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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41092

FusionGeneSummary for USP34_USP34

check button Fusion gene summary
Fusion gene informationFusion gene name: USP34_USP34
Fusion gene ID: 41092
HgeneTgene
Gene symbol

USP34

USP34

Gene ID

9736

9736

Gene nameubiquitin specific peptidase 34ubiquitin specific peptidase 34
Synonyms--
Cytomap

2p15

2p15

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34
Modification date2018052320180523
UniProtAcc

Q70CQ2

Q70CQ2

Ensembl transtripts involved in fusion geneENST00000398571, ENST00000472689, 
ENST00000398571, ENST00000472689, 
Fusion gene scores* DoF score18 X 14 X 10=25206 X 7 X 2=84
# samples 207
** MAII scorelog2(20/2520*10)=-3.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP34 [Title/Abstract] AND USP34 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP34

GO:0016579

protein deubiquitination

14715245

HgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

HgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061

TgeneUSP34

GO:0016579

protein deubiquitination

14715245

TgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

TgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF885872USP34chr2

61417674

-USP34chr2

61417753

+
ChiTaRS3.1AW296692USP34chr2

61417775

-USP34chr2

61417838

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398571ENST00000398571USP34chr2

61417674

-USP34chr2

61417753

+
intron-intronENST00000398571ENST00000472689USP34chr2

61417674

-USP34chr2

61417753

+
intron-3CDSENST00000472689ENST00000398571USP34chr2

61417674

-USP34chr2

61417753

+
intron-intronENST00000472689ENST00000472689USP34chr2

61417674

-USP34chr2

61417753

+
intron-intronENST00000398571ENST00000398571USP34chr2

61417775

-USP34chr2

61417838

+
intron-intronENST00000398571ENST00000472689USP34chr2

61417775

-USP34chr2

61417838

+
intron-intronENST00000472689ENST00000398571USP34chr2

61417775

-USP34chr2

61417838

+
intron-intronENST00000472689ENST00000472689USP34chr2

61417775

-USP34chr2

61417838

+

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FusionProtFeatures for USP34_USP34


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP34

Q70CQ2

USP34

Q70CQ2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP34_USP34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP34_USP34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP34_USP34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP34_USP34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource