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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41090

FusionGeneSummary for USP34_RFC4

check button Fusion gene summary
Fusion gene informationFusion gene name: USP34_RFC4
Fusion gene ID: 41090
HgeneTgene
Gene symbol

USP34

RFC4

Gene ID

9736

5984

Gene nameubiquitin specific peptidase 34replication factor C subunit 4
Synonyms-A1|RFC37
Cytomap

2p15

3q27.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34replication factor C subunit 4A1 37 kDa subunitRF-C 37 kDa subunitRFC 37 kDa subunitactivator 1 37 kDa subunitactivator 1 subunit 4replication factor C (activator 1) 4, 37kDareplication factor C 37 kDa subunit
Modification date2018052320180523
UniProtAcc

Q70CQ2

P35249

Ensembl transtripts involved in fusion geneENST00000398571, ENST00000472689, 
ENST00000433496, ENST00000392481, 
ENST00000296273, 
Fusion gene scores* DoF score18 X 14 X 10=25203 X 3 X 2=18
# samples 203
** MAII scorelog2(20/2520*10)=-3.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: USP34 [Title/Abstract] AND RFC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP34

GO:0016579

protein deubiquitination

14715245

HgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

HgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061

TgeneRFC4

GO:1900264

positive regulation of DNA-directed DNA polymerase activity

12930902


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV347166USP34chr2

61667113

-RFC4chr3

186509629

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398571ENST00000433496USP34chr2

61667113

-RFC4chr3

186509629

-
intron-3CDSENST00000398571ENST00000392481USP34chr2

61667113

-RFC4chr3

186509629

-
intron-3CDSENST00000398571ENST00000296273USP34chr2

61667113

-RFC4chr3

186509629

-
intron-3CDSENST00000472689ENST00000433496USP34chr2

61667113

-RFC4chr3

186509629

-
intron-3CDSENST00000472689ENST00000392481USP34chr2

61667113

-RFC4chr3

186509629

-
intron-3CDSENST00000472689ENST00000296273USP34chr2

61667113

-RFC4chr3

186509629

-

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FusionProtFeatures for USP34_RFC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP34

Q70CQ2

RFC4

P35249

The elongation of primed DNA templates by DNA polymerasedelta and epsilon requires the action of the accessory proteinsproliferating cell nuclear antigen (PCNA) and activator 1. Thissubunit may be involved in the elongation of the multiprimed DNAtemplate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP34_RFC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP34_RFC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP34_RFC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP34_RFC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource