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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41111

FusionGeneSummary for USP38_RIT2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP38_RIT2
Fusion gene ID: 41111
HgeneTgene
Gene symbol

USP38

RIT2

Gene ID

84640

6014

Gene nameubiquitin specific peptidase 38Ras like without CAAX 2
SynonymsHP43.8KDRIBA|RIN|ROC2
Cytomap

4q31.21

18q12.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 38deubiquitinating enzyme 38ubiquitin specific protease 38ubiquitin thioesterase 38ubiquitin thiolesterase 38ubiquitin-specific-processing protease 38GTP-binding protein Rit2GTP-binding protein Roc2Ric-like, expressed in neuronsras-like protein expressed in neuronsras-like without CAAX protein 2
Modification date2018051920180519
UniProtAcc

Q8NB14

Q99578

Ensembl transtripts involved in fusion geneENST00000510377, ENST00000307017, 
ENST00000589109, ENST00000326695, 
ENST00000590910, ENST00000282028, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 1 X 2=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: USP38 [Title/Abstract] AND RIT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP38

GO:0016579

protein deubiquitination

14715245

TgeneRIT2

GO:0035556

intracellular signal transduction

21957239


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A6YR-01AUSP38chr4

144109114

+RIT2chr18

40323685

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000510377ENST00000589109USP38chr4

144109114

+RIT2chr18

40323685

-
5CDS-3UTRENST00000510377ENST00000326695USP38chr4

144109114

+RIT2chr18

40323685

-
5CDS-3UTRENST00000510377ENST00000590910USP38chr4

144109114

+RIT2chr18

40323685

-
5CDS-intronENST00000510377ENST00000282028USP38chr4

144109114

+RIT2chr18

40323685

-
5CDS-3UTRENST00000307017ENST00000589109USP38chr4

144109114

+RIT2chr18

40323685

-
5CDS-3UTRENST00000307017ENST00000326695USP38chr4

144109114

+RIT2chr18

40323685

-
5CDS-3UTRENST00000307017ENST00000590910USP38chr4

144109114

+RIT2chr18

40323685

-
5CDS-intronENST00000307017ENST00000282028USP38chr4

144109114

+RIT2chr18

40323685

-

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FusionProtFeatures for USP38_RIT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP38

Q8NB14

RIT2

Q99578

Deubiquitinating enzyme exhibiting a preference towards'Lys-63'-linked ubiquitin chains. {ECO:0000269|PubMed:22689415}. Binds and exchanges GTP and GDP. Binds and modulates theactivation of POU4F1 as gene expression regulator.{ECO:0000250|UniProtKB:P70425}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP38_RIT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP38_RIT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP38HSPB1, LGALS7, RPL7, RPS12, HMX3, VAV2, SHFM1, HIST1H1D, ADAR, AHSG, GNB5RIT2POU4F1, CALM1, RAB5A, RLF, SOS1, APP, SRPK2, LZTR1, RIT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP38_RIT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP38_RIT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource