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Fusion gene ID: 4112 |
FusionGeneSummary for BDP1_PMCHL2 |
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Fusion gene information | Fusion gene name: BDP1_PMCHL2 | Fusion gene ID: 4112 | Hgene | Tgene | Gene symbol | BDP1 | PMCHL2 | Gene ID | 55814 | 5370 |
Gene name | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | pro-melanin concentrating hormone like 2 (pseudogene) | |
Synonyms | HSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR | - | |
Cytomap | 5q13.2 | 5q13.2 | |
Type of gene | protein-coding | pseudo | |
Description | transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear | - | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | A6H8Y1 | ||
Ensembl transtripts involved in fusion gene | ENST00000358731, ENST00000380675, | ENST00000450213, | |
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/60*10)=0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: BDP1 [Title/Abstract] AND PMCHL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-BB-A5HY-01A | BDP1 | chr5 | 70779723 | + | PMCHL2 | chr5 | 70673333 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000358731 | ENST00000450213 | BDP1 | chr5 | 70779723 | + | PMCHL2 | chr5 | 70673333 | + |
5UTR-3UTR | ENST00000380675 | ENST00000450213 | BDP1 | chr5 | 70779723 | + | PMCHL2 | chr5 | 70673333 | + |
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FusionProtFeatures for BDP1_PMCHL2 |
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Hgene | Tgene |
BDP1 | PMCHL2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BDP1_PMCHL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BDP1_PMCHL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BDP1 | ZBTB43, BAX, MYH6, POLR2F, YWHAZ, RAPGEF2, POLR3E, RGMA, CDCA5 | PMCHL2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BDP1_PMCHL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BDP1_PMCHL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |