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Fusion gene ID: 41111 |
FusionGeneSummary for USP38_RIT2 |
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Fusion gene information | Fusion gene name: USP38_RIT2 | Fusion gene ID: 41111 | Hgene | Tgene | Gene symbol | USP38 | RIT2 | Gene ID | 84640 | 6014 |
Gene name | ubiquitin specific peptidase 38 | Ras like without CAAX 2 | |
Synonyms | HP43.8KD | RIBA|RIN|ROC2 | |
Cytomap | 4q31.21 | 18q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 38deubiquitinating enzyme 38ubiquitin specific protease 38ubiquitin thioesterase 38ubiquitin thiolesterase 38ubiquitin-specific-processing protease 38 | GTP-binding protein Rit2GTP-binding protein Roc2Ric-like, expressed in neuronsras-like protein expressed in neuronsras-like without CAAX protein 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8NB14 | Q99578 | |
Ensembl transtripts involved in fusion gene | ENST00000510377, ENST00000307017, | ENST00000589109, ENST00000326695, ENST00000590910, ENST00000282028, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 1 X 2=4 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: USP38 [Title/Abstract] AND RIT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | USP38 | GO:0016579 | protein deubiquitination | 14715245 |
Tgene | RIT2 | GO:0035556 | intracellular signal transduction | 21957239 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A6YR-01A | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000510377 | ENST00000589109 | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
5CDS-3UTR | ENST00000510377 | ENST00000326695 | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
5CDS-3UTR | ENST00000510377 | ENST00000590910 | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
5CDS-intron | ENST00000510377 | ENST00000282028 | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
5CDS-3UTR | ENST00000307017 | ENST00000589109 | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
5CDS-3UTR | ENST00000307017 | ENST00000326695 | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
5CDS-3UTR | ENST00000307017 | ENST00000590910 | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
5CDS-intron | ENST00000307017 | ENST00000282028 | USP38 | chr4 | 144109114 | + | RIT2 | chr18 | 40323685 | - |
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FusionProtFeatures for USP38_RIT2 |
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Hgene | Tgene |
USP38 | RIT2 |
Deubiquitinating enzyme exhibiting a preference towards'Lys-63'-linked ubiquitin chains. {ECO:0000269|PubMed:22689415}. | Binds and exchanges GTP and GDP. Binds and modulates theactivation of POU4F1 as gene expression regulator.{ECO:0000250|UniProtKB:P70425}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP38_RIT2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP38_RIT2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
USP38 | HSPB1, LGALS7, RPL7, RPS12, HMX3, VAV2, SHFM1, HIST1H1D, ADAR, AHSG, GNB5 | RIT2 | POU4F1, CALM1, RAB5A, RLF, SOS1, APP, SRPK2, LZTR1, RIT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP38_RIT2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP38_RIT2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |