPF1, UPF2, DCP2, XRN1, EXOSC10, EXOSC2, EXOSC4, PARN, UPF3A, SMG1, POLD1, ELAVL1, RNPS1, PAIP1, PRPF31, MMS22L, RBM8A, HBB, TP63, RPS15, RPL5, RPS7, PHB2, MAP1LC3B, NOB1, RPL13, SERBP1, BLM, KRT18, TUBB2A, ENO1, ATP1B3, ITGB1, MRPL40, TOP3B, CALR, E4F1, HBZ, ZBTB48, HS3ST3A1, HSF2BP, CIZ1, NOMO1, RRP7A, WNK1, ZGPAT, SUMO3, TYMS, MIF, RPS6, COMTD1, NDUFA7, LDHA, RPL8, CYBA, TK1, SERF2, CENPU, GADD45GIP1, HMGA1, AGPAT1, GLTSCR2, MTERF3, ZNF44, RSRC2, TNNI2, ABCF2, PITX1, DPF2, EXOSC8, EXOSC6, ZNF408, ZFP36, DCP1B, EXOSC1, LSM1, SKIV2L2, MYB, MAP1A, ART4, LGR4, PUF60, FUS, SMARCD1, SMARCD2, SMARCD3, TRIP10, NTRK1, XPO1, KIF15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-17211105_112911821273UPF1
TgeneUPF2chr10:11532831chr10:11973781ENST00000356352-17211167_120711821273UPF1
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-18221105_112911821273UPF1
TgeneUPF2chr10:11532831chr10:11973781ENST00000357604-18221167_120711821273UPF1
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-18221105_112911821273UPF1
TgeneUPF2chr10:11532831chr10:11973781ENST00000397053-18221167_120711821273UPF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP6NL_UPF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP6NL_UPF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP6NLC0025202melanoma1CTD_human