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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4109

FusionGeneSummary for BDP1_BDP1

check button Fusion gene summary
Fusion gene informationFusion gene name: BDP1_BDP1
Fusion gene ID: 4109
HgeneTgene
Gene symbol

BDP1

BDP1

Gene ID

55814

55814

Gene nameB double prime 1, subunit of RNA polymerase III transcription initiation factor IIIBB double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
SynonymsHSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNRHSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR
Cytomap

5q13.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear
Modification date2018052320180523
UniProtAcc

A6H8Y1

A6H8Y1

Ensembl transtripts involved in fusion geneENST00000358731, ENST00000380675, 
ENST00000358731, ENST00000380675, 
Fusion gene scores* DoF score4 X 5 X 3=603 X 4 X 3=36
# samples 64
** MAII scorelog2(6/60*10)=0log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BDP1 [Title/Abstract] AND BDP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA056281BDP1chr5

70808255

+BDP1chr5

70798399

+
ChiTaRS3.1AB033067BDP1chr5

70807178

+BDP1chr5

70787755

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358731ENST00000358731BDP1chr5

70808255

+BDP1chr5

70798399

+
5CDS-intronENST00000358731ENST00000380675BDP1chr5

70808255

+BDP1chr5

70798399

+
5UTR-intronENST00000380675ENST00000358731BDP1chr5

70808255

+BDP1chr5

70798399

+
5UTR-intronENST00000380675ENST00000380675BDP1chr5

70808255

+BDP1chr5

70798399

+
intron-intronENST00000358731ENST00000358731BDP1chr5

70807178

+BDP1chr5

70787755

+
intron-intronENST00000358731ENST00000380675BDP1chr5

70807178

+BDP1chr5

70787755

+
intron-intronENST00000380675ENST00000358731BDP1chr5

70807178

+BDP1chr5

70787755

+
intron-intronENST00000380675ENST00000380675BDP1chr5

70807178

+BDP1chr5

70787755

+

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FusionProtFeatures for BDP1_BDP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BDP1

A6H8Y1

BDP1

A6H8Y1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BDP1_BDP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BDP1_BDP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BDP1_BDP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BDP1_BDP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource