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Fusion gene ID: 41086 |
FusionGeneSummary for USP34_HSDL2 |
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Fusion gene information | Fusion gene name: USP34_HSDL2 | Fusion gene ID: 41086 | Hgene | Tgene | Gene symbol | USP34 | HSDL2 | Gene ID | 9736 | 84263 |
Gene name | ubiquitin specific peptidase 34 | hydroxysteroid dehydrogenase like 2 | |
Synonyms | - | C9orf99|SDR13C1 | |
Cytomap | 2p15 | 9q32 | |
Type of gene | protein-coding | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34 | hydroxysteroid dehydrogenase-like protein 2short chain dehydrogenase/reductase family 13C member 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q70CQ2 | Q6YN16 | |
Ensembl transtripts involved in fusion gene | ENST00000398571, ENST00000472689, | ENST00000398805, ENST00000398803, ENST00000488101, ENST00000262542, ENST00000539114, | |
Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 5 X 6 X 5=150 |
# samples | 20 | 6 | |
** MAII score | log2(20/2520*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: USP34 [Title/Abstract] AND HSDL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | USP34 | GO:0016579 | protein deubiquitination | 14715245 |
Hgene | USP34 | GO:0071108 | protein K48-linked deubiquitination | 21383061 |
Hgene | USP34 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 21383061 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE148707 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000398571 | ENST00000398805 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000398571 | ENST00000398803 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000398571 | ENST00000488101 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000398571 | ENST00000262542 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000398571 | ENST00000539114 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000472689 | ENST00000398805 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000472689 | ENST00000398803 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000472689 | ENST00000488101 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000472689 | ENST00000262542 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
intron-intron | ENST00000472689 | ENST00000539114 | USP34 | chr2 | 61483546 | + | HSDL2 | chr9 | 115190711 | - |
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FusionProtFeatures for USP34_HSDL2 |
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Hgene | Tgene |
USP34 | HSDL2 |
Has apparently no steroid dehydrogenase activity.{ECO:0000269|PubMed:19703561}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP34_HSDL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP34_HSDL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP34_HSDL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP34_HSDL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HSDL2 | C0023903 | Liver neoplasms | 1 | CTD_human |