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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41165

FusionGeneSummary for USP4_RHOA

check button Fusion gene summary
Fusion gene informationFusion gene name: USP4_RHOA
Fusion gene ID: 41165
HgeneTgene
Gene symbol

USP4

RHOA

Gene ID

7375

387

Gene nameubiquitin specific peptidase 4ras homolog family member A
SynonymsUNP|UnphARH12|ARHA|RHO12|RHOH12
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 4deubiquitinating enzyme 4ubiquitin carboxyl-terminal esterase 4ubiquitin specific peptidase 4 (proto-oncogene)ubiquitin specific protease 4 (proto-oncogene)ubiquitin thioesterase 4ubiquitin thiolesterase 4ubiqtransforming protein RhoAAplysia ras-related homolog 12oncogene RHO H12small GTP binding protein RhoA
Modification date2018052220180527
UniProtAcc

Q13107

P61586

Ensembl transtripts involved in fusion geneENST00000351842, ENST00000265560, 
ENST00000488520, ENST00000416417, 
ENST00000415188, 
ENST00000418115, 
ENST00000454011, ENST00000422781, 
ENST00000265538, 
Fusion gene scores* DoF score6 X 5 X 5=15010 X 9 X 4=360
# samples 611
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP4 [Title/Abstract] AND RHOA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP4

GO:0016579

protein deubiquitination

16316627|16339847|16472766

HgeneUSP4

GO:0031647

regulation of protein stability

16472766

HgeneUSP4

GO:0034394

protein localization to cell surface

16339847

TgeneRHOA

GO:0007266

Rho protein signal transduction

26529257

TgeneRHOA

GO:0016477

cell migration

26529257

TgeneRHOA

GO:0032956

regulation of actin cytoskeleton organization

25911094

TgeneRHOA

GO:0035385

Roundabout signaling pathway

26529257

TgeneRHOA

GO:0036089

cleavage furrow formation

16103226

TgeneRHOA

GO:0051496

positive regulation of stress fiber assembly

15467718

TgeneRHOA

GO:0060193

positive regulation of lipase activity

19887681

TgeneRHOA

GO:0071222

cellular response to lipopolysaccharide

19734146

TgeneRHOA

GO:0071902

positive regulation of protein serine/threonine kinase activity

8617235


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-E7-A7PW-01AUSP4chr3

49377357

-RHOAchr3

49405981

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000351842ENST00000418115USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000351842ENST00000454011USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000351842ENST00000422781USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000351842ENST00000265538USP4chr3

49377357

-RHOAchr3

49405981

-
In-frameENST00000265560ENST00000418115USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000265560ENST00000454011USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000265560ENST00000422781USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000265560ENST00000265538USP4chr3

49377357

-RHOAchr3

49405981

-
intron-3CDSENST00000488520ENST00000418115USP4chr3

49377357

-RHOAchr3

49405981

-
intron-intronENST00000488520ENST00000454011USP4chr3

49377357

-RHOAchr3

49405981

-
intron-intronENST00000488520ENST00000422781USP4chr3

49377357

-RHOAchr3

49405981

-
intron-intronENST00000488520ENST00000265538USP4chr3

49377357

-RHOAchr3

49405981

-
In-frameENST00000416417ENST00000418115USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000416417ENST00000454011USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000416417ENST00000422781USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000416417ENST00000265538USP4chr3

49377357

-RHOAchr3

49405981

-
In-frameENST00000415188ENST00000418115USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000415188ENST00000454011USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000415188ENST00000422781USP4chr3

49377357

-RHOAchr3

49405981

-
5CDS-intronENST00000415188ENST00000265538USP4chr3

49377357

-RHOAchr3

49405981

-

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FusionProtFeatures for USP4_RHOA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP4

