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Fusion gene ID: 41094 |
FusionGeneSummary for USP34_ZNF2 |
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Fusion gene information | Fusion gene name: USP34_ZNF2 | Fusion gene ID: 41094 | Hgene | Tgene | Gene symbol | USP34 | ZNF2 | Gene ID | 9736 | 7549 |
Gene name | ubiquitin specific peptidase 34 | zinc finger protein 2 | |
Synonyms | - | A1-5|ZNF661|Zfp661 | |
Cytomap | 2p15 | 2q11.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34 | zinc finger protein 2zinc finger protein 2.2zinc finger protein 661 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q70CQ2 | Q9BSG1 | |
Ensembl transtripts involved in fusion gene | ENST00000398571, ENST00000472689, | ENST00000398107, ENST00000340539, ENST00000425369, ENST00000295210, ENST00000453539, | |
Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 1 X 1 X 1=1 |
# samples | 20 | 1 | |
** MAII score | log2(20/2520*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: USP34 [Title/Abstract] AND ZNF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | USP34 | GO:0016579 | protein deubiquitination | 14715245 |
Hgene | USP34 | GO:0071108 | protein K48-linked deubiquitination | 21383061 |
Hgene | USP34 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21383061 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-56-8083-01A | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000398571 | ENST00000398107 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5CDS-5UTR | ENST00000398571 | ENST00000340539 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5CDS-intron | ENST00000398571 | ENST00000425369 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5CDS-5UTR | ENST00000398571 | ENST00000295210 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5CDS-5UTR | ENST00000398571 | ENST00000453539 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5UTR-intron | ENST00000472689 | ENST00000398107 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5UTR-5UTR | ENST00000472689 | ENST00000340539 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5UTR-intron | ENST00000472689 | ENST00000425369 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5UTR-5UTR | ENST00000472689 | ENST00000295210 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
5UTR-5UTR | ENST00000472689 | ENST00000453539 | USP34 | chr2 | 61449754 | - | ZNF2 | chr2 | 95841933 | + |
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FusionProtFeatures for USP34_ZNF2 |
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Hgene | Tgene |
USP34 | ZNF2 |
May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP34_ZNF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP34_ZNF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
USP34 | ATM, SIRT7, UBE2C, UFC1, UFM1, ZRANB2, UBE2V2, SRXN1, STAM, AHCYL1, UBE4B, UBQLN1, UBXN7, UBA2, UBE2L3, UBE2V1, TTLL12, UCHL3, UBQLN2, UBXN1, ZFYVE19, SULT1A1, UBE2D1, UBQLN4, ATP6V1B2, LAGE3, SSSCA1, UBL7, USP9X, SEC24A, UNK, VPS4B, SOX2, CD2AP, ELP2, KIAA1033, SNRNP200, CSNK1A1, ZNF707, EIF3M, PCGF1, DPPA4, NANOG, POU5F1, EGFR, EPHA1, ZNF214, ZNF785, ZNF764, SUV39H1, ZNF669, ERMAP, ZNF550, LYPD4, TSPYL6, ZNF354C, ZNF211, RBM3, MTNR1A, MTNR1B, TRIM25 | ZNF2 | APP, TRIM28, PRMT5, TSGA10, KRTAP10-7, CCND3, KIAA0020, ZFP62, TAF1B, ZNF800, RRP8, BUD13, RPF2, ZNF770, GLYR1, RPL37A, DDX10, CDK12, TAF1D, BRIX1, RBM28, GNL2, MAK16, WHSC1, MRPS35, RBM34, MPHOSPH10, DHX30, ZNF121, PAPD5, ZNF184, NOC3L, IMP4, RBM19, DDX54, ZNF189, DKC1, PTCD3, RRS1, ZNF771, DNTTIP2, ZC3HAV1, ZNF22, RPL3, CENPU, UTP3, GTPBP4, PPAN-P2RY11, PRPF4B, ZCCHC9, C9orf114, MRPS9, DDX31, NOP56, PRDM15, ZSCAN25, REXO4, PAK1IP1, RPL7A, DDX24, CEBPZ, AATF, RPS3A, MRPL52, BMS1, HERC5, MRPS7, RPL17, CCDC137, CTCF, STAU2, CDK13 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP34_ZNF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP34_ZNF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |