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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4118

FusionGeneSummary for BEND7_FRMD4A

check button Fusion gene summary
Fusion gene informationFusion gene name: BEND7_FRMD4A
Fusion gene ID: 4118
HgeneTgene
Gene symbol

BEND7

FRMD4A

Gene ID

222389

55691

Gene nameBEN domain containing 7FERM domain containing 4A
SynonymsC10orf30CCAFCA|FRMD4|bA295P9.4
Cytomap

10p13

10p13

Type of geneprotein-codingprotein-coding
DescriptionBEN domain-containing protein 7FERM domain-containing protein 4AFERM domain containing 4
Modification date2018051920180519
UniProtAcc

Q8N7W2

Q9P2Q2

Ensembl transtripts involved in fusion geneENST00000486542, ENST00000396900, 
ENST00000341083, ENST00000396898, 
ENST00000378605, 		ENST00000358621, 
ENST00000357447, ENST00000378503, 
ENST00000342409, ENST00000493380, 
ENST00000475141, ENST00000492155, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 7 X 6=378
# samples 310
** MAII scorelog2(3/8*10)=1.90689059560852log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BEND7 [Title/Abstract] AND FRMD4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-V1-A8WV-01ABEND7chr10

13541739

-FRMD4Achr10

13900912

-
TCGALDPRADTCGA-YJ-A8SW-01ABEND7chr10

13568138

-FRMD4Achr10

13838588

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000486542ENST00000358621BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000486542ENST00000357447BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000486542ENST00000378503BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000486542ENST00000342409BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000486542ENST00000493380BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000486542ENST00000475141BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000486542ENST00000492155BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000396900ENST00000358621BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000396900ENST00000357447BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000396900ENST00000378503BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000396900ENST00000342409BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000396900ENST00000493380BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000396900ENST00000475141BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000396900ENST00000492155BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000341083ENST00000358621BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000341083ENST00000357447BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000341083ENST00000378503BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000341083ENST00000342409BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000341083ENST00000493380BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000341083ENST00000475141BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-intronENST00000341083ENST00000492155BEND7chr10

13541739

-FRMD4Achr10

13900912

-
Frame-shiftENST00000396898ENST00000358621BEND7chr10

13541739

-FRMD4Achr10

13900912

-
Frame-shiftENST00000396898ENST00000357447BEND7chr10

13541739

-FRMD4Achr10

13900912

-
Frame-shiftENST00000396898ENST00000378503BEND7chr10

13541739

-FRMD4Achr10

13900912

-
Frame-shiftENST00000396898ENST00000342409BEND7chr10

13541739

-FRMD4Achr10

13900912

-
5CDS-intronENST00000396898ENST00000493380BEND7chr10

13541739

-FRMD4Achr10

13900912

-
5CDS-intronENST00000396898ENST00000475141BEND7chr10

13541739

-FRMD4Achr10

13900912

-
5CDS-intronENST00000396898ENST00000492155BEND7chr10

13541739

-FRMD4Achr10

13900912

-
Frame-shiftENST00000378605ENST00000358621BEND7chr10

13541739

-FRMD4Achr10

13900912

-
Frame-shiftENST00000378605ENST00000357447BEND7chr10

13541739

-FRMD4Achr10

13900912

-
Frame-shiftENST00000378605ENST00000378503BEND7chr10

13541739

-FRMD4Achr10

13900912

-
Frame-shiftENST00000378605ENST00000342409BEND7chr10

13541739

-FRMD4Achr10

13900912

-
5CDS-intronENST00000378605ENST00000493380BEND7chr10

13541739

-FRMD4Achr10

13900912

-
5CDS-intronENST00000378605ENST00000475141BEND7chr10

13541739

-FRMD4Achr10

13900912

-
5CDS-intronENST00000378605ENST00000492155BEND7chr10

13541739

-FRMD4Achr10

13900912

-
intron-3CDSENST00000486542ENST00000358621BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000486542ENST00000357447BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000486542ENST00000378503BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000486542ENST00000342409BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000486542ENST00000493380BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000486542ENST00000475141BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000486542ENST00000492155BEND7chr10

13568138

-FRMD4Achr10

13838588

-
Frame-shiftENST00000396900ENST00000358621BEND7chr10

13568138

-FRMD4Achr10

13838588

-
Frame-shiftENST00000396900ENST00000357447BEND7chr10

13568138

-FRMD4Achr10

13838588

-
Frame-shiftENST00000396900ENST00000378503BEND7chr10

13568138

-FRMD4Achr10

13838588

-
Frame-shiftENST00000396900ENST00000342409BEND7chr10

13568138

-FRMD4Achr10

13838588

-
5CDS-intronENST00000396900ENST00000493380BEND7chr10

13568138

-FRMD4Achr10

13838588

-
5CDS-intronENST00000396900ENST00000475141BEND7chr10

13568138

-FRMD4Achr10

13838588

-
5CDS-intronENST00000396900ENST00000492155BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000341083ENST00000358621BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000341083ENST00000357447BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000341083ENST00000378503BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000341083ENST00000342409BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000341083ENST00000493380BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000341083ENST00000475141BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000341083ENST00000492155BEND7chr10

13568138

-FRMD4Achr10

13838588

-
Frame-shiftENST00000396898ENST00000358621BEND7chr10

13568138

-FRMD4Achr10

13838588

-
Frame-shiftENST00000396898ENST00000357447BEND7chr10

13568138

-FRMD4Achr10

13838588

-
Frame-shiftENST00000396898ENST00000378503BEND7chr10

13568138

-FRMD4Achr10

13838588

-
Frame-shiftENST00000396898ENST00000342409BEND7chr10

13568138

-FRMD4Achr10

13838588

-
5CDS-intronENST00000396898ENST00000493380BEND7chr10

13568138

-FRMD4Achr10

13838588

-
5CDS-intronENST00000396898ENST00000475141BEND7chr10

13568138

-FRMD4Achr10

13838588

-
5CDS-intronENST00000396898ENST00000492155BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000378605ENST00000358621BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000378605ENST00000357447BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000378605ENST00000378503BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-3CDSENST00000378605ENST00000342409BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000378605ENST00000493380BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000378605ENST00000475141BEND7chr10

13568138

-FRMD4Achr10

13838588

-
intron-intronENST00000378605ENST00000492155BEND7chr10

13568138

-FRMD4Achr10

13838588

-

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FusionProtFeatures for BEND7_FRMD4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BEND7

Q8N7W2

FRMD4A

Q9P2Q2

Scaffolding protein that regulates epithelial cellpolarity by connecting ARF6 activation with the PAR3 complex (Bysimilarity). Plays a redundant role with FRMD4B in epithelialpolarization (By similarity). May regulate MAPT secretion byactivating ARF6-signaling (PubMed:27044754).{ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BEND7_FRMD4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BEND7_FRMD4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BEND7NIF3L1, PPP1R37, SDCBP2, EMD, U2AF2, PSMF1, PLEKHF2, BYSL, CHD2, DDX6, MFAP1, PIM1, SMARCA2, RAB29, PPIG, MORF4L2, USP20, MORF4L1, ZCCHC10, C11orf57, CDCA7L, LYAR, EAF2, CEP44, EIF1AD, EAF1, CIB3, BEND7, FAM133A, TRIM27, C1QBP, LRP4, ZNF219, MBD3L1, FAM124A, NAP1L3, MYO15B, DGCR8FRMD4AHNRNPA1, TRAF3IP1, YEATS4, WDR83


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BEND7_FRMD4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BEND7_FRMD4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFRMD4AC0236969Substance-Related Disorders1CTD_human