Q13107

RHOA

P61586

Hydrolase that deubiquitinates target proteins such asthe receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination ofADORA2A increases the amount of functional receptor at the cellsurface. May regulate mRNA splicing through deubiquitination ofthe U4 spliceosomal protein PRPF3. This may prevent itsrecognition by the U5 component PRPF8 thereby destabilizinginteractions within the U4/U6.U5 snRNP. May also play a role inthe regulation of quality control in the ER.{ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847,ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234,ECO:0000269|PubMed:7784062}. Regulates a signal transduction pathway linking plasmamembrane receptors to the assembly of focal adhesions and actinstress fibers. Involved in a microtubule-dependent signal that isrequired for the myosin contractile ring formation during cellcycle cytokinesis. Plays an essential role in cleavage furrowformation. Required for the apical junction formation ofkeratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity.May be an activator of PLCE1. Activated by ARHGEF2, which promotesthe exchange of GDP for GTP. Essential for the SPATA13-mediatedregulation of cell migration and adhesion assembly anddisassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays animportant role in ERBB2-dependent stabilization of microtubules atthe cell cortex. It controls the localization of APC and CLASP2 tothe cell membrane, via the regulation of GSK3B activity. In turn,membrane-bound APC allows the localization of the MACF1 to thecell membrane, which is required for microtubule capture andstabilization. Regulates a signal transduction pathway linkingplasma membrane receptors to the assembly of focal adhesions andactin stress fibers. Involved in a microtubule-dependent signalthat is required for the myosin contractile ring formation duringcell cycle cytokinesis. Plays an essential role in cleavage furrowformation. Required for the apical junction formation ofkeratinocyte cell-cell adhesion. May be an activator of PLCE1.Activated by ARHGEF2, which promotes the exchange of GDP for GTP.Essential for the SPATA13-mediated regulation of cell migrationand adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1signaling pathway plays an important role in ERBB2-dependentstabilization of microtubules at the cell cortex. It controls thelocalization of APC and CLASP2 to the cell membrane, via theregulation of GSK3B activity. In turn, membrane-bound APC allowsthe localization of the MACF1 to the cell membrane, which isrequired for microtubule capture and stabilization (Bysimilarity). Regulates KCNA2 potassium channel activity byreducing its location at the cell surface in response to CHRM1activation; promotes KCNA2 endocytosis (PubMed:9635436,PubMed:19403695). {ECO:0000250, ECO:0000269|PubMed:12900402,ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794,ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854,ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:8910519,ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}. (Microbial infection) Serves as a target for the yopTcysteine peptidase from Yersinia pestis, vector of the plague.{ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}. (Microbial infection) Serves as a target for the yopTcysteine peptidase from Yersinia pseudotuberculosis, which causesgastrointestinal disorders. {ECO:0000269|PubMed:12062101,ECO:0000269|PubMed:12538863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRHOAchr3:49377357chr3:49405981ENST00000418115-15182_18752194Compositional biasNote=Arg/Lys-rich (basic)
TgeneRHOAchr3:49377357chr3:49405981ENST00000418115-15117_12052194Nucleotide bindingGTP
TgeneRHOAchr3:49377357chr3:49405981ENST00000418115-1559_6352194Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP4chr3:49377357chr3:49405981ENST00000265560-12211_12233964DomainDUSP
HgeneUSP4chr3:49377357chr3:49405981ENST00000265560-122142_22633964DomainNote=Ubiquitin-like 1
HgeneUSP4chr3:49377357chr3:49405981ENST00000265560-122302_92333964DomainNote=USP
HgeneUSP4chr3:49377357chr3:49405981ENST00000265560-122483_57133964DomainNote=Ubiquitin-like 2
HgeneUSP4chr3:49377357chr3:49405981ENST00000351842-12111_12233917DomainDUSP
HgeneUSP4chr3:49377357chr3:49405981ENST00000351842-121142_22633917DomainNote=Ubiquitin-like 1
HgeneUSP4chr3:49377357chr3:49405981ENST00000351842-121302_92333917DomainNote=USP
HgeneUSP4chr3:49377357chr3:49405981ENST00000351842-121483_57133917DomainNote=Ubiquitin-like 2
HgeneUSP4chr3:49377357chr3:49405981ENST00000416417-1711_12233314DomainDUSP
HgeneUSP4chr3:49377357chr3:49405981ENST00000416417-17142_22633314DomainNote=Ubiquitin-like 1
HgeneUSP4chr3:49377357chr3:49405981ENST00000416417-17302_92333314DomainNote=USP
HgeneUSP4chr3:49377357chr3:49405981ENST00000416417-17483_57133314DomainNote=Ubiquitin-like 2
HgeneUSP4chr3:49377357chr3:49405981ENST00000265560-122133_14133964MotifNuclear export signal
HgeneUSP4chr3:49377357chr3:49405981ENST00000265560-122767_77233964MotifNuclear localization signal
HgeneUSP4chr3:49377357chr3:49405981ENST00000351842-121133_14133917MotifNuclear export signal
HgeneUSP4chr3:49377357chr3:49405981ENST00000351842-121767_77233917MotifNuclear localization signal
HgeneUSP4chr3:49377357chr3:49405981ENST00000416417-17133_14133314MotifNuclear export signal
HgeneUSP4chr3:49377357chr3:49405981ENST00000416417-17767_77233314MotifNuclear localization signal
TgeneRHOAchr3:49377357chr3:49405981ENST00000418115-1534_4252194MotifEffector region
TgeneRHOAchr3:49377357chr3:49405981ENST00000418115-1512_1952194Nucleotide bindingGTP


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FusionGeneSequence for USP4_RHOA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP4_RHOA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP4TP53BP2, RB1, RBL1, RBL2, TRIM21, ADSL, USP11, USP1, PRPF4, PRPF3, AKAP7, EIF4E2, PPIH, LSM6, LSM4, PRPF31, LSM7, LSM8, DCP1A, MEPCE, LSM2, TUT1, EDC3, USP32, DCP1B, SART3, IGKV2D-29, UBC, USP4, TRAF2, TRAF6, TK1, CDKN1A, SMN1, RCC1, ANXA7, HUWE1, PDK1, MAP3K7, IKBKB, RIPK1, TNFRSF1A, TGFBR1, AKT1, YWHAH, SFN, USP15, USP19, CUL4B, NLK, LGALS1, PSMD11, FAM96B, PSAP, ATP1B3, LAMA5, NPC2, PSMA6, ATP1B1, PLOD1, PPIA, ASS1, PGM1, PSMC5, TRIM63, TRIM55, TRIM54, USP21, USP28, BRAP, DDX58, PTEN, PLA2G2A, PRPF19, PCNA, CT55, OBFC1, TCEAL1, ELMO1, NTRK1, TCF7L2, RORC, HDAC2, RAD50, MRE11A, RBBP8, PTP4A3, CTNNB1, RNPS1, TCP10L, CABP1, JUNB, RNF19B, RAB30, FAM196A, MAP3K6, BSPRY, LGALS7, TRMT1, ENSA, RIPPLY2, ATP6V0D1, EXOC1, C6orf141, SLX1A, FAM46A, SRP9, IRF8, SMAD4RHOAPDE6D, RAP1GDS1, ARHGAP1, ARHGDIA, BID, TNFRSF10B, EZR, FADD, FASLG, MAPK8, MSN, CASP10, CASP8, FAS, TNFRSF1A, ARHGEF25, DEF6, ARHGAP32, ARHGAP5, ROCK1, PKN1, DIAPH1, CIT, RHPN2, KTN1, ITPR1, TRPC1, ARHGEF1, PLD1, RTKN, NET1, CRMP1, DPYSL2, ARHGEF12, HSPA1A, PLCG1, ARHGEF3, AKAP13, PKN2, ICMT, VAV3, ARHGEF18, ARHGAP26, ARHGAP10, KCNA2, ARHGEF4, ARHGEF2, ARHGAP35, ARHGEF11, RIPK4, MPRIP, OPHN1, DGKQ, ROCK2, TRIO, MCF2, PLEKHG2, ARHGDIG, MCF2L, BCR, PLXNB1, SMURF1, SMURF2, OTUB1, CUL3, SRGAP1, CAV1, HTR1A, MAP3K1, MDM2, PSMD10, MARK2, LRRK2, PPP1R12A, RPS27A, CLNS1A, MPV17, PON2, PRDX6, NUBP2, SLC25A5, PLIN3, CPT1A, RPL18, DDX1, BAIAP2, DIAPH3, CDKN1B, GNB2L1, RPN2, FAM65B, SMAD2, TBXA2R, BIRC2, IKBKG, KCTD13, TNFAIP1, TRIP6, IKZF3, UBC, DCUN1D1, KLHL20, MBD5, SERPINB5, TM4SF20, DIRAS3, LDB3, NFKBIA, TSC22D4, RASL10A, APOA1BP, ARHGDIB, GORASP2, PAFAH1B2, PRRC1, NUTF2, RPE, SHMT2, SLC25A12, CNKSR1, RHPN1, MED20, RPGR, LIMA1, ATP6AP2, NVL, UBE2V2, FUBP3, BAZ1A, STK39, SYNPO2, DAAM1, RASSF1, S100A4, ANLN, U2AF2, SH3GLB2, GOSR1, AGAP2, AGAP1, RHOC, PKN3, DNAL1, RABL3, AK9, IRGC, RAP2C, HDAC7, GLB1, VASH1, CTSA, FGB, LUM, PTEN, COX15, DLST, HSD17B10, PDHA1, SOD1, KRAS, NOTCH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP4_RHOA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP4_RHOA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRHOAC0038356Stomach Neoplasms3CTD_human
TgeneRHOAC0020981Angioimmunoblastic Lymphadenopathy2CTD_human
TgeneRHOAC0079774Peripheral T-Cell Lymphoma2CTD_human
TgeneRHOAC0005695Bladder Neoplasm1CTD_human
TgeneRHOAC0027626Neoplasm Invasiveness1CTD_human
TgeneRHOAC0033687Proteinuria1CTD_human
TgeneRHOAC0079772T-Cell Lymphoma1CTD_human
TgeneRHOAC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneRHOAC0235833Congenital diaphragmatic hernia1CTD_